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The map label for this gene is sir [H]

Identifier: 126696156

GI number: 126696156

Start: 706348

End: 708135

Strand: Reverse

Name: sir [H]

Synonym: P9301_08181

Alternate gene names: 126696156

Gene position: 708135-706348 (Counterclockwise)

Preceding gene: 126696158

Following gene: 126696144

Centisome position: 43.13

GC content: 33.61

Gene sequence:

>1788_bases
TTGATCAAGGTTGAGAAAGTAAAAAAGAAAAAAGATTCTGCAAAGGAAGAGACTGTTTGTTTAGCAAATGGACTAGAAGT
CTCTAAATTTGAAAATTTTAAGAAAAGTAGCCAATTTCTTAAGGAGCCACTTGCTACAGAATTAGTCAATGAAAGTGATC
ATTTTACTAATGATGCAGTCCAGTTATTAAAATTTCATGGTAGTTATCAACAAGATAACAGGGAAAATAGAAGGCCGGGC
AAAAGTAAAGATTGGCAAATGATGCTTAGGTTAAGAAATCCGGGTGGTGAAGTCCCTGGGAAATTATTTTTAGCATTAGA
TGAATTATCTGACAAACTAGGTAATGGAACACTTAGGGCCACTACAAGACAAGCCTTTCAAATGCATGGAATCAGAAAGG
AGAAGCTGAAGGAAGTAATTCAAACAATAGTAAATTCAATGGGCTCCACATTAGCTGCATGTGGAGACATTAATAGAAAC
GTTATGGCACCTGCGGCTCCATTTGACTCGCCAGAATATAATATTGCAAGAGCATTGGCAAAAAAAGTTGCAGATCTTCT
CACCCCAATGGCTGGCCAAGGCACTTTCTTAGAGCTTTGGGCTGACGGAGATTTAGAGTACACCATAAAGCCTGACAAAG
ATATTGAAGCAATTAGGAAGCTCCAATTCAAAGATAATGTTTTTAGTGGAATAAAAGATGAGCCTCTTTATGGTTCAACT
TATTTACCGAGAAAATTCAAATGTGCTGTGACAGTTCCTGGGGACAATTCTGTTGATCTTCTTACTAATGACATAGGAAT
AGTTGCCTTTACTTCTAAAGATGGAAACTTAGAAGGGTGCAACTTCTATGTTGGAGGTGGTATGGGTCGCACACATAATA
ATGAGGAGACCTTTGCCAGAATTGCAGATCCACTTGGATATGTTGAAGAACCTGATGTTTATGAATTAATACAAAGCATT
GTGGCTATTCAAAGAGATTATGGTGATAGAAAATCAAGAAAAAATTCGAGAATGAAATATCTTCTTCATAAAAAAGGTAT
TAAATGGTTCAAAAAGATACTTTCTGATAAATATTTCAAAAAAGAAATTAAAAAAATTAGAAAAGAACCTGATAAGGCTC
TTATTGATTACCTAGGTTGGCATAAACAAAATAAAACCTCCCATTTCGTAGGTTTACCATTATTATCGGGAAGATTATCT
GGAGAGAAGAAGAATACCATCTCGAGTATTGTTAAAAAATATAATTTAGATTTAAGACTCACACCTAATCAAGATATTTT
ACTTTGTAATATCGCCAATAAAAACAAAAGCGCAATTCAAAATTCTCTTTCAAAAATTGGATACGAAAATTTAGATAACA
TTAATGAAATACAAAGACACGCTTTAGCTTGTCCTGCTTTACCACTTTGTGGTCTTGCAATGACTGAAGCTGAAAGAATA
TTACCTGATGTACTAAAAAGGATTGAAAATTTACTTTTAGATCTAAAAATACAAAAGACAATATTATTTAGAATGACAGG
ATGTCCGAATGGATGTACCAGGCCTTATATGGCCGAATTAGCACTTGTTGGTAGTGGGCAAAACAAATACCAATTATGGT
TGGGGGGAAGTAAAAATCTACAAAGGCTTGCTAAACCATTTTTACAAAGAATGGAACTTAACGATTTAGAAAAAACTCTA
CAACCATTATTTGATAATTGGAAGAGTAATTTGGATTTGGATTTCGGAGATTTTATAAATACTCAAGATGAAAATTATAT
ATTAAATTTACTAAATGAAAATCAATAG

Upstream 100 bases:

>100_bases
AATATTTAGACAAGAAAAAAATATGACTATTCTTACTATAATTTACTACCAGTTAAATAAGCTTTTCGCTAATGTATAAA
AAGAGATATGTTTTGGTCCT

Downstream 100 bases:

>100_bases
AATTTAAATTTTTCCATAAAGGGCATTTGCTTTTTTATTTTTCCAAGCCCATAATTGATCACCATAACTAAAATGCCACC
ATTCATTAGGATGTTGAGCA

Product: sulfite reductase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MIKVEKVKKKKDSAKEETVCLANGLEVSKFENFKKSSQFLKEPLATELVNESDHFTNDAVQLLKFHGSYQQDNRENRRPG
KSKDWQMMLRLRNPGGEVPGKLFLALDELSDKLGNGTLRATTRQAFQMHGIRKEKLKEVIQTIVNSMGSTLAACGDINRN
VMAPAAPFDSPEYNIARALAKKVADLLTPMAGQGTFLELWADGDLEYTIKPDKDIEAIRKLQFKDNVFSGIKDEPLYGST
YLPRKFKCAVTVPGDNSVDLLTNDIGIVAFTSKDGNLEGCNFYVGGGMGRTHNNEETFARIADPLGYVEEPDVYELIQSI
VAIQRDYGDRKSRKNSRMKYLLHKKGIKWFKKILSDKYFKKEIKKIRKEPDKALIDYLGWHKQNKTSHFVGLPLLSGRLS
GEKKNTISSIVKKYNLDLRLTPNQDILLCNIANKNKSAIQNSLSKIGYENLDNINEIQRHALACPALPLCGLAMTEAERI
LPDVLKRIENLLLDLKIQKTILFRMTGCPNGCTRPYMAELALVGSGQNKYQLWLGGSKNLQRLAKPFLQRMELNDLEKTL
QPLFDNWKSNLDLDFGDFINTQDENYILNLLNENQ

Sequences:

>Translated_595_residues
MIKVEKVKKKKDSAKEETVCLANGLEVSKFENFKKSSQFLKEPLATELVNESDHFTNDAVQLLKFHGSYQQDNRENRRPG
KSKDWQMMLRLRNPGGEVPGKLFLALDELSDKLGNGTLRATTRQAFQMHGIRKEKLKEVIQTIVNSMGSTLAACGDINRN
VMAPAAPFDSPEYNIARALAKKVADLLTPMAGQGTFLELWADGDLEYTIKPDKDIEAIRKLQFKDNVFSGIKDEPLYGST
YLPRKFKCAVTVPGDNSVDLLTNDIGIVAFTSKDGNLEGCNFYVGGGMGRTHNNEETFARIADPLGYVEEPDVYELIQSI
VAIQRDYGDRKSRKNSRMKYLLHKKGIKWFKKILSDKYFKKEIKKIRKEPDKALIDYLGWHKQNKTSHFVGLPLLSGRLS
GEKKNTISSIVKKYNLDLRLTPNQDILLCNIANKNKSAIQNSLSKIGYENLDNINEIQRHALACPALPLCGLAMTEAERI
LPDVLKRIENLLLDLKIQKTILFRMTGCPNGCTRPYMAELALVGSGQNKYQLWLGGSKNLQRLAKPFLQRMELNDLEKTL
QPLFDNWKSNLDLDFGDFINTQDENYILNLLNENQ
>Mature_595_residues
MIKVEKVKKKKDSAKEETVCLANGLEVSKFENFKKSSQFLKEPLATELVNESDHFTNDAVQLLKFHGSYQQDNRENRRPG
KSKDWQMMLRLRNPGGEVPGKLFLALDELSDKLGNGTLRATTRQAFQMHGIRKEKLKEVIQTIVNSMGSTLAACGDINRN
VMAPAAPFDSPEYNIARALAKKVADLLTPMAGQGTFLELWADGDLEYTIKPDKDIEAIRKLQFKDNVFSGIKDEPLYGST
YLPRKFKCAVTVPGDNSVDLLTNDIGIVAFTSKDGNLEGCNFYVGGGMGRTHNNEETFARIADPLGYVEEPDVYELIQSI
VAIQRDYGDRKSRKNSRMKYLLHKKGIKWFKKILSDKYFKKEIKKIRKEPDKALIDYLGWHKQNKTSHFVGLPLLSGRLS
GEKKNTISSIVKKYNLDLRLTPNQDILLCNIANKNKSAIQNSLSKIGYENLDNINEIQRHALACPALPLCGLAMTEAERI
LPDVLKRIENLLLDLKIQKTILFRMTGCPNGCTRPYMAELALVGSGQNKYQLWLGGSKNLQRLAKPFLQRMELNDLEKTL
QPLFDNWKSNLDLDFGDFINTQDENYILNLLNENQ

Specific function: This Enzyme Catalyzes The 6-Electron Reduction Of Sulfite To Sulfide. This Is One Of Several Activities Required For The Biosynthesis Of L-Cysteine From Sulfate. [C]

COG id: COG0155

COG function: function code P; Sulfite reductase, beta subunit (hemoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family [H]

Homologues:

Organism=Escherichia coli, GI1789122, Length=561, Percent_Identity=31.9073083778966, Blast_Score=281, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6322597, Length=575, Percent_Identity=36.5217391304348, Blast_Score=348, Evalue=1e-96,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005117
- InterPro:   IPR006067
- InterPro:   IPR006066
- InterPro:   IPR011787 [H]

Pfam domain/function: PF01077 NIR_SIR; PF03460 NIR_SIR_ferr [H]

EC number: =1.8.7.1 [H]

Molecular weight: Translated: 67405; Mature: 67405

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS00365 NIR_SIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVEKVKKKKDSAKEETVCLANGLEVSKFENFKKSSQFLKEPLATELVNESDHFTNDAV
CCCHHHHHHHHCCHHHHHEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
QLLKFHGSYQQDNRENRRPGKSKDWQMMLRLRNPGGEVPGKLFLALDELSDKLGNGTLRA
HHHHHCCCCCCCCCHHCCCCCCCCHHHHEEECCCCCCCCHHHEEHHHHHHHHHCCCCEEH
TTRQAFQMHGIRKEKLKEVIQTIVNSMGSTLAACGDINRNVMAPAAPFDSPEYNIARALA
HHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
KKVADLLTPMAGQGTFLELWADGDLEYTIKPDKDIEAIRKLQFKDNVFSGIKDEPLYGST
HHHHHHHCCCCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
YLPRKFKCAVTVPGDNSVDLLTNDIGIVAFTSKDGNLEGCNFYVGGGMGRTHNNEETFAR
CCCCEEEEEEECCCCCCCEEEECCCEEEEEECCCCCCCCCEEEEECCCCCCCCCHHHHHH
IADPLGYVEEPDVYELIQSIVAIQRDYGDRKSRKNSRMKYLLHKKGIKWFKKILSDKYFK
HHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KEIKKIRKEPDKALIDYLGWHKQNKTSHFVGLPLLSGRLSGEKKNTISSIVKKYNLDLRL
HHHHHHHCCCHHHHHHHHCCCCCCCCCEEEECHHHCCCCCCCHHHHHHHHHHHHCCCEEE
TPNQDILLCNIANKNKSAIQNSLSKIGYENLDNINEIQRHALACPALPLCGLAMTEAERI
CCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
LPDVLKRIENLLLDLKIQKTILFRMTGCPNGCTRPYMAELALVGSGQNKYQLWLGGSKNL
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHEEECCCCEEEEEECCCCCH
QRLAKPFLQRMELNDLEKTLQPLFDNWKSNLDLDFGDFINTQDENYILNLLNENQ
HHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHCCCCCC
>Mature Secondary Structure
MIKVEKVKKKKDSAKEETVCLANGLEVSKFENFKKSSQFLKEPLATELVNESDHFTNDAV
CCCHHHHHHHHCCHHHHHEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
QLLKFHGSYQQDNRENRRPGKSKDWQMMLRLRNPGGEVPGKLFLALDELSDKLGNGTLRA
HHHHHCCCCCCCCCHHCCCCCCCCHHHHEEECCCCCCCCHHHEEHHHHHHHHHCCCCEEH
TTRQAFQMHGIRKEKLKEVIQTIVNSMGSTLAACGDINRNVMAPAAPFDSPEYNIARALA
HHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
KKVADLLTPMAGQGTFLELWADGDLEYTIKPDKDIEAIRKLQFKDNVFSGIKDEPLYGST
HHHHHHHCCCCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
YLPRKFKCAVTVPGDNSVDLLTNDIGIVAFTSKDGNLEGCNFYVGGGMGRTHNNEETFAR
CCCCEEEEEEECCCCCCCEEEECCCEEEEEECCCCCCCCCEEEEECCCCCCCCCHHHHHH
IADPLGYVEEPDVYELIQSIVAIQRDYGDRKSRKNSRMKYLLHKKGIKWFKKILSDKYFK
HHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KEIKKIRKEPDKALIDYLGWHKQNKTSHFVGLPLLSGRLSGEKKNTISSIVKKYNLDLRL
HHHHHHHCCCHHHHHHHHCCCCCCCCCEEEECHHHCCCCCCCHHHHHHHHHHHHCCCEEE
TPNQDILLCNIANKNKSAIQNSLSKIGYENLDNINEIQRHALACPALPLCGLAMTEAERI
CCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
LPDVLKRIENLLLDLKIQKTILFRMTGCPNGCTRPYMAELALVGSGQNKYQLWLGGSKNL
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHEEECCCCEEEEEECCCCCH
QRLAKPFLQRMELNDLEKTLQPLFDNWKSNLDLDFGDFINTQDENYILNLLNENQ
HHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8347657 [H]