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The map label for this gene is pksE [H]

Identifier: 126447790

GI number: 126447790

Start: 1057370

End: 1058728

Strand: Reverse

Name: pksE [H]

Synonym: BMA10247_A1125

Alternate gene names: 126447790

Gene position: 1058728-1057370 (Counterclockwise)

Preceding gene: 126445760

Following gene: 126447581

Centisome position: 45.0

GC content: 70.05

Gene sequence:

>1359_bases
GTGCGTTCGACCCCGGCCGCGCATCCGGCCGCGGCGCACGTGCGCTTCGCGCGCGCCTGCGGCCGTCGACCGGCCGTCGA
CCGACGCGGGCAATCGACGCGGGAACGGTCCGCTTCGCACGGCGCGCCGCCGGCTGGGCCCGCATTGACCGATGCGCGAC
GCGCGGGAGGCGAGATGCTGAATACTTTCATGTTTCCGGGCCAAGGTTCGCAAGCGAAGGGAATGGGCGGCGCCCTGTTC
GATCGCTTCGCCGATCTCACCGCGCAGGCCGACGCCGTGCTCGGTTATTCGATCCGCGCGCTGTGCGTCGACGATCCGCG
CGACGAGCTCGGCCGCACGCAATTCACGCAGCCGGCGCTATACGTCGTCAATGCCTTGACGTACTACGCGAAATGCGAGG
ACAGCGGCGAGACGCCCGATTTTCTCGCCGGCCACAGCCTGGGCGAATTCAACGCGCTGCTCGCGGCGGGCTGCTTCGAC
TTCGAGGCCGGCCTGAAGCTCGTCGCCCGGCGCGCAGAGTTGATGAGCCAGGCCCGCGACGGCGCGATGGCCGCGATCGT
CAACGCGAGCCGCGAGCAGATCGAGCGCACGCTCGACGAGCACGGCCTCGTCGATACCGCGATCGCGAACGACAACACGC
CGTCGCAACTCGTCATCTCCGGCCCCGCCCACGAAATCGCGCGGGCCGAGGCGCTGTTCCAGCACGATCGGGTGCGGTAT
CTGCGGCTCAATACCAGCGGCGCGTTCCACTCGAAATTCATGCGGCCCGCGCAGCAGGCATTCGCCGCGCATCTACAGTC
GTTCCGGCTCGCGGACCCGGCGATCCCGGTGATCTCGAACGTATCGGCGCGCCCTTACGAGAACGGCCGCGTGAGCGAAG
GGCTCGCGCAGCAGATCGCAAGCCCGGTGCGATGGTGCGAGAGCATTCGCTATCTGCTCGCGCTGGCCGCCGAGCGCGGA
GAAGCGATCGAATTCACCGAGCTCGGACACGGCGACGTACTGACACGGCTCGTCCATACGATCCGGCGGCAGACACCGGC
CCCGGCAGCGGCCCCGGCGGCGGCCGCGACGCCGGCGCGCGCTCGCCCGACGCCGCCCGGCGAGCCCGAGCGGCTCGCGC
AGCAGACGGCGGCCGCGCCGCGCGCATCCGACTCCGCATCCGCATCGCTCGGCGCGGCCGAACGGGTCGCCGCGTGGAAT
CGGGACTACCCCGTCGGCACCCGCGTTCGCTCGTCGCTGATACACGACGACGTTCTCGAAACGCGGACCCCGGCAACCGT
GCTGTTCGGCCATCGCGCCGCGGTGTACATGAAGGGCTACAACGGCTACTTCGATCTCGCCGAAGTGACGCCCGCCTGA

Upstream 100 bases:

>100_bases
ACCCGACGAAACGCCGCGCGACACGGCGAAATTTCGGATATTCGTTTTTCTATTCCAAGTTTCGCCGCCGCTGAAACGCC
TGCCGCCTCGCCTTGCTATA

Downstream 100 bases:

>100_bases
GCGCGCGACGCGCGCCCGAAGCCGGCGCGCCTCGACGTCGCCGCCCCGCCGGTCGCGCCGCGCGCCCTCGGAAACGGGCG
CGGCCGTTGGCGCGCGCGGC

Product: malonyl CoA-acyl carrier protein transacylase

Products: NA

Alternate protein names: Malonyl CoA-acyl carrier protein transacylase; MCT [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MRSTPAAHPAAAHVRFARACGRRPAVDRRGQSTRERSASHGAPPAGPALTDARRAGGEMLNTFMFPGQGSQAKGMGGALF
DRFADLTAQADAVLGYSIRALCVDDPRDELGRTQFTQPALYVVNALTYYAKCEDSGETPDFLAGHSLGEFNALLAAGCFD
FEAGLKLVARRAELMSQARDGAMAAIVNASREQIERTLDEHGLVDTAIANDNTPSQLVISGPAHEIARAEALFQHDRVRY
LRLNTSGAFHSKFMRPAQQAFAAHLQSFRLADPAIPVISNVSARPYENGRVSEGLAQQIASPVRWCESIRYLLALAAERG
EAIEFTELGHGDVLTRLVHTIRRQTPAPAAAPAAAATPARARPTPPGEPERLAQQTAAAPRASDSASASLGAAERVAAWN
RDYPVGTRVRSSLIHDDVLETRTPATVLFGHRAAVYMKGYNGYFDLAEVTPA

Sequences:

>Translated_452_residues
MRSTPAAHPAAAHVRFARACGRRPAVDRRGQSTRERSASHGAPPAGPALTDARRAGGEMLNTFMFPGQGSQAKGMGGALF
DRFADLTAQADAVLGYSIRALCVDDPRDELGRTQFTQPALYVVNALTYYAKCEDSGETPDFLAGHSLGEFNALLAAGCFD
FEAGLKLVARRAELMSQARDGAMAAIVNASREQIERTLDEHGLVDTAIANDNTPSQLVISGPAHEIARAEALFQHDRVRY
LRLNTSGAFHSKFMRPAQQAFAAHLQSFRLADPAIPVISNVSARPYENGRVSEGLAQQIASPVRWCESIRYLLALAAERG
EAIEFTELGHGDVLTRLVHTIRRQTPAPAAAPAAAATPARARPTPPGEPERLAQQTAAAPRASDSASASLGAAERVAAWN
RDYPVGTRVRSSLIHDDVLETRTPATVLFGHRAAVYMKGYNGYFDLAEVTPA
>Mature_452_residues
MRSTPAAHPAAAHVRFARACGRRPAVDRRGQSTRERSASHGAPPAGPALTDARRAGGEMLNTFMFPGQGSQAKGMGGALF
DRFADLTAQADAVLGYSIRALCVDDPRDELGRTQFTQPALYVVNALTYYAKCEDSGETPDFLAGHSLGEFNALLAAGCFD
FEAGLKLVARRAELMSQARDGAMAAIVNASREQIERTLDEHGLVDTAIANDNTPSQLVISGPAHEIARAEALFQHDRVRY
LRLNTSGAFHSKFMRPAQQAFAAHLQSFRLADPAIPVISNVSARPYENGRVSEGLAQQIASPVRWCESIRYLLALAAERG
EAIEFTELGHGDVLTRLVHTIRRQTPAPAAAPAAAATPARARPTPPGEPERLAQQTAAAPRASDSASASLGAAERVAAWN
RDYPVGTRVRSSLIHDDVLETRTPATVLFGHRAAVYMKGYNGYFDLAEVTPA

Specific function: Probably involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. Probably has an acyl transferase activity and could also have a flavin mononucleotide-dependent oxidoreductas

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=329, Percent_Identity=31.306990881459, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI27477045, Length=129, Percent_Identity=37.984496124031, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1787334, Length=289, Percent_Identity=34.9480968858132, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71984332, Length=298, Percent_Identity=30.2013422818792, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=171, Percent_Identity=30.4093567251462, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24665753, Length=306, Percent_Identity=31.0457516339869, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004136
- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR013785
- InterPro:   IPR004410
- InterPro:   IPR016036
- InterPro:   IPR014179 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF03060 NPD [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 48489; Mature: 48489

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSTPAAHPAAAHVRFARACGRRPAVDRRGQSTRERSASHGAPPAGPALTDARRAGGEML
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
NTFMFPGQGSQAKGMGGALFDRFADLTAQADAVLGYSIRALCVDDPRDELGRTQFTQPAL
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHCCCCCCCHHH
YVVNALTYYAKCEDSGETPDFLAGHSLGEFNALLAAGCFDFEAGLKLVARRAELMSQARD
HHHHHHHHHHCCCCCCCCCCHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
GAMAAIVNASREQIERTLDEHGLVDTAIANDNTPSQLVISGPAHEIARAEALFQHDRVRY
CHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHCCEEE
LRLNTSGAFHSKFMRPAQQAFAAHLQSFRLADPAIPVISNVSARPYENGRVSEGLAQQIA
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHH
SPVRWCESIRYLLALAAERGEAIEFTELGHGDVLTRLVHTIRRQTPAPAAAPAAAATPAR
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
ARPTPPGEPERLAQQTAAAPRASDSASASLGAAERVAAWNRDYPVGTRVRSSLIHDDVLE
CCCCCCCCHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
TRTPATVLFGHRAAVYMKGYNGYFDLAEVTPA
CCCCCEEEECCCEEEEEECCCCEEECCCCCCC
>Mature Secondary Structure
MRSTPAAHPAAAHVRFARACGRRPAVDRRGQSTRERSASHGAPPAGPALTDARRAGGEML
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
NTFMFPGQGSQAKGMGGALFDRFADLTAQADAVLGYSIRALCVDDPRDELGRTQFTQPAL
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHCCCCCCCHHH
YVVNALTYYAKCEDSGETPDFLAGHSLGEFNALLAAGCFDFEAGLKLVARRAELMSQARD
HHHHHHHHHHCCCCCCCCCCHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
GAMAAIVNASREQIERTLDEHGLVDTAIANDNTPSQLVISGPAHEIARAEALFQHDRVRY
CHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHCCEEE
LRLNTSGAFHSKFMRPAQQAFAAHLQSFRLADPAIPVISNVSARPYENGRVSEGLAQQIA
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHH
SPVRWCESIRYLLALAAERGEAIEFTELGHGDVLTRLVHTIRRQTPAPAAAPAAAATPAR
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
ARPTPPGEPERLAQQTAAAPRASDSASASLGAAERVAAWNRDYPVGTRVRSSLIHDDVLE
CCCCCCCCHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
TRTPATVLFGHRAAVYMKGYNGYFDLAEVTPA
CCCCCEEEECCCEEEEEECCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]