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The map label for this gene is sdhB-2 [H]

Identifier: 126445717

GI number: 126445717

Start: 2217791

End: 2218504

Strand: Reverse

Name: sdhB-2 [H]

Synonym: BMA10247_A2285

Alternate gene names: 126445717

Gene position: 2218504-2217791 (Counterclockwise)

Preceding gene: 126447586

Following gene: 126446692

Centisome position: 94.3

GC content: 67.65

Gene sequence:

>714_bases
ATGACGATGGCCGATACCCGCATTCTCGACATCTACCGCTACGATCCGGACGACGGGCGCGCGCCGCGCATGCAGCGCTA
TGAGCTCGCGCCGCGCGCGGAAGACCGGATGCTGCTCGACGTGCTCGGCCGCGTGAAGGCGCAGGACGAGACGCTGTCGT
ATCGCCGCTCGTGCCGCGAGGGCGTGTGCGGCTCCGACGCGATGAACATCAACGGCCGCAACGGGCTCGCCTGCGTGACG
AGCATGCAGGCGCTGCCGCGCGAAATCGTGCTGCGGCCGCTGCCGGGGCTGCCCGTCGTGCGCGATCTGATCGTCGACAT
GACGAGCTTCTTCAATCAGTACCATTCGGTCCGCCCGTATCTCGTCAACGAAGGCGTGCCGCCCGAACGAGAGCGCCTGC
AGACGCCGCAAGAGCGCGAGCAGCTCGACGGCCTCTACGAATGCATCCTGTGCGCGTGCTGCTCGAGCGCGTGCCCGAGC
TACTGGTGGAATCCCGACAAGTTCGTCGGGCCGGCGGGGCTGCTGCAGGCGTACCGCTTCATCGTCGATTCGCGCGACGA
CGCGAGCGCCGCGCGCCTCGACGATCTCGAGGACCCGTACCGGCTGTTCCGCTGCCGGACCATCATGAACTGTGTCGATG
TCTGTCCGAAAGGCCTGAACCCGGCGCGCGCGATCGGACAGATCCGCACGATGCTCGCGCGGCGCGCGGTATAG

Upstream 100 bases:

>100_bases
GACGTCGCGCGTTGCCGGCCGTGATCCGCGGCGCGGCCGCTCGCGCGCGGCGGGCACGCCGCTTGCATCGCGCTGAGCTT
TCGCGGCAGCGCGCACGACA

Downstream 100 bases:

>100_bases
CGCGCCGTGGCCGGGCGCAACGGGCACGCGCGCTTGGCGCGGCTCGCTCCAGACGATGCGCGCCGACCGGAGCCGGCGCT
TCGCTCGATGTTCGCTTTCG

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MTMADTRILDIYRYDPDDGRAPRMQRYELAPRAEDRMLLDVLGRVKAQDETLSYRRSCREGVCGSDAMNINGRNGLACVT
SMQALPREIVLRPLPGLPVVRDLIVDMTSFFNQYHSVRPYLVNEGVPPERERLQTPQEREQLDGLYECILCACCSSACPS
YWWNPDKFVGPAGLLQAYRFIVDSRDDASAARLDDLEDPYRLFRCRTIMNCVDVCPKGLNPARAIGQIRTMLARRAV

Sequences:

>Translated_237_residues
MTMADTRILDIYRYDPDDGRAPRMQRYELAPRAEDRMLLDVLGRVKAQDETLSYRRSCREGVCGSDAMNINGRNGLACVT
SMQALPREIVLRPLPGLPVVRDLIVDMTSFFNQYHSVRPYLVNEGVPPERERLQTPQEREQLDGLYECILCACCSSACPS
YWWNPDKFVGPAGLLQAYRFIVDSRDDASAARLDDLEDPYRLFRCRTIMNCVDVCPKGLNPARAIGQIRTMLARRAV
>Mature_236_residues
TMADTRILDIYRYDPDDGRAPRMQRYELAPRAEDRMLLDVLGRVKAQDETLSYRRSCREGVCGSDAMNINGRNGLACVTS
MQALPREIVLRPLPGLPVVRDLIVDMTSFFNQYHSVRPYLVNEGVPPERERLQTPQEREQLDGLYECILCACCSSACPSY
WWNPDKFVGPAGLLQAYRFIVDSRDDASAARLDDLEDPYRLFRCRTIMNCVDVCPKGLNPARAIGQIRTMLARRAV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=228, Percent_Identity=53.5087719298246, Blast_Score=257, Evalue=7e-69,
Organism=Escherichia coli, GI1786943, Length=232, Percent_Identity=63.3620689655172, Blast_Score=318, Evalue=3e-88,
Organism=Escherichia coli, GI1790596, Length=221, Percent_Identity=35.2941176470588, Blast_Score=142, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17533915, Length=232, Percent_Identity=47.4137931034483, Blast_Score=242, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6322987, Length=231, Percent_Identity=49.3506493506493, Blast_Score=243, Evalue=1e-65,
Organism=Drosophila melanogaster, GI17137106, Length=234, Percent_Identity=50.8547008547009, Blast_Score=256, Evalue=9e-69,
Organism=Drosophila melanogaster, GI24643156, Length=231, Percent_Identity=51.9480519480519, Blast_Score=246, Evalue=8e-66,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26985; Mature: 26854

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
8.4 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
8.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMADTRILDIYRYDPDDGRAPRMQRYELAPRAEDRMLLDVLGRVKAQDETLSYRRSCRE
CCCCCCEEEEEEEECCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHC
GVCGSDAMNINGRNGLACVTSMQALPREIVLRPLPGLPVVRDLIVDMTSFFNQYHSVRPY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCE
LVNEGVPPERERLQTPQEREQLDGLYECILCACCSSACPSYWWNPDKFVGPAGLLQAYRF
EECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
IVDSRDDASAARLDDLEDPYRLFRCRTIMNCVDVCPKGLNPARAIGQIRTMLARRAV
HHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TMADTRILDIYRYDPDDGRAPRMQRYELAPRAEDRMLLDVLGRVKAQDETLSYRRSCRE
CCCCCEEEEEEEECCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHC
GVCGSDAMNINGRNGLACVTSMQALPREIVLRPLPGLPVVRDLIVDMTSFFNQYHSVRPY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCE
LVNEGVPPERERLQTPQEREQLDGLYECILCACCSSACPSYWWNPDKFVGPAGLLQAYRF
EECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
IVDSRDDASAARLDDLEDPYRLFRCRTIMNCVDVCPKGLNPARAIGQIRTMLARRAV
HHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]