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The map label for this gene is lpxC

Identifier: 126207512

GI number: 126207512

Start: 27704

End: 28624

Strand: Direct

Name: lpxC

Synonym: APL_0024

Alternate gene names: 126207512

Gene position: 27704-28624 (Clockwise)

Preceding gene: 126207511

Following gene: 126207513

Centisome position: 1.22

GC content: 39.74

Gene sequence:

>921_bases
ATGATTAAACAAAGAACATTAAAACAAGCGACTAAAGTCACCGGTATCGGTTTGCACAGCGGTAAAAAAGTAACGCTAAC
GTTACGTCCCGCACCGGCTAATACGGGGATTGTTTATGCTCGTACGGATTTAGAACCGGCGGTGTATTTTCCTGCAAGTG
CGGAATCTATTCGTGATACGCAGCTTTGTACTTGTATGATTAATGATGACGGTGTACGTATTTCAACGGTTGAACACTTA
AATGCGGCAATGGCTTCATTAGGTTTGGATAACTTAATCGTTGAAGTGGATGCGCCTGAAATTCCGATTATGGACGGCAG
TGCGAGTCCGTTCATCTATTTATTATTAGATGCCGGTATTGAAGAGCAAGACGCACCGAAGAAATTTATTCGTATCAGAG
AAACGGTACGTGTGGAAGAAGGCGATAAATGGGCGGAAATGAAGCCTTATAGCAAAGGCTTAAAACTAGATTTCACCATC
GATTTTAGCCATCCGATGATCAGTAAGGATGTGCGTAATTTCAAAATGGAATTATCTGCCGAAAACTTTATTCACAAAAT
CAGCCGTGCAAGAACTTTCACCTTTATGAAAGATGTTGAATATCTTCAATCAATCGGCTTAGCATTAGGCGGTAGCCTTG
ATAATGCGATAGTATTAGATGAATATCGTATCTTGAATGAAGAAGGCTTACGCTATAAAGACGAATTGGTTAAGCACAAA
ATGTTGGACTCAATCGGCGACTTATTTATGTGCGGTTATAATATCCTTGGTGATTTCAGTGCATATAAATCGGGACACGG
TTTAAATAACAAATTATTACGTGCAATCCTTGCTAACGAAAATGCTTGGGAATTTGTAACCTTTGAAGATAAAGAACAAG
CGCCGGAAGGTTATCGTATTGGCGAACAAGTCTTTATCTAA

Upstream 100 bases:

>100_bases
GCAGGTGGATTCTTCCCAAGTTTGGTCTCCTAATTCGATTCCGGGATTTATGAGAAACGGTCAATAACGCCGTTACCCAA
ACGGGGAATAAGGATAGAAT

Downstream 100 bases:

>100_bases
TAGTAAGATGAATTAGTTTGAAAATCCTCGTTGATGAAAATCAGCGAGGATTTTTTTATGGTAAGCGGCCGGATTCAGCA
AAAATTTTGCAAAAACACTT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIKQRTLKQATKVTGIGLHSGKKVTLTLRPAPANTGIVYARTDLEPAVYFPASAESIRDTQLCTCMINDDGVRISTVEHL
NAAMASLGLDNLIVEVDAPEIPIMDGSASPFIYLLLDAGIEEQDAPKKFIRIRETVRVEEGDKWAEMKPYSKGLKLDFTI
DFSHPMISKDVRNFKMELSAENFIHKISRARTFTFMKDVEYLQSIGLALGGSLDNAIVLDEYRILNEEGLRYKDELVKHK
MLDSIGDLFMCGYNILGDFSAYKSGHGLNNKLLRAILANENAWEFVTFEDKEQAPEGYRIGEQVFI

Sequences:

>Translated_306_residues
MIKQRTLKQATKVTGIGLHSGKKVTLTLRPAPANTGIVYARTDLEPAVYFPASAESIRDTQLCTCMINDDGVRISTVEHL
NAAMASLGLDNLIVEVDAPEIPIMDGSASPFIYLLLDAGIEEQDAPKKFIRIRETVRVEEGDKWAEMKPYSKGLKLDFTI
DFSHPMISKDVRNFKMELSAENFIHKISRARTFTFMKDVEYLQSIGLALGGSLDNAIVLDEYRILNEEGLRYKDELVKHK
MLDSIGDLFMCGYNILGDFSAYKSGHGLNNKLLRAILANENAWEFVTFEDKEQAPEGYRIGEQVFI
>Mature_306_residues
MIKQRTLKQATKVTGIGLHSGKKVTLTLRPAPANTGIVYARTDLEPAVYFPASAESIRDTQLCTCMINDDGVRISTVEHL
NAAMASLGLDNLIVEVDAPEIPIMDGSASPFIYLLLDAGIEEQDAPKKFIRIRETVRVEEGDKWAEMKPYSKGLKLDFTI
DFSHPMISKDVRNFKMELSAENFIHKISRARTFTFMKDVEYLQSIGLALGGSLDNAIVLDEYRILNEEGLRYKDELVKHK
MLDSIGDLFMCGYNILGDFSAYKSGHGLNNKLLRAILANENAWEFVTFEDKEQAPEGYRIGEQVFI

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=305, Percent_Identity=66.5573770491803, Blast_Score=450, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_ACTP2 (A3MY96)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001052737.1
- ProteinModelPortal:   A3MY96
- SMR:   A3MY96
- STRING:   A3MY96
- GeneID:   4848703
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0024
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- PhylomeDB:   A3MY96
- ProtClustDB:   PRK13186
- BioCyc:   APLE416269:APL_0024-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 34350; Mature: 34350

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQRTLKQATKVTGIGLHSGKKVTLTLRPAPANTGIVYARTDLEPAVYFPASAESIRDT
CCCHHHHHHHHHEEEEEECCCCEEEEEEECCCCCCCEEEEECCCCCEEECCCCCCCCCCC
QLCTCMINDDGVRISTVEHLNAAMASLGLDNLIVEVDAPEIPIMDGSASPFIYLLLDAGI
EEEEEEECCCCEEEEHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCEEEEEEECCC
EEQDAPKKFIRIRETVRVEEGDKWAEMKPYSKGLKLDFTIDFSHPMISKDVRNFKMELSA
CCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHEEEECH
ENFIHKISRARTFTFMKDVEYLQSIGLALGGSLDNAIVLDEYRILNEEGLRYKDELVKHK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHHH
MLDSIGDLFMCGYNILGDFSAYKSGHGLNNKLLRAILANENAWEFVTFEDKEQAPEGYRI
HHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCHHCCCCCCCC
GEQVFI
CCEECC
>Mature Secondary Structure
MIKQRTLKQATKVTGIGLHSGKKVTLTLRPAPANTGIVYARTDLEPAVYFPASAESIRDT
CCCHHHHHHHHHEEEEEECCCCEEEEEEECCCCCCCEEEEECCCCCEEECCCCCCCCCCC
QLCTCMINDDGVRISTVEHLNAAMASLGLDNLIVEVDAPEIPIMDGSASPFIYLLLDAGI
EEEEEEECCCCEEEEHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCEEEEEEECCC
EEQDAPKKFIRIRETVRVEEGDKWAEMKPYSKGLKLDFTIDFSHPMISKDVRNFKMELSA
CCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHEEEECH
ENFIHKISRARTFTFMKDVEYLQSIGLALGGSLDNAIVLDEYRILNEEGLRYKDELVKHK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHHH
MLDSIGDLFMCGYNILGDFSAYKSGHGLNNKLLRAILANENAWEFVTFEDKEQAPEGYRI
HHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCHHCCCCCCCC
GEQVFI
CCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA