Click here to switch to the map view.

The map label for this gene is dmlR [H]

Identifier: 126447888

GI number: 126447888

Start: 885270

End: 886169

Strand: Reverse

Name: dmlR [H]

Synonym: BMA10247_A0934

Alternate gene names: 126447888

Gene position: 886169-885270 (Counterclockwise)

Preceding gene: 126447122

Following gene: 126447422

Centisome position: 37.67

GC content: 71.0

Gene sequence:

>900_bases
ATGGATCGAATCACCGCGATGCAGGTGTTCGTCGAGACGGCCGAGCGCGGCAGCGTGTCGGCCGCCGCGCAGCATCTGGA
CATGTCGCGCGCGATGGCGTCGCGCTACGTCGCGTTCGTCGAGCAGTGGACCGGCGCGCGGATGCTGCACCGAACCACGC
GGCGCCTCACGCTGACCGCCGCGGGCGCGCAGATGCTGCCGCTCTGCCGCGACATGCTCGGGCTCGCCGAGCATGTCGCC
ACCGTCGTCGCGGAGCCGGGCGATGCGCCGCGCGGCGCGCTGAGGATCACCGCCAGCGCGATCTTCGCGCAGACGCACGT
GACCGATGCCGTGCTCGACTACCTGGCCCGCTACCCGACCGTGTCGGTCGACTTGCTCGTCACCGACCGTACCGCCGACC
TCGTCGACGAACGCATCGACCTGGCCATCCGGATCACGAACGCAGTCGACCCGAGCCTGATCGCGCGCCGGCTCGGCACG
TGCCGCTCGGCGCTGTGCGCGTCGCCCGGCTATCTGGCCGAGCATGGCGCGCCGAAGCGGCCGCACGATCTCACTCGGCA
CAACTGCCTGACGTATGCGTATTTCGGGCAGAGCCTGTGGCACCTGACGCGCGACGGCGAGCCGGCGACGGTGCCCGTGC
AGGGCAATCTGAGCGCGAACGACGCGCTCGTGCTGCTGCGCGCGGCGACCGCGGGCGGCGGCATCGCGCTGCTGCCGACA
TTCGCGGCCGCCGAGCCGATTCGCACGGGCGCGCTCGTGCGCGTGCTGCCCGACTGCGCGGCGCCCGAGCTCGGCATCTA
TGCGGTCTATGCATCGCGCAAGCAGATGCCGCTCGCAATGCGCACGATGATCGATTTCCTGGCGGAGCGTTTCGGCGATA
CGCCCGCGTGGGACGCATGA

Upstream 100 bases:

>100_bases
CGTTCACTCAAGAAAAATGAAAGTGAAACGAGTCTATTCGATATCCAATCGATCAAATACAATGCACCGGTCGACAATTT
GTTGCATGGATTGAGCGAAT

Downstream 100 bases:

>100_bases
CGGCGCGACTTCGACGCGCCGCGCCGTAGCGCCGCCGCTCGGCAGCGGCGCGACCGGGCGGCCAGGCGAAGCGGGACGAA
GCGGACGAAGCCGAACCCGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: D-malate degradation protein R [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MDRITAMQVFVETAERGSVSAAAQHLDMSRAMASRYVAFVEQWTGARMLHRTTRRLTLTAAGAQMLPLCRDMLGLAEHVA
TVVAEPGDAPRGALRITASAIFAQTHVTDAVLDYLARYPTVSVDLLVTDRTADLVDERIDLAIRITNAVDPSLIARRLGT
CRSALCASPGYLAEHGAPKRPHDLTRHNCLTYAYFGQSLWHLTRDGEPATVPVQGNLSANDALVLLRAATAGGGIALLPT
FAAAEPIRTGALVRVLPDCAAPELGIYAVYASRKQMPLAMRTMIDFLAERFGDTPAWDA

Sequences:

>Translated_299_residues
MDRITAMQVFVETAERGSVSAAAQHLDMSRAMASRYVAFVEQWTGARMLHRTTRRLTLTAAGAQMLPLCRDMLGLAEHVA
TVVAEPGDAPRGALRITASAIFAQTHVTDAVLDYLARYPTVSVDLLVTDRTADLVDERIDLAIRITNAVDPSLIARRLGT
CRSALCASPGYLAEHGAPKRPHDLTRHNCLTYAYFGQSLWHLTRDGEPATVPVQGNLSANDALVLLRAATAGGGIALLPT
FAAAEPIRTGALVRVLPDCAAPELGIYAVYASRKQMPLAMRTMIDFLAERFGDTPAWDA
>Mature_299_residues
MDRITAMQVFVETAERGSVSAAAQHLDMSRAMASRYVAFVEQWTGARMLHRTTRRLTLTAAGAQMLPLCRDMLGLAEHVA
TVVAEPGDAPRGALRITASAIFAQTHVTDAVLDYLARYPTVSVDLLVTDRTADLVDERIDLAIRITNAVDPSLIARRLGT
CRSALCASPGYLAEHGAPKRPHDLTRHNCLTYAYFGQSLWHLTRDGEPATVPVQGNLSANDALVLLRAATAGGGIALLPT
FAAAEPIRTGALVRVLPDCAAPELGIYAVYASRKQMPLAMRTMIDFLAERFGDTPAWDA

Specific function: Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081978, Length=294, Percent_Identity=35.0340136054422, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI1789639, Length=292, Percent_Identity=32.8767123287671, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1789440, Length=284, Percent_Identity=30.9859154929577, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI1786401, Length=293, Percent_Identity=31.0580204778157, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI145693193, Length=295, Percent_Identity=31.1864406779661, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1787128, Length=284, Percent_Identity=27.8169014084507, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787589, Length=295, Percent_Identity=29.4915254237288, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790011, Length=281, Percent_Identity=25.9786476868327, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1789173, Length=269, Percent_Identity=26.3940520446097, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32280; Mature: 32280

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRITAMQVFVETAERGSVSAAAQHLDMSRAMASRYVAFVEQWTGARMLHRTTRRLTLTA
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEEEE
AGAQMLPLCRDMLGLAEHVATVVAEPGDAPRGALRITASAIFAQTHVTDAVLDYLARYPT
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCC
VSVDLLVTDRTADLVDERIDLAIRITNAVDPSLIARRLGTCRSALCASPGYLAEHGAPKR
CEEEEEEECCHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCC
PHDLTRHNCLTYAYFGQSLWHLTRDGEPATVPVQGNLSANDALVLLRAATAGGGIALLPT
CCHHHHHCCEEHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCEEEEEH
FAAAEPIRTGALVRVLPDCAAPELGIYAVYASRKQMPLAMRTMIDFLAERFGDTPAWDA
HHHCCCHHCCHHHEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDRITAMQVFVETAERGSVSAAAQHLDMSRAMASRYVAFVEQWTGARMLHRTTRRLTLTA
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEEEE
AGAQMLPLCRDMLGLAEHVATVVAEPGDAPRGALRITASAIFAQTHVTDAVLDYLARYPT
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCC
VSVDLLVTDRTADLVDERIDLAIRITNAVDPSLIARRLGTCRSALCASPGYLAEHGAPKR
CEEEEEEECCHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCC
PHDLTRHNCLTYAYFGQSLWHLTRDGEPATVPVQGNLSANDALVLLRAATAGGGIALLPT
CCHHHHHCCEEHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCEEEEEH
FAAAEPIRTGALVRVLPDCAAPELGIYAVYASRKQMPLAMRTMIDFLAERFGDTPAWDA
HHHCCCHHCCHHHEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]