BacMap

Definition	Burkholderia mallei NCTC 10247 chromosome II, complete genome.
Accession	NC_009079
Length	2,352,693

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The map label for this gene is budC [H]

Identifier: 126446012

GI number: 126446012

Start: 1758500

End: 1759354

Strand: Direct

Name: budC [H]

Synonym: BMA10247_A1828

Alternate gene names: 126446012

Gene position: 1758500-1759354 (Clockwise)

Preceding gene: 126446923

Following gene: 126446572

Centisome position: 74.74

GC content: 71.23

Gene sequence:

>855_bases
ATGCGCATCGTGCGCATCGCCGAACAAGAATCGCGATCACTCGGGAGACACCCACGCATGGCTGCAATCGATCTGCTGAA
ACCGTACGCCGGGCTGCGCGTACTCGTGACGGGCGGCGCGTCCGGCATCGGGCTCGCGATCGCCGACGCGTTCGCCGAAT
GCGGCGGCCAGGTCCACGTCTGCGACGCATCCGGGAAGGCGCTCGCCGCGCTCGCGCAGCGCCCCTCGCGCGCCGCGCTC
GGCGCGACGCTCGCCGACGTCGCCGACGCGGCCGCGGTCGAGCGCGTGTTCGACGACGTCACGCGCACGCTCGGCGGGCT
CGACGTGCTCGTGAACAACGCCGGCATCGCCGGGCCGACGGGCGGCATCGACGAGATCGATCCCGCGCAATGGGAACAGA
CGGTCGCGGTCAACCTGAACGCGCAGTTCCAGTTCGCGCGCCGCGCGGTGCCGATGCTGCGCGACGCGCCGCACGGCGGC
GCGATCATCGCGCTGTCGTCGGTCGCGGGGCGTCTCGGCTATGCGTTGCGCACGCCGTACTCGGCCACGAAATGGGCCGT
CGTCGGCCTCGTGAAAAGCCTCGCGATCGAGCTCGGCCCGCTCGGCATCCGCGTGAACGCGATCCAGCCGGGCATCGTGC
GCGGCCCGCGCATCCGCCGCGTGATCGAGGCGCGCGCCGCGCAACTCGGCATCGGCTACGACGAGATGCAGGCGCGCTAT
CTCGAGAAGATCTCGCTGCGCCGGATGACCGATCCGGACGAGATCGCCGCGACCGCGCTGTTCCTCTGCTCACCGGGCGG
GCACGGGATTTCCGGGCAGGCGATTTCCGTCTGCGGCAACGTCGAGGCGCTCTGA

Upstream 100 bases:

>100_bases
CGAACGCGCGCGTCTCGGCCCGCGCCGGCTCGCGAACGAATAGCGGCGCGCCGCGCGCAGGCGGCGCCGCCCGCCTCGCG
CGCGCATCACCAATATCGCG

Downstream 100 bases:

>100_bases
CGCGCCGCCCTTCACCGCCGAGCATCGAAAGGAGCCCTAACGTGGCCAGCCCCCGCAAAGTCATCATCACCTGCGCGCCG
ACGGGCGCGATCCATACACC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: Acetoin(diacetyl) reductase; AR; Meso-2,3-butanediol dehydrogenase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MRIVRIAEQESRSLGRHPRMAAIDLLKPYAGLRVLVTGGASGIGLAIADAFAECGGQVHVCDASGKALAALAQRPSRAAL
GATLADVADAAAVERVFDDVTRTLGGLDVLVNNAGIAGPTGGIDEIDPAQWEQTVAVNLNAQFQFARRAVPMLRDAPHGG
AIIALSSVAGRLGYALRTPYSATKWAVVGLVKSLAIELGPLGIRVNAIQPGIVRGPRIRRVIEARAAQLGIGYDEMQARY
LEKISLRRMTDPDEIAATALFLCSPGGHGISGQAISVCGNVEAL

Sequences:

>Translated_284_residues
MRIVRIAEQESRSLGRHPRMAAIDLLKPYAGLRVLVTGGASGIGLAIADAFAECGGQVHVCDASGKALAALAQRPSRAAL
GATLADVADAAAVERVFDDVTRTLGGLDVLVNNAGIAGPTGGIDEIDPAQWEQTVAVNLNAQFQFARRAVPMLRDAPHGG
AIIALSSVAGRLGYALRTPYSATKWAVVGLVKSLAIELGPLGIRVNAIQPGIVRGPRIRRVIEARAAQLGIGYDEMQARY
LEKISLRRMTDPDEIAATALFLCSPGGHGISGQAISVCGNVEAL
>Mature_284_residues
MRIVRIAEQESRSLGRHPRMAAIDLLKPYAGLRVLVTGGASGIGLAIADAFAECGGQVHVCDASGKALAALAQRPSRAAL
GATLADVADAAAVERVFDDVTRTLGGLDVLVNNAGIAGPTGGIDEIDPAQWEQTVAVNLNAQFQFARRAVPMLRDAPHGG
AIIALSSVAGRLGYALRTPYSATKWAVVGLVKSLAIELGPLGIRVNAIQPGIVRGPRIRRVIEARAAQLGIGYDEMQARY
LEKISLRRMTDPDEIAATALFLCSPGGHGISGQAISVCGNVEAL

Specific function: Catalyzes the reversible reduction of (S)-acetoin to 2,3-butanediol in the presence of NADH [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=265, Percent_Identity=29.4339622641509, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI59889578, Length=215, Percent_Identity=33.4883720930233, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI15277342, Length=259, Percent_Identity=30.1158301158301, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=27.5303643724696, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI66933014, Length=231, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI19923817, Length=254, Percent_Identity=27.9527559055118, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI31542939, Length=231, Percent_Identity=31.6017316017316, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI126723191, Length=204, Percent_Identity=30.3921568627451, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI126723750, Length=274, Percent_Identity=25.1824817518248, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI10190704, Length=248, Percent_Identity=28.2258064516129, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI142976729, Length=201, Percent_Identity=28.8557213930348, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI210032110, Length=203, Percent_Identity=26.6009852216749, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4503817, Length=196, Percent_Identity=31.6326530612245, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI33667109, Length=182, Percent_Identity=29.1208791208791, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI7705925, Length=258, Percent_Identity=28.2945736434109, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI38348362, Length=173, Percent_Identity=35.8381502890173, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4504505, Length=190, Percent_Identity=34.7368421052632, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI40548397, Length=262, Percent_Identity=28.2442748091603, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI214010158, Length=262, Percent_Identity=28.2442748091603, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI214010156, Length=262, Percent_Identity=28.2442748091603, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI22758144, Length=262, Percent_Identity=28.2442748091603, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI109715829, Length=243, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI38424085, Length=201, Percent_Identity=34.3283582089552, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI4503301, Length=235, Percent_Identity=26.3829787234043, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI224922801, Length=167, Percent_Identity=32.3353293413174, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI40807363, Length=194, Percent_Identity=27.8350515463918, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI310128830, Length=182, Percent_Identity=30.2197802197802, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI310115468, Length=182, Percent_Identity=30.2197802197802, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4758504, Length=208, Percent_Identity=31.25, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI302344755, Length=110, Percent_Identity=32.7272727272727, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI7657478, Length=183, Percent_Identity=30.6010928961749, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI44680136, Length=195, Percent_Identity=27.1794871794872, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI44680133, Length=195, Percent_Identity=27.1794871794872, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI17738292, Length=195, Percent_Identity=27.1794871794872, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1789057, Length=252, Percent_Identity=30.5555555555556, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=30.5220883534137, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=29.4820717131474, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790717, Length=256, Percent_Identity=27.734375, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI87082100, Length=247, Percent_Identity=34.412955465587, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786812, Length=253, Percent_Identity=33.201581027668, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=29.0836653386454, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI2367365, Length=253, Percent_Identity=31.2252964426877, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1789378, Length=253, Percent_Identity=26.8774703557312, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI2367175, Length=262, Percent_Identity=28.6259541984733, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788459, Length=183, Percent_Identity=29.5081967213115, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1786701, Length=183, Percent_Identity=33.879781420765, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=26.4822134387352, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787820, Length=192, Percent_Identity=30.7291666666667, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787526, Length=186, Percent_Identity=27.9569892473118, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=32.4110671936759, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=32.7935222672065, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=33.0645161290323, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17561402, Length=267, Percent_Identity=29.2134831460674, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=247, Percent_Identity=29.5546558704453, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538182, Length=210, Percent_Identity=33.8095238095238, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=194, Percent_Identity=27.8350515463918, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=190, Percent_Identity=32.6315789473684, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=260, Percent_Identity=30, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=196, Percent_Identity=31.6326530612245, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17564282, Length=216, Percent_Identity=26.8518518518519, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI72000259, Length=198, Percent_Identity=29.2929292929293, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=27.9527559055118, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=257, Percent_Identity=28.0155642023346, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=27.2030651340996, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=192, Percent_Identity=28.6458333333333, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=169, Percent_Identity=30.1775147928994, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=193, Percent_Identity=30.0518134715026, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32563809, Length=250, Percent_Identity=27.6, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17507613, Length=250, Percent_Identity=27.6, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=202, Percent_Identity=30.1980198019802, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=275, Percent_Identity=27.6363636363636, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=199, Percent_Identity=26.6331658291457, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=176, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=181, Percent_Identity=32.0441988950276, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=189, Percent_Identity=31.2169312169312, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=201, Percent_Identity=29.3532338308458, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=199, Percent_Identity=29.6482412060301, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=194, Percent_Identity=28.8659793814433, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=200, Percent_Identity=29, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17557780, Length=197, Percent_Identity=28.9340101522843, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=187, Percent_Identity=31.0160427807487, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324126, Length=265, Percent_Identity=26.0377358490566, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323882, Length=188, Percent_Identity=28.1914893617021, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322227, Length=189, Percent_Identity=26.4550264550265, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21355319, Length=260, Percent_Identity=30.7692307692308, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24644339, Length=259, Percent_Identity=30.1158301158301, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=29.0196078431373, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28571526, Length=259, Percent_Identity=32.046332046332, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281364892, Length=205, Percent_Identity=32.6829268292683, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI23397609, Length=249, Percent_Identity=30.9236947791165, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24644337, Length=264, Percent_Identity=31.0606060606061, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24643142, Length=190, Percent_Identity=33.1578947368421, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21357041, Length=259, Percent_Identity=29.7297297297297, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24641232, Length=195, Percent_Identity=30.7692307692308, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356301, Length=195, Percent_Identity=29.2307692307692, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18859837, Length=190, Percent_Identity=28.9473684210526, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24665243, Length=190, Percent_Identity=26.8421052631579, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014007
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.304 [H]

Molecular weight: Translated: 29601; Mature: 29601

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00061 ADH_SHORT ; PS00196 COPPER_BLUE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVRIAEQESRSLGRHPRMAAIDLLKPYAGLRVLVTGGASGIGLAIADAFAECGGQVHV
CCEEEECCHHHHHHCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEE
CDASGKALAALAQRPSRAALGATLADVADAAAVERVFDDVTRTLGGLDVLVNNAGIAGPT
ECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
GGIDEIDPAQWEQTVAVNLNAQFQFARRAVPMLRDAPHGGAIIALSSVAGRLGYALRTPY
CCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCC
SATKWAVVGLVKSLAIELGPLGIRVNAIQPGIVRGPRIRRVIEARAAQLGIGYDEMQARY
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
LEKISLRRMTDPDEIAATALFLCSPGGHGISGQAISVCGNVEAL
HHHHHHHCCCCHHHHHHHEEEEECCCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MRIVRIAEQESRSLGRHPRMAAIDLLKPYAGLRVLVTGGASGIGLAIADAFAECGGQVHV
CCEEEECCHHHHHHCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEE
CDASGKALAALAQRPSRAALGATLADVADAAAVERVFDDVTRTLGGLDVLVNNAGIAGPT
ECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
GGIDEIDPAQWEQTVAVNLNAQFQFARRAVPMLRDAPHGGAIIALSSVAGRLGYALRTPY
CCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCC
SATKWAVVGLVKSLAIELGPLGIRVNAIQPGIVRGPRIRRVIEARAAQLGIGYDEMQARY
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
LEKISLRRMTDPDEIAATALFLCSPGGHGISGQAISVCGNVEAL
HHHHHHHCCCCHHHHHHHEEEEECCCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11173520 [H]