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The map label for this gene is thrS

Identifier: 126695961

GI number: 126695961

Start: 550624

End: 552540

Strand: Reverse

Name: thrS

Synonym: P9301_06231

Alternate gene names: 126695961

Gene position: 552540-550624 (Counterclockwise)

Preceding gene: 126695962

Following gene: 126695960

Centisome position: 33.65

GC content: 31.51

Gene sequence:

>1917_bases
ATGCCAATAATTACCTTGCCTGATGGTTCAAAGAAGGTTTTCGAAAAATCTGTAACTATTTTAGAAATTGCCCAGAGTAT
AGGCGCTGGATTAGCTAAAGCAACAATTGCTGGAAGAGTAAATGATGTTCTTCTTGATGCAACAATTCCTATAAATAAAG
ATTCCAAAGTTGTAATCATCACATCAAAAGATAAAGAAGGAATTGAAATAATAAGGCATTCTTTCGCTCACCTTATTGGT
CATGCAGTTAAACAAATTTACTCTGATATAAAAATGGCGATTGGGCCTGTAATCGAAGATGGTTTTTATTACGATATTTT
CTCTGAATACAGATTTACTCCTGAAGATTTAATAAAAATCGAAAATAGAATTAATAAATTAATAAAAACAAACTATGACG
TTGAAATTTTACAAGTTTCTAAAGAAGAGGCAATTAAAACTTTTAAAGAAAGAGATGAGACTTTTAAATTAAGAATAATT
GAAGAAATTCCTGAAGAAGGTCTCATCAATTTATACAAGCACGAAGAATACATCGACATGTGTAGAGGGCCTCACGTTCC
TAACACTAGACATTTGAGACACTTTAAATTACTTAAATTATCAGGTTCATATTGGAGAGGTAATAGTGAGAATGAATCAT
TACAGAGAATATATGGAACTGCATGGGCAAAAGAAAAAGAACTCAAAGATTATTTAACAAGAATTGAAGAAGCGGAAAAA
AGAGATCACAGAAAACTTGGTAAAAAACATTCACTATTTCACATACAAGAAGAATCTCCAGGAATGATTTTTTGGCATCC
AAATGGATGGACAATCTACCAAGTACTTGAAAAGTACATAAGAGAAATACTCAAAAAAAATGATTATTTAGAAATCAAAA
CCCCACAAGCTGTTGATAAATCTCTTTGGGAAAAATCCGGTCATTGGGAGAAATTTAGAGACGATATGTTCACTACTGCA
TCAGAAAATCGAACATATGCGATTAAACCAATGAATTGTCCATGCCATATTCAAGTATTTAATCAAGGTTTAAAAAGTTA
TAAAGATTTACCAATTCGTCTTGCTGAATTTGGTTCTTGTCACAGAAACGAGCCCTCAGGTGCACTACATGGTTTGATGA
GAGTAAGAAACTTTACTCAAGATGATGCACACATATTCTGTACAGAAGAGCAAATTCAAGAAGAGGTATCTACCTTCATA
GATCTTGTTTTCGAAGTTTATAAAACTTTTGGTTTTGATGAAATCATTATAAAATTATCAACACGTCCTGAAAAAAGGGT
AGGTAGTGAAGATATTTGGGATAAATCAGAAGAGGCTCTTACTAAAGCGCTCGATAATAAGAATCTTAAATGGGAACTAC
AACCTGGAGAAGGTGCTTTTTATGGTCCAAAAATAGAATTCTCGTTAAAGGATTGTCTTAGTAGAGTTTGGCAATGCGGA
ACTATCCAGGTTGATTTCTCAATGCCTATTAGATTAGATGCAACTTATGTAGATATAGACAATGAAAAAAGAAATCCAGT
TATGCTGCATAGAGCAATTTTAGGATCCTTTGAAAGATTTATAGGAATCTTAATTGAACAATATGAGGCAAAATTCCCAA
TTTGGCTTGCGCCATATCAAATAATTTTGTTAAGCATTACTGATAGAAATATTGAAAAATGTTTAAAGTTTAATGAATTA
ATAAATAATAATGGTTATAGATCAAAAGTTGATATTAGGAATGAAAAAATAGGATATAAAATACGAGAGGCAACTCTTGG
CAGAGTTCCTTTAATTGCAGTTATTGGTGATAAAGAAGAGGAAATTGATTCAGTCGCCTTAAGAGCTTTGAATGGAAAAA
ATTTAGGAATTTTCAATTTACCAAATCTTTTCAAATTAATGGATGAATTAATAGAAAAAAAAGGGAGAACAGAATAA

Upstream 100 bases:

>100_bases
AATCCTTAATGAAGGGAAGGAAAAAGCTGAAGATTTAGCGAATCAGACTTTAAAAAGAGTTAAATCAAAATTGGGATTTT
TTGAAATGGAGAAATAAATT

Downstream 100 bases:

>100_bases
TTTCTTATATATGAATTTTCTTGCTTGTGATTTAGGAGGTACAAAGGTTCTATTAGGAATTTTCAAAAAAGAAATAAATA
ATAATCCGCCTAAGTTAATA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MPIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGRVNDVLLDATIPINKDSKVVIITSKDKEGIEIIRHSFAHLIG
HAVKQIYSDIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKIENRINKLIKTNYDVEILQVSKEEAIKTFKERDETFKLRII
EEIPEEGLINLYKHEEYIDMCRGPHVPNTRHLRHFKLLKLSGSYWRGNSENESLQRIYGTAWAKEKELKDYLTRIEEAEK
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDKSLWEKSGHWEKFRDDMFTTA
SENRTYAIKPMNCPCHIQVFNQGLKSYKDLPIRLAEFGSCHRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFI
DLVFEVYKTFGFDEIIIKLSTRPEKRVGSEDIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLSRVWQCG
TIQVDFSMPIRLDATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQIILLSITDRNIEKCLKFNEL
INNNGYRSKVDIRNEKIGYKIREATLGRVPLIAVIGDKEEEIDSVALRALNGKNLGIFNLPNLFKLMDELIEKKGRTE

Sequences:

>Translated_638_residues
MPIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGRVNDVLLDATIPINKDSKVVIITSKDKEGIEIIRHSFAHLIG
HAVKQIYSDIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKIENRINKLIKTNYDVEILQVSKEEAIKTFKERDETFKLRII
EEIPEEGLINLYKHEEYIDMCRGPHVPNTRHLRHFKLLKLSGSYWRGNSENESLQRIYGTAWAKEKELKDYLTRIEEAEK
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDKSLWEKSGHWEKFRDDMFTTA
SENRTYAIKPMNCPCHIQVFNQGLKSYKDLPIRLAEFGSCHRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFI
DLVFEVYKTFGFDEIIIKLSTRPEKRVGSEDIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLSRVWQCG
TIQVDFSMPIRLDATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQIILLSITDRNIEKCLKFNEL
INNNGYRSKVDIRNEKIGYKIREATLGRVPLIAVIGDKEEEIDSVALRALNGKNLGIFNLPNLFKLMDELIEKKGRTE
>Mature_637_residues
PIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGRVNDVLLDATIPINKDSKVVIITSKDKEGIEIIRHSFAHLIGH
AVKQIYSDIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKIENRINKLIKTNYDVEILQVSKEEAIKTFKERDETFKLRIIE
EIPEEGLINLYKHEEYIDMCRGPHVPNTRHLRHFKLLKLSGSYWRGNSENESLQRIYGTAWAKEKELKDYLTRIEEAEKR
DHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDKSLWEKSGHWEKFRDDMFTTAS
ENRTYAIKPMNCPCHIQVFNQGLKSYKDLPIRLAEFGSCHRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFID
LVFEVYKTFGFDEIIIKLSTRPEKRVGSEDIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLSRVWQCGT
IQVDFSMPIRLDATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQIILLSITDRNIEKCLKFNELI
NNNGYRSKVDIRNEKIGYKIREATLGRVPLIAVIGDKEEEIDSVALRALNGKNLGIFNLPNLFKLMDELIEKKGRTE

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=602, Percent_Identity=41.0299003322259, Blast_Score=475, Evalue=1e-134,
Organism=Homo sapiens, GI38202255, Length=637, Percent_Identity=39.403453689168, Blast_Score=474, Evalue=1e-133,
Organism=Homo sapiens, GI20070344, Length=648, Percent_Identity=35.6481481481481, Blast_Score=409, Evalue=1e-114,
Organism=Escherichia coli, GI1788013, Length=635, Percent_Identity=57.9527559055118, Blast_Score=800, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=161, Percent_Identity=24.8447204968944, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71984192, Length=648, Percent_Identity=40.1234567901235, Blast_Score=483, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71984184, Length=648, Percent_Identity=40.1234567901235, Blast_Score=483, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322112, Length=625, Percent_Identity=37.12, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6322654, Length=393, Percent_Identity=38.4223918575064, Blast_Score=298, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24583839, Length=639, Percent_Identity=38.3411580594679, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24583842, Length=639, Percent_Identity=38.3411580594679, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI28574141, Length=639, Percent_Identity=38.3411580594679, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_PROM0 (A3PBX1)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001090847.1
- ProteinModelPortal:   A3PBX1
- SMR:   A3PBX1
- STRING:   A3PBX1
- GeneID:   4911129
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_06231
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- ProtClustDB:   PRK00413
- BioCyc:   PMAR167546:P9301ORF_0638-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 74056; Mature: 73925

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGRVNDVLLDATIPINKDSKVVII
CCEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCEEEEE
TSKDKEGIEIIRHSFAHLIGHAVKQIYSDIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKI
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCHHHHHHH
ENRINKLIKTNYDVEILQVSKEEAIKTFKERDETFKLRIIEEIPEEGLINLYKHEEYIDM
HHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCEEEEEEHHHCCCCCHHHHHHHHHHHHH
CRGPHVPNTRHLRHFKLLKLSGSYWRGNSENESLQRIYGTAWAKEKELKDYLTRIEEAEK
HCCCCCCCCCCHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDK
HHHHHCCCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHH
SLWEKSGHWEKFRDDMFTTASENRTYAIKPMNCPCHIQVFNQGLKSYKDLPIRLAEFGSC
HHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCCCEEHHHHHHHHHHHCCCCEEHHHHCCC
HRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFIDLVFEVYKTFGFDEIIIKLS
CCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
TRPEKRVGSEDIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLSRVWQCG
CCCCHHCCCCHHCCCHHHHHHHHHCCCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCCC
TIQVDFSMPIRLDATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQ
EEEEEECCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEE
IILLSITDRNIEKCLKFNELINNNGYRSKVDIRNEKIGYKIREATLGRVPLIAVIGDKEE
EEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCCCCCCEEEEECCCHH
EIDSVALRALNGKNLGIFNLPNLFKLMDELIEKKGRTE
HHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGRVNDVLLDATIPINKDSKVVII
CEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCEEEEE
TSKDKEGIEIIRHSFAHLIGHAVKQIYSDIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKI
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCHHHHHHH
ENRINKLIKTNYDVEILQVSKEEAIKTFKERDETFKLRIIEEIPEEGLINLYKHEEYIDM
HHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCEEEEEEHHHCCCCCHHHHHHHHHHHHH
CRGPHVPNTRHLRHFKLLKLSGSYWRGNSENESLQRIYGTAWAKEKELKDYLTRIEEAEK
HCCCCCCCCCCHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDK
HHHHHCCCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHH
SLWEKSGHWEKFRDDMFTTASENRTYAIKPMNCPCHIQVFNQGLKSYKDLPIRLAEFGSC
HHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCCCEEHHHHHHHHHHHCCCCEEHHHHCCC
HRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFIDLVFEVYKTFGFDEIIIKLS
CCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
TRPEKRVGSEDIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLSRVWQCG
CCCCHHCCCCHHCCCHHHHHHHHHCCCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCCC
TIQVDFSMPIRLDATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQ
EEEEEECCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEE
IILLSITDRNIEKCLKFNELINNNGYRSKVDIRNEKIGYKIREATLGRVPLIAVIGDKEE
EEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCCCCCCEEEEECCCHH
EIDSVALRALNGKNLGIFNLPNLFKLMDELIEKKGRTE
HHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA