Click here to switch to the map view.

The map label for this gene is dxs

Identifier: 126207695

GI number: 126207695

Start: 225625

End: 227478

Strand: Direct

Name: dxs

Synonym: APL_0207

Alternate gene names: 126207695

Gene position: 225625-227478 (Clockwise)

Preceding gene: 126207694

Following gene: 126207707

Centisome position: 9.92

GC content: 45.47

Gene sequence:

>1854_bases
ATGCAAAACAAATATCCTCTGTTAAGCCAAATCAATTCTCCGGAAGATTTGCGTTTGCTTGCAAAAGAGCAATTACAGTC
TGTGGCGGATGAGCTTCGCGCTTATTTACTCGAATCGGTTAGCCAAACAAGCGGTCATTTAGCCTCCGGTTTAGGCGTGG
TGGAACTTACGGTGGCTTTGCATTATGTTTATCAAACCCCTTTTGACCAATTGATTTGGGATGTCGGTCATCAGGCCTAT
CCGCATAAAATTCTTACCGGTCGTCGTGACCAAATGCATACCATTCGCCAAAAAAACGGTATCCATCCTTTCCCTTGGCG
TGAAGAAAGTCTTTATGATGTGTTAAGTGTCGGTCATTCTTCTACTTCAATCAGTGCCGGTGTCGGCATTGCCGTCGCGG
CGGAAAAAGAGAATGCCGGGCGTAAAACCGTATGCGTAATCGGCGACGGTGCAATTACCGCCGGTATGGCGTTTGAAGCA
ATGAATCATGCCGGTGCGTTGCATACGGATATGTTAGTTATTTTAAATGATAACGAAATGTCGATTTCCGAGAATGTCGG
TGCGTTAAATAATCACTTAGCACGTATTTTCTCCGGTTCAATCTATACAACTGTGCGTGACGGCAGCAAAAAAGTCCTAG
ATAAAGTCCCTACCATTAAAAACTTCATGAAGAAAAGTGAAGAGCATATGAAAGGGGTGATCTCGCCGGAAAGCACCCTG
TTTGAAGAGCTTGGTTTTAACTATATCGGTCCGATTGACGGTCATAATATTGACGAGTTGGTAAAAACGTTAAGCAATAT
GCGTGAGTTGAAAGGTCCGCAGTTCTTACATATTCGTACCAAAAAAGGTAAAGGCTACGAACCGGCGGAAAATGATCCGA
TCGGTTATCACGGCGTACCTAAATTTGACCCGACGTGCGGACAATTACCGAAATCAAAAACGATTCCGACCTATTCGGAT
ATTTTCGGTAATTGGTTATGCGAAATGGCAGAGCAAGACAGCAAGTTAATCGGGATTACACCGGCAATGCGCGAAGGTTC
GGGTATGGTTGAATTTTCAAAACGCTTCCCGGAACAATACTTTGATGTTGCGATTGCCGAACAGCATGCGGTCACTTTCG
GCGCCGGTTTGGCGATTGCCGGTTATAAGCCGGTGGTGGCGATTTATTCGAGTTTCTTGCAACGTGCTTATGATCAGCTG
ATTCACGATGTGGCGATTCAAAATTTACCGGTGATCTTTGCGATTGACCGAGCCGGGATTGTCGGTGCGGACGGGCAGAC
TCACCAAGGTGCGTTTGACGTGAGTTTTATGCGCTGTATCCCGAATATGACGATTATGTGTCCGTCGGACGAAAATGAAA
TGCGTCAAATGCTTTATACGGCTTATCGTATGAATACGCCGACAGCGGTACGTTATCCGAGAGGTAATGCTCAAGGCGTG
GCGTTAGCACCGATGCAAGCGCTTGAAGTCGGTAAAGGTAAATTGATTCAGCAAGGGCAAAAAGTGGCGATCCTAAATTT
TGGTCCATTGCTAAATGAAGCGCGTATCGTGGCGGAAAAACATAACTATACGCTGGCAGATATGCGTTTTGTAAAACCGC
TTGATGAACAATTGGTAGCGGAATTAGCGGATTCGCATGAATTATTGGTGACTTTGGAAGAAAACGCGATTCAAGGCGGC
GCAGGCAGTGCGGTAAATGAATATTTACAAAAAATCGGTAAAATTCGACCGCTTGTTATGCTTGGTATTCCTGATTTCTT
CGTGCCACAAGCGACCCAAGCGGAAAGCTATGCGGATTTAGGCTTAGATGCGGCAGGCATTGAGCAGAGAATTCAAGCGG
TAGTCAATCAATAA

Upstream 100 bases:

>100_bases
TTACACGGATAAGGCAAGTAAGCGGTCGAATTTTCCGCTTATTTTGCAATATCCGTGTTAATTCGTGTGGGACGTGGGTT
AAATTAAAAAAGAAAACATT

Downstream 100 bases:

>100_bases
ACAAAAAAGCTCATCTTATGATCTGACCCCAAAAAGTTAGACTGTTTAATTTAAGGACTGAGTTCTGTATTGTACAAGGC
TCAGTCCTTTTAATTTCACT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MQNKYPLLSQINSPEDLRLLAKEQLQSVADELRAYLLESVSQTSGHLASGLGVVELTVALHYVYQTPFDQLIWDVGHQAY
PHKILTGRRDQMHTIRQKNGIHPFPWREESLYDVLSVGHSSTSISAGVGIAVAAEKENAGRKTVCVIGDGAITAGMAFEA
MNHAGALHTDMLVILNDNEMSISENVGALNNHLARIFSGSIYTTVRDGSKKVLDKVPTIKNFMKKSEEHMKGVISPESTL
FEELGFNYIGPIDGHNIDELVKTLSNMRELKGPQFLHIRTKKGKGYEPAENDPIGYHGVPKFDPTCGQLPKSKTIPTYSD
IFGNWLCEMAEQDSKLIGITPAMREGSGMVEFSKRFPEQYFDVAIAEQHAVTFGAGLAIAGYKPVVAIYSSFLQRAYDQL
IHDVAIQNLPVIFAIDRAGIVGADGQTHQGAFDVSFMRCIPNMTIMCPSDENEMRQMLYTAYRMNTPTAVRYPRGNAQGV
ALAPMQALEVGKGKLIQQGQKVAILNFGPLLNEARIVAEKHNYTLADMRFVKPLDEQLVAELADSHELLVTLEENAIQGG
AGSAVNEYLQKIGKIRPLVMLGIPDFFVPQATQAESYADLGLDAAGIEQRIQAVVNQ

Sequences:

>Translated_617_residues
MQNKYPLLSQINSPEDLRLLAKEQLQSVADELRAYLLESVSQTSGHLASGLGVVELTVALHYVYQTPFDQLIWDVGHQAY
PHKILTGRRDQMHTIRQKNGIHPFPWREESLYDVLSVGHSSTSISAGVGIAVAAEKENAGRKTVCVIGDGAITAGMAFEA
MNHAGALHTDMLVILNDNEMSISENVGALNNHLARIFSGSIYTTVRDGSKKVLDKVPTIKNFMKKSEEHMKGVISPESTL
FEELGFNYIGPIDGHNIDELVKTLSNMRELKGPQFLHIRTKKGKGYEPAENDPIGYHGVPKFDPTCGQLPKSKTIPTYSD
IFGNWLCEMAEQDSKLIGITPAMREGSGMVEFSKRFPEQYFDVAIAEQHAVTFGAGLAIAGYKPVVAIYSSFLQRAYDQL
IHDVAIQNLPVIFAIDRAGIVGADGQTHQGAFDVSFMRCIPNMTIMCPSDENEMRQMLYTAYRMNTPTAVRYPRGNAQGV
ALAPMQALEVGKGKLIQQGQKVAILNFGPLLNEARIVAEKHNYTLADMRFVKPLDEQLVAELADSHELLVTLEENAIQGG
AGSAVNEYLQKIGKIRPLVMLGIPDFFVPQATQAESYADLGLDAAGIEQRIQAVVNQ
>Mature_617_residues
MQNKYPLLSQINSPEDLRLLAKEQLQSVADELRAYLLESVSQTSGHLASGLGVVELTVALHYVYQTPFDQLIWDVGHQAY
PHKILTGRRDQMHTIRQKNGIHPFPWREESLYDVLSVGHSSTSISAGVGIAVAAEKENAGRKTVCVIGDGAITAGMAFEA
MNHAGALHTDMLVILNDNEMSISENVGALNNHLARIFSGSIYTTVRDGSKKVLDKVPTIKNFMKKSEEHMKGVISPESTL
FEELGFNYIGPIDGHNIDELVKTLSNMRELKGPQFLHIRTKKGKGYEPAENDPIGYHGVPKFDPTCGQLPKSKTIPTYSD
IFGNWLCEMAEQDSKLIGITPAMREGSGMVEFSKRFPEQYFDVAIAEQHAVTFGAGLAIAGYKPVVAIYSSFLQRAYDQL
IHDVAIQNLPVIFAIDRAGIVGADGQTHQGAFDVSFMRCIPNMTIMCPSDENEMRQMLYTAYRMNTPTAVRYPRGNAQGV
ALAPMQALEVGKGKLIQQGQKVAILNFGPLLNEARIVAEKHNYTLADMRFVKPLDEQLVAELADSHELLVTLEENAIQGG
AGSAVNEYLQKIGKIRPLVMLGIPDFFVPQATQAESYADLGLDAAGIEQRIQAVVNQ

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=672, Percent_Identity=20.8333333333333, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI4507521, Length=672, Percent_Identity=20.8333333333333, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI225637463, Length=530, Percent_Identity=22.2641509433962, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI225637459, Length=530, Percent_Identity=22.2641509433962, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI225637461, Length=530, Percent_Identity=22.2641509433962, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI133778974, Length=628, Percent_Identity=20.7006369426752, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1786622, Length=612, Percent_Identity=71.7320261437908, Blast_Score=925, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=630, Percent_Identity=22.6984126984127, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24666278, Length=615, Percent_Identity=24.7154471544715, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45551847, Length=615, Percent_Identity=23.2520325203252, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45550715, Length=615, Percent_Identity=23.2520325203252, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24645119, Length=517, Percent_Identity=23.9845261121857, Blast_Score=89, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_ACTP2 (A3MYS9)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001052920.1
- ProteinModelPortal:   A3MYS9
- SMR:   A3MYS9
- STRING:   A3MYS9
- GeneID:   4849947
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0207
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   A3MYS9
- ProtClustDB:   PRK05444
- BioCyc:   APLE416269:APL_0207-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67842; Mature: 67842

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKYPLLSQINSPEDLRLLAKEQLQSVADELRAYLLESVSQTSGHLASGLGVVELTVAL
CCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHH
HYVYQTPFDQLIWDVGHQAYPHKILTGRRDQMHTIRQKNGIHPFPWREESLYDVLSVGHS
HHHHHCCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC
STSISAGVGIAVAAEKENAGRKTVCVIGDGAITAGMAFEAMNHAGALHTDMLVILNDNEM
CCCCCCCCEEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
SISENVGALNNHLARIFSGSIYTTVRDGSKKVLDKVPTIKNFMKKSEEHMKGVISPESTL
CHHHCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHH
FEELGFNYIGPIDGHNIDELVKTLSNMRELKGPQFLHIRTKKGKGYEPAENDPIGYHGVP
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
KFDPTCGQLPKSKTIPTYSDIFGNWLCEMAEQDSKLIGITPAMREGSGMVEFSKRFPEQY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHCCHHH
FDVAIAEQHAVTFGAGLAIAGYKPVVAIYSSFLQRAYDQLIHDVAIQNLPVIFAIDRAGI
HHHHHHHHHHEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCE
VGADGQTHQGAFDVSFMRCIPNMTIMCPSDENEMRQMLYTAYRMNTPTAVRYPRGNAQGV
ECCCCCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCE
ALAPMQALEVGKGKLIQQGQKVAILNFGPLLNEARIVAEKHNYTLADMRFVKPLDEQLVA
EECCHHHHHCCCCHHHHCCCEEEEEECCCCCCCHHEEEECCCCCHHHHHHHCCHHHHHHH
ELADSHELLVTLEENAIQGGAGSAVNEYLQKIGKIRPLVMLGIPDFFVPQATQAESYADL
HHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHC
GLDAAGIEQRIQAVVNQ
CCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNKYPLLSQINSPEDLRLLAKEQLQSVADELRAYLLESVSQTSGHLASGLGVVELTVAL
CCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHH
HYVYQTPFDQLIWDVGHQAYPHKILTGRRDQMHTIRQKNGIHPFPWREESLYDVLSVGHS
HHHHHCCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC
STSISAGVGIAVAAEKENAGRKTVCVIGDGAITAGMAFEAMNHAGALHTDMLVILNDNEM
CCCCCCCCEEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
SISENVGALNNHLARIFSGSIYTTVRDGSKKVLDKVPTIKNFMKKSEEHMKGVISPESTL
CHHHCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHH
FEELGFNYIGPIDGHNIDELVKTLSNMRELKGPQFLHIRTKKGKGYEPAENDPIGYHGVP
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
KFDPTCGQLPKSKTIPTYSDIFGNWLCEMAEQDSKLIGITPAMREGSGMVEFSKRFPEQY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHCCHHH
FDVAIAEQHAVTFGAGLAIAGYKPVVAIYSSFLQRAYDQLIHDVAIQNLPVIFAIDRAGI
HHHHHHHHHHEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCE
VGADGQTHQGAFDVSFMRCIPNMTIMCPSDENEMRQMLYTAYRMNTPTAVRYPRGNAQGV
ECCCCCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCE
ALAPMQALEVGKGKLIQQGQKVAILNFGPLLNEARIVAEKHNYTLADMRFVKPLDEQLVA
EECCHHHHHCCCCHHHHCCCEEEEEECCCCCCCHHEEEECCCCCHHHHHHHCCHHHHHHH
ELADSHELLVTLEENAIQGGAGSAVNEYLQKIGKIRPLVMLGIPDFFVPQATQAESYADL
HHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHC
GLDAAGIEQRIQAVVNQ
CCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA