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The map label for this gene is pqqL [C]

Identifier: 126696144

GI number: 126696144

Start: 694525

End: 695769

Strand: Reverse

Name: pqqL [C]

Synonym: P9301_08061

Alternate gene names: 126696144

Gene position: 695769-694525 (Counterclockwise)

Preceding gene: 126696156

Following gene: 126696143

Centisome position: 42.38

GC content: 29.4

Gene sequence:

>1245_bases
ATGAACTTAGGAGATGTTAACTACTACACCCATTCAAGCAAAACTAGATGTGTGTTTGTGGATAATAAAGAATTGCCGCT
TATAAGCATTGATATTTGGTGCAAAGCAGGTTCTTCATTTGAGGATGTTGATAAAAACGGTACTGCTCATTTTCTAGAAC
ATATGATTTTTAAAGGATCTAACAAAATAATGCCAGGTGAGTTTGACCATAAAATTGAATCACTAGGGGGGTTAAGTAAC
GCTTCAACAGGTTATGATGATGTACATTACCATGTCCTTGTTCCACCCAATAACTTTAAAGAATCACTAGCTCTTTTGAC
AAATATTGTTGTTGCTCCAGTTTTTAATCCTGATGAATTTATAAAAGAAAAAGGGGTAGTTATTGATGAAATAAAACAAC
AAAATGATCAGCCTGAAGAAAGATTATTTAATTATTTTTTGAAAAGGATTTGGCTAAATCCTATTTATGGCAATTCGATT
CTGGGAACTGAACATAGTATTAAAAACTTGGAGATAAATGACCTTATTAAATTTCATACCAAACATTACACTACCGAAAA
AATTTGTATTGCAATTGCTGGAAATCTCTCAGAAGATATTTATAAAATTTTTCAAAAAAGTGATTTATCTGGAATAAATA
AAACTCCAAATTCAATAAATCTAAAGAATAAACCTTCTTTAAAAATTAGGAAAGGTAGAGAGTCAGTTAAGTTTGATAAT
TTAGAGTTTTCAAGAATATTTATGGCTTGGTTTATCCCAAACCTCAATAATCAAAAAAATATTATTGGACTTGAGATTTT
AGCATCAATACTCTCTGTTGGAAGAAACAGCAGATTAGTTAAAATTTTAAAAGAAGATAGTAATCTTGTTGAATCGGTAT
ATGTAGATGTAAATGCTGGAGAATTAGGCGGATTATTTATAATGGAAGCAAGTTGTGAGTCCAAAGATATTGATTTAGTA
GAAAAGCAAATTAATAAAACAATTGATGAGATCTCAAATTCTAGAGTCCTGACTTTGGATGAAATAAAAAAAGCAATAAA
TATTGTAAAAAGTAATTATATTTTTAATTTAGAGACATCTACACAACTTTCTTCATTCTTTGGAAATGAACATCTTTGGG
GAAGAAATTCTTCAATAAATAATTTAGAAAGTCATTTAAATTATTGGAGTGATTTGGATAATTTCGAGGAGATCACTAAT
TATATCCGTGAAGAAAAATTCACTTTGGTTGCATCACCTCGCTAA

Upstream 100 bases:

>100_bases
AATAAGTCCAAAATAAGAGGGTCAGTTAATTTTGTTTTAGTTAAAGATTCAGACAACAAGGCTAAAAAGTACCAAAATAG
AATTTAAAGAGAGAACCTAA

Downstream 100 bases:

>100_bases
TGTTAGAAAGATATTTTTTAAATATTAAAAAAAGGAATTTTTCAACTGCTTCAATTTGGATTAAAGGAGGGAGTGATGCG
GATAGTGTTGGCAAAAAAGG

Product: Zn-dependent peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MNLGDVNYYTHSSKTRCVFVDNKELPLISIDIWCKAGSSFEDVDKNGTAHFLEHMIFKGSNKIMPGEFDHKIESLGGLSN
ASTGYDDVHYHVLVPPNNFKESLALLTNIVVAPVFNPDEFIKEKGVVIDEIKQQNDQPEERLFNYFLKRIWLNPIYGNSI
LGTEHSIKNLEINDLIKFHTKHYTTEKICIAIAGNLSEDIYKIFQKSDLSGINKTPNSINLKNKPSLKIRKGRESVKFDN
LEFSRIFMAWFIPNLNNQKNIIGLEILASILSVGRNSRLVKILKEDSNLVESVYVDVNAGELGGLFIMEASCESKDIDLV
EKQINKTIDEISNSRVLTLDEIKKAINIVKSNYIFNLETSTQLSSFFGNEHLWGRNSSINNLESHLNYWSDLDNFEEITN
YIREEKFTLVASPR

Sequences:

>Translated_414_residues
MNLGDVNYYTHSSKTRCVFVDNKELPLISIDIWCKAGSSFEDVDKNGTAHFLEHMIFKGSNKIMPGEFDHKIESLGGLSN
ASTGYDDVHYHVLVPPNNFKESLALLTNIVVAPVFNPDEFIKEKGVVIDEIKQQNDQPEERLFNYFLKRIWLNPIYGNSI
LGTEHSIKNLEINDLIKFHTKHYTTEKICIAIAGNLSEDIYKIFQKSDLSGINKTPNSINLKNKPSLKIRKGRESVKFDN
LEFSRIFMAWFIPNLNNQKNIIGLEILASILSVGRNSRLVKILKEDSNLVESVYVDVNAGELGGLFIMEASCESKDIDLV
EKQINKTIDEISNSRVLTLDEIKKAINIVKSNYIFNLETSTQLSSFFGNEHLWGRNSSINNLESHLNYWSDLDNFEEITN
YIREEKFTLVASPR
>Mature_414_residues
MNLGDVNYYTHSSKTRCVFVDNKELPLISIDIWCKAGSSFEDVDKNGTAHFLEHMIFKGSNKIMPGEFDHKIESLGGLSN
ASTGYDDVHYHVLVPPNNFKESLALLTNIVVAPVFNPDEFIKEKGVVIDEIKQQNDQPEERLFNYFLKRIWLNPIYGNSI
LGTEHSIKNLEINDLIKFHTKHYTTEKICIAIAGNLSEDIYKIFQKSDLSGINKTPNSINLKNKPSLKIRKGRESVKFDN
LEFSRIFMAWFIPNLNNQKNIIGLEILASILSVGRNSRLVKILKEDSNLVESVYVDVNAGELGGLFIMEASCESKDIDLV
EKQINKTIDEISNSRVLTLDEIKKAINIVKSNYIFNLETSTQLSSFFGNEHLWGRNSSINNLESHLNYWSDLDNFEEITN
YIREEKFTLVASPR

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=400, Percent_Identity=25.25, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI46593007, Length=384, Percent_Identity=20.8333333333333, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71999683, Length=190, Percent_Identity=27.3684210526316, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17553678, Length=415, Percent_Identity=20.9638554216867, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323192, Length=359, Percent_Identity=23.6768802228412, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357875, Length=377, Percent_Identity=23.0769230769231, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24646943, Length=377, Percent_Identity=23.0769230769231, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24641429, Length=289, Percent_Identity=23.5294117647059, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24667786, Length=176, Percent_Identity=26.7045454545455, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 47237; Mature: 47237

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLGDVNYYTHSSKTRCVFVDNKELPLISIDIWCKAGSSFEDVDKNGTAHFLEHMIFKGS
CCCCCCEEEECCCCEEEEEECCCCCCEEEEEEEECCCCCHHHHCCCCHHHHHHHHHHCCC
NKIMPGEFDHKIESLGGLSNASTGYDDVHYHVLVPPNNFKESLALLTNIVVAPVFNPDEF
CCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHEECCCHHHH
IKEKGVVIDEIKQQNDQPEERLFNYFLKRIWLNPIYGNSILGTEHSIKNLEINDLIKFHT
HHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCHHHHHHHHH
KHYTTEKICIAIAGNLSEDIYKIFQKSDLSGINKTPNSINLKNKPSLKIRKGRESVKFDN
HHCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEECC
LEFSRIFMAWFIPNLNNQKNIIGLEILASILSVGRNSRLVKILKEDSNLVESVYVDVNAG
CHHHHHEEHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEHHCCCEEEEEEEEECCC
ELGGLFIMEASCESKDIDLVEKQINKTIDEISNSRVLTLDEIKKAINIVKSNYIFNLETS
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCEEEEECCH
TQLSSFFGNEHLWGRNSSINNLESHLNYWSDLDNFEEITNYIREEKFTLVASPR
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEECCC
>Mature Secondary Structure
MNLGDVNYYTHSSKTRCVFVDNKELPLISIDIWCKAGSSFEDVDKNGTAHFLEHMIFKGS
CCCCCCEEEECCCCEEEEEECCCCCCEEEEEEEECCCCCHHHHCCCCHHHHHHHHHHCCC
NKIMPGEFDHKIESLGGLSNASTGYDDVHYHVLVPPNNFKESLALLTNIVVAPVFNPDEF
CCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHEECCCHHHH
IKEKGVVIDEIKQQNDQPEERLFNYFLKRIWLNPIYGNSILGTEHSIKNLEINDLIKFHT
HHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCHHHHHHHHH
KHYTTEKICIAIAGNLSEDIYKIFQKSDLSGINKTPNSINLKNKPSLKIRKGRESVKFDN
HHCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEECC
LEFSRIFMAWFIPNLNNQKNIIGLEILASILSVGRNSRLVKILKEDSNLVESVYVDVNAG
CHHHHHEEHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEHHCCCEEEEEEEEECCC
ELGGLFIMEASCESKDIDLVEKQINKTIDEISNSRVLTLDEIKKAINIVKSNYIFNLETS
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCEEEEECCH
TQLSSFFGNEHLWGRNSSINNLESHLNYWSDLDNFEEITNYIREEKFTLVASPR
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]