Click here to switch to the map view.

The map label for this gene is thiL [H]

Identifier: 126207690

GI number: 126207690

Start: 221347

End: 222309

Strand: Direct

Name: thiL [H]

Synonym: APL_0202

Alternate gene names: 126207690

Gene position: 221347-222309 (Clockwise)

Preceding gene: 126207689

Following gene: 126207691

Centisome position: 9.73

GC content: 43.51

Gene sequence:

>963_bases
ATGGAATTTGAAGTTATTGCACAATATTTTAAACGTAAGAATTTACGTTCGGATGTAGATTTATCCGTAGGAGATGATTG
TGCAGTCACCACCTTAAAACCGAATGAGCGTTTAGCCGTTACTACCGATACATTGGTATCGGGAACCCATTTTCTTCCGT
CTATTTCCGCTGCGGATCTAGCCTATAAAACTTTAGCGGTCAATTTGAGTGATTTGGCTGCAATGGGAGCTGCTCCTGCA
TGGGTTTCTTTAGCTTTAACTTTACCGAAAGTTGATCATCAGTGGCTTGCCGAATTTAGCCAAAGTCTATTTGCTGTGTT
AGATCGTTATCATGTGGATTTGATCGGTGGTGATACTACCGGTGGGCCGCTTTCGCTAACGCTTACCGCACAAGGTATTT
TACCGCAAGATCAGGGATTGTTTCGACATCAAGCGCAAGTCGGTGACTGGATTTTTGTGTCCGGCAGTCTTGGCGATAGT
GCGGCAGGTTTATCGATATTGTTGGATAATTGCAAAATTTCGGATGAATCCGACCGCTATTTGGTACAACGCCATTTACG
ACCTACACCAAGAGTCGAATTGGGGCTTGCTCTACGAGCGTTTTCCTGTTGTGCGATCGACATTTCTGACGGTTTATTAG
CGGATTTAGGTCATATTTTGGAACGCAGTCAAGTTGGTGCCGAAATCGAATTGGATAATATACCGCTTTCTACGCATTTA
ACGACTAAATATAGTGAGAAAGAAGCGCTTCATTTTGCTTTGACCGGTGGCGAAGATTATGAATTGTGTTTTACGGTATC
GGATGACAAGCGGTCGGAAATGGAGCGAATTTTACGTTCTCAAGGGATTAAGGTAAGCTGTATCGGTAGGATTACGCCGG
CAGCAAGCGGTCTGATTTTACGCCAAAATGGCAAACAGGTTCCGTTACCAACTCAATCCGGTTTTGATCATTTCAAGTCA
TAA

Upstream 100 bases:

>100_bases
GATAAATTAGCACCGGCTTTAGGTCGTAAATAATTTATGGATAAAAAGAAGGTGAGCGTAGGTTTGCCTTCTTTTTTTGT
GCTGTTACGGAGGAAAAATG

Downstream 100 bases:

>100_bases
TAAAAAATAACGATGAAAAATTTTAACTTAAAAAATCCGATTCATTTATTCGCTTGCGGTTTCGGCTCCGGTTTATTAAA
GCCGGCTCCGGGAACTTGGG

Product: thiamine-monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MEFEVIAQYFKRKNLRSDVDLSVGDDCAVTTLKPNERLAVTTDTLVSGTHFLPSISAADLAYKTLAVNLSDLAAMGAAPA
WVSLALTLPKVDHQWLAEFSQSLFAVLDRYHVDLIGGDTTGGPLSLTLTAQGILPQDQGLFRHQAQVGDWIFVSGSLGDS
AAGLSILLDNCKISDESDRYLVQRHLRPTPRVELGLALRAFSCCAIDISDGLLADLGHILERSQVGAEIELDNIPLSTHL
TTKYSEKEALHFALTGGEDYELCFTVSDDKRSEMERILRSQGIKVSCIGRITPAASGLILRQNGKQVPLPTQSGFDHFKS

Sequences:

>Translated_320_residues
MEFEVIAQYFKRKNLRSDVDLSVGDDCAVTTLKPNERLAVTTDTLVSGTHFLPSISAADLAYKTLAVNLSDLAAMGAAPA
WVSLALTLPKVDHQWLAEFSQSLFAVLDRYHVDLIGGDTTGGPLSLTLTAQGILPQDQGLFRHQAQVGDWIFVSGSLGDS
AAGLSILLDNCKISDESDRYLVQRHLRPTPRVELGLALRAFSCCAIDISDGLLADLGHILERSQVGAEIELDNIPLSTHL
TTKYSEKEALHFALTGGEDYELCFTVSDDKRSEMERILRSQGIKVSCIGRITPAASGLILRQNGKQVPLPTQSGFDHFKS
>Mature_320_residues
MEFEVIAQYFKRKNLRSDVDLSVGDDCAVTTLKPNERLAVTTDTLVSGTHFLPSISAADLAYKTLAVNLSDLAAMGAAPA
WVSLALTLPKVDHQWLAEFSQSLFAVLDRYHVDLIGGDTTGGPLSLTLTAQGILPQDQGLFRHQAQVGDWIFVSGSLGDS
AAGLSILLDNCKISDESDRYLVQRHLRPTPRVELGLALRAFSCCAIDISDGLLADLGHILERSQVGAEIELDNIPLSTHL
TTKYSEKEALHFALTGGEDYELCFTVSDDKRSEMERILRSQGIKVSCIGRITPAASGLILRQNGKQVPLPTQSGFDHFKS

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=321, Percent_Identity=52.0249221183801, Blast_Score=327, Evalue=7e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 34783; Mature: 34783

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00079 MULTICOPPER_OXIDASE1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFEVIAQYFKRKNLRSDVDLSVGDDCAVTTLKPNERLAVTTDTLVSGTHFLPSISAADL
CCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEHHHHCCCCCCCCCCHHHH
AYKTLAVNLSDLAAMGAAPAWVSLALTLPKVDHQWLAEFSQSLFAVLDRYHVDLIGGDTT
HHHHEEECHHHHHHHCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCC
GGPLSLTLTAQGILPQDQGLFRHQAQVGDWIFVSGSLGDSAAGLSILLDNCKISDESDRY
CCCEEEEEEECCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCHHH
LVQRHLRPTPRVELGLALRAFSCCAIDISDGLLADLGHILERSQVGAEIELDNIPLSTHL
HHHHHCCCCCCEEHHHHEEEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEE
TTKYSEKEALHFALTGGEDYELCFTVSDDKRSEMERILRSQGIKVSCIGRITPAASGLIL
EECCCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEEEECCCCCCEEE
RQNGKQVPLPTQSGFDHFKS
CCCCCCCCCCCCCCCHHHCC
>Mature Secondary Structure
MEFEVIAQYFKRKNLRSDVDLSVGDDCAVTTLKPNERLAVTTDTLVSGTHFLPSISAADL
CCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEHHHHCCCCCCCCCCHHHH
AYKTLAVNLSDLAAMGAAPAWVSLALTLPKVDHQWLAEFSQSLFAVLDRYHVDLIGGDTT
HHHHEEECHHHHHHHCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCC
GGPLSLTLTAQGILPQDQGLFRHQAQVGDWIFVSGSLGDSAAGLSILLDNCKISDESDRY
CCCEEEEEEECCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCHHH
LVQRHLRPTPRVELGLALRAFSCCAIDISDGLLADLGHILERSQVGAEIELDNIPLSTHL
HHHHHCCCCCCEEHHHHEEEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEE
TTKYSEKEALHFALTGGEDYELCFTVSDDKRSEMERILRSQGIKVSCIGRITPAASGLIL
EECCCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEEEECCCCCCEEE
RQNGKQVPLPTQSGFDHFKS
CCCCCCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]