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The map label for this gene is guaB [C]

Identifier: 126696506

GI number: 126696506

Start: 977462

End: 978625

Strand: Reverse

Name: guaB [C]

Synonym: P9301_11681

Alternate gene names: 126696506

Gene position: 978625-977462 (Counterclockwise)

Preceding gene: 126696509

Following gene: 126696505

Centisome position: 59.6

GC content: 39.43

Gene sequence:

>1164_bases
GTGAATAATGAACTTGGTTTAAATAAAGAAGTCAGACGGGCTTATGGCATTGATGAAATAGCTTTAGTCCCTGGTAAAAG
AACACTTGATTACGATTTGACTGATCCTTCTTGGTCAATAGGTGATTTCAAAAGAGAAGTTCCGATCGTAGCTAGTGCCA
TGGATAGTGTTGTCGATGTCAATACAGCTGTAGAGCTCACAAAATTAGGTTCCCTAGGGGTTATTAATATGGAGGGCGTA
CAAACACGATATGAAAACCCTGATGAAATATTGAAGCAAATAGCATCAGTTGGGAAGAATGATTTTGTTCCATTAATGCA
GAAAATATACAGTGAACCGGTCAAGGAAGGATTGATTTTAAAAAGAATAAATGAGGTCAAAGAAAGAGGAGGTATCGCAG
CTTTTAGTGGGACTCCTCAAGCCGCCATCAAGTTTAAAGAAACACTAAATAATTCCAAAATAGATTTATTTTTTCTTCAA
GGAACAGTTGTTTCAACTGAACATCTTGGAATGGAAGGTAAGGAAACCTTAAATATTAAAGATCTCTGCCAATCTATGAA
TGTTCCAGTTGTAGCTGGTAATTGTGTTACTTACGAAGTTGCAAAACTTCTCATGAATGCTGGAGTTGCGGGATTGATGG
TTGGGATAGGACCAGGAGCAGCATGTACATCAAGAGGAGTATTGGGAATTGGAATCCCTCAAGCAACTGCAATTGCTGAT
TGTAGTGCGGCAAGAAATGATTACTTTGAAGAAAGTGGTCGTTATATACCTATTATTGGTGATGGAGGAATTGTTACTGG
CGGAGATATTTGTAAATGTTTAGCATGTGGAGCAGATGCAGTAATGATTGGATCACCAATAGCTAAATCTTCAAACGCCC
CAGGTAAAGGATTTCACTGGGGTATGGCTACTCCAAGTCCAGTGTTGCCGAGGGGCACAAGAATTGAAGTTGGTTCTACA
GGATCCTTGGAAAGGATAATTAAAGGCCCGGCCCTACTTGATGATGGGACACATAACTTATTAGGAGCCATTAGAACATC
AATGAGTACTCTTGGTGCAAAAAATATTAAAGAAATGCAAGAAGTTGAAATAGTTATCGCACCATCGCTTCTTACTGAGG
GTAAGGTTTATCAAAAAGCTCAGCAGCTCGGGATGGGTAAGTAG

Upstream 100 bases:

>100_bases
CATTTACACACAAATCAAAATAAAACCTGTTGTTTTTGAATAAACCTTGGCTTATTACCCCTTTAGTTGTTAATTTAATC
AGAATAAAAAGAAAACTATC

Downstream 100 bases:

>100_bases
TTCATCTAGAGCAAAATGAGAAAAAACCTTAGTGAATAAGTTATTAAATTGAAAAATTTTCTAATTAGGAGTTATTATTA
AATGATGGGGGAAACCCCAT

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MNNELGLNKEVRRAYGIDEIALVPGKRTLDYDLTDPSWSIGDFKREVPIVASAMDSVVDVNTAVELTKLGSLGVINMEGV
QTRYENPDEILKQIASVGKNDFVPLMQKIYSEPVKEGLILKRINEVKERGGIAAFSGTPQAAIKFKETLNNSKIDLFFLQ
GTVVSTEHLGMEGKETLNIKDLCQSMNVPVVAGNCVTYEVAKLLMNAGVAGLMVGIGPGAACTSRGVLGIGIPQATAIAD
CSAARNDYFEESGRYIPIIGDGGIVTGGDICKCLACGADAVMIGSPIAKSSNAPGKGFHWGMATPSPVLPRGTRIEVGST
GSLERIIKGPALLDDGTHNLLGAIRTSMSTLGAKNIKEMQEVEIVIAPSLLTEGKVYQKAQQLGMGK

Sequences:

>Translated_387_residues
MNNELGLNKEVRRAYGIDEIALVPGKRTLDYDLTDPSWSIGDFKREVPIVASAMDSVVDVNTAVELTKLGSLGVINMEGV
QTRYENPDEILKQIASVGKNDFVPLMQKIYSEPVKEGLILKRINEVKERGGIAAFSGTPQAAIKFKETLNNSKIDLFFLQ
GTVVSTEHLGMEGKETLNIKDLCQSMNVPVVAGNCVTYEVAKLLMNAGVAGLMVGIGPGAACTSRGVLGIGIPQATAIAD
CSAARNDYFEESGRYIPIIGDGGIVTGGDICKCLACGADAVMIGSPIAKSSNAPGKGFHWGMATPSPVLPRGTRIEVGST
GSLERIIKGPALLDDGTHNLLGAIRTSMSTLGAKNIKEMQEVEIVIAPSLLTEGKVYQKAQQLGMGK
>Mature_387_residues
MNNELGLNKEVRRAYGIDEIALVPGKRTLDYDLTDPSWSIGDFKREVPIVASAMDSVVDVNTAVELTKLGSLGVINMEGV
QTRYENPDEILKQIASVGKNDFVPLMQKIYSEPVKEGLILKRINEVKERGGIAAFSGTPQAAIKFKETLNNSKIDLFFLQ
GTVVSTEHLGMEGKETLNIKDLCQSMNVPVVAGNCVTYEVAKLLMNAGVAGLMVGIGPGAACTSRGVLGIGIPQATAIAD
CSAARNDYFEESGRYIPIIGDGGIVTGGDICKCLACGADAVMIGSPIAKSSNAPGKGFHWGMATPSPVLPRGTRIEVGST
GSLERIIKGPALLDDGTHNLLGAIRTSMSTLGAKNIKEMQEVEIVIAPSLLTEGKVYQKAQQLGMGK

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. [C

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=258, Percent_Identity=31.3953488372093, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI50541954, Length=377, Percent_Identity=25.4641909814324, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI50541952, Length=377, Percent_Identity=25.4641909814324, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI50541948, Length=377, Percent_Identity=25.4641909814324, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI50541956, Length=384, Percent_Identity=25.2604166666667, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI217035150, Length=113, Percent_Identity=43.3628318584071, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI217035146, Length=113, Percent_Identity=43.3628318584071, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI217035152, Length=112, Percent_Identity=43.75, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI34328930, Length=112, Percent_Identity=43.75, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI217035148, Length=113, Percent_Identity=43.3628318584071, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI34328928, Length=112, Percent_Identity=43.75, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156616279, Length=112, Percent_Identity=43.75, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156104880, Length=190, Percent_Identity=29.4736842105263, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786293, Length=354, Percent_Identity=25.7062146892655, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788855, Length=241, Percent_Identity=29.8755186721992, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994385, Length=142, Percent_Identity=38.7323943661972, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71994389, Length=142, Percent_Identity=38.7323943661972, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17560440, Length=187, Percent_Identity=30.4812834224599, Blast_Score=79, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6322012, Length=112, Percent_Identity=36.6071428571429, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323464, Length=113, Percent_Identity=35.3982300884956, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323585, Length=113, Percent_Identity=34.5132743362832, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24641071, Length=168, Percent_Identity=36.3095238095238, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24641073, Length=168, Percent_Identity=36.3095238095238, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28571163, Length=170, Percent_Identity=35.8823529411765, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 41011; Mature: 41011

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNELGLNKEVRRAYGIDEIALVPGKRTLDYDLTDPSWSIGDFKREVPIVASAMDSVVDV
CCCCCCCCHHHHHHCCCCCEEECCCCCEEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHH
NTAVELTKLGSLGVINMEGVQTRYENPDEILKQIASVGKNDFVPLMQKIYSEPVKEGLIL
HHHHHHEECCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KRINEVKERGGIAAFSGTPQAAIKFKETLNNSKIDLFFLQGTVVSTEHLGMEGKETLNIK
HHHHHHHHHCCEEEECCCCHHHHHHHHHCCCCCEEEEEEECEEEEHHHCCCCCCCCCCHH
DLCQSMNVPVVAGNCVTYEVAKLLMNAGVAGLMVGIGPGAACTSRGVLGIGIPQATAIAD
HHHHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEECCCCHHHHHH
CSAARNDYFEESGRYIPIIGDGGIVTGGDICKCLACGADAVMIGSPIAKSSNAPGKGFHW
HHHHHHHHHHHCCCEEEEEECCCEEECHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEC
GMATPSPVLPRGTRIEVGSTGSLERIIKGPALLDDGTHNLLGAIRTSMSTLGAKNIKEMQ
CCCCCCCCCCCCCEEEECCCCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHCHHHHHHHH
EVEIVIAPSLLTEGKVYQKAQQLGMGK
HEEEEEECCHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure
MNNELGLNKEVRRAYGIDEIALVPGKRTLDYDLTDPSWSIGDFKREVPIVASAMDSVVDV
CCCCCCCCHHHHHHCCCCCEEECCCCCEEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHH
NTAVELTKLGSLGVINMEGVQTRYENPDEILKQIASVGKNDFVPLMQKIYSEPVKEGLIL
HHHHHHEECCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KRINEVKERGGIAAFSGTPQAAIKFKETLNNSKIDLFFLQGTVVSTEHLGMEGKETLNIK
HHHHHHHHHCCEEEECCCCHHHHHHHHHCCCCCEEEEEEECEEEEHHHCCCCCCCCCCHH
DLCQSMNVPVVAGNCVTYEVAKLLMNAGVAGLMVGIGPGAACTSRGVLGIGIPQATAIAD
HHHHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEECCCCHHHHHH
CSAARNDYFEESGRYIPIIGDGGIVTGGDICKCLACGADAVMIGSPIAKSSNAPGKGFHW
HHHHHHHHHHHCCCEEEEEECCCEEECHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEC
GMATPSPVLPRGTRIEVGSTGSLERIIKGPALLDDGTHNLLGAIRTSMSTLGAKNIKEMQ
CCCCCCCCCCCCCEEEECCCCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHCHHHHHHHH
EVEIVIAPSLLTEGKVYQKAQQLGMGK
HEEEEEECCHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA