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The map label for this gene is ndk

Identifier: 126207835

GI number: 126207835

Start: 393225

End: 393641

Strand: Reverse

Name: ndk

Synonym: APL_0351

Alternate gene names: 126207835

Gene position: 393641-393225 (Counterclockwise)

Preceding gene: 126207836

Following gene: 126207829

Centisome position: 17.31

GC content: 44.12

Gene sequence:

>417_bases
ATGATTCAACAAACACTCTGTTTAATTAAACCCGATGCGACACAACGCAATCTTATCGGTAAAATTCTTAGCCATCTGGA
AGAAGCCGGTTTAACTATTAAAGCACTTAAAAAAGTACAGCTTAATCAAGAACAAGCTGAAGGTTTTTACGCCGAGCATC
AAGGTAAGGAATTTTTTGCTCCGCTCGTGGAATTTATGATTTCCGCACCGATTGTCGCGGTCGTGCTTGAAGGCGAAAAT
GCAATCGCTCACTACCGTGAATTAATGGGCGCAACCAATCCGGAACAACGTAAAGCCGGTACGATTCGCGCCCTTTACGC
TATCAGCGGACGTGAAAATTCGGTACACGGTTCGGACTCCGAGCAATCGGCAAAACGTGAAATCGCTTATTTCTTCACGC
CGAATGAAATTCTCTAA

Upstream 100 bases:

>100_bases
TCAGCGGATGAAGGTATCCGCCCGGGTATGCAAGTAAAATAATAGCTATAGTAAAAAAGGCGGTAAAAATTACCGCTTTT
TTTGCGAACAAGGAGAAAAA

Downstream 100 bases:

>100_bases
ACGATAGCCAAAAAGAAAGCCGTTTGTCTTACACAAACGGCTTTTTTATCGCTAATACAAGCGGTCCGTTTCTTGCAAAA
TCTTACGAAAAACAGACCGC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 138; Mature: 138

Protein sequence:

>138_residues
MIQQTLCLIKPDATQRNLIGKILSHLEEAGLTIKALKKVQLNQEQAEGFYAEHQGKEFFAPLVEFMISAPIVAVVLEGEN
AIAHYRELMGATNPEQRKAGTIRALYAISGRENSVHGSDSEQSAKREIAYFFTPNEIL

Sequences:

>Translated_138_residues
MIQQTLCLIKPDATQRNLIGKILSHLEEAGLTIKALKKVQLNQEQAEGFYAEHQGKEFFAPLVEFMISAPIVAVVLEGEN
AIAHYRELMGATNPEQRKAGTIRALYAISGRENSVHGSDSEQSAKREIAYFFTPNEIL
>Mature_138_residues
MIQQTLCLIKPDATQRNLIGKILSHLEEAGLTIKALKKVQLNQEQAEGFYAEHQGKEFFAPLVEFMISAPIVAVVLEGEN
AIAHYRELMGATNPEQRKAGTIRALYAISGRENSVHGSDSEQSAKREIAYFFTPNEIL

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=41.9117647058824, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=38.6861313868613, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=38.6861313868613, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=38.6861313868613, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=38.6861313868613, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=38.6861313868613, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=39.7058823529412, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=39.7058823529412, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=33.0882352941176, Blast_Score=97, Evalue=4e-21,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=36.8421052631579, Blast_Score=96, Evalue=8e-21,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=36.8421052631579, Blast_Score=96, Evalue=8e-21,
Organism=Homo sapiens, GI5031951, Length=139, Percent_Identity=39.568345323741, Blast_Score=90, Evalue=7e-19,
Organism=Homo sapiens, GI148839372, Length=136, Percent_Identity=39.7058823529412, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI4505413, Length=134, Percent_Identity=34.3283582089552, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=31.8518518518519, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=56.6176470588235, Blast_Score=156, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=40.7407407407407, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=42.6470588235294, Blast_Score=117, Evalue=4e-28,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=39.7058823529412, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18860097, Length=131, Percent_Identity=41.2213740458015, Blast_Score=94, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_ACTP2 (A3MZ69)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053060.1
- ProteinModelPortal:   A3MZ69
- SMR:   A3MZ69
- STRING:   A3MZ69
- GeneID:   4849819
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0351
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   A3MZ69
- ProtClustDB:   CLSK918889
- BioCyc:   APLE416269:APL_0351-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15343; Mature: 15343

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 116-116 BINDING 10-10 BINDING 58-58 BINDING 86-86 BINDING 92-92 BINDING 103-103 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQQTLCLIKPDATQRNLIGKILSHLEEAGLTIKALKKVQLNQEQAEGFYAEHQGKEFFA
CCCCCEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHCCCHHHHCCHHHHH
PLVEFMISAPIVAVVLEGENAIAHYRELMGATNPEQRKAGTIRALYAISGRENSVHGSDS
HHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHCCCEEEEEEECCCCCCCCCCCC
EQSAKREIAYFFTPNEIL
HHHHHHEEEEEECCCCCC
>Mature Secondary Structure
MIQQTLCLIKPDATQRNLIGKILSHLEEAGLTIKALKKVQLNQEQAEGFYAEHQGKEFFA
CCCCCEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHCCCHHHHCCHHHHH
PLVEFMISAPIVAVVLEGENAIAHYRELMGATNPEQRKAGTIRALYAISGRENSVHGSDS
HHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHCCCEEEEEEECCCCCCCCCCCC
EQSAKREIAYFFTPNEIL
HHHHHHEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA