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The map label for this gene is msrA [H]

Identifier: 126696241

GI number: 126696241

Start: 775552

End: 776280

Strand: Reverse

Name: msrA [H]

Synonym: P9301_09031

Alternate gene names: 126696241

Gene position: 776280-775552 (Counterclockwise)

Preceding gene: 126696242

Following gene: 126696239

Centisome position: 47.28

GC content: 30.45

Gene sequence:

>729_bases
ATGTTTAAATTCCTAAAAAATATTATGAATAATGAGGAGTCAAATTTAACTAATGATCCATATTCATTACATAGAGTATT
AAAAACAGATATCAAAAAAGATCCTAATGAAAAAGAAGATGAAATAATTTTTGGATGTGGTTGTTTCTGGGGAGCCGAAA
AATGTTTTTGGAAACTTCCAGGAGTTATCACAACTTCTGTGGGTTATGCTGGAGGTGAAAAAATCAATCCAACTTATTAT
GAAGTTTGTTCCGGCTTAACTGGTCATTCAGAAGTAGTAAGAGTTATATGGGATAAAAGGGAAATAGATGTAAGTGATTT
ATTAAAAATGTTTTGGGAATGTCATGACCCTACCCAAAAAAACAGGCAAGGAAATGATATGGGAACACAATATAGATCAG
CAATATATTATAAAAATGAAAATAACATTAATACTATATTAGCCAGTAAGGAACAATATCAAACGGAACTAAGCAAAAAA
AATCTTGGTTTAATTGAAACGGAAATAAAAATGATTGATTCATATTTTTATGCGGAACAATACCATCAACAATATCTTGC
ATCAGCTGGAAGCAGACAGTATTGTTCTGCTTCACCTACAAAAGTTAAGTTAGGAGTTTTTACTGGAAGTGATTATAAGT
TAGAGGACCATATATGGGAAAACTTTAATTGGGAAGTTGAAAAGTGCGTATTGAGATCTGATAACAATCCTATAAAGAAT
AACATTTAA

Upstream 100 bases:

>100_bases
GTGAATGGGCTATATAAACAACTTTGGGAAAGAGAACTAGCTACTAAAATTGTTAAGAGCTAAAAAGAAATTTATTTACT
TATAATAATATTTTTAAATT

Downstream 100 bases:

>100_bases
ATCAATCTAATCTTTATAGTAAAGACACGGGGCGTAGCGCAGTTTGGTAGCGCACCACTTTGGGGTAGTGGGGGTCGTGG
GTTCAAATCCCGCCGTTCCG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MFKFLKNIMNNEESNLTNDPYSLHRVLKTDIKKDPNEKEDEIIFGCGCFWGAEKCFWKLPGVITTSVGYAGGEKINPTYY
EVCSGLTGHSEVVRVIWDKREIDVSDLLKMFWECHDPTQKNRQGNDMGTQYRSAIYYKNENNINTILASKEQYQTELSKK
NLGLIETEIKMIDSYFYAEQYHQQYLASAGSRQYCSASPTKVKLGVFTGSDYKLEDHIWENFNWEVEKCVLRSDNNPIKN
NI

Sequences:

>Translated_242_residues
MFKFLKNIMNNEESNLTNDPYSLHRVLKTDIKKDPNEKEDEIIFGCGCFWGAEKCFWKLPGVITTSVGYAGGEKINPTYY
EVCSGLTGHSEVVRVIWDKREIDVSDLLKMFWECHDPTQKNRQGNDMGTQYRSAIYYKNENNINTILASKEQYQTELSKK
NLGLIETEIKMIDSYFYAEQYHQQYLASAGSRQYCSASPTKVKLGVFTGSDYKLEDHIWENFNWEVEKCVLRSDNNPIKN
NI
>Mature_242_residues
MFKFLKNIMNNEESNLTNDPYSLHRVLKTDIKKDPNEKEDEIIFGCGCFWGAEKCFWKLPGVITTSVGYAGGEKINPTYY
EVCSGLTGHSEVVRVIWDKREIDVSDLLKMFWECHDPTQKNRQGNDMGTQYRSAIYYKNENNINTILASKEQYQTELSKK
NLGLIETEIKMIDSYFYAEQYHQQYLASAGSRQYCSASPTKVKLGVFTGSDYKLEDHIWENFNWEVEKCVLRSDNNPIKN
NI

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=170, Percent_Identity=52.3529411764706, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI208609995, Length=170, Percent_Identity=52.3529411764706, Blast_Score=178, Evalue=4e-45,
Organism=Homo sapiens, GI208609993, Length=120, Percent_Identity=50, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI1790665, Length=166, Percent_Identity=48.7951807228916, Blast_Score=160, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17533973, Length=142, Percent_Identity=36.6197183098592, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=172, Percent_Identity=36.046511627907, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24664627, Length=157, Percent_Identity=34.3949044585987, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24664631, Length=157, Percent_Identity=33.7579617834395, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45553131, Length=144, Percent_Identity=34.7222222222222, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 28100; Mature: 28100

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKFLKNIMNNEESNLTNDPYSLHRVLKTDIKKDPNEKEDEIIFGCGCFWGAEKCFWKLP
CHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHCCHHHHHHCC
GVITTSVGYAGGEKINPTYYEVCSGLTGHSEVVRVIWDKREIDVSDLLKMFWECHDPTQK
CCEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHC
NRQGNDMGTQYRSAIYYKNENNINTILASKEQYQTELSKKNLGLIETEIKMIDSYFYAEQ
CCCCCHHHHHHHHEEEEECCCCCEEEEECHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
YHQQYLASAGSRQYCSASPTKVKLGVFTGSDYKLEDHIWENFNWEVEKCVLRSDNNPIKN
HHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCEEHHHHHCCCCCEEHHHEEECCCCCCCC
NI
CC
>Mature Secondary Structure
MFKFLKNIMNNEESNLTNDPYSLHRVLKTDIKKDPNEKEDEIIFGCGCFWGAEKCFWKLP
CHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHCCHHHHHHCC
GVITTSVGYAGGEKINPTYYEVCSGLTGHSEVVRVIWDKREIDVSDLLKMFWECHDPTQK
CCEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHC
NRQGNDMGTQYRSAIYYKNENNINTILASKEQYQTELSKKNLGLIETEIKMIDSYFYAEQ
CCCCCHHHHHHHHEEEEECCCCCEEEEECHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
YHQQYLASAGSRQYCSASPTKVKLGVFTGSDYKLEDHIWENFNWEVEKCVLRSDNNPIKN
HHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCEEHHHHHCCCCCEEHHHEEECCCCCCCC
NI
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA