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The map label for this gene is wecA [H]

Identifier: 126209018

GI number: 126209018

Start: 1776632

End: 1777705

Strand: Reverse

Name: wecA [H]

Synonym: APL_1554

Alternate gene names: 126209018

Gene position: 1777705-1776632 (Counterclockwise)

Preceding gene: 126209020

Following gene: 126209017

Centisome position: 78.16

GC content: 46.46

Gene sequence:

>1074_bases
ATGTGGCTTACTTTTCTTGCTGTTTTTGTGGTGTCGTTCGCCAGTCTGATTTTTATGAGACCGGTTGCGGAAAAAATCGG
TTTGGTCGATAAACCGAACTTTCGTAAACGTCACCAAGGCTTAATTCCGTTAATCGGCGGGATAGCCCTATTTTTAGGTA
ATCTGACCTTCTATTTTATGGAATGGCAAGATATGCGTTTACCTTGGTTGTATCTTGCGGCGGTGACTATTCTATTGGTT
ATCGGGGTGTTGGACGACCGTTTTGACGTAAGCCCGTTTTTACGCGCCAGCATTCAAGCCGGGTTAGCCGGCCTCATGAT
TTATAACGGACTGTCTTTAGATAGCTTAGGGCAAGTGATTGCGCCGTTTAGTATCGAGCTTGGGATTCTCGGCATTATTT
TTACCGTGTTTGTCACGATCGGCGTGATTAATGCGTTTAATATGGTGGACGGTATCGACGGCTTATTAGCCGGCCTTTCC
AGCGCCAGTTTTGCCGGTATCGGCGTGCTGATGTGGCTGGACGAGCAATACACGTTAGCCTATTGGTGTTTTGCGATTAT
TGTCGTCTTGATTCCGTATGCGATGTTTAACCTCAGCGTATTCGGCGCCAAATGGAAAGTTTTTATGGGCGATTCGGGCA
GTACCCTAATTGGGTTTACGATTATTTGGATTCTGTTGCTTAGCACCCAAGGTCAAGGGCATACGATTAGTCCGATTACC
GGTTTATGGCTGATTGCCGTGCCGCTAATCGATATGGTGGCGGTCATTATTCGCCGTTTGAAAAAGGGCAAAAGTCCGTT
CAGACCGGACCGTTTACACTTACACCATTTAATGATGCGCGCCGGTTTAACTTCTCGCCAAGCACTGGCAGTCATTACCT
TCGGGGCGGCGATTTGCTCTACCATCGGCGTATTAGGCGAATACTACTATTGGAATCAATGGTTGATGACGATCGGCTTT
ATCGGTTTATTCTTTATCTATGCCTATTCGATTACGCATGCGTGGCGAGTGACACGCTTTATTCGTCGTATGAAACGCAG
AGCGAAAAGAAAGCTCAAAATCGGTAGTGAGTAA

Upstream 100 bases:

>100_bases
TAAAAAAAAGCCCAAATAACCTAAAAAAATTTGAGAGTCCTCGCCTTTGTGATATTCTTTACACACTTTTTTATATTGAT
TTTGAGGGAGCTAACCCCTT

Downstream 100 bases:

>100_bases
CTGAGAGTAAACAGTCGAATTTTTAGGATTATTTATGCTATTACGTTATTTGTTCACGTTAATTATAAGTACTGCCGTCG
GTGTGGCGGGCGGATTCGGA

Product: putative undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MWLTFLAVFVVSFASLIFMRPVAEKIGLVDKPNFRKRHQGLIPLIGGIALFLGNLTFYFMEWQDMRLPWLYLAAVTILLV
IGVLDDRFDVSPFLRASIQAGLAGLMIYNGLSLDSLGQVIAPFSIELGILGIIFTVFVTIGVINAFNMVDGIDGLLAGLS
SASFAGIGVLMWLDEQYTLAYWCFAIIVVLIPYAMFNLSVFGAKWKVFMGDSGSTLIGFTIIWILLLSTQGQGHTISPIT
GLWLIAVPLIDMVAVIIRRLKKGKSPFRPDRLHLHHLMMRAGLTSRQALAVITFGAAICSTIGVLGEYYYWNQWLMTIGF
IGLFFIYAYSITHAWRVTRFIRRMKRRAKRKLKIGSE

Sequences:

>Translated_357_residues
MWLTFLAVFVVSFASLIFMRPVAEKIGLVDKPNFRKRHQGLIPLIGGIALFLGNLTFYFMEWQDMRLPWLYLAAVTILLV
IGVLDDRFDVSPFLRASIQAGLAGLMIYNGLSLDSLGQVIAPFSIELGILGIIFTVFVTIGVINAFNMVDGIDGLLAGLS
SASFAGIGVLMWLDEQYTLAYWCFAIIVVLIPYAMFNLSVFGAKWKVFMGDSGSTLIGFTIIWILLLSTQGQGHTISPIT
GLWLIAVPLIDMVAVIIRRLKKGKSPFRPDRLHLHHLMMRAGLTSRQALAVITFGAAICSTIGVLGEYYYWNQWLMTIGF
IGLFFIYAYSITHAWRVTRFIRRMKRRAKRKLKIGSE
>Mature_357_residues
MWLTFLAVFVVSFASLIFMRPVAEKIGLVDKPNFRKRHQGLIPLIGGIALFLGNLTFYFMEWQDMRLPWLYLAAVTILLV
IGVLDDRFDVSPFLRASIQAGLAGLMIYNGLSLDSLGQVIAPFSIELGILGIIFTVFVTIGVINAFNMVDGIDGLLAGLS
SASFAGIGVLMWLDEQYTLAYWCFAIIVVLIPYAMFNLSVFGAKWKVFMGDSGSTLIGFTIIWILLLSTQGQGHTISPIT
GLWLIAVPLIDMVAVIIRRLKKGKSPFRPDRLHLHHLMMRAGLTSRQALAVITFGAAICSTIGVLGEYYYWNQWLMTIGF
IGLFFIYAYSITHAWRVTRFIRRMKRRAKRKLKIGSE

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55) [H]

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=327, Percent_Identity=55.9633027522936, Blast_Score=348, Evalue=2e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012750
- InterPro:   IPR000715
- InterPro:   IPR018480 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 40006; Mature: 40006

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWLTFLAVFVVSFASLIFMRPVAEKIGLVDKPNFRKRHQGLIPLIGGIALFLGNLTFYFM
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHEEE
EWQDMRLPWLYLAAVTILLVIGVLDDRFDVSPFLRASIQAGLAGLMIYNGLSLDSLGQVI
ECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
APFSIELGILGIIFTVFVTIGVINAFNMVDGIDGLLAGLSSASFAGIGVLMWLDEQYTLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEECCCHHHH
YWCFAIIVVLIPYAMFNLSVFGAKWKVFMGDSGSTLIGFTIIWILLLSTQGQGHTISPIT
HHHHHHHHHHHHHHHHHHHEECCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHH
GLWLIAVPLIDMVAVIIRRLKKGKSPFRPDRLHLHHLMMRAGLTSRQALAVITFGAAICS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
TIGVLGEYYYWNQWLMTIGFIGLFFIYAYSITHAWRVTRFIRRMKRRAKRKLKIGSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MWLTFLAVFVVSFASLIFMRPVAEKIGLVDKPNFRKRHQGLIPLIGGIALFLGNLTFYFM
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHEEE
EWQDMRLPWLYLAAVTILLVIGVLDDRFDVSPFLRASIQAGLAGLMIYNGLSLDSLGQVI
ECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
APFSIELGILGIIFTVFVTIGVINAFNMVDGIDGLLAGLSSASFAGIGVLMWLDEQYTLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEECCCHHHH
YWCFAIIVVLIPYAMFNLSVFGAKWKVFMGDSGSTLIGFTIIWILLLSTQGQGHTISPIT
HHHHHHHHHHHHHHHHHHHEECCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHH
GLWLIAVPLIDMVAVIIRRLKKGKSPFRPDRLHLHHLMMRAGLTSRQALAVITFGAAICS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
TIGVLGEYYYWNQWLMTIGFIGLFFIYAYSITHAWRVTRFIRRMKRRAKRKLKIGSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]