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The map label for this gene is nrdZ [H]

Identifier: 126446010

GI number: 126446010

Start: 2245483

End: 2247552

Strand: Direct

Name: nrdZ [H]

Synonym: BMA10247_A2317

Alternate gene names: 126446010

Gene position: 2245483-2247552 (Clockwise)

Preceding gene: 126446743

Following gene: 126447577

Centisome position: 95.44

GC content: 74.25

Gene sequence:

>2070_bases
ATGCCGCTCGCCGCGCCGCTCGCCGCACCGCCCGCCATGTCGCTCGCCGTGCCGCTCACCGCACCACCCGCCATGTCGCT
TGCCGTGCCGCTCACCGCACCACCCGCCATGTCGCTTGCCGTGCCGCTCACCGCACCACCCGCCATGTCGCTTGCCGCGC
CGCTCGTCGTACCGTCTTCGTACCGCTCCTCGTACCGCCCGCCGCACCGCGCGGCTCGCGCATGCCGCTTGCGGACGATC
AACAAACGCACGCGCACCATTGCCCACGCCGATTCGTTCGTCCGCATGATCGGCGACATGGACGACCAACCGATCTGCGA
CGCCGTATTCGCCGACCGCTACGCGCTGCCCGGCGAGCATTCGCGCGCTCAGGCGTGCGCGCGGGTCGCGCGTGCGCTCG
CGCTCGCGGAGCCGATGGCGACCCGTTCGGGCGCGGCGCGGCGCTTCTACCGGAACCTGCTGAACGGCGCGTTCGGCGCG
GGCCGCATCATGGCGCGCGCGGGCGCCGCGCCGGATCAGACGATGGCGAGCTGCTTCGTGCATCCGATCCGCGCCCCCGC
CGCGCTCACGCGCTTTCATCCGAACCTCGACGAGGCGCTCGACGAAGCGCGCCTCGCGCTCGCGATGGGCGCCGACATCG
GCTACGACTTCTCGGCCATCCCGCCCGCCGGCGCGCGGCCCGACGCGGACCATCCCGATTCGCCCGGCGTGTGCGCGGCG
CTCGACCGGTTCGACCGGATCGGCACGCAGGCGGGCGAGCGCGACGGCCGCCGCCGCGCGCAGCTCGCGGTGCTGCGCTG
CGATCACCCGGATCTGCTCGCGTTCGCCGCCGCGAAGCACCGGCATGCGGGCAGGCATGCGCGCTGGACGACGCTCGAGC
TCGCGGTGGCCGCCACCGACGCATTCATGCAGGCGGTCGAGCAGGATCTGCCGTGGACGCTGCGGCACACGGCGCCGCCG
CGCGACGCGCCGGGCGGCGCGCTGCCCGGCGCGGACGGCGCATGGACGTACGCGAGCGTGCCCGCGCGCCACGTGTGGCG
CGAGATCGTGTCGGCCGCGCGCGACGGCGCGGGGCCCGGCCTCGTATTCGTCGATGCGATCGACGCCGCCGATCCGCTGC
GCGGCCGCGAGCGGATCGACGCGACGAGCCCGTGCGGCGCGCAGCCGCTGCCGCCCTACGGCAGCGCGATGCTCGGCGCG
ATCGATCTGTCGCGCTTCGTGCGCAATCCGTTCGGCGCCGGCGGCGAGCCGCGCTTCGATTTCGCCGCGTTCGACACGGC
CGTGCGCATCGAGGTGCGCCTGCTCGACAACGCGCTCGACGTCACGCGCTGGCCGCTCGCCGCGCATGCGCGCGAGTCGT
ATCAGAAGCGGCGGATCGGCGTCGGCGTGACGGGGCTCGCGGACATGCTCGCGATGATGCGGCTGCGCTACGATTCGCCG
GCCGCGCGCGAGATGGCGCGCTATATCGCGTCCGACCTGCGCCACCACGCGTACGCGGCGTCGGCCGAGCTCGCCGCCGA
GCGCGGCGCGTATCCGCTGTGCGACCGCCACGCGCATCTCGACGCGCTGCGCGCGGGGCCGCCGCTGCCGCACGCGGTCT
GCCACGCGATCGAGCGCGACGGGCTGCGCCACAGTCATCTGACGTCGTTCGCGCCCGTCATCGGCGTGAGCCTCGCGTTC
GGCGATCACTGCTCGCCCGGCATCGAGCCGGCCCGCGCGTGGATCGAGCACCGCCCGGTGCGCGCGGGCGCCGCCGGCGC
GCCGGGCATGCGCGCGGAAAACCACGCGCACCGGCTGTTCCGGTCGCTGCGCGGCGAGCGCGCCGCGCTGCCGGACTACT
TCGCGACCGATGCGGACGTCGCGCCGGGCGAGCGCCTCGCGATGCGCGTGGCGCTGCAGCCGTATGTCGACGCGGGAATC
GACAATACGCTGACCCTCGCGAACCATTATTCGCTCGAAGAGGTCAACGCATTGCTGTTCGCCGCGTGGCGCGCGAAGCT
GAAGAGCGTGGCGATACGGCGCGCGGATCTCGCGCGCGACGCGCAGCCGAGCGACGACGACGGCGTTTAG

Upstream 100 bases:

>100_bases
CGCGGCCCACCGCCGAGCGTGCGGAGCGCCGCATCGCGCACTGAGCCGCCCCCGGCACCATCCGCGACCGCGCAACGCGC
CGCTCGCCGCGCTGCCCGTC

Downstream 100 bases:

>100_bases
GCAGGCCCGCGGCCCACGCGACGCGCGCGGGCGCTTGACCCACGTCAAGCCGGCGCCCCGCGCGATCGGGTCGAATGACG
ACGGGCGCCGTCGCGGCGCG

Product: ribonucleotide reductase-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 689; Mature: 688

Protein sequence:

>689_residues
MPLAAPLAAPPAMSLAVPLTAPPAMSLAVPLTAPPAMSLAVPLTAPPAMSLAAPLVVPSSYRSSYRPPHRAARACRLRTI
NKRTRTIAHADSFVRMIGDMDDQPICDAVFADRYALPGEHSRAQACARVARALALAEPMATRSGAARRFYRNLLNGAFGA
GRIMARAGAAPDQTMASCFVHPIRAPAALTRFHPNLDEALDEARLALAMGADIGYDFSAIPPAGARPDADHPDSPGVCAA
LDRFDRIGTQAGERDGRRRAQLAVLRCDHPDLLAFAAAKHRHAGRHARWTTLELAVAATDAFMQAVEQDLPWTLRHTAPP
RDAPGGALPGADGAWTYASVPARHVWREIVSAARDGAGPGLVFVDAIDAADPLRGRERIDATSPCGAQPLPPYGSAMLGA
IDLSRFVRNPFGAGGEPRFDFAAFDTAVRIEVRLLDNALDVTRWPLAAHARESYQKRRIGVGVTGLADMLAMMRLRYDSP
AAREMARYIASDLRHHAYAASAELAAERGAYPLCDRHAHLDALRAGPPLPHAVCHAIERDGLRHSHLTSFAPVIGVSLAF
GDHCSPGIEPARAWIEHRPVRAGAAGAPGMRAENHAHRLFRSLRGERAALPDYFATDADVAPGERLAMRVALQPYVDAGI
DNTLTLANHYSLEEVNALLFAAWRAKLKSVAIRRADLARDAQPSDDDGV

Sequences:

>Translated_689_residues
MPLAAPLAAPPAMSLAVPLTAPPAMSLAVPLTAPPAMSLAVPLTAPPAMSLAAPLVVPSSYRSSYRPPHRAARACRLRTI
NKRTRTIAHADSFVRMIGDMDDQPICDAVFADRYALPGEHSRAQACARVARALALAEPMATRSGAARRFYRNLLNGAFGA
GRIMARAGAAPDQTMASCFVHPIRAPAALTRFHPNLDEALDEARLALAMGADIGYDFSAIPPAGARPDADHPDSPGVCAA
LDRFDRIGTQAGERDGRRRAQLAVLRCDHPDLLAFAAAKHRHAGRHARWTTLELAVAATDAFMQAVEQDLPWTLRHTAPP
RDAPGGALPGADGAWTYASVPARHVWREIVSAARDGAGPGLVFVDAIDAADPLRGRERIDATSPCGAQPLPPYGSAMLGA
IDLSRFVRNPFGAGGEPRFDFAAFDTAVRIEVRLLDNALDVTRWPLAAHARESYQKRRIGVGVTGLADMLAMMRLRYDSP
AAREMARYIASDLRHHAYAASAELAAERGAYPLCDRHAHLDALRAGPPLPHAVCHAIERDGLRHSHLTSFAPVIGVSLAF
GDHCSPGIEPARAWIEHRPVRAGAAGAPGMRAENHAHRLFRSLRGERAALPDYFATDADVAPGERLAMRVALQPYVDAGI
DNTLTLANHYSLEEVNALLFAAWRAKLKSVAIRRADLARDAQPSDDDGV
>Mature_688_residues
PLAAPLAAPPAMSLAVPLTAPPAMSLAVPLTAPPAMSLAVPLTAPPAMSLAAPLVVPSSYRSSYRPPHRAARACRLRTIN
KRTRTIAHADSFVRMIGDMDDQPICDAVFADRYALPGEHSRAQACARVARALALAEPMATRSGAARRFYRNLLNGAFGAG
RIMARAGAAPDQTMASCFVHPIRAPAALTRFHPNLDEALDEARLALAMGADIGYDFSAIPPAGARPDADHPDSPGVCAAL
DRFDRIGTQAGERDGRRRAQLAVLRCDHPDLLAFAAAKHRHAGRHARWTTLELAVAATDAFMQAVEQDLPWTLRHTAPPR
DAPGGALPGADGAWTYASVPARHVWREIVSAARDGAGPGLVFVDAIDAADPLRGRERIDATSPCGAQPLPPYGSAMLGAI
DLSRFVRNPFGAGGEPRFDFAAFDTAVRIEVRLLDNALDVTRWPLAAHARESYQKRRIGVGVTGLADMLAMMRLRYDSPA
AREMARYIASDLRHHAYAASAELAAERGAYPLCDRHAHLDALRAGPPLPHAVCHAIERDGLRHSHLTSFAPVIGVSLAFG
DHCSPGIEPARAWIEHRPVRAGAAGAPGMRAENHAHRLFRSLRGERAALPDYFATDADVAPGERLAMRVALQPYVDAGID
NTLTLANHYSLEEVNALLFAAWRAKLKSVAIRRADLARDAQPSDDDGV

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=431, Percent_Identity=22.5058004640371, Blast_Score=99, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17555242, Length=544, Percent_Identity=22.4264705882353, Blast_Score=104, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320914, Length=358, Percent_Identity=23.1843575418994, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322123, Length=366, Percent_Identity=23.7704918032787, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17352481, Length=433, Percent_Identity=22.4018475750577, Blast_Score=94, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 73829; Mature: 73698

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLAAPLAAPPAMSLAVPLTAPPAMSLAVPLTAPPAMSLAVPLTAPPAMSLAAPLVVPSS
CCCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCEEEEECCCCCHHHHHCCEECCCH
YRSSYRPPHRAARACRLRTINKRTRTIAHADSFVRMIGDMDDQPICDAVFADRYALPGEH
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC
SRAQACARVARALALAEPMATRSGAARRFYRNLLNGAFGAGRIMARAGAAPDQTMASCFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHH
HPIRAPAALTRFHPNLDEALDEARLALAMGADIGYDFSAIPPAGARPDADHPDSPGVCAA
HHHCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LDRFDRIGTQAGERDGRRRAQLAVLRCDHPDLLAFAAAKHRHAGRHARWTTLELAVAATD
HHHHHHHHCCCCHHCHHHHHHEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHH
AFMQAVEQDLPWTLRHTAPPRDAPGGALPGADGAWTYASVPARHVWREIVSAARDGAGPG
HHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCC
LVFVDAIDAADPLRGRERIDATSPCGAQPLPPYGSAMLGAIDLSRFVRNPFGAGGEPRFD
EEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
FAAFDTAVRIEVRLLDNALDVTRWPLAAHARESYQKRRIGVGVTGLADMLAMMRLRYDSP
HHHHCCEEEEEEEECCCHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCH
AAREMARYIASDLRHHAYAASAELAAERGAYPLCDRHAHLDALRAGPPLPHAVCHAIERD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHC
GLRHSHLTSFAPVIGVSLAFGDHCSPGIEPARAWIEHRPVRAGAAGAPGMRAENHAHRLF
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
RSLRGERAALPDYFATDADVAPGERLAMRVALQPYVDAGIDNTLTLANHYSLEEVNALLF
HHHCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
AAWRAKLKSVAIRRADLARDAQPSDDDGV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PLAAPLAAPPAMSLAVPLTAPPAMSLAVPLTAPPAMSLAVPLTAPPAMSLAAPLVVPSS
CCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCEEEEECCCCCHHHHHCCEECCCH
YRSSYRPPHRAARACRLRTINKRTRTIAHADSFVRMIGDMDDQPICDAVFADRYALPGEH
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC
SRAQACARVARALALAEPMATRSGAARRFYRNLLNGAFGAGRIMARAGAAPDQTMASCFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHH
HPIRAPAALTRFHPNLDEALDEARLALAMGADIGYDFSAIPPAGARPDADHPDSPGVCAA
HHHCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LDRFDRIGTQAGERDGRRRAQLAVLRCDHPDLLAFAAAKHRHAGRHARWTTLELAVAATD
HHHHHHHHCCCCHHCHHHHHHEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHH
AFMQAVEQDLPWTLRHTAPPRDAPGGALPGADGAWTYASVPARHVWREIVSAARDGAGPG
HHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCC
LVFVDAIDAADPLRGRERIDATSPCGAQPLPPYGSAMLGAIDLSRFVRNPFGAGGEPRFD
EEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
FAAFDTAVRIEVRLLDNALDVTRWPLAAHARESYQKRRIGVGVTGLADMLAMMRLRYDSP
HHHHCCEEEEEEEECCCHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCH
AAREMARYIASDLRHHAYAASAELAAERGAYPLCDRHAHLDALRAGPPLPHAVCHAIERD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHC
GLRHSHLTSFAPVIGVSLAFGDHCSPGIEPARAWIEHRPVRAGAAGAPGMRAENHAHRLF
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
RSLRGERAALPDYFATDADVAPGERLAMRVALQPYVDAGIDNTLTLANHYSLEEVNALLF
HHHCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
AAWRAKLKSVAIRRADLARDAQPSDDDGV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]