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The map label for this gene is argB

Identifier: 126207731

GI number: 126207731

Start: 260923

End: 261777

Strand: Direct

Name: argB

Synonym: APL_0243

Alternate gene names: 126207731

Gene position: 260923-261777 (Clockwise)

Preceding gene: 126207730

Following gene: 126207732

Centisome position: 11.47

GC content: 41.64

Gene sequence:

>855_bases
ATGTTACAAAACGAAGTTGAAAATTTTGCAAATCTGTTAGAACAAGCGACCGTTTATCTTGCTCCGTATCAAGAAAAAAT
TATTGTGGTGAAGTACGGCGGCAATGCGATGATCAATGAAGATCGTAAAAAATTGGTAATGCAAGACATTTTATTGCTGA
ACCAATTAGGCGTGAAAGTGGTATTAGTGCATGGCGGCGGGCCGGAAATTTCACAGGGGGTGAAGTTACTCGGCAAAGAA
CCGCAATTTATCAATGGCTTACGAGTTACCGATCAAGATACGATTAATGTGGTATTACAAATGCTCGCTGGTAAAGTGAA
TAAAAGTTTGGTGGCGTTATTAAAAGGTAAAGGCGTTGGCTTATGCGGTATTGATGCGAATATGTTGCAATGCGAAAAGT
TACAAGCTGAAGTAGATTACGGCTTTGTCGGTGAGATTGTGAAAGTAAATACTCAATTATTGGAACTTGCGTTAAGTGCA
AATTTAATTCCGGTGATTTCTACGGTTGGCGTAGATGATCAAGGCGTAGCTTATAATATCAATGCGGATACAGTAGCGAG
TGAAATTGCCATGGCACTAGGAGCGGCGAAACTTGTGAGTATGACGGACATCGCCGGCTTATTACGCGATCGTTTTGATG
AGAGTACGCTGATTCCTGAAGTTGAGGTCAGCGAGGTGCAAGGCTTAATTGATCAAGGCATTATTGCCGGCGGTATGATT
CCGAAAATCGCCTGCTGTACCGATTTTATTAATGCCGGCGGCATTGAAGCGAATATCATTGACGGACGAGTACCGCATGC
CATTTTAGTCTCATTATTCGGCGGTAAAAACGGTACGCTTTTTTATAAAAAATAA

Upstream 100 bases:

>100_bases
CATCCGGTGCGGCGGTACAATGTATGAATATTATGCTAGGTCGTGAAGAAACAGCCGGACTAGACGTGTAGTCAGCGTGA
GATATTATTTGGGGTTTAGA

Downstream 100 bases:

>100_bases
TTAGGAAGACAATATGAACAGCAACGACATCAAACAATTAGATGCGGATTATATCGCACAAACTTACGGTAGATTTAACC
TCGCCCTTTCACACGGAAAA

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MLQNEVENFANLLEQATVYLAPYQEKIIVVKYGGNAMINEDRKKLVMQDILLLNQLGVKVVLVHGGGPEISQGVKLLGKE
PQFINGLRVTDQDTINVVLQMLAGKVNKSLVALLKGKGVGLCGIDANMLQCEKLQAEVDYGFVGEIVKVNTQLLELALSA
NLIPVISTVGVDDQGVAYNINADTVASEIAMALGAAKLVSMTDIAGLLRDRFDESTLIPEVEVSEVQGLIDQGIIAGGMI
PKIACCTDFINAGGIEANIIDGRVPHAILVSLFGGKNGTLFYKK

Sequences:

>Translated_284_residues
MLQNEVENFANLLEQATVYLAPYQEKIIVVKYGGNAMINEDRKKLVMQDILLLNQLGVKVVLVHGGGPEISQGVKLLGKE
PQFINGLRVTDQDTINVVLQMLAGKVNKSLVALLKGKGVGLCGIDANMLQCEKLQAEVDYGFVGEIVKVNTQLLELALSA
NLIPVISTVGVDDQGVAYNINADTVASEIAMALGAAKLVSMTDIAGLLRDRFDESTLIPEVEVSEVQGLIDQGIIAGGMI
PKIACCTDFINAGGIEANIIDGRVPHAILVSLFGGKNGTLFYKK
>Mature_284_residues
MLQNEVENFANLLEQATVYLAPYQEKIIVVKYGGNAMINEDRKKLVMQDILLLNQLGVKVVLVHGGGPEISQGVKLLGKE
PQFINGLRVTDQDTINVVLQMLAGKVNKSLVALLKGKGVGLCGIDANMLQCEKLQAEVDYGFVGEIVKVNTQLLELALSA
NLIPVISTVGVDDQGVAYNINADTVASEIAMALGAAKLVSMTDIAGLLRDRFDESTLIPEVEVSEVQGLIDQGIIAGGMI
PKIACCTDFINAGGIEANIIDGRVPHAILVSLFGGKNGTLFYKK

Specific function: Arginine biosynthesis; second step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetylglutamate kinase family

Homologues:

Organism=Escherichia coli, GI145693208, Length=220, Percent_Identity=33.6363636363636, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1789181, Length=272, Percent_Identity=24.2647058823529, Blast_Score=80, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320913, Length=206, Percent_Identity=26.6990291262136, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGB_ACTP2 (A3MYW5)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001052956.1
- ProteinModelPortal:   A3MYW5
- SMR:   A3MYW5
- STRING:   A3MYW5
- GeneID:   4850320
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0243
- eggNOG:   COG0548
- HOGENOM:   HBG497643
- OMA:   MDIVEMV
- PhylomeDB:   A3MYW5
- ProtClustDB:   PRK00942
- BioCyc:   APLE416269:APL_0243-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00082_B
- InterPro:   IPR004662
- InterPro:   IPR001048
- InterPro:   IPR001057
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF000728
- PRINTS:   PR00474
- TIGRFAMs:   TIGR00761

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.2.8

Molecular weight: Translated: 30319; Mature: 30319

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: BINDING 88-88 BINDING 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQNEVENFANLLEQATVYLAPYQEKIIVVKYGGNAMINEDRKKLVMQDILLLNQLGVKV
CCHHHHHHHHHHHHHHEEEEECCCCEEEEEEECCCEEECHHHHHHHHHHHHHHHHCCEEE
VLVHGGGPEISQGVKLLGKEPQFINGLRVTDQDTINVVLQMLAGKVNKSLVALLKGKGVG
EEEECCCCCHHHHHHHHCCCCCHHCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LCGIDANMLQCEKLQAEVDYGFVGEIVKVNTQLLELALSANLIPVISTVGVDDQGVAYNI
EECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCEEEEC
NADTVASEIAMALGAAKLVSMTDIAGLLRDRFDESTLIPEVEVSEVQGLIDQGIIAGGMI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
PKIACCTDFINAGGIEANIIDGRVPHAILVSLFGGKNGTLFYKK
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MLQNEVENFANLLEQATVYLAPYQEKIIVVKYGGNAMINEDRKKLVMQDILLLNQLGVKV
CCHHHHHHHHHHHHHHEEEEECCCCEEEEEEECCCEEECHHHHHHHHHHHHHHHHCCEEE
VLVHGGGPEISQGVKLLGKEPQFINGLRVTDQDTINVVLQMLAGKVNKSLVALLKGKGVG
EEEECCCCCHHHHHHHHCCCCCHHCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LCGIDANMLQCEKLQAEVDYGFVGEIVKVNTQLLELALSANLIPVISTVGVDDQGVAYNI
EECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCEEEEC
NADTVASEIAMALGAAKLVSMTDIAGLLRDRFDESTLIPEVEVSEVQGLIDQGIIAGGMI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
PKIACCTDFINAGGIEANIIDGRVPHAILVSLFGGKNGTLFYKK
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA