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The map label for this gene is umuC [H]

Identifier: 126696259

GI number: 126696259

Start: 793253

End: 794539

Strand: Reverse

Name: umuC [H]

Synonym: P9301_09211

Alternate gene names: 126696259

Gene position: 794539-793253 (Counterclockwise)

Preceding gene: 126696260

Following gene: 126696258

Centisome position: 48.39

GC content: 31.0

Gene sequence:

>1287_bases
ATGAGAATTTCAAATATTGATGCAATAGCTCTTATAGATGCTAATAATTTTTACGCGTCATGCGAACAAAATATTAATCC
TCATTTGAGAAATAAACCAGTAGTAATTTTATCTAATAATGACGGATGTATCATTGCAAGAAGTCCTGAAGCGCGAGCTT
TAAAAATTAAAATGGGAACTCCGTATTTTAAGGTCAAAGAAAGATTAAATAAATTAGATGTAGCAGTCTTAAGCTCAAAC
TACTCGCTTTACGGCGATATTAGCAGAAGACTAATGAATTTACTGAAAAACTATTGTGAAGATATAGAAATTTATTCTAT
TGACGAAGCATTCGTCTCGATTTGCAGGCCTAATGATGAAAATCTATATCCTTGGGCAAGAAGCATAAGATCATTAATAT
ATCAGAATCTAGGGATTACCATAACAGTAGGAATAGGGGAAAATAAAGTAAGAGCAAAAATTGCTAATAAACTAGCTAAA
AATATTGATTATTCAGCTGGAATATTTGATTTAGCTAGAACCGAAAATGAGAATAATTATTTGAAAGGAATTAGTATAGA
TAAGATATGGGGAGTCGGGAAACAAACCTCTAATTGGTTACAAAGTAAAGGTATTAAAAATGCGAGAGAACTAAGAGATA
TGGAAGAAAATGAAATCATTAAGAAATTAGGCATCGTAGGGAAAAGACTGCAATTAGAACTTAAAGGCCATAGATGCCTG
CCCATAGAAAAAAACAAGAAATCAAAAAAAGAAATTCAGGTGAGCAGGAGTTTCGGCACGCCTATCACAAAATTAGAAGA
CTTAACTCAAGCACTGGCGGTTCACGCAATAAAAGCCTCTGAAAAAATGAGAAGTCAGAATTTGCAATCATCTGATATTA
GAGTATTTGCCAGAACCAGTAAATATTCAAGTCAAAATTATCAAAGAAGTGCTCATAGAAAACTTACAAATGCAACAGAT
GACACAAATAAAATTTTAAAAATAGTAGTTGAATTATCTAAAGAAATTTATAATCCCGAATATAAATTCTCAAAAGCTGG
CGTTTTAATGCAGGATTTAACTAATAGCGAATATTTACAGCAATCAGTTATCAATTACAAATCTCAGAAAGACTTAAAAA
AATCAGCAAATCTTATGAGAACGATTGATTTATTAAATAAAAGATTTAATAACAATGCAATTACATGGGCCATTACAAAA
AATCCACAAAGTTGGAAGATGAATAAGAATTTCTTAAGTCGCTCATCTACAACTGATATAGAACAAATCCCAACTATAAT
GAAGTAA

Upstream 100 bases:

>100_bases
ATTTAAAAGCAGAAAATCATAATTATCCTGATTTTAGATTTAAAAACCATATTGATGTACAGATATGGGGAGTTGTTATT
TATTCAATACATAGCTATTT

Downstream 100 bases:

>100_bases
ACAAAATAGAATGGAATTTATATTATTTTTGAGCAAATTAGATAAAGAGATTCTTAACTTATTAAATAAAGCAAACTACA
TAGTTGAAGAAAATAAAATT

Product: putative UmuC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MRISNIDAIALIDANNFYASCEQNINPHLRNKPVVILSNNDGCIIARSPEARALKIKMGTPYFKVKERLNKLDVAVLSSN
YSLYGDISRRLMNLLKNYCEDIEIYSIDEAFVSICRPNDENLYPWARSIRSLIYQNLGITITVGIGENKVRAKIANKLAK
NIDYSAGIFDLARTENENNYLKGISIDKIWGVGKQTSNWLQSKGIKNARELRDMEENEIIKKLGIVGKRLQLELKGHRCL
PIEKNKKSKKEIQVSRSFGTPITKLEDLTQALAVHAIKASEKMRSQNLQSSDIRVFARTSKYSSQNYQRSAHRKLTNATD
DTNKILKIVVELSKEIYNPEYKFSKAGVLMQDLTNSEYLQQSVINYKSQKDLKKSANLMRTIDLLNKRFNNNAITWAITK
NPQSWKMNKNFLSRSSTTDIEQIPTIMK

Sequences:

>Translated_428_residues
MRISNIDAIALIDANNFYASCEQNINPHLRNKPVVILSNNDGCIIARSPEARALKIKMGTPYFKVKERLNKLDVAVLSSN
YSLYGDISRRLMNLLKNYCEDIEIYSIDEAFVSICRPNDENLYPWARSIRSLIYQNLGITITVGIGENKVRAKIANKLAK
NIDYSAGIFDLARTENENNYLKGISIDKIWGVGKQTSNWLQSKGIKNARELRDMEENEIIKKLGIVGKRLQLELKGHRCL
PIEKNKKSKKEIQVSRSFGTPITKLEDLTQALAVHAIKASEKMRSQNLQSSDIRVFARTSKYSSQNYQRSAHRKLTNATD
DTNKILKIVVELSKEIYNPEYKFSKAGVLMQDLTNSEYLQQSVINYKSQKDLKKSANLMRTIDLLNKRFNNNAITWAITK
NPQSWKMNKNFLSRSSTTDIEQIPTIMK
>Mature_428_residues
MRISNIDAIALIDANNFYASCEQNINPHLRNKPVVILSNNDGCIIARSPEARALKIKMGTPYFKVKERLNKLDVAVLSSN
YSLYGDISRRLMNLLKNYCEDIEIYSIDEAFVSICRPNDENLYPWARSIRSLIYQNLGITITVGIGENKVRAKIANKLAK
NIDYSAGIFDLARTENENNYLKGISIDKIWGVGKQTSNWLQSKGIKNARELRDMEENEIIKKLGIVGKRLQLELKGHRCL
PIEKNKKSKKEIQVSRSFGTPITKLEDLTQALAVHAIKASEKMRSQNLQSSDIRVFARTSKYSSQNYQRSAHRKLTNATD
DTNKILKIVVELSKEIYNPEYKFSKAGVLMQDLTNSEYLQQSVINYKSQKDLKKSANLMRTIDLLNKRFNNNAITWAITK
NPQSWKMNKNFLSRSSTTDIEQIPTIMK

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=418, Percent_Identity=36.3636363636364, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1786425, Length=226, Percent_Identity=24.7787610619469, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19923006, Length=304, Percent_Identity=23.6842105263158, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 48938; Mature: 48938

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISNIDAIALIDANNFYASCEQNINPHLRNKPVVILSNNDGCIIARSPEARALKIKMGT
CCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCEEEEECCCCEEEEECCCCEEEEEEECC
PYFKVKERLNKLDVAVLSSNYSLYGDISRRLMNLLKNYCEDIEIYSIDEAFVSICRPNDE
CHHHHHHHHHHHEEEEEECCCEEEHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCC
NLYPWARSIRSLIYQNLGITITVGIGENKVRAKIANKLAKNIDYSAGIFDLARTENENNY
CCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCE
LKGISIDKIWGVGKQTSNWLQSKGIKNARELRDMEENEIIKKLGIVGKRLQLELKGHRCL
EECCCHHHHHCCCCHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCCCCEEEEEECCCEEC
PIEKNKKSKKEIQVSRSFGTPITKLEDLTQALAVHAIKASEKMRSQNLQSSDIRVFARTS
CCCCCCCCHHHEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
KYSSQNYQRSAHRKLTNATDDTNKILKIVVELSKEIYNPEYKFSKAGVLMQDLTNSEYLQ
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHCCCHHHHH
QSVINYKSQKDLKKSANLMRTIDLLNKRFNNNAITWAITKNPQSWKMNKNFLSRSSTTDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCCCCCH
EQIPTIMK
HHCCHHCC
>Mature Secondary Structure
MRISNIDAIALIDANNFYASCEQNINPHLRNKPVVILSNNDGCIIARSPEARALKIKMGT
CCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCEEEEECCCCEEEEECCCCEEEEEEECC
PYFKVKERLNKLDVAVLSSNYSLYGDISRRLMNLLKNYCEDIEIYSIDEAFVSICRPNDE
CHHHHHHHHHHHEEEEEECCCEEEHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCC
NLYPWARSIRSLIYQNLGITITVGIGENKVRAKIANKLAKNIDYSAGIFDLARTENENNY
CCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCE
LKGISIDKIWGVGKQTSNWLQSKGIKNARELRDMEENEIIKKLGIVGKRLQLELKGHRCL
EECCCHHHHHCCCCHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCCCCEEEEEECCCEEC
PIEKNKKSKKEIQVSRSFGTPITKLEDLTQALAVHAIKASEKMRSQNLQSSDIRVFARTS
CCCCCCCCHHHEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
KYSSQNYQRSAHRKLTNATDDTNKILKIVVELSKEIYNPEYKFSKAGVLMQDLTNSEYLQ
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHCCCHHHHH
QSVINYKSQKDLKKSANLMRTIDLLNKRFNNNAITWAITKNPQSWKMNKNFLSRSSTTDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCCCCCH
EQIPTIMK
HHCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]