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The map label for this gene is thrB

Identifier: 126695959

GI number: 126695959

Start: 548622

End: 549569

Strand: Reverse

Name: thrB

Synonym: P9301_06211

Alternate gene names: 126695959

Gene position: 549569-548622 (Counterclockwise)

Preceding gene: 126695960

Following gene: 126695958

Centisome position: 33.47

GC content: 40.4

Gene sequence:

>948_bases
ATGTCTATTCCTGAAGTAGGTAAAAAAATAAGGGTAACAGTGCCTTCCACAACTGCCAATTTAGGGCCTGGATTCGATTG
TCTTGGAGCAGCATTAGATTTATATAATGAATTTATTTTTACAAGAATTGAAGGTGGTGGAGATAGATTTGATTTAATAA
TGGAAAGTACAGATGGTAATCATTTAAGAGGAGGACCTGAAAACTTAGTTTTTAGAGCAGCTCAGAAAGTGTGGGAGAGC
GCAAATATGGATCCTTTTGCACTTGAAGCAAGGGTTAAGTTAGCAGTGCCCCCTGCACGCGGACTTGGTAGTAGTGCTAC
AGCAATAGTTGCTGGACTAATCGGAGCAAATGCAATAATGAACTCTCCGTTGTCCAAAGAAAAACTCCTTGAACTTGCCA
TTGATATAGAAGGTCATCCTGATAATGTAGTGCCCTCTCTGCTTGGTGGGCTATGTTTAACAGCCAGGTCTTCTTCTCAA
AGATGGAGAATCATTAGATGTGAATGGCACTACTCAATTAAAGCTGTTGTAGCAATACCTGCAATTCGTCTAAGCACAAG
TGAAGCAAGAAAGGTTATGCCTAGGAATGTACCTATATCTGATGCAGTGACAAATATGGGGGCACTCACTTTGTTACTAA
ATGGATTAAAGACAGGAAATGAGGAACTCATAAAAGAGGGAATGTTTGATAAGTTACATGAACCGTATAGATGGAAACTT
ATTAAAGGCGGACTAGAAGTCAAAGATGCCGCACTAAATGCAGGTGCTCTAGGATGCGCAATTAGTGGAGCTGGACCAAG
TATCTTAGCTTTGTGTAAAAAAGAAAATGGTAAAAACGTCAGTCAAGCCATGGTTAAGGCATGGGAAATGTCAGGTGTAG
CTAGCAGAGCACCATTCTTAAACGTTCAAACTACAGGCAGCCAATTTAGCACTATCTCTGGTAAGTAG

Upstream 100 bases:

>100_bases
TCTTAAAACAATACCTATAAAAGTAATTTTAGATGAAGAGTTTGGACTTTTTAGTGCAGCCTGCAGAGCAAAAATGCTTT
TAAAAACTTAAAAACAAAAA

Downstream 100 bases:

>100_bases
TTTTACTTAGGCATTTTTAATGTTATAGTCTCAAGCTAGTACAACTTCAACTAGAATAAAAAAATTATTCATTCCATAAA
TGAATTTAGAATCTTTTCCC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSIPEVGKKIRVTVPSTTANLGPGFDCLGAALDLYNEFIFTRIEGGGDRFDLIMESTDGNHLRGGPENLVFRAAQKVWES
ANMDPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIMNSPLSKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQ
RWRIIRCEWHYSIKAVVAIPAIRLSTSEARKVMPRNVPISDAVTNMGALTLLLNGLKTGNEELIKEGMFDKLHEPYRWKL
IKGGLEVKDAALNAGALGCAISGAGPSILALCKKENGKNVSQAMVKAWEMSGVASRAPFLNVQTTGSQFSTISGK

Sequences:

>Translated_315_residues
MSIPEVGKKIRVTVPSTTANLGPGFDCLGAALDLYNEFIFTRIEGGGDRFDLIMESTDGNHLRGGPENLVFRAAQKVWES
ANMDPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIMNSPLSKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQ
RWRIIRCEWHYSIKAVVAIPAIRLSTSEARKVMPRNVPISDAVTNMGALTLLLNGLKTGNEELIKEGMFDKLHEPYRWKL
IKGGLEVKDAALNAGALGCAISGAGPSILALCKKENGKNVSQAMVKAWEMSGVASRAPFLNVQTTGSQFSTISGK
>Mature_314_residues
SIPEVGKKIRVTVPSTTANLGPGFDCLGAALDLYNEFIFTRIEGGGDRFDLIMESTDGNHLRGGPENLVFRAAQKVWESA
NMDPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIMNSPLSKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQR
WRIIRCEWHYSIKAVVAIPAIRLSTSEARKVMPRNVPISDAVTNMGALTLLLNGLKTGNEELIKEGMFDKLHEPYRWKLI
KGGLEVKDAALNAGALGCAISGAGPSILALCKKENGKNVSQAMVKAWEMSGVASRAPFLNVQTTGSQFSTISGK

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=293, Percent_Identity=30.3754266211604, Blast_Score=114, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6321814, Length=338, Percent_Identity=30.7692307692308, Blast_Score=150, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_PROM0 (A3PBW9)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001090845.1
- ProteinModelPortal:   A3PBW9
- SMR:   A3PBW9
- STRING:   A3PBW9
- GeneID:   4911327
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_06211
- eggNOG:   COG0083
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- ProtClustDB:   PRK01212
- BioCyc:   PMAR167546:P9301ORF_0636-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 33579; Mature: 33448

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPEVGKKIRVTVPSTTANLGPGFDCLGAALDLYNEFIFTRIEGGGDRFDLIMESTDGN
CCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCEEEEEEECCCCC
HLRGGPENLVFRAAQKVWESANMDPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIM
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
NSPLSKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQRWRIIRCEWHYSIKAVVAIP
CCCCCHHHHEEEEEECCCCCCCHHHHHHHHHEEEECCCCCCEEEEEEEECCCEEEEEEEC
AIRLSTSEARKVMPRNVPISDAVTNMGALTLLLNGLKTGNEELIKEGMFDKLHEPYRWKL
EEEECCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEE
IKGGLEVKDAALNAGALGCAISGAGPSILALCKKENGKNVSQAMVKAWEMSGVASRAPFL
EECCCEEEHHHCCCCCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEE
NVQTTGSQFSTISGK
EEEECCCCCCCCCCC
>Mature Secondary Structure 
SIPEVGKKIRVTVPSTTANLGPGFDCLGAALDLYNEFIFTRIEGGGDRFDLIMESTDGN
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCEEEEEEECCCCC
HLRGGPENLVFRAAQKVWESANMDPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIM
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
NSPLSKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQRWRIIRCEWHYSIKAVVAIP
CCCCCHHHHEEEEEECCCCCCCHHHHHHHHHEEEECCCCCCEEEEEEEECCCEEEEEEEC
AIRLSTSEARKVMPRNVPISDAVTNMGALTLLLNGLKTGNEELIKEGMFDKLHEPYRWKL
EEEECCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEE
IKGGLEVKDAALNAGALGCAISGAGPSILALCKKENGKNVSQAMVKAWEMSGVASRAPFL
EECCCEEEHHHCCCCCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEE
NVQTTGSQFSTISGK
EEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA