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The map label for this gene is thrB [H]

Identifier: 126207737

GI number: 126207737

Start: 270367

End: 271317

Strand: Reverse

Name: thrB [H]

Synonym: APL_0249

Alternate gene names: 126207737

Gene position: 271317-270367 (Counterclockwise)

Preceding gene: 126207738

Following gene: 126207736

Centisome position: 11.93

GC content: 44.58

Gene sequence:

>951_bases
ATGACGACATTACGAATTTATGCTCCGGCATCAAGTGCCAATCTAAGTGTCGGTTTTGACTCGTTAGGTGCGGCGATTTC
ACCGATTGACGGCTCGTTACTCGGTGACGTAGTACAAATTGAAGATTGCGAAACCGCTTTTGAGCTGGAAAGCGCCGGTT
ATTTCGTGCGTAAATTACCAAAAGAGCCGCAAAAAAATATTGTTTATCAAGCCTACGTATTATTTAGCGAACGCTTGAAA
TTACGCGGCGGTTCAGTCAAAAACTTACGTCTTACCCTTGAAAAAAATATGCCGATTGGTTCCGGTTTAGGTTCAAGCGC
CTGTTCAATCGTAGCGGCATTGGTTGCACTGAATAAATTCCATGACGAACCGTTTTCTAAAATGGAATTATTGGAAATGA
TGGGCGAATTGGAAGGACGAATTTCCGGCTCAATCCACTACGACAACGTCGCACCTTGCTATTTAGGCGGTTTGCAGTTA
ATGACGCAATCGCTCGGTAATATTTGCCAAACCATTCCGTTCTTTGACGAATGGTATTGGGTACTCGCTTATCCGGGCGT
TGAAGTTTCAACGGCGGAAGCTCGAGCGATTTTACCGAAAAACTATACTCGTCAAGATATGATTCAACAGGCGCGTTACC
TCGGTTCGTTCGTACACGCTTGTCATACGCATCAAGATATCTTAGCGGCGACAATGATGAAGGATTTAATTGCCGAGCCG
TATCGTGAAAATCTATTGCCGAACTTTGCCGAAGTTCGCCAAGGCTGTAAAGATCTCGGCGCATTATCAGTAGGTATTTC
CGGTTCGGGCCCGACAATGTTTGCCATTGCGCCGGATTTGGAACACGCTCAAAAACTGGCCGCTTATCTTGAAAAAGAGT
ATCTACAAAACAACGAAGGCTTTATTCATATCTGTAAAGTCGATAACCAAGGCGCGCGTGAATTGAAATAA

Upstream 100 bases:

>100_bases
CGATTCCGCTCTTATTAAGAGGTTACGGTGCAGGTACGGACGTAACTGCCGCCGGTATTTTTGCCGATATTCTGCGTACA
TTACACGGAGGTTCAAACTA

Downstream 100 bases:

>100_bases
TTCGCAGTGTATTTAGCCTATACAAGCGGTCGGATTTTGCAAAAAAATTGTAAAATCCGACCGCTTTTTTAGTGTGATTA
TCCTCGTCTTTTGAACAAGT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTTLRIYAPASSANLSVGFDSLGAAISPIDGSLLGDVVQIEDCETAFELESAGYFVRKLPKEPQKNIVYQAYVLFSERLK
LRGGSVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELEGRISGSIHYDNVAPCYLGGLQL
MTQSLGNICQTIPFFDEWYWVLAYPGVEVSTAEARAILPKNYTRQDMIQQARYLGSFVHACHTHQDILAATMMKDLIAEP
YRENLLPNFAEVRQGCKDLGALSVGISGSGPTMFAIAPDLEHAQKLAAYLEKEYLQNNEGFIHICKVDNQGARELK

Sequences:

>Translated_316_residues
MTTLRIYAPASSANLSVGFDSLGAAISPIDGSLLGDVVQIEDCETAFELESAGYFVRKLPKEPQKNIVYQAYVLFSERLK
LRGGSVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELEGRISGSIHYDNVAPCYLGGLQL
MTQSLGNICQTIPFFDEWYWVLAYPGVEVSTAEARAILPKNYTRQDMIQQARYLGSFVHACHTHQDILAATMMKDLIAEP
YRENLLPNFAEVRQGCKDLGALSVGISGSGPTMFAIAPDLEHAQKLAAYLEKEYLQNNEGFIHICKVDNQGARELK
>Mature_315_residues
TTLRIYAPASSANLSVGFDSLGAAISPIDGSLLGDVVQIEDCETAFELESAGYFVRKLPKEPQKNIVYQAYVLFSERLKL
RGGSVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELEGRISGSIHYDNVAPCYLGGLQLM
TQSLGNICQTIPFFDEWYWVLAYPGVEVSTAEARAILPKNYTRQDMIQQARYLGSFVHACHTHQDILAATMMKDLIAEPY
RENLLPNFAEVRQGCKDLGALSVGISGSGPTMFAIAPDLEHAQKLAAYLEKEYLQNNEGFIHICKVDNQGARELK

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=313, Percent_Identity=60.0638977635783, Blast_Score=392, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 34780; Mature: 34649

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLRIYAPASSANLSVGFDSLGAAISPIDGSLLGDVVQIEDCETAFELESAGYFVRKLP
CCEEEEEECCCCCCEEECHHHHCCCCCCCCCHHHHCEEEECCCHHHHHHHHCCHHHHHCC
KEPQKNIVYQAYVLFSERLKLRGGSVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKF
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
HDEPFSKMELLEMMGELEGRISGSIHYDNVAPCYLGGLQLMTQSLGNICQTIPFFDEWYW
CCCCHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCEE
VLAYPGVEVSTAEARAILPKNYTRQDMIQQARYLGSFVHACHTHQDILAATMMKDLIAEP
EEEECCCEEECCHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
YRENLLPNFAEVRQGCKDLGALSVGISGSGPTMFAIAPDLEHAQKLAAYLEKEYLQNNEG
HHHHCCCCHHHHHHHHHHHCCEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCC
FIHICKVDNQGARELK
EEEEEEECCCCCCCCC
>Mature Secondary Structure 
TTLRIYAPASSANLSVGFDSLGAAISPIDGSLLGDVVQIEDCETAFELESAGYFVRKLP
CEEEEEECCCCCCEEECHHHHCCCCCCCCCHHHHCEEEECCCHHHHHHHHCCHHHHHCC
KEPQKNIVYQAYVLFSERLKLRGGSVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKF
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
HDEPFSKMELLEMMGELEGRISGSIHYDNVAPCYLGGLQLMTQSLGNICQTIPFFDEWYW
CCCCHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCEE
VLAYPGVEVSTAEARAILPKNYTRQDMIQQARYLGSFVHACHTHQDILAATMMKDLIAEP
EEEECCCEEECCHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
YRENLLPNFAEVRQGCKDLGALSVGISGSGPTMFAIAPDLEHAQKLAAYLEKEYLQNNEG
HHHHCCCCHHHHHHHHHHHCCEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCC
FIHICKVDNQGARELK
EEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA