Definition Burkholderia mallei NCTC 10247 chromosome II, complete genome.
Accession NC_009079
Length 2,352,693

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The map label for this gene is cmlA [H]

Identifier: 126446263

GI number: 126446263

Start: 1967187

End: 1968398

Strand: Reverse

Name: cmlA [H]

Synonym: BMA10247_A2033

Alternate gene names: 126446263

Gene position: 1968398-1967187 (Counterclockwise)

Preceding gene: 126447618

Following gene: 126447097

Centisome position: 83.67

GC content: 67.82

Gene sequence:

>1212_bases
ATGAACACGACCGAAACAAACACATTGTCCGACCGGGGCTGGCTAAGCCTGCTGATGCTCGTCGTCTGCTTGCCGCGCAT
GACGATCGACGCATATCTGCCGTCGCTGCCCGCGATGGCGGACGCGCTTCACGGCACCGACGCGCAGATGCAACTGACGC
TCACGATGTACATGGCCGGCTACGCACTGTCGATGCTGCTATCCGGGCCGTTGTCCGACCGTTACGGGCGCAGGCCGGTG
CTGCTCGCCGGCATGCTCGTGTATCTCGGCGCGAGCGTCGCATGCGCGACGGCGACGAGCGTTCAGGGCATCGTCGTCGC
GCGGATCGGCCAGGCGCTGGGCGGCTGCTGCGGCACCGTGATCGGCCGCGTGATCGTCCGCGAACGCTTCGGTACGGCGA
TGCAAGCGGCGATGCTCAGCCGGATATCGGCGGGCATGGCGTTGTCGCCCGTCGTCGCGCCGCTTGCCGGCCACGTCGTC
GCGCAGTGGCTCGGCTGGCGCGGCGTTTTCGCGTTGCTCGCGTTCGGCGGCGGCGCCGCCGCGCTGATGGTGCATCGCTT
TCTGCCGGAGACCCGCGTGCGCGCGGCGGCGAGCGAACGCGGCGCGGGCCTGGCGAAGACTTACCTGTCGCTGCTTCGCG
ACCGCCGGTTCGTGCGTTACTCACTCGCGATCGGCTTCGTCTATTGCACGTATTTTCCGTTCATCGCCGAATCGTCTGCG
CTGTTTCAACGCACGCTTCGCGCCTCCGGCGCTGTCTATGCGGCGATATTCGGGATCACGGTGCTCGGCTACCTGATCGG
CTCGAGCGTGTTTCGCCGGGCGAGCGGCCGGTTCGGAATCGATGCGATCATCGCGTCGGCCGCCTTCGTCAATCTAGTCG
GCGCGGCCGCGCTGTGGATCGGGACGTCGGTCGCGCCGCCGAGCGTCTGGTCGATCGCGTTGCCGATGTTCGTCGTCATG
GTGTCGGTCGGCGTTTCGATCCCGGCGTGCCAGTTCGCGGTGCTGCAGCCGTTCGCGAAGCTCGCGGGCACCGCTTCCGG
ATTGTTCTTCTTCATTCAGATGGCGATGACGGCCGGGTGCGGCGGGATGCTGAGCCGGCTGTCCGACGGCTCCGCGCGGC
CGATGGCCGTCGTCACCGCCGCATCGAGCGCGGCGTTCATGGCCGTCGTCATGCTCGTGCGAACGCGCGGCGTGAACGGT
CGGCGCGGTTGA

Upstream 100 bases:

>100_bases
GGTCTATTCAACATTCGAACAAGTGGTTCTTCGGCTTATACCACATTGCGTTTAGATTCCGGCTTGCGCCAATCGATCCA
GGCCGCGAGAACCTCGCCGA

Downstream 100 bases:

>100_bases
GCGGCGTCGGCCTGCCGCTGTTCGCGATCGCGCCCGAGAGCGGATGCCTTGCACGGCCGCCGCTTCCTGCCGCGAGCGGC
GTGATCCTGCCGGCATTGCC

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MNTTETNTLSDRGWLSLLMLVVCLPRMTIDAYLPSLPAMADALHGTDAQMQLTLTMYMAGYALSMLLSGPLSDRYGRRPV
LLAGMLVYLGASVACATATSVQGIVVARIGQALGGCCGTVIGRVIVRERFGTAMQAAMLSRISAGMALSPVVAPLAGHVV
AQWLGWRGVFALLAFGGGAAALMVHRFLPETRVRAAASERGAGLAKTYLSLLRDRRFVRYSLAIGFVYCTYFPFIAESSA
LFQRTLRASGAVYAAIFGITVLGYLIGSSVFRRASGRFGIDAIIASAAFVNLVGAAALWIGTSVAPPSVWSIALPMFVVM
VSVGVSIPACQFAVLQPFAKLAGTASGLFFFIQMAMTAGCGGMLSRLSDGSARPMAVVTAASSAAFMAVVMLVRTRGVNG
RRG

Sequences:

>Translated_403_residues
MNTTETNTLSDRGWLSLLMLVVCLPRMTIDAYLPSLPAMADALHGTDAQMQLTLTMYMAGYALSMLLSGPLSDRYGRRPV
LLAGMLVYLGASVACATATSVQGIVVARIGQALGGCCGTVIGRVIVRERFGTAMQAAMLSRISAGMALSPVVAPLAGHVV
AQWLGWRGVFALLAFGGGAAALMVHRFLPETRVRAAASERGAGLAKTYLSLLRDRRFVRYSLAIGFVYCTYFPFIAESSA
LFQRTLRASGAVYAAIFGITVLGYLIGSSVFRRASGRFGIDAIIASAAFVNLVGAAALWIGTSVAPPSVWSIALPMFVVM
VSVGVSIPACQFAVLQPFAKLAGTASGLFFFIQMAMTAGCGGMLSRLSDGSARPMAVVTAASSAAFMAVVMLVRTRGVNG
RRG
>Mature_403_residues
MNTTETNTLSDRGWLSLLMLVVCLPRMTIDAYLPSLPAMADALHGTDAQMQLTLTMYMAGYALSMLLSGPLSDRYGRRPV
LLAGMLVYLGASVACATATSVQGIVVARIGQALGGCCGTVIGRVIVRERFGTAMQAAMLSRISAGMALSPVVAPLAGHVV
AQWLGWRGVFALLAFGGGAAALMVHRFLPETRVRAAASERGAGLAKTYLSLLRDRRFVRYSLAIGFVYCTYFPFIAESSA
LFQRTLRASGAVYAAIFGITVLGYLIGSSVFRRASGRFGIDAIIASAAFVNLVGAAALWIGTSVAPPSVWSIALPMFVVM
VSVGVSIPACQFAVLQPFAKLAGTASGLFFFIQMAMTAGCGGMLSRLSDGSARPMAVVTAASSAAFMAVVMLVRTRGVNG
RRG

Specific function: Appears to provoke a reduction of the content of the major porins ompA and ompC [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=363, Percent_Identity=26.4462809917355, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1790146, Length=233, Percent_Identity=30.0429184549356, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI87082312, Length=323, Percent_Identity=26.3157894736842, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI48994889, Length=327, Percent_Identity=25.9938837920489, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787065, Length=256, Percent_Identity=29.6875, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790794, Length=282, Percent_Identity=27.3049645390071, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787880, Length=241, Percent_Identity=26.9709543568465, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319480, Length=191, Percent_Identity=27.7486910994764, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324264, Length=166, Percent_Identity=30.1204819277108, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42273; Mature: 42273

Theoretical pI: Translated: 10.85; Mature: 10.85

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure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HHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1648560; 1658833 [H]