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The map label for this gene is ilvA [H]

Identifier: 126696289

GI number: 126696289

Start: 818628

End: 820169

Strand: Reverse

Name: ilvA [H]

Synonym: P9301_09511

Alternate gene names: 126696289

Gene position: 820169-818628 (Counterclockwise)

Preceding gene: 126696291

Following gene: 126696288

Centisome position: 49.95

GC content: 32.49

Gene sequence:

>1542_bases
ATGGATGATTATTTTGAAAAAATACTTCAAGCTGAAGTCTATGAAGTCGCAAAAAAAACACCACTAGAGAAAGCTCATAA
TTTAAGTAATACACTTAATAATGAAGTTTTTCTAAAAAGAGAAGATCTTCAGGATGTATTTTCATTCAAAATAAGAGGTG
CCTATAACAAAATGAGTAAGCTCACTAATTCACAGCTTGCTCAGGGAGTAATTACTTCTAGTGCTGGTAATCATGCTCAA
GGGGTTGCACTAAGTGCCCTTAAGTTAAATTGCCAAGCAACCATATTAATGCCCATTACCACACCTCTAGTAAAAGTTAA
TGCAGTAAAAAATTTAAAAGCAAAAGTTATATTATATGGCGATAACTATGATGAAACCTACAGAGAGGCAATAAGGATTA
GCCAAGAAAGAAATTTATGCTTCATTCATCCCTTTGATGATCCAGAAGTAATAGCAGGACAAGGTACTATAGCTATAGAA
CTTGAACAGCAGCTTAATGAAAAACCTTATGCAATTTATATTGCTGTAGGTGGTGGGGGATTGATATCAGGAATATCCTT
ATACGTTAAAAAAATATGGCCTGAAGTAAAAATAATTGGTGTAGAGCCTGAAGATGCAGACGCTATGACGAAATCCTTGG
AAGAAGAAAAAATTGTTGAACTATCTTCTGTTGGTCAATTTGCAGATGGAGTGGCGGTAAAAAAAATTGGTAAAAATACT
TTTGATATTGGTAGAAAGTATATAGATAAGATGATTAGGGTTAATACTGACGAAATCTGTGCTGCTATAAAAGATGTTTT
TGAGGATACTAGATCAATACTAGAACCTGCAGGTGCCTTATCAATTGCGGGAATGAAAAAAGATATTTTTAATTCGAATC
ATTCAAATAGAAAAATGGTTGCGATTGCATGTGGTGCAAATATGAATTTTGAGAGGCTTAGATTTGTTGCAGAAAGAGCA
GAACTTGGAGAGTGTAAAGAAGTAATGTTGGCTGTTGAAATTCCTGAACGTGCTGGTAGTCTTATTGATTTTTGTAAGTT
ACTTGATAGTAGAAATTTAACTGAATTTAGCTATAGGATGTCGAATTCTAAGAATGCACAGATCTTTGTAGGGGTTCAAG
TTTATGGTTTAAATGATAAAAAAAATCTATTAAATGTATTTAGAAATTCTGAGTACTCATTTATTGACATAAGTGATGAT
GAATTATCTAAAAATCATCTCAGACATATGGTAGGTGGAAGATTACCAAGGGATTTTAAAGAGATGGAATATAGAAACTT
TATTGAACTTTTATACAGATTTGAGTTTCCTGAAAGGCCTGGCGCATTAATAAACTTCTTAAATAATATGAAATCTAATT
GGTCTATAAGCGTATTTCACTACAGGAATTATGGAGCTGATGTAGGGAAAATTGTTATTGGAGTTTTGATCGATAAAAAT
GAGATTTTAGAGTGGAATAATTTTGTAAAAATTCTAGGCTATAAATTCTGGGATGAAACGCAAAACGATACATATAGATT
ATTCCTTGGTGCATCAGATTAA

Upstream 100 bases:

>100_bases
TCTATATAATCTAAAACGCCGAGGTGCAAAATGAGTATTTTTTTTGAAATAGATCATGTAATGTTTTATTAGATTAATAA
TTAATGCTAAAAATATATAT

Downstream 100 bases:

>100_bases
ATTTAAGGTAAATTAGGAAAGATTTCGGTAATTAAAATCAATCAATCTGATATAAATACCACGCCAATATCTGATATAGA
TCTAGTTACAAAAGTTGAAG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MDDYFEKILQAEVYEVAKKTPLEKAHNLSNTLNNEVFLKREDLQDVFSFKIRGAYNKMSKLTNSQLAQGVITSSAGNHAQ
GVALSALKLNCQATILMPITTPLVKVNAVKNLKAKVILYGDNYDETYREAIRISQERNLCFIHPFDDPEVIAGQGTIAIE
LEQQLNEKPYAIYIAVGGGGLISGISLYVKKIWPEVKIIGVEPEDADAMTKSLEEEKIVELSSVGQFADGVAVKKIGKNT
FDIGRKYIDKMIRVNTDEICAAIKDVFEDTRSILEPAGALSIAGMKKDIFNSNHSNRKMVAIACGANMNFERLRFVAERA
ELGECKEVMLAVEIPERAGSLIDFCKLLDSRNLTEFSYRMSNSKNAQIFVGVQVYGLNDKKNLLNVFRNSEYSFIDISDD
ELSKNHLRHMVGGRLPRDFKEMEYRNFIELLYRFEFPERPGALINFLNNMKSNWSISVFHYRNYGADVGKIVIGVLIDKN
EILEWNNFVKILGYKFWDETQNDTYRLFLGASD

Sequences:

>Translated_513_residues
MDDYFEKILQAEVYEVAKKTPLEKAHNLSNTLNNEVFLKREDLQDVFSFKIRGAYNKMSKLTNSQLAQGVITSSAGNHAQ
GVALSALKLNCQATILMPITTPLVKVNAVKNLKAKVILYGDNYDETYREAIRISQERNLCFIHPFDDPEVIAGQGTIAIE
LEQQLNEKPYAIYIAVGGGGLISGISLYVKKIWPEVKIIGVEPEDADAMTKSLEEEKIVELSSVGQFADGVAVKKIGKNT
FDIGRKYIDKMIRVNTDEICAAIKDVFEDTRSILEPAGALSIAGMKKDIFNSNHSNRKMVAIACGANMNFERLRFVAERA
ELGECKEVMLAVEIPERAGSLIDFCKLLDSRNLTEFSYRMSNSKNAQIFVGVQVYGLNDKKNLLNVFRNSEYSFIDISDD
ELSKNHLRHMVGGRLPRDFKEMEYRNFIELLYRFEFPERPGALINFLNNMKSNWSISVFHYRNYGADVGKIVIGVLIDKN
EILEWNNFVKILGYKFWDETQNDTYRLFLGASD
>Mature_513_residues
MDDYFEKILQAEVYEVAKKTPLEKAHNLSNTLNNEVFLKREDLQDVFSFKIRGAYNKMSKLTNSQLAQGVITSSAGNHAQ
GVALSALKLNCQATILMPITTPLVKVNAVKNLKAKVILYGDNYDETYREAIRISQERNLCFIHPFDDPEVIAGQGTIAIE
LEQQLNEKPYAIYIAVGGGGLISGISLYVKKIWPEVKIIGVEPEDADAMTKSLEEEKIVELSSVGQFADGVAVKKIGKNT
FDIGRKYIDKMIRVNTDEICAAIKDVFEDTRSILEPAGALSIAGMKKDIFNSNHSNRKMVAIACGANMNFERLRFVAERA
ELGECKEVMLAVEIPERAGSLIDFCKLLDSRNLTEFSYRMSNSKNAQIFVGVQVYGLNDKKNLLNVFRNSEYSFIDISDD
ELSKNHLRHMVGGRLPRDFKEMEYRNFIELLYRFEFPERPGALINFLNNMKSNWSISVFHYRNYGADVGKIVIGVLIDKN
EILEWNNFVKILGYKFWDETQNDTYRLFLGASD

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=300, Percent_Identity=34.6666666666667, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI33469958, Length=311, Percent_Identity=29.903536977492, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI19923959, Length=332, Percent_Identity=27.4096385542169, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1790207, Length=510, Percent_Identity=46.8627450980392, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1789505, Length=315, Percent_Identity=37.1428571428571, Blast_Score=178, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI71991565, Length=327, Percent_Identity=31.4984709480122, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17537387, Length=330, Percent_Identity=31.8181818181818, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17508781, Length=296, Percent_Identity=27.3648648648649, Blast_Score=122, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320930, Length=524, Percent_Identity=45.6106870229008, Blast_Score=448, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6322631, Length=304, Percent_Identity=36.1842105263158, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6319788, Length=327, Percent_Identity=27.82874617737, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322024, Length=188, Percent_Identity=28.1914893617021, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21355833, Length=331, Percent_Identity=35.3474320241692, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24645328, Length=252, Percent_Identity=34.1269841269841, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 58100; Mature: 58100

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDYFEKILQAEVYEVAKKTPLEKAHNLSNTLNNEVFLKREDLQDVFSFKIRGAYNKMSK
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCHHHHHHH
LTNSQLAQGVITSSAGNHAQGVALSALKLNCQATILMPITTPLVKVNAVKNLKAKVILYG
HHHHHHHHHHHCCCCCCCCCCEEEEEEEECCEEEEEEECCCCEEEEEEECCCEEEEEEEE
DNYDETYREAIRISQERNLCFIHPFDDPEVIAGQGTIAIELEQQLNEKPYAIYIAVGGGG
CCCCHHHHHHHHHHCCCCEEEEECCCCCCEEECCCEEEEEEHHHCCCCCEEEEEEECCCH
LISGISLYVKKIWPEVKIIGVEPEDADAMTKSLEEEKIVELSSVGQFADGVAVKKIGKNT
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCHHHHHHHHHCCHHHCCHHHHHHCCCH
FDIGRKYIDKMIRVNTDEICAAIKDVFEDTRSILEPAGALSIAGMKKDIFNSNHSNRKMV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHCCCCCCCEEE
AIACGANMNFERLRFVAERAELGECKEVMLAVEIPERAGSLIDFCKLLDSRNLTEFSYRM
EEEECCCCCHHHHHHHHHHHHHCCHHEEEEEEECCHHHCHHHHHHHHHCCCCCCHHHHHH
SNSKNAQIFVGVQVYGLNDKKNLLNVFRNSEYSFIDISDDELSKNHLRHMVGGRLPRDFK
CCCCCCEEEEEEEEEECCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHH
EMEYRNFIELLYRFEFPERPGALINFLNNMKSNWSISVFHYRNYGADVGKIVIGVLIDKN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCHHHEEEEEEECCC
EILEWNNFVKILGYKFWDETQNDTYRLFLGASD
HHHHHHHHHHHHCCHHCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MDDYFEKILQAEVYEVAKKTPLEKAHNLSNTLNNEVFLKREDLQDVFSFKIRGAYNKMSK
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCHHHHHHH
LTNSQLAQGVITSSAGNHAQGVALSALKLNCQATILMPITTPLVKVNAVKNLKAKVILYG
HHHHHHHHHHHCCCCCCCCCCEEEEEEEECCEEEEEEECCCCEEEEEEECCCEEEEEEEE
DNYDETYREAIRISQERNLCFIHPFDDPEVIAGQGTIAIELEQQLNEKPYAIYIAVGGGG
CCCCHHHHHHHHHHCCCCEEEEECCCCCCEEECCCEEEEEEHHHCCCCCEEEEEEECCCH
LISGISLYVKKIWPEVKIIGVEPEDADAMTKSLEEEKIVELSSVGQFADGVAVKKIGKNT
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCHHHHHHHHHCCHHHCCHHHHHHCCCH
FDIGRKYIDKMIRVNTDEICAAIKDVFEDTRSILEPAGALSIAGMKKDIFNSNHSNRKMV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHCCCCCCCEEE
AIACGANMNFERLRFVAERAELGECKEVMLAVEIPERAGSLIDFCKLLDSRNLTEFSYRM
EEEECCCCCHHHHHHHHHHHHHCCHHEEEEEEECCHHHCHHHHHHHHHCCCCCCHHHHHH
SNSKNAQIFVGVQVYGLNDKKNLLNVFRNSEYSFIDISDDELSKNHLRHMVGGRLPRDFK
CCCCCCEEEEEEEEEECCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHH
EMEYRNFIELLYRFEFPERPGALINFLNNMKSNWSISVFHYRNYGADVGKIVIGVLIDKN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCHHHEEEEEEECCC
EILEWNNFVKILGYKFWDETQNDTYRLFLGASD
HHHHHHHHHHHHCCHHCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA