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The map label for this gene is lexA [H]

Identifier: 126696785

GI number: 126696785

Start: 1218918

End: 1219535

Strand: Reverse

Name: lexA [H]

Synonym: P9301_14471

Alternate gene names: 126696785

Gene position: 1219535-1218918 (Counterclockwise)

Preceding gene: 126696786

Following gene: 126696784

Centisome position: 74.28

GC content: 36.08

Gene sequence:

>618_bases
GTGATAACTTCTTCAGGCGATAAACTTACAGTTGCTCAAAGTGCTCTTTATGGATGGATTAAAGATTACATGAGAGAATA
TCAGCATAGTCCATCAATCAGACAGATGATGCAAGCTATGGGCTTAAAGTCTCCAGCCCCAATTCAAAGTCGATTAAAAC
ATTTACAAGAAAAGGGATATATTTCATGGCAAGAAGGAAAAGCTAGAACTCTGCAAATAATTGATGAAGTCTTAGAAGGA
GTTCCGATTATGGGGTCAGTTGCTGCAGGGGGTTTGATTGATACTTATTCAGATGTACAAGAAAATTTGGACATTTCAGA
AGTTTTGAAAAAGAAGGATATTTTTGCACTGAGCGTCAACGGAGATTCAATGATTGATGCCTTTATAGCTCATGGTGATA
TGGTCTTGATGGAGCCAATTTTAGATTCATATTCTTTGAGAAATGGAATGATTGTTAGTGCATTGGTTCCAGGACTTGGG
ACTACATTGAAATATTTTTTTAAAAAAGGAAGACAGATATCTTTAGAGGCCGCTAATCCAGCTTATGAACCTATTCTTAT
AGATCAAGATCAAGTTTCGATTCAAGGAAAGTTACTTGCTGTATGGAGAAAAATGTAA

Upstream 100 bases:

>100_bases
TGCACGCTCAACAAGCACTTTTAGCATGTCTTCTTGCATAAAAAAAACTTGCTTTTTACCTCGTAAAAAGGTACAAATGT
ATTAGTAATTAAATTTTTCT

Downstream 100 bases:

>100_bases
TTTTTTATTTAAGAAGAATCGATCATTTAACGTATAATAAATATAAAATCTCTGAAAATATTGAATAAGTTAAAATTAAG
AAATTTTTTAATCTATTTAC

Product: SOS function regulatory protein, LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MITSSGDKLTVAQSALYGWIKDYMREYQHSPSIRQMMQAMGLKSPAPIQSRLKHLQEKGYISWQEGKARTLQIIDEVLEG
VPIMGSVAAGGLIDTYSDVQENLDISEVLKKKDIFALSVNGDSMIDAFIAHGDMVLMEPILDSYSLRNGMIVSALVPGLG
TTLKYFFKKGRQISLEAANPAYEPILIDQDQVSIQGKLLAVWRKM

Sequences:

>Translated_205_residues
MITSSGDKLTVAQSALYGWIKDYMREYQHSPSIRQMMQAMGLKSPAPIQSRLKHLQEKGYISWQEGKARTLQIIDEVLEG
VPIMGSVAAGGLIDTYSDVQENLDISEVLKKKDIFALSVNGDSMIDAFIAHGDMVLMEPILDSYSLRNGMIVSALVPGLG
TTLKYFFKKGRQISLEAANPAYEPILIDQDQVSIQGKLLAVWRKM
>Mature_205_residues
MITSSGDKLTVAQSALYGWIKDYMREYQHSPSIRQMMQAMGLKSPAPIQSRLKHLQEKGYISWQEGKARTLQIIDEVLEG
VPIMGSVAAGGLIDTYSDVQENLDISEVLKKKDIFALSVNGDSMIDAFIAHGDMVLMEPILDSYSLRNGMIVSALVPGLG
TTLKYFFKKGRQISLEAANPAYEPILIDQDQVSIQGKLLAVWRKM

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=199, Percent_Identity=29.6482412060301, Blast_Score=87, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 22769; Mature: 22769

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITSSGDKLTVAQSALYGWIKDYMREYQHSPSIRQMMQAMGLKSPAPIQSRLKHLQEKGY
CCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
ISWQEGKARTLQIIDEVLEGVPIMGSVAAGGLIDTYSDVQENLDISEVLKKKDIFALSVN
EEECCCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHCCCHHHHHHHCCEEEEEEC
GDSMIDAFIAHGDMVLMEPILDSYSLRNGMIVSALVPGLGTTLKYFFKKGRQISLEAANP
CCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEHHHHHCCHHHHHHHHHHCCCEEEEECCCC
AYEPILIDQDQVSIQGKLLAVWRKM
CCCCEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MITSSGDKLTVAQSALYGWIKDYMREYQHSPSIRQMMQAMGLKSPAPIQSRLKHLQEKGY
CCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
ISWQEGKARTLQIIDEVLEGVPIMGSVAAGGLIDTYSDVQENLDISEVLKKKDIFALSVN
EEECCCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHCCCHHHHHHHCCEEEEEEC
GDSMIDAFIAHGDMVLMEPILDSYSLRNGMIVSALVPGLGTTLKYFFKKGRQISLEAANP
CCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEHHHHHCCHHHHHHHHHHCCCEEEEECCCC
AYEPILIDQDQVSIQGKLLAVWRKM
CCCCEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA