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The map label for this gene is proC [H]

Identifier: 126207648

GI number: 126207648

Start: 178027

End: 178857

Strand: Reverse

Name: proC [H]

Synonym: APL_0160

Alternate gene names: 126207648

Gene position: 178857-178027 (Counterclockwise)

Preceding gene: 126207651

Following gene: 126207647

Centisome position: 7.86

GC content: 45.01

Gene sequence:

>831_bases
ATGAGGGTAAAAATGAATCATCAAAAACTTGCCTTTATCGGCACCGGCAATATGGCATACGCTATCATTCAAGGCTTACT
CAAAAGCCATTATCCCGCCTCGCAAATCATCGCTTGCAACAAAAGCAATTTAGTTCGCCGAGCAGAATTACAAGCGGTCG
GAATTGCGACAAATTTTACCAATCGTGCAGCAGTTGAACAGGCGGAAGTCGTTGTGTTAGCGGTCAAACCGCAAATGATG
GCGGAGGTTTGTAGTGAATTTTCAGCGGTGGATTTTTCGAATAAAACAGTGATCTCTGTCGCAGCAGGGATTTCAGTTGC
TCGTTTAGAACAGCTTTTACCGACAGCAAAAAATATTATCCGCACCATGCCGAATACCCCTTCGCTAATCGGTGAGGGAA
TGACCGGGTTATTTGCAAAAAAATCAGTAAATTCGACCGCTTGCCAATTTGCCGAGAGTTTAATGTCGGCGGTCGGAAAA
TGCTATTGGGTCGAACAAGAACAGCAAATCAATCACATTATTGCAGTGACCGGTTCCAGCCCTGCCTATTTCTTCCGTTT
TATGGAAGCGATGCAACAAAGTGCAATGCAAATGGGATTTAGCGAAGCTGATGCACGTTTACTGGTGCAACAAGCTGCAT
TAGGCGCAGCCAAATTAGTCGAAGCAAATCCGAATACACCTCTTTCAACCTTGCGAGAAAACGTTACTTCAAAAGGCGGA
ACAACGGCTAAAGCATTGGAAGTTTTTGAACAACACGCATTAGCGGAAACAGTCGATCAAGCAATGTGGGCAGCCATTCA
CCGTGCAGAAGAAATGGAGCAGCAGCTATGA

Upstream 100 bases:

>100_bases
CTAATCAAATCTCCCCTTCCTTTTTTCTAAAAAAGGGAATTTTAGGGCTGATTGGAGAACCGCTCCCCTCTTTTATAAAG
AGGGGCTGGGGGAGATTTTT

Downstream 100 bases:

>100_bases
TCAAGCTAACGCCGTTCCAATGGTCGGCATTTAATTTCTTCGGCTTCTTTTGTGCCTACGGAGTATTTTTACCCTTTTTA
CCGGTTTGGTTAAAACAATA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MRVKMNHQKLAFIGTGNMAYAIIQGLLKSHYPASQIIACNKSNLVRRAELQAVGIATNFTNRAAVEQAEVVVLAVKPQMM
AEVCSEFSAVDFSNKTVISVAAGISVARLEQLLPTAKNIIRTMPNTPSLIGEGMTGLFAKKSVNSTACQFAESLMSAVGK
CYWVEQEQQINHIIAVTGSSPAYFFRFMEAMQQSAMQMGFSEADARLLVQQAALGAAKLVEANPNTPLSTLRENVTSKGG
TTAKALEVFEQHALAETVDQAMWAAIHRAEEMEQQL

Sequences:

>Translated_276_residues
MRVKMNHQKLAFIGTGNMAYAIIQGLLKSHYPASQIIACNKSNLVRRAELQAVGIATNFTNRAAVEQAEVVVLAVKPQMM
AEVCSEFSAVDFSNKTVISVAAGISVARLEQLLPTAKNIIRTMPNTPSLIGEGMTGLFAKKSVNSTACQFAESLMSAVGK
CYWVEQEQQINHIIAVTGSSPAYFFRFMEAMQQSAMQMGFSEADARLLVQQAALGAAKLVEANPNTPLSTLRENVTSKGG
TTAKALEVFEQHALAETVDQAMWAAIHRAEEMEQQL
>Mature_276_residues
MRVKMNHQKLAFIGTGNMAYAIIQGLLKSHYPASQIIACNKSNLVRRAELQAVGIATNFTNRAAVEQAEVVVLAVKPQMM
AEVCSEFSAVDFSNKTVISVAAGISVARLEQLLPTAKNIIRTMPNTPSLIGEGMTGLFAKKSVNSTACQFAESLMSAVGK
CYWVEQEQQINHIIAVTGSSPAYFFRFMEAMQQSAMQMGFSEADARLLVQQAALGAAKLVEANPNTPLSTLRENVTSKGG
TTAKALEVFEQHALAETVDQAMWAAIHRAEEMEQQL

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=268, Percent_Identity=30.5970149253731, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI21361454, Length=269, Percent_Identity=32.7137546468402, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI24797095, Length=274, Percent_Identity=30.6569343065693, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI24797097, Length=274, Percent_Identity=30.6569343065693, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1786585, Length=274, Percent_Identity=33.2116788321168, Blast_Score=131, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17569021, Length=265, Percent_Identity=32.0754716981132, Blast_Score=130, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17540664, Length=288, Percent_Identity=32.2916666666667, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320861, Length=288, Percent_Identity=28.4722222222222, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=32.4626865671642, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24648116, Length=281, Percent_Identity=30.9608540925267, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=32.1637426900585, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29930; Mature: 29930

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVKMNHQKLAFIGTGNMAYAIIQGLLKSHYPASQIIACNKSNLVRRAELQAVGIATNFT
CCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCHHHEEEECCCCHHHHHHHHEEEEEECCC
NRAAVEQAEVVVLAVKPQMMAEVCSEFSAVDFSNKTVISVAAGISVARLEQLLPTAKNII
CHHHHHHCCEEEEEECHHHHHHHHHHHHCCCCCCCEEEHHHHCCHHHHHHHHHHHHHHHH
RTMPNTPSLIGEGMTGLFAKKSVNSTACQFAESLMSAVGKCYWVEQEQQINHIIAVTGSS
HHCCCCHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCHHHCCCEEEEEECCC
PAYFFRFMEAMQQSAMQMGFSEADARLLVQQAALGAAKLVEANPNTPLSTLRENVTSKGG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHEECCCCCCHHHHHHHHHCCCC
TTAKALEVFEQHALAETVDQAMWAAIHRAEEMEQQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVKMNHQKLAFIGTGNMAYAIIQGLLKSHYPASQIIACNKSNLVRRAELQAVGIATNFT
CCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCHHHEEEECCCCHHHHHHHHEEEEEECCC
NRAAVEQAEVVVLAVKPQMMAEVCSEFSAVDFSNKTVISVAAGISVARLEQLLPTAKNII
CHHHHHHCCEEEEEECHHHHHHHHHHHHCCCCCCCEEEHHHHCCHHHHHHHHHHHHHHHH
RTMPNTPSLIGEGMTGLFAKKSVNSTACQFAESLMSAVGKCYWVEQEQQINHIIAVTGSS
HHCCCCHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCHHHCCCEEEEEECCC
PAYFFRFMEAMQQSAMQMGFSEADARLLVQQAALGAAKLVEANPNTPLSTLRENVTSKGG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHEECCCCCCHHHHHHHHHCCCC
TTAKALEVFEQHALAETVDQAMWAAIHRAEEMEQQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]