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The map label for this gene is pyrH

Identifier: 126695886

GI number: 126695886

Start: 477922

End: 478626

Strand: Reverse

Name: pyrH

Synonym: P9301_05481

Alternate gene names: 126695886

Gene position: 478626-477922 (Counterclockwise)

Preceding gene: 126695887

Following gene: 126695885

Centisome position: 29.15

GC content: 38.44

Gene sequence:

>705_bases
ATGGCTTACAAAAGAGTTCTCTTAAAACTTAGTGGTGAAGCACTAATGGGTGAAAAACCTTATGGTATTGATCCTGCTAT
AGTCCAGTCAATTGCAGAGGATGTTTCAAAAGTAGTCGAAAATAATGTGCAACTTGCAATAGTTGTTGGGGGCGGGAATA
TTTTTAGGGGGCTTAAAGGGTCTGCAGATGGCATGGATAGAGCTACAGCTGATTATGTTGGAATGCTTGCGACAGTAATG
AATGCTATTTCACTTCAAGATGGCTTAGAAAGGGTAGGAGTTGCAACCAGAGTTCAAACTGCAATAGAAATGCAGGAAAT
TGCCGAACCCTATATCAGAAGAAGAGCTATGAGACACCTTGAAAAAGGGAGAGTTGTGGTCTTCGGAGGTGGATGCGGAA
ATCCATTTTTCACAACTGATACTACAGCGGCTCTTAGGGCAGCGGAGATAAATGCTGAAGTTGTTATGAAGGCGACCAAA
GTTGATGGAGTATATAATTGTGATCCTAATAAATTTAAAGATGCAAAAAAATATTCCTCTCTTAGTTATCAGCAAGTTCT
TAGCGATGAAATTGCAGTAATGGATAGTACTGCAATTGCACTATGCAAAGATAACAATATTCCTATCATGGTATTTGATA
TATTCAAAAAAGGGAACATTTCTAAAGCTGTTGATGGGGATCCTATAGGTTCATTAATTAGTTAA

Upstream 100 bases:

>100_bases
TTTAGGCAAGTTTAGAAATGTTTAAAGACGCAAGCAATCTCTGAACAAAAAATAAATTTGGTGCATTTACTTGCTAAGGT
CTTAAAAGTACAATCATTGA

Downstream 100 bases:

>100_bases
AGCTTATTTAATTTTTTTTATTATGAAAGAACAAGAAATTCAAGAAAATATGAATAAAAGTATTGAAGCCACTCAAAGAA
ACTTTAATACAATTAGGACT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MAYKRVLLKLSGEALMGEKPYGIDPAIVQSIAEDVSKVVENNVQLAIVVGGGNIFRGLKGSADGMDRATADYVGMLATVM
NAISLQDGLERVGVATRVQTAIEMQEIAEPYIRRRAMRHLEKGRVVVFGGGCGNPFFTTDTTAALRAAEINAEVVMKATK
VDGVYNCDPNKFKDAKKYSSLSYQQVLSDEIAVMDSTAIALCKDNNIPIMVFDIFKKGNISKAVDGDPIGSLIS

Sequences:

>Translated_234_residues
MAYKRVLLKLSGEALMGEKPYGIDPAIVQSIAEDVSKVVENNVQLAIVVGGGNIFRGLKGSADGMDRATADYVGMLATVM
NAISLQDGLERVGVATRVQTAIEMQEIAEPYIRRRAMRHLEKGRVVVFGGGCGNPFFTTDTTAALRAAEINAEVVMKATK
VDGVYNCDPNKFKDAKKYSSLSYQQVLSDEIAVMDSTAIALCKDNNIPIMVFDIFKKGNISKAVDGDPIGSLIS
>Mature_233_residues
AYKRVLLKLSGEALMGEKPYGIDPAIVQSIAEDVSKVVENNVQLAIVVGGGNIFRGLKGSADGMDRATADYVGMLATVMN
AISLQDGLERVGVATRVQTAIEMQEIAEPYIRRRAMRHLEKGRVVVFGGGCGNPFFTTDTTAALRAAEINAEVVMKATKV
DGVYNCDPNKFKDAKKYSSLSYQQVLSDEIAVMDSTAIALCKDNNIPIMVFDIFKKGNISKAVDGDPIGSLIS

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=45.6896551724138, Blast_Score=220, Evalue=8e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_PROM0 (A3PBP6)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001090772.1
- ProteinModelPortal:   A3PBP6
- SMR:   A3PBP6
- STRING:   A3PBP6
- GeneID:   4912157
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_05481
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   PMAR167546:P9301ORF_0561-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25172; Mature: 25041

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: BINDING 51-51 BINDING 52-52 BINDING 56-56 BINDING 71-71 BINDING 159-159 BINDING 165-165 BINDING 168-168

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYKRVLLKLSGEALMGEKPYGIDPAIVQSIAEDVSKVVENNVQLAIVVGGGNIFRGLKG
CCHHHEEHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHCCCCC
SADGMDRATADYVGMLATVMNAISLQDGLERVGVATRVQTAIEMQEIAEPYIRRRAMRHL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKGRVVVFGGGCGNPFFTTDTTAALRAAEINAEVVMKATKVDGVYNCDPNKFKDAKKYSS
HCCCEEEEECCCCCCCCCCCHHHHHHHHHCCHHHEEEEHHCCCEEECCCHHHHHHHHHHH
LSYQQVLSDEIAVMDSTAIALCKDNNIPIMVFDIFKKGNISKAVDGDPIGSLIS
HHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHCC
>Mature Secondary Structure 
AYKRVLLKLSGEALMGEKPYGIDPAIVQSIAEDVSKVVENNVQLAIVVGGGNIFRGLKG
CHHHEEHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHCCCCC
SADGMDRATADYVGMLATVMNAISLQDGLERVGVATRVQTAIEMQEIAEPYIRRRAMRHL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKGRVVVFGGGCGNPFFTTDTTAALRAAEINAEVVMKATKVDGVYNCDPNKFKDAKKYSS
HCCCEEEEECCCCCCCCCCCHHHHHHHHHCCHHHEEEEHHCCCEEECCCHHHHHHHHHHH
LSYQQVLSDEIAVMDSTAIALCKDNNIPIMVFDIFKKGNISKAVDGDPIGSLIS
HHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA