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The map label for this gene is pepQ

Identifier: 126207579

GI number: 126207579

Start: 97683

End: 99014

Strand: Reverse

Name: pepQ

Synonym: APL_0091

Alternate gene names: 126207579

Gene position: 99014-97683 (Counterclockwise)

Preceding gene: 126207581

Following gene: 126207578

Centisome position: 4.35

GC content: 41.59

Gene sequence:

>1332_bases
ATGAAACAATTATTTACACAACATATCAAGCGACTACAACAAGTCGTTCAAACGATTTTAGAAACTAATTTTCTCAGCGG
TTTATGGATTCATTCCGGCACGGCTCGCTATCATTTTTTAGATGATCAAACCGCCCCCTTTAAAATAAACCCGCATTTTA
ACTACTTATTCCCTTTTCCGACAGCAGAAAATTGCTGGTTGTTTTTAGACGGTAAAAATAAACCGACCGTCTATTTCTAT
GCACCGAACGATTATTGGCATACACCGCCGGTTGCTCCGACAGATGCGTTCTTTGCCGATGAATTTCAATGGGTGATTTT
GCAAGATAGCCAAGAAATTGCAAAATTTATCCAAAATCCGACCGCTTGCACCTTTATCGGTGAAGATGAAAACTTGGCAG
AATCGCTCGGTTTTAACCAAATCAATCCGCAAAAAGTGCTGAATCAGTTCCATTTTGAACGTTCAATTAAAAGTGAATTT
GAAATCGAAGCAATCTATCAAGCACAATTTGCGGCGTTAAAAGGGCATCAGGCGGCAAAACAAGCCTTTTTTGAGGGGAA
AAGTGAGTTTGAAATTAACCTCGCTTATCTAAAAGCCAGTCAGCAATCCGATTTAAACGTGCCTTACGGCAATATTGTTG
CCATTAATCAACATTCGGCTATTTTACACTATACTCAGCTTGATTACGCCCCTAATCCGCAACAGCAGAGTTTTCTGATC
GATGCCGGTGCAACCATACACGGTTATGCCTCCGATATTACTCGTACTTATGCGGCTGATCCTAATAGCGAATTTGCGGC
AATGATTAAGCAAATGGAGCAATACAAATATCGCATTATCGATCAACTCACTGTGGGCGTGAACTATCTAAGCTATCATA
CGCAAATGCAACAATGGATTGCCGAAATGTTATACGAATATGATTTTGTTCGTCTTACACCGGAACAAATTTTTGAAGAA
GGAATTTCGAGAGCCTTTTTGCCACACGGTTTAGGGCATTTGCTTGGGCTACAAGTACACGATGCCGCCGGCTTCCAACA
AAATCCTCGTGGCACTCGCAAATCGCCACCGGAGGTTTATCCAAGCCTGCGTTGTACCCGTGATTTGGCTGAAAATATGG
TGCTGACAATTGAACCGGGCTTCTATTTCATTGATATGTTGCTGAATCCGTTGCAAAATAGCCCGCTTGCACGTCATATT
AATTGGCAAAAGATCGCTGAATTTAAACAATTCGGCGGCATCCGTACCGAAGACAATATTGTAATGCGTTCGCAAGGCGC
GGAGAATTTAACCCAAAAAGCGGAAATTGAACTTCAACTTTCCGATCATTAA

Upstream 100 bases:

>100_bases
TTGCGTGTAAGCATTACCGGCTCCGGACAACGTAGCCCAAGTGTATCTAGTGTTTGGTCAATTTTTATATCTGTCATATT
TTTCTCTTATTTTTTATCTT

Downstream 100 bases:

>100_bases
AGCATTCAAATAAGGAACTGCTATGCCATTTCTTTTTATTTTATTCGGCATTTTTCTGTATATCTACTTCGAGATCTCAT
TATTGGTCTCAATCGGATCA

Product: proline dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MKQLFTQHIKRLQQVVQTILETNFLSGLWIHSGTARYHFLDDQTAPFKINPHFNYLFPFPTAENCWLFLDGKNKPTVYFY
APNDYWHTPPVAPTDAFFADEFQWVILQDSQEIAKFIQNPTACTFIGEDENLAESLGFNQINPQKVLNQFHFERSIKSEF
EIEAIYQAQFAALKGHQAAKQAFFEGKSEFEINLAYLKASQQSDLNVPYGNIVAINQHSAILHYTQLDYAPNPQQQSFLI
DAGATIHGYASDITRTYAADPNSEFAAMIKQMEQYKYRIIDQLTVGVNYLSYHTQMQQWIAEMLYEYDFVRLTPEQIFEE
GISRAFLPHGLGHLLGLQVHDAAGFQQNPRGTRKSPPEVYPSLRCTRDLAENMVLTIEPGFYFIDMLLNPLQNSPLARHI
NWQKIAEFKQFGGIRTEDNIVMRSQGAENLTQKAEIELQLSDH

Sequences:

>Translated_443_residues
MKQLFTQHIKRLQQVVQTILETNFLSGLWIHSGTARYHFLDDQTAPFKINPHFNYLFPFPTAENCWLFLDGKNKPTVYFY
APNDYWHTPPVAPTDAFFADEFQWVILQDSQEIAKFIQNPTACTFIGEDENLAESLGFNQINPQKVLNQFHFERSIKSEF
EIEAIYQAQFAALKGHQAAKQAFFEGKSEFEINLAYLKASQQSDLNVPYGNIVAINQHSAILHYTQLDYAPNPQQQSFLI
DAGATIHGYASDITRTYAADPNSEFAAMIKQMEQYKYRIIDQLTVGVNYLSYHTQMQQWIAEMLYEYDFVRLTPEQIFEE
GISRAFLPHGLGHLLGLQVHDAAGFQQNPRGTRKSPPEVYPSLRCTRDLAENMVLTIEPGFYFIDMLLNPLQNSPLARHI
NWQKIAEFKQFGGIRTEDNIVMRSQGAENLTQKAEIELQLSDH
>Mature_443_residues
MKQLFTQHIKRLQQVVQTILETNFLSGLWIHSGTARYHFLDDQTAPFKINPHFNYLFPFPTAENCWLFLDGKNKPTVYFY
APNDYWHTPPVAPTDAFFADEFQWVILQDSQEIAKFIQNPTACTFIGEDENLAESLGFNQINPQKVLNQFHFERSIKSEF
EIEAIYQAQFAALKGHQAAKQAFFEGKSEFEINLAYLKASQQSDLNVPYGNIVAINQHSAILHYTQLDYAPNPQQQSFLI
DAGATIHGYASDITRTYAADPNSEFAAMIKQMEQYKYRIIDQLTVGVNYLSYHTQMQQWIAEMLYEYDFVRLTPEQIFEE
GISRAFLPHGLGHLLGLQVHDAAGFQQNPRGTRKSPPEVYPSLRCTRDLAENMVLTIEPGFYFIDMLLNPLQNSPLARHI
NWQKIAEFKQFGGIRTEDNIVMRSQGAENLTQKAEIELQLSDH

Specific function: Splits dipeptides with a prolyl residue in the C- terminal position

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily

Homologues:

Organism=Homo sapiens, GI149589008, Length=289, Percent_Identity=29.757785467128, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI260593665, Length=289, Percent_Identity=29.757785467128, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI260593663, Length=276, Percent_Identity=30.7971014492754, Blast_Score=121, Evalue=2e-27,
Organism=Escherichia coli, GI1790282, Length=442, Percent_Identity=42.5339366515837, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1789275, Length=290, Percent_Identity=27.5862068965517, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508215, Length=463, Percent_Identity=26.3498920086393, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321118, Length=410, Percent_Identity=27.8048780487805, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI21357079, Length=287, Percent_Identity=32.0557491289199, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PEPQ_ACTP2 (A3MYG3)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001052804.1
- STRING:   A3MYG3
- MEROPS:   M24.003
- GeneID:   4850267
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0091
- eggNOG:   COG0006
- HOGENOM:   HBG296884
- OMA:   PYGNIVA
- PhylomeDB:   A3MYG3
- ProtClustDB:   PRK13607
- BioCyc:   APLE416269:APL_0091-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01279
- InterPro:   IPR000994
- InterPro:   IPR001131
- InterPro:   IPR022846
- Gene3D:   G3DSA:3.90.230.10
- PANTHER:   PTHR10804

Pfam domain/function: PF00557 Peptidase_M24; SSF55920 Peptidase_M24_cat_core

EC number: =3.4.13.9

Molecular weight: Translated: 50998; Mature: 50998

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLFTQHIKRLQQVVQTILETNFLSGLWIHSGTARYHFLDDQTAPFKINPHFNYLFPFP
CHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCEEECCCEEEEECCC
TAENCWLFLDGKNKPTVYFYAPNDYWHTPPVAPTDAFFADEFQWVILQDSQEIAKFIQNP
CCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCHHCCCEEEEEEECCHHHHHHHCCC
TACTFIGEDENLAESLGFNQINPQKVLNQFHFERSIKSEFEIEAIYQAQFAALKGHQAAK
CEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHH
QAFFEGKSEFEINLAYLKASQQSDLNVPYGNIVAINQHSAILHYTQLDYAPNPQQQSFLI
HHHHCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEECCCEEEEEEECCCCCCCCCCEEEE
DAGATIHGYASDITRTYAADPNSEFAAMIKQMEQYKYRIIDQLTVGVNYLSYHTQMQQWI
ECCCEEEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEMLYEYDFVRLTPEQIFEEGISRAFLPHGLGHLLGLQVHDAAGFQQNPRGTRKSPPEVY
HHHHHHCCEEEECHHHHHHHHHHHHHHHCCHHHHHCEEEECCCCCCCCCCCCCCCCHHHC
PSLRCTRDLAENMVLTIEPGFYFIDMLLNPLQNSPLARHINWQKIAEFKQFGGIRTEDNI
CCHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHCCCCCCCCE
VMRSQGAENLTQKAEIELQLSDH
EEECCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MKQLFTQHIKRLQQVVQTILETNFLSGLWIHSGTARYHFLDDQTAPFKINPHFNYLFPFP
CHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCEEECCCEEEEECCC
TAENCWLFLDGKNKPTVYFYAPNDYWHTPPVAPTDAFFADEFQWVILQDSQEIAKFIQNP
CCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCHHCCCEEEEEEECCHHHHHHHCCC
TACTFIGEDENLAESLGFNQINPQKVLNQFHFERSIKSEFEIEAIYQAQFAALKGHQAAK
CEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHH
QAFFEGKSEFEINLAYLKASQQSDLNVPYGNIVAINQHSAILHYTQLDYAPNPQQQSFLI
HHHHCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEECCCEEEEEEECCCCCCCCCCEEEE
DAGATIHGYASDITRTYAADPNSEFAAMIKQMEQYKYRIIDQLTVGVNYLSYHTQMQQWI
ECCCEEEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEMLYEYDFVRLTPEQIFEEGISRAFLPHGLGHLLGLQVHDAAGFQQNPRGTRKSPPEVY
HHHHHHCCEEEECHHHHHHHHHHHHHHHCCHHHHHCEEEECCCCCCCCCCCCCCCCHHHC
PSLRCTRDLAENMVLTIEPGFYFIDMLLNPLQNSPLARHINWQKIAEFKQFGGIRTEDNI
CCHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHCCCCCCCCE
VMRSQGAENLTQKAEIELQLSDH
EEECCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA