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The map label for this gene is obgE

Identifier: 126207528

GI number: 126207528

Start: 44225

End: 45400

Strand: Direct

Name: obgE

Synonym: APL_0040

Alternate gene names: 126207528

Gene position: 44225-45400 (Clockwise)

Preceding gene: 126207527

Following gene: 126207529

Centisome position: 1.94

GC content: 46.34

Gene sequence:

>1176_bases
ATGAAATTTATTGATGAAGCCCTGATTCGTGTAGAAGCAGGCGATGGCGGTAACGGTTGCGTGAGTTTCCGCCGTGAAAA
ATATATCCCGAAAGGCGGGCCGGACGGCGGCGACGGCGGTGACGGCGGTGATGTTTATTTAATCGCTGACGAAAACCTAA
ATACGCTTATCGACTACCGTTTTGAAAAACGTTATGCCGCAGGTCGTGGCGAGAACGGTCGTAGTGCCGGTTGTACCGGT
CACCGTGGTAACGATATTACCTTACGTGTGCCGGTCGGTACGCGAGCAATCGATAATGACACCCAAGAAGTCATCGGTGA
CTTAACCAAACACGGTATGAAAATGTTGGTGGCAAAAGGCGGTTATCACGGTTTAGGTAATACCCGTTTTAAATCGTCGG
TAAACCGTGCGCCTCGTCAAAAAACGAACGGTACACCGGGCGAAAAACGTGATTTATTACTGGAGTTAATGCTACTTGCC
GATGTTGGTATGCTTGGCTTACCGAATGCCGGTAAATCAACCTTTATCCGTGCCGTATCGGCTGCAAAACCGAAAGTAGC
AGATTATCCGTTTACTACGCTTGTGCCAAGTTTGGGCGTAGCGCGTGTCGGTGCGGATCGCAGTTTTGTGGTGGCGGACA
TTCCGGGCTTAATCGAAGGTGCGGCGGACGGTGCCGGTTTAGGTATTCGTTTCTTAAAACATCTTGAACGTTGCCGTGTG
TTAATTCACTTAGTCGATATTATGCCGATTGACGAAAGCGATCCGGCACAAAATATTTCGGTGATTGAAAGCGAGCTTTA
CCAATATAGCGAAAAATTATCGGAAAAACCGACTTGGTTAGTCTTCAATAAGATTGATACAATTGGCGAAGAAGAAGCAC
AAGCTCGTGCGCAAGAAATCGCAGAACAAATTGGTTGGGAAGGCGATTATTACCTAATTTCTGCTGCAACCGGTCAAAAC
GTACAAAATCTTACCCGTGACATTATGGACTTTATCGAAGCGAACCCTCGTGAAGTCGCAGAAGAAAATACAGAAGCGGA
TGAAGTGAAATTCAAATGGGATGACTACCATCAACAAGCAATGCAAAACCCTATCGAAGAAGATTGGGATAACTTTGATG
ATGATTGGTCGGAAGAAGATGAAGAAGGCGTGGAATTTGTTTACACCCGTAGTTAA

Upstream 100 bases:

>100_bases
TACAAGCGGTGAAATTTCTCCAATATTTTGCAAATTTTAGATCTAACAAATCTCCCCCTGCCCTTCTTTGCTTAAAGAGG
GGAGTAAAAAAGGAATAACA

Downstream 100 bases:

>100_bases
TCCTAGCTAATGACAAGCGGTTGAATTTGCGAAAAAATTTACAAATTCGACCGCTTTTTATTTGAGGAACCAAAATGCTA
AATGCCAAAAGTTGTGAATT

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKFIDEALIRVEAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVYLIADENLNTLIDYRFEKRYAAGRGENGRSAGCTG
HRGNDITLRVPVGTRAIDNDTQEVIGDLTKHGMKMLVAKGGYHGLGNTRFKSSVNRAPRQKTNGTPGEKRDLLLELMLLA
DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVARVGADRSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
LIHLVDIMPIDESDPAQNISVIESELYQYSEKLSEKPTWLVFNKIDTIGEEEAQARAQEIAEQIGWEGDYYLISAATGQN
VQNLTRDIMDFIEANPREVAEENTEADEVKFKWDDYHQQAMQNPIEEDWDNFDDDWSEEDEEGVEFVYTRS

Sequences:

>Translated_391_residues
MKFIDEALIRVEAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVYLIADENLNTLIDYRFEKRYAAGRGENGRSAGCTG
HRGNDITLRVPVGTRAIDNDTQEVIGDLTKHGMKMLVAKGGYHGLGNTRFKSSVNRAPRQKTNGTPGEKRDLLLELMLLA
DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVARVGADRSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
LIHLVDIMPIDESDPAQNISVIESELYQYSEKLSEKPTWLVFNKIDTIGEEEAQARAQEIAEQIGWEGDYYLISAATGQN
VQNLTRDIMDFIEANPREVAEENTEADEVKFKWDDYHQQAMQNPIEEDWDNFDDDWSEEDEEGVEFVYTRS
>Mature_391_residues
MKFIDEALIRVEAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVYLIADENLNTLIDYRFEKRYAAGRGENGRSAGCTG
HRGNDITLRVPVGTRAIDNDTQEVIGDLTKHGMKMLVAKGGYHGLGNTRFKSSVNRAPRQKTNGTPGEKRDLLLELMLLA
DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVARVGADRSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
LIHLVDIMPIDESDPAQNISVIESELYQYSEKLSEKPTWLVFNKIDTIGEEEAQARAQEIAEQIGWEGDYYLISAATGQN
VQNLTRDIMDFIEANPREVAEENTEADEVKFKWDDYHQQAMQNPIEEDWDNFDDDWSEEDEEGVEFVYTRS

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=332, Percent_Identity=40.6626506024096, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI111955139, Length=314, Percent_Identity=37.8980891719745, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI111955063, Length=150, Percent_Identity=42, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4758796, Length=186, Percent_Identity=30.1075268817204, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI58761500, Length=135, Percent_Identity=32.5925925925926, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1789574, Length=390, Percent_Identity=71.5384615384615, Blast_Score=499, Evalue=1e-143,
Organism=Escherichia coli, GI1787454, Length=128, Percent_Identity=32.03125, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17552324, Length=309, Percent_Identity=32.3624595469256, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17508313, Length=296, Percent_Identity=41.8918918918919, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17509631, Length=129, Percent_Identity=34.8837209302326, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17555344, Length=118, Percent_Identity=33.0508474576271, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=175, Percent_Identity=36.5714285714286, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6319281, Length=192, Percent_Identity=27.0833333333333, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24585318, Length=311, Percent_Identity=38.2636655948553, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI20129375, Length=326, Percent_Identity=37.1165644171779, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24640873, Length=128, Percent_Identity=32.8125, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640877, Length=128, Percent_Identity=32.8125, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640875, Length=128, Percent_Identity=32.8125, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_ACTP2 (A3MYB2)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001052753.1
- ProteinModelPortal:   A3MYB2
- SMR:   A3MYB2
- STRING:   A3MYB2
- GeneID:   4849935
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0040
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   LIDYRFN
- PhylomeDB:   A3MYB2
- ProtClustDB:   PRK12298
- BioCyc:   APLE416269:APL_0040-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 43140; Mature: 43140

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00905 GTP1_OBG; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFIDEALIRVEAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVYLIADENLNTLIDYR
CCCHHCCCEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHH
FEKRYAAGRGENGRSAGCTGHRGNDITLRVPVGTRAIDNDTQEVIGDLTKHGMKMLVAKG
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEHCCC
GYHGLGNTRFKSSVNRAPRQKTNGTPGEKRDLLLELMLLADVGMLGLPNAGKSTFIRAVS
CCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLVPSLGVARVGADRSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHHCCCHHEECCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHH
LIHLVDIMPIDESDPAQNISVIESELYQYSEKLSEKPTWLVFNKIDTIGEEEAQARAQEI
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHCCCHHHHHHHHHH
AEQIGWEGDYYLISAATGQNVQNLTRDIMDFIEANPREVAEENTEADEVKFKWDDYHQQA
HHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCHHEEEECHHHHHHH
MQNPIEEDWDNFDDDWSEEDEEGVEFVYTRS
HCCCHHHHHCCCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MKFIDEALIRVEAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVYLIADENLNTLIDYR
CCCHHCCCEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHH
FEKRYAAGRGENGRSAGCTGHRGNDITLRVPVGTRAIDNDTQEVIGDLTKHGMKMLVAKG
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEHCCC
GYHGLGNTRFKSSVNRAPRQKTNGTPGEKRDLLLELMLLADVGMLGLPNAGKSTFIRAVS
CCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLVPSLGVARVGADRSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHHCCCHHEECCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHH
LIHLVDIMPIDESDPAQNISVIESELYQYSEKLSEKPTWLVFNKIDTIGEEEAQARAQEI
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHCCCHHHHHHHHHH
AEQIGWEGDYYLISAATGQNVQNLTRDIMDFIEANPREVAEENTEADEVKFKWDDYHQQA
HHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCHHEEEECHHHHHHH
MQNPIEEDWDNFDDDWSEEDEEGVEFVYTRS
HCCCHHHHHCCCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA