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The map label for this gene is acsA-1

Identifier: 126447916

GI number: 126447916

Start: 1990934

End: 1992916

Strand: Reverse

Name: acsA-1

Synonym: BMA10247_A2054

Alternate gene names: 126447916

Gene position: 1992916-1990934 (Counterclockwise)

Preceding gene: 126447637

Following gene: 126446259

Centisome position: 84.71

GC content: 68.28

Gene sequence:

>1983_bases
ATGTCTGCGATTGAATCGGTTCTGCACGAACGCCGCCAGTTCGCGCCGCCCGCCGCCGTGGAGAAGGCGGCAGCCATTTC
CGGGATGGCGGCTTATCGGGCGCTCGCCGAAGAGGCTGAGCGCGATTACGAAGGATTCTGGGCGCGTCTCGCGCGCGAGA
CGCTCGAATGGCGCAAGCCGTTCGGCAAGGTGCTCGACGAGACGAACGCGCCGTTCTACAAGTGGTTCGAGGACGGCGAG
CTGAACGCGTCGTACAACTGCCTCGACCGCCACGTCGCCGCGGGCTTGGGCGAGCGCGTCGCGGTGATCTTCGAGGCCGA
CGACGGCACCGTCACGCGCGTCACCTACGCCGATCTGCTCGCGCGCGTGTCGCGCTTCGCGAACGCGCTGAAGAAGCGCG
GCGTCGGCCGCGGCGACCGCGTCGTCATCTACATTCCGATGTCGGTCGAAGGCATCGTCGCGATGCAGGCGTGCGCGCGG
ATCGGCGCGACGCACTCGGTGGTGTTCGGCGGCTTCTCGTCGAAGTCGCTGCACGAGCGCATCGTCGACGTCGGCGCGAC
CGCGCTCGTCACCGCCGACGAGCAGATGCGCGGCGGCAAGACGCTGCCGCTCAAGAGCATCGCCGACGAGGCGCTCGCGA
TGGGCGGCTGCGACGCGGTGAAGACCGTCGTCGTGTATCGCCGCACGGGCGGCAATGTCGACTGGCACGCGGGCCGCGAC
GTCTGGATGCACGAGATGGTCGCGAACGAGTCCGACGCGTGCGAGCCCGAATGGGTCGGCGCCGAGCATCCGCTGTTCAT
CCTGTACACGTCCGGCTCGACCGGCAAGCCGAAGGGCGTCCAGCACAGCACGGCCGGCTATCTGCTATGGGTCGCGCAGA
CGATGAAGTGGACGTTCGACTGGAAGCCCGACGACGTGTTCTGGTGCACGGCCGACATCGGCTGGGTCACGGGCCACTCG
TATATCACGTATGGGCCGCTCGCCGTCGGCGCGACGCAGGTGGTGTTCGAGGGCGTGCCGACCTATCCGAACGCGGGCCG
CTTCTGGAAGATGATCGGCGACCACAAGGTCACCGTGTTCTACACCGCGCCGACCGCGATCCGCTCGCTGATCAAGGCGG
CCGAGGCCGACGACCGCGTGCATCCGAGGAGCTACGATCTGTCGAGCCTGCGGATCATCGGCACGGTCGGCGAGCCGATC
AATCCGGAAGCGTGGATCTGGTATCACAAGAACGTCGGGCAGGCGCGCTGCCCGATCGTCGACACCTGGTGGCAGACCGA
AACGGGCGGCCACATGATCACGCCGCTACCGGGCGCGACGCCGACGGTGCCGGGCTCGTGCACGCTGCCGCTGCCGGGCA
TCATGGCCGCGGTCGTCGACGAGACGGGCCAGGACGTGCCGAACGGGCAGGGCGGCATTCTCGTCGTCAAGCGCCCGTGG
CCGGCGATGGCGCGCACGATCTGGGGCGACCCGGAGCGCTTCAAGAAGAGCTATTTCCCCGAGGAGCTCGGCGGCCGCCT
GTATCTGGCGGGCGACGGCACCGTGCGGGACAAGGAAACCGGCTACTTCACGATCATGGGCCGCATCGACGACGTGCTGA
ACGTATCGGGGCACCGGCTCGGCACGATGGAGATCGAATCGGCGCTCGTGTCGCACGAGCTCGTCGCCGAGGCGGCCGTC
GTCGGACGGCCGGACGACACGACGGGCGAGGCGGTCGTCGCGTTCGTCGTGCTCAAGCGCTCGCGGCCGGAAGGCGAGGA
GGCGGCCGCGCTCGCGAAGACGCTGCGCGACTGGGTCGGCAAGGAGATCGGGCCGATCGCGAAGCCGAAGGACATCCGTT
TCGGCGATAACCTGCCGAAGACGCGTTCGGGCAAGATCATGCGGCGCCTGCTGCGCTCGCTCGCGAAGGGCGAGGCGATC
ACGCAGGATACGTCGACGCTCGAGAACCCCGCGATTCTCGAACAGCTCGCCGAAGTGCGCTGA

Upstream 100 bases:

>100_bases
GCGCGCAGGGTGGGAGACAGGCGCGTCGCGCGCCGATTAGACACGGCGCGCCTGATCGCGCCGGCACGTAGTGGGTTCCA
TGTTCACCAAGGGGTAGTCG

Downstream 100 bases:

>100_bases
ACACCCCGGAGCGCGGCGCGCCGCCGAACGCGCGCCGCGCGAGCCCCTGCGCGGCAATCCCGATTGCCCGCGCAGGGGCT
TTTTGCTACACAAGCGCATG

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MSAIESVLHERRQFAPPAAVEKAAAISGMAAYRALAEEAERDYEGFWARLARETLEWRKPFGKVLDETNAPFYKWFEDGE
LNASYNCLDRHVAAGLGERVAVIFEADDGTVTRVTYADLLARVSRFANALKKRGVGRGDRVVIYIPMSVEGIVAMQACAR
IGATHSVVFGGFSSKSLHERIVDVGATALVTADEQMRGGKTLPLKSIADEALAMGGCDAVKTVVVYRRTGGNVDWHAGRD
VWMHEMVANESDACEPEWVGAEHPLFILYTSGSTGKPKGVQHSTAGYLLWVAQTMKWTFDWKPDDVFWCTADIGWVTGHS
YITYGPLAVGATQVVFEGVPTYPNAGRFWKMIGDHKVTVFYTAPTAIRSLIKAAEADDRVHPRSYDLSSLRIIGTVGEPI
NPEAWIWYHKNVGQARCPIVDTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
PAMARTIWGDPERFKKSYFPEELGGRLYLAGDGTVRDKETGYFTIMGRIDDVLNVSGHRLGTMEIESALVSHELVAEAAV
VGRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAI
TQDTSTLENPAILEQLAEVR

Sequences:

>Translated_660_residues
MSAIESVLHERRQFAPPAAVEKAAAISGMAAYRALAEEAERDYEGFWARLARETLEWRKPFGKVLDETNAPFYKWFEDGE
LNASYNCLDRHVAAGLGERVAVIFEADDGTVTRVTYADLLARVSRFANALKKRGVGRGDRVVIYIPMSVEGIVAMQACAR
IGATHSVVFGGFSSKSLHERIVDVGATALVTADEQMRGGKTLPLKSIADEALAMGGCDAVKTVVVYRRTGGNVDWHAGRD
VWMHEMVANESDACEPEWVGAEHPLFILYTSGSTGKPKGVQHSTAGYLLWVAQTMKWTFDWKPDDVFWCTADIGWVTGHS
YITYGPLAVGATQVVFEGVPTYPNAGRFWKMIGDHKVTVFYTAPTAIRSLIKAAEADDRVHPRSYDLSSLRIIGTVGEPI
NPEAWIWYHKNVGQARCPIVDTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
PAMARTIWGDPERFKKSYFPEELGGRLYLAGDGTVRDKETGYFTIMGRIDDVLNVSGHRLGTMEIESALVSHELVAEAAV
VGRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAI
TQDTSTLENPAILEQLAEVR
>Mature_659_residues
SAIESVLHERRQFAPPAAVEKAAAISGMAAYRALAEEAERDYEGFWARLARETLEWRKPFGKVLDETNAPFYKWFEDGEL
NASYNCLDRHVAAGLGERVAVIFEADDGTVTRVTYADLLARVSRFANALKKRGVGRGDRVVIYIPMSVEGIVAMQACARI
GATHSVVFGGFSSKSLHERIVDVGATALVTADEQMRGGKTLPLKSIADEALAMGGCDAVKTVVVYRRTGGNVDWHAGRDV
WMHEMVANESDACEPEWVGAEHPLFILYTSGSTGKPKGVQHSTAGYLLWVAQTMKWTFDWKPDDVFWCTADIGWVTGHSY
ITYGPLAVGATQVVFEGVPTYPNAGRFWKMIGDHKVTVFYTAPTAIRSLIKAAEADDRVHPRSYDLSSLRIIGTVGEPIN
PEAWIWYHKNVGQARCPIVDTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPWP
AMARTIWGDPERFKKSYFPEELGGRLYLAGDGTVRDKETGYFTIMGRIDDVLNVSGHRLGTMEIESALVSHELVAEAAVV
GRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAIT
QDTSTLENPAILEQLAEVR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

Homologues:

Organism=Homo sapiens, GI8923896, Length=683, Percent_Identity=48.0234260614934, Blast_Score=615, Evalue=1e-176,
Organism=Homo sapiens, GI253970489, Length=694, Percent_Identity=47.5504322766571, Blast_Score=612, Evalue=1e-175,
Organism=Homo sapiens, GI28416953, Length=636, Percent_Identity=47.7987421383648, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI13375727, Length=638, Percent_Identity=37.7742946708464, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI42544132, Length=532, Percent_Identity=28.3834586466165, Blast_Score=179, Evalue=9e-45,
Organism=Homo sapiens, GI122937307, Length=533, Percent_Identity=28.5178236397749, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI31982927, Length=654, Percent_Identity=25.6880733944954, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI38505220, Length=540, Percent_Identity=29.2592592592593, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI58082049, Length=524, Percent_Identity=27.2900763358779, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI115511026, Length=590, Percent_Identity=26.6101694915254, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI157311624, Length=504, Percent_Identity=26.7857142857143, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI157311622, Length=504, Percent_Identity=26.7857142857143, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI187761345, Length=397, Percent_Identity=27.455919395466, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI187761343, Length=397, Percent_Identity=27.455919395466, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI42544134, Length=299, Percent_Identity=24.7491638795987, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI195947378, Length=412, Percent_Identity=24.7572815533981, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1790505, Length=634, Percent_Identity=51.1041009463722, Blast_Score=640, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=637, Percent_Identity=38.4615384615385, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1788107, Length=562, Percent_Identity=25.9786476868327, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI145693145, Length=544, Percent_Identity=22.9779411764706, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786810, Length=559, Percent_Identity=22.8980322003578, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71983001, Length=666, Percent_Identity=44.7447447447448, Blast_Score=509, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI71982997, Length=666, Percent_Identity=44.7447447447448, Blast_Score=509, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17569507, Length=653, Percent_Identity=23.583460949464, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17558820, Length=545, Percent_Identity=23.8532110091743, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71985884, Length=407, Percent_Identity=26.5356265356265, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71994703, Length=576, Percent_Identity=23.7847222222222, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=578, Percent_Identity=23.8754325259516, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71994690, Length=578, Percent_Identity=23.8754325259516, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17538037, Length=598, Percent_Identity=23.5785953177258, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17559526, Length=561, Percent_Identity=23.1729055258467, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=643, Percent_Identity=47.1228615863142, Blast_Score=570, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319264, Length=665, Percent_Identity=46.7669172932331, Blast_Score=554, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6319699, Length=557, Percent_Identity=23.1597845601436, Blast_Score=106, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24667955, Length=673, Percent_Identity=46.5081723625557, Blast_Score=587, Evalue=1e-168,
Organism=Drosophila melanogaster, GI62472339, Length=560, Percent_Identity=50, Blast_Score=542, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24667959, Length=529, Percent_Identity=49.5274102079395, Blast_Score=505, Evalue=1e-143,
Organism=Drosophila melanogaster, GI21355225, Length=650, Percent_Identity=35.2307692307692, Blast_Score=355, Evalue=8e-98,
Organism=Drosophila melanogaster, GI21355181, Length=560, Percent_Identity=22.6785714285714, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24581924, Length=209, Percent_Identity=34.4497607655502, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACSA_BURM7 (A3MG40)

Other databases:

- EMBL:   CP000547
- RefSeq:   YP_001079226.1
- ProteinModelPortal:   A3MG40
- SMR:   A3MG40
- GeneID:   4890506
- GenomeReviews:   CP000547_GR
- KEGG:   bmn:BMA10247_A2054
- TIGR:   BMA10247_A2054
- HOGENOM:   HBG547964
- OMA:   ETASEHC
- ProtClustDB:   PRK00174
- BioCyc:   BMAL320389:BMA10247_A2054-MONOMER
- HAMAP:   MF_01123
- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873
- TIGRFAMs:   TIGR02188

Pfam domain/function: PF00501 AMP-binding

EC number: =6.2.1.1

Molecular weight: Translated: 72283; Mature: 72152

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00455 AMP_BINDING

Important sites: ACT_SITE 530-530

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIESVLHERRQFAPPAAVEKAAAISGMAAYRALAEEAERDYEGFWARLARETLEWRKP
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGKVLDETNAPFYKWFEDGELNASYNCLDRHVAAGLGERVAVIFEADDGTVTRVTYADLL
HHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEHHHHH
ARVSRFANALKKRGVGRGDRVVIYIPMSVEGIVAMQACARIGATHSVVFGGFSSKSLHER
HHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
IVDVGATALVTADEQMRGGKTLPLKSIADEALAMGGCDAVKTVVVYRRTGGNVDWHAGRD
HHHCCCEEEEECHHHHCCCCCCCHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCCCCCCH
VWMHEMVANESDACEPEWVGAEHPLFILYTSGSTGKPKGVQHSTAGYLLWVAQTMKWTFD
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEHHEEEEC
WKPDDVFWCTADIGWVTGHSYITYGPLAVGATQVVFEGVPTYPNAGRFWKMIGDHKVTVF
CCCCCEEEEECCCCEEECCCEEEECCHHHCHHHHHHCCCCCCCCCCCHHHEECCCEEEEE
YTAPTAIRSLIKAAEADDRVHPRSYDLSSLRIIGTVGEPINPEAWIWYHKNVGQARCPIV
EECHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCEE
DTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
ECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PAMARTIWGDPERFKKSYFPEELGGRLYLAGDGTVRDKETGYFTIMGRIDDVLNVSGHRL
HHHHHHHCCCHHHHHHHCCCHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVSHELVAEAAVVGRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVG
EHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
KEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAITQDTSTLENPAILEQLAEVR
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
SAIESVLHERRQFAPPAAVEKAAAISGMAAYRALAEEAERDYEGFWARLARETLEWRKP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGKVLDETNAPFYKWFEDGELNASYNCLDRHVAAGLGERVAVIFEADDGTVTRVTYADLL
HHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEHHHHH
ARVSRFANALKKRGVGRGDRVVIYIPMSVEGIVAMQACARIGATHSVVFGGFSSKSLHER
HHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
IVDVGATALVTADEQMRGGKTLPLKSIADEALAMGGCDAVKTVVVYRRTGGNVDWHAGRD
HHHCCCEEEEECHHHHCCCCCCCHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCCCCCCH
VWMHEMVANESDACEPEWVGAEHPLFILYTSGSTGKPKGVQHSTAGYLLWVAQTMKWTFD
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEHHEEEEC
WKPDDVFWCTADIGWVTGHSYITYGPLAVGATQVVFEGVPTYPNAGRFWKMIGDHKVTVF
CCCCCEEEEECCCCEEECCCEEEECCHHHCHHHHHHCCCCCCCCCCCHHHEECCCEEEEE
YTAPTAIRSLIKAAEADDRVHPRSYDLSSLRIIGTVGEPINPEAWIWYHKNVGQARCPIV
EECHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCEE
DTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
ECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PAMARTIWGDPERFKKSYFPEELGGRLYLAGDGTVRDKETGYFTIMGRIDDVLNVSGHRL
HHHHHHHCCCHHHHHHHCCCHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVSHELVAEAAVVGRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVG
EHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
KEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAITQDTSTLENPAILEQLAEVR
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA