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The map label for this gene is glmU [H]

Identifier: 126696743

GI number: 126696743

Start: 1172930

End: 1174000

Strand: Reverse

Name: glmU [H]

Synonym: P9301_14051

Alternate gene names: 126696743

Gene position: 1174000-1172930 (Counterclockwise)

Preceding gene: 126696744

Following gene: 126696737

Centisome position: 71.5

GC content: 26.61

Gene sequence:

>1071_bases
ATGAAAAGGAATTTTTTTATTAAAAACTGTAGAGATTTTTCTGTAAACATTAAGGATAATGTAGGGGAAGCTATTCAAAA
GATAAATAAAGGTGGCTTCCAAATTTGTCTAGTTTTTAACGAGCAAAATTATTTGGAAGGAATAATAACTGATAGTGATT
TAAGAAGAGGAATTTTAAATGGCGTTTCAAAAAGTAGTAAATTATCTGATGTAATAAACTATCAACCTATTAAAGTTCAT
GAATTTTTATCAGAAGAAAAAATTTATAGATTAATGATAAAGAATCATATTTTTCATATACCTTTAGTTGATGAAAATAA
TAAATTTAAGGGCATCTTTGTTTCTAATAATTTAATAGAAGAGAGTTTTATTAATGAAACCTTTTTTATATTAGCTGGAG
GTAAAGGTTTAAGAATGAGACCTTTAACTAAAAATCTTCCTAAACCAATGTTGCATATAAGTGGTAAGCCAATGATCGAA
TTAATAATTAATAATGCAAAGGAGTTTGGCTTCAGAAATTTTGTCCTGTCAATTGGTTATTTGGGAGAGGTAATAAAGGA
ATATTTTGGTAATGGGGATAAATTTGGGATTAATATAAGCTATATTCAAGAAGAAAAACCCCTGGGGACTGCAGGTTCAT
TAGCATATTTAAAAAAAGATTTGCTTACTGATTATGTTTTTATTACCAATGGTGATGTTGTAACATCATTAGAATATAGT
AATATGTTGAATTTTGCCAAATATACAAAAGCTGATGGAGTAATTGCTGTTAAAGAATTTGGATTGCAAAATCCATTTGG
AGTAATTGAAACTAGTAATGATAATTTTATTGGAATTTCTGAAAAACCAATATATAAATCTACAATTAATGCTGGAGTTT
ATGTTGTTTCAAAAAATTTGATTGGTTTAATAGAAAAGGGGAAACATATTGATATGAATCAATTATTTGAACTAGGTATA
AATAAGAAAAAAATTTTAAAAGTTTTTGCTTTGCATGAAGAATGGACGGATGTAGGAAGACCTGAAGATTATAAAAGGAT
TAGAAATTCAAGTAAAGCTAATGAAATCTAA

Upstream 100 bases:

>100_bases
ATAAAGTTTGTACTTATATAAAAACTATACATATAATTGATTCAAGTATAAAAAAGTTTAGAAAAATCTTTAAAGACTAT
AAATTTAATTTATTGTAAGT

Downstream 100 bases:

>100_bases
TTTACTTGTGATAAAAAATTTTCAAATTTAGAAAAATTTATTTCCTTGAAATATTTTTCATAATACTTTGACTTTAAATA
TATCTTGATGGAACTATCAA

Product: nucleoside-diphosphate-sugar pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MKRNFFIKNCRDFSVNIKDNVGEAIQKINKGGFQICLVFNEQNYLEGIITDSDLRRGILNGVSKSSKLSDVINYQPIKVH
EFLSEEKIYRLMIKNHIFHIPLVDENNKFKGIFVSNNLIEESFINETFFILAGGKGLRMRPLTKNLPKPMLHISGKPMIE
LIINNAKEFGFRNFVLSIGYLGEVIKEYFGNGDKFGINISYIQEEKPLGTAGSLAYLKKDLLTDYVFITNGDVVTSLEYS
NMLNFAKYTKADGVIAVKEFGLQNPFGVIETSNDNFIGISEKPIYKSTINAGVYVVSKNLIGLIEKGKHIDMNQLFELGI
NKKKILKVFALHEEWTDVGRPEDYKRIRNSSKANEI

Sequences:

>Translated_356_residues
MKRNFFIKNCRDFSVNIKDNVGEAIQKINKGGFQICLVFNEQNYLEGIITDSDLRRGILNGVSKSSKLSDVINYQPIKVH
EFLSEEKIYRLMIKNHIFHIPLVDENNKFKGIFVSNNLIEESFINETFFILAGGKGLRMRPLTKNLPKPMLHISGKPMIE
LIINNAKEFGFRNFVLSIGYLGEVIKEYFGNGDKFGINISYIQEEKPLGTAGSLAYLKKDLLTDYVFITNGDVVTSLEYS
NMLNFAKYTKADGVIAVKEFGLQNPFGVIETSNDNFIGISEKPIYKSTINAGVYVVSKNLIGLIEKGKHIDMNQLFELGI
NKKKILKVFALHEEWTDVGRPEDYKRIRNSSKANEI
>Mature_356_residues
MKRNFFIKNCRDFSVNIKDNVGEAIQKINKGGFQICLVFNEQNYLEGIITDSDLRRGILNGVSKSSKLSDVINYQPIKVH
EFLSEEKIYRLMIKNHIFHIPLVDENNKFKGIFVSNNLIEESFINETFFILAGGKGLRMRPLTKNLPKPMLHISGKPMIE
LIINNAKEFGFRNFVLSIGYLGEVIKEYFGNGDKFGINISYIQEEKPLGTAGSLAYLKKDLLTDYVFITNGDVVTSLEYS
NMLNFAKYTKADGVIAVKEFGLQNPFGVIETSNDNFIGISEKPIYKSTINAGVYVVSKNLIGLIEKGKHIDMNQLFELGI
NKKKILKVFALHEEWTDVGRPEDYKRIRNSSKANEI

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=227, Percent_Identity=31.7180616740088, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI11761619, Length=227, Percent_Identity=31.7180616740088, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI133931050, Length=226, Percent_Identity=33.1858407079646, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17509979, Length=185, Percent_Identity=30.8108108108108, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17509981, Length=178, Percent_Identity=29.7752808988764, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=226, Percent_Identity=33.6283185840708, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21355443, Length=226, Percent_Identity=30.0884955752212, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24644084, Length=226, Percent_Identity=30.0884955752212, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24653912, Length=196, Percent_Identity=30.6122448979592, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 40461; Mature: 40461

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRNFFIKNCRDFSVNIKDNVGEAIQKINKGGFQICLVFNEQNYLEGIITDSDLRRGILN
CCCCEEEECCCEEEEEECHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCHHHHHHHHH
GVSKSSKLSDVINYQPIKVHEFLSEEKIYRLMIKNHIFHIPLVDENNKFKGIFVSNNLIE
HCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCHHH
ESFINETFFILAGGKGLRMRPLTKNLPKPMLHISGKPMIELIINNAKEFGFRNFVLSIGY
HHHCCCEEEEEECCCCCEECCHHHCCCCCEEEECCCCEEEEEECCHHHCCHHHHHHHHHH
LGEVIKEYFGNGDKFGINISYIQEEKPLGTAGSLAYLKKDLLTDYVFITNGDVVTSLEYS
HHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHCEEEEECCCEEEEEEHH
NMLNFAKYTKADGVIAVKEFGLQNPFGVIETSNDNFIGISEKPIYKSTINAGVYVVSKNL
HHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCEEECCCCCCCHHHCCCCEEEEECCH
IGLIEKGKHIDMNQLFELGINKKKILKVFALHEEWTDVGRPEDYKRIRNSSKANEI
HHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKRNFFIKNCRDFSVNIKDNVGEAIQKINKGGFQICLVFNEQNYLEGIITDSDLRRGILN
CCCCEEEECCCEEEEEECHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCHHHHHHHHH
GVSKSSKLSDVINYQPIKVHEFLSEEKIYRLMIKNHIFHIPLVDENNKFKGIFVSNNLIE
HCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCHHH
ESFINETFFILAGGKGLRMRPLTKNLPKPMLHISGKPMIELIINNAKEFGFRNFVLSIGY
HHHCCCEEEEEECCCCCEECCHHHCCCCCEEEECCCCEEEEEECCHHHCCHHHHHHHHHH
LGEVIKEYFGNGDKFGINISYIQEEKPLGTAGSLAYLKKDLLTDYVFITNGDVVTSLEYS
HHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHCEEEEECCCEEEEEEHH
NMLNFAKYTKADGVIAVKEFGLQNPFGVIETSNDNFIGISEKPIYKSTINAGVYVVSKNL
HHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCEEECCCCCCCHHHCCCCEEEEECCH
IGLIEKGKHIDMNQLFELGINKKKILKVFALHEEWTDVGRPEDYKRIRNSSKANEI
HHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]