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The map label for this gene is gabT [H]

Identifier: 126444447

GI number: 126444447

Start: 448706

End: 449989

Strand: Reverse

Name: gabT [H]

Synonym: BURPS668_A0494

Alternate gene names: 126444447

Gene position: 449989-448706 (Counterclockwise)

Preceding gene: 126442981

Following gene: 126442487

Centisome position: 14.39

GC content: 69.24

Gene sequence:

>1284_bases
GTGAACAATGCCGATCTGCACGCCCGCAAGAACGCCGCGACGCCGCGTGGCGTCGGCGTGATGTGCGATTTCTACGCGTC
GCGCGCCGAGAACGCCGAGCTGTGGGATGTCGAGGGCCGCCGCTTCATCGATTTCGCGGCCGGCATCGCGGTCCTGAACA
CGGGCCATCGCCATCCGAGGATCGTGAAGGCGATCGCCGACCAGCTCGGGCAATTCACGCATACCGCGTATCAGATCGTG
CCGTACGCGTCGTACGTCGAGCTCGCCGAGAAGATCAACGCGCGCGCGCCGATCGCGCAGCCGAAGAAGACCGCGTTCTT
CACGACGGGCGCGGAAGCGGTCGAGAACGCGGTGAAGATCGCGCGCGCCTACACCGGCCGGCCGGGCGTGATCGCGTTCG
CGGGCGGCTTCCACGGCCGCACGATGATGGGCATGGCGCTCACCGGCAAGGTCGCGCCGTACAAGATCGGCTTCGGCCCG
TTCCCGGGCGACGTGTTCCACGCGCCGTACCCGAACGCGTTGCACGGCGTGACGAGCGCCGATTCGATCGCGGCCGTCGA
AACGCTGTTCAAGGCCGACATCGATCCGAAGCGCGTCGCCGCGATCATCTTCGAGCCGGTGCAGGGCGAAGGCGGCTTCA
ACCCGGCGCCCGCCGAGTTCGTGCGCGCGCTGCGCAAGCTGTGCGACGCGCACGGCATTCTCCTCATCGCCGACGAAGTG
CAGACGGGCTTCGCGCGCACGGGCAAGCTGTTCGCGATGGAGCACTACGACGTCTCGGCCGACCTGATGACGATCGCGAA
GAGCCTCGCGGGCGGGATGCCGCTGTCGGGCGTCGTCGGCCGCGCGGACGTGATGGACGCGGCCGCGCCGGGTGGCCTGG
GCGGCACATACGCGGGCAATCCGCTCGCCGTGGCCGCCGCGCACGCGGTGCTCGACGTGATCGACGAGGAGAAGCTCGCC
GAGCGCGCGACCGTGCTCGGCGACAAGCTGAAGGCGAAGCTCGCCGCGCTGCGCGCCGAGCTGCCGCAGATCGTCGACGT
GCGCGGCCCGGGCGCGATGGTCGCCGCGGAATTCGTCGATCCGCACACGCGCGCGTCCGATGCCGCGTTCACGAAGCGCG
TGCAGACGCTCGCGCTCGAGCGCGGGCTGCTGCTGCTCATCTGCGGCGTCGACGCGAACGTGATACGTTTCCTGTTTCCT
CTCACCATCGAGGATGCCGTGTTCGACGAAGCGCTCGGCATTCTCGAGAGCGTGCTGAGGGAAGCGGTGGGCGTGCCCGC
CTGA

Upstream 100 bases:

>100_bases
GAGCCAAGTTTGATTATAGTCGTTTCGACGCGCACGCCCGACGACGTGCCCGCCGGCGGCCGTCGCCGCCGGCGCATCCG
AACCCCGAGGAGAGACGACT

Downstream 100 bases:

>100_bases
GTCTTTCGCCGCCCGCGCGCGGGCGGCGCCAATCGTTTCCGGATACGGCCGACACTGATGACTACAGCTCACGAAACCCT
TGCACTGAAAGATCCCGCGC

Product: 4-aminobutyrate transaminase

Products: NA

Alternate protein names: GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MNNADLHARKNAATPRGVGVMCDFYASRAENAELWDVEGRRFIDFAAGIAVLNTGHRHPRIVKAIADQLGQFTHTAYQIV
PYASYVELAEKINARAPIAQPKKTAFFTTGAEAVENAVKIARAYTGRPGVIAFAGGFHGRTMMGMALTGKVAPYKIGFGP
FPGDVFHAPYPNALHGVTSADSIAAVETLFKADIDPKRVAAIIFEPVQGEGGFNPAPAEFVRALRKLCDAHGILLIADEV
QTGFARTGKLFAMEHYDVSADLMTIAKSLAGGMPLSGVVGRADVMDAAAPGGLGGTYAGNPLAVAAAHAVLDVIDEEKLA
ERATVLGDKLKAKLAALRAELPQIVDVRGPGAMVAAEFVDPHTRASDAAFTKRVQTLALERGLLLLICGVDANVIRFLFP
LTIEDAVFDEALGILESVLREAVGVPA

Sequences:

>Translated_427_residues
MNNADLHARKNAATPRGVGVMCDFYASRAENAELWDVEGRRFIDFAAGIAVLNTGHRHPRIVKAIADQLGQFTHTAYQIV
PYASYVELAEKINARAPIAQPKKTAFFTTGAEAVENAVKIARAYTGRPGVIAFAGGFHGRTMMGMALTGKVAPYKIGFGP
FPGDVFHAPYPNALHGVTSADSIAAVETLFKADIDPKRVAAIIFEPVQGEGGFNPAPAEFVRALRKLCDAHGILLIADEV
QTGFARTGKLFAMEHYDVSADLMTIAKSLAGGMPLSGVVGRADVMDAAAPGGLGGTYAGNPLAVAAAHAVLDVIDEEKLA
ERATVLGDKLKAKLAALRAELPQIVDVRGPGAMVAAEFVDPHTRASDAAFTKRVQTLALERGLLLLICGVDANVIRFLFP
LTIEDAVFDEALGILESVLREAVGVPA
>Mature_427_residues
MNNADLHARKNAATPRGVGVMCDFYASRAENAELWDVEGRRFIDFAAGIAVLNTGHRHPRIVKAIADQLGQFTHTAYQIV
PYASYVELAEKINARAPIAQPKKTAFFTTGAEAVENAVKIARAYTGRPGVIAFAGGFHGRTMMGMALTGKVAPYKIGFGP
FPGDVFHAPYPNALHGVTSADSIAAVETLFKADIDPKRVAAIIFEPVQGEGGFNPAPAEFVRALRKLCDAHGILLIADEV
QTGFARTGKLFAMEHYDVSADLMTIAKSLAGGMPLSGVVGRADVMDAAAPGGLGGTYAGNPLAVAAAHAVLDVIDEEKLA
ERATVLGDKLKAKLAALRAELPQIVDVRGPGAMVAAEFVDPHTRASDAAFTKRVQTLALERGLLLLICGVDANVIRFLFP
LTIEDAVFDEALGILESVLREAVGVPA

Specific function: Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=408, Percent_Identity=34.0686274509804, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI13994255, Length=359, Percent_Identity=33.983286908078, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI37574042, Length=438, Percent_Identity=30.365296803653, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI284507298, Length=324, Percent_Identity=34.8765432098765, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI226442709, Length=392, Percent_Identity=31.1224489795918, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI226442705, Length=438, Percent_Identity=29.6803652968037, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI188536080, Length=445, Percent_Identity=29.438202247191, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI38679950, Length=445, Percent_Identity=29.438202247191, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI38679946, Length=445, Percent_Identity=29.438202247191, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI24119277, Length=414, Percent_Identity=26.0869565217391, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=69.5961995249406, Blast_Score=585, Evalue=1e-168,
Organism=Escherichia coli, GI1789016, Length=422, Percent_Identity=54.0284360189574, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1789759, Length=409, Percent_Identity=34.9633251833741, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI1788044, Length=390, Percent_Identity=35.6410256410256, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI145693181, Length=383, Percent_Identity=36.2924281984334, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1786991, Length=373, Percent_Identity=32.4396782841823, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786349, Length=375, Percent_Identity=32, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI32564660, Length=425, Percent_Identity=32.2352941176471, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25144271, Length=404, Percent_Identity=33.6633663366337, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71992977, Length=424, Percent_Identity=30.6603773584906, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25144274, Length=289, Percent_Identity=34.6020761245675, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=430, Percent_Identity=25.5813953488372, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71981843, Length=160, Percent_Identity=31.875, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324432, Length=414, Percent_Identity=32.8502415458937, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6323470, Length=399, Percent_Identity=34.3358395989975, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6321456, Length=366, Percent_Identity=27.8688524590164, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6324386, Length=341, Percent_Identity=25.2199413489736, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357415, Length=408, Percent_Identity=32.5980392156863, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI28574759, Length=436, Percent_Identity=30.9633027522936, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI161085790, Length=419, Percent_Identity=31.5035799522673, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI21356575, Length=424, Percent_Identity=31.1320754716981, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI281366494, Length=370, Percent_Identity=29.1891891891892, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24667139, Length=370, Percent_Identity=29.1891891891892, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24667143, Length=370, Percent_Identity=29.1891891891892, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19 [H]

Molecular weight: Translated: 45135; Mature: 45135

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNADLHARKNAATPRGVGVMCDFYASRAENAELWDVEGRRFIDFAAGIAVLNTGHRHPR
CCCCCCCCCCCCCCCCCCCEEEHHHHCCCCCCEEEECCCCEEHHHHHHHHHCCCCCCCHH
IVKAIADQLGQFTHTAYQIVPYASYVELAEKINARAPIAQPKKTAFFTTGAEAVENAVKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHH
ARAYTGRPGVIAFAGGFHGRTMMGMALTGKVAPYKIGFGPFPGDVFHAPYPNALHGVTSA
HHHHCCCCCEEEEECCCCCCEEECEEEECCCCCEEECCCCCCCCCCCCCCCHHHCCCCCC
DSIAAVETLFKADIDPKRVAAIIFEPVQGEGGFNPAPAEFVRALRKLCDAHGILLIADEV
HHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCH
QTGFARTGKLFAMEHYDVSADLMTIAKSLAGGMPLSGVVGRADVMDAAAPGGLGGTYAGN
HHCHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCC
PLAVAAAHAVLDVIDEEKLAERATVLGDKLKAKLAALRAELPQIVDVRGPGAMVAAEFVD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCCEEEEHHCC
PHTRASDAAFTKRVQTLALERGLLLLICGVDANVIRFLFPLTIEDAVFDEALGILESVLR
CCCCCCHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAVGVPA
HHHCCCC
>Mature Secondary Structure
MNNADLHARKNAATPRGVGVMCDFYASRAENAELWDVEGRRFIDFAAGIAVLNTGHRHPR
CCCCCCCCCCCCCCCCCCCEEEHHHHCCCCCCEEEECCCCEEHHHHHHHHHCCCCCCCHH
IVKAIADQLGQFTHTAYQIVPYASYVELAEKINARAPIAQPKKTAFFTTGAEAVENAVKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHH
ARAYTGRPGVIAFAGGFHGRTMMGMALTGKVAPYKIGFGPFPGDVFHAPYPNALHGVTSA
HHHHCCCCCEEEEECCCCCCEEECEEEECCCCCEEECCCCCCCCCCCCCCCHHHCCCCCC
DSIAAVETLFKADIDPKRVAAIIFEPVQGEGGFNPAPAEFVRALRKLCDAHGILLIADEV
HHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCH
QTGFARTGKLFAMEHYDVSADLMTIAKSLAGGMPLSGVVGRADVMDAAAPGGLGGTYAGN
HHCHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCC
PLAVAAAHAVLDVIDEEKLAERATVLGDKLKAKLAALRAELPQIVDVRGPGAMVAAEFVD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCCEEEEHHCC
PHTRASDAAFTKRVQTLALERGLLLLICGVDANVIRFLFPLTIEDAVFDEALGILESVLR
CCCCCCHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAVGVPA
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]