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The map label for this gene is ftsI [H]

Identifier: 126207500

GI number: 126207500

Start: 11670

End: 13730

Strand: Direct

Name: ftsI [H]

Synonym: APL_0012

Alternate gene names: 126207500

Gene position: 11670-13730 (Clockwise)

Preceding gene: 126207499

Following gene: 126207501

Centisome position: 0.51

GC content: 45.08

Gene sequence:

>2061_bases
ATGGCAAAGTCAGTTAAATTAAAGCGTAAACCCGTGGCTATCGAGCCGAATACAGAAGTAAAAAAGCAAACTAATACTAA
AAATGAACCGAGTTATCTCCCGATTCGTTTTGGTGTGGTCGGTTTTTTCATCCTTGTAATGGCGGGAATGCTGATTGCTA
AAGCGGCTCATATTCAGTTATTTGATTCCGAACGCCTGATTAATGAAGCGAATAACCGCTCATTGCGTACTAAAGAGCTG
CCTTTCACCCGAGGACGTATTCTTGATCGTAACGGTCGATTCTTATCCATTAGTGTACCGATGTACTCTCTCACCCTCGA
TCCTCGAGAATATTTTGACAGCAAATTACGCCGAAGCCCTGAACGTTGGAAATTACTGGCAATGGAAATGGGTGCCTCCA
AAAGTAAAATTGAAAAAAACGTCAATGATTTCATAGAGAAAAAGAATACTTCAAAAGAAAAAGTAGCCTTTGATCCTCGT
TCTATTCTCAATACAAAAAGTGAAGATTACTGGACGCTTTTAGCGCAATCGACCGGGCTGGATTACAATACGTTAATCCA
ATCGGTGAGAAATAATCCGAGTTCCGCATTCTTAATGCAGGAAATTTCCGCCTCGCAACTCGAACGTTCTAAACTTGAAG
CGATTGCCAAAGCGACCGGCGAAAAATATAACGACCTGATGGCGCGTTTATATAAAGCGGTGCGCCAGCGTTTTATCTAC
ATCGCACGCCACGAGCCGGAGAGTATCGCCAATTATGCGCAAGAACTGAAAATCGACGGTATGGTATTGAAAGCCGAATC
ACGCCGTTTTTATCCGCTGGCGGAAGAAGCCTCGCAATTAATCGGTTTTACCGATATTGATGACGTACACGGTACGGAAG
GTTTAGAGCGTAGTTTCGATTCTTTATTAATCGGTAAAAACGGTCGCCAAGTGATTCGTAAAGATGCGCGCGGTAATGTG
ATTGAAAATATTCGCGATGAAAAACAATACGATCCGCAAGACGTTATGTTGAGTATCGATGAAGAATTACAATCCGAAGT
ATATAAAAAAATTAAAGAAGCGGTTATTGCCAATAATGCCGAATCCGGCACGGCGGTGTTGGTTGATGTGCAAACCGGCG
AAATTTTGGCGATGGCGAATGCGCCTTCGTTTAACCCGAACAAACGGGACAGTTTTAAGCCGGAATTAATGCGTAACCGA
GCGATTACCGATACTTTCGAACCGGGTTCGACGGTTAAGCCGTTAGTGGTTTTAACCGCATTGCAAAACGGGGCGACTTA
TCGCGACGAAGTGATTAATACGCGTCCGTTTGTGGTAAACGGGCATACGATTAAAGACGTTGCGCCGCGTGAAAGTTTAT
CGCTGACCGGTATTTTACAGAAATCGAGTAATATCGGGGTAAGCCGTTTGGCGTTACGTATGCCGTCCACCGCACTGGTC
GATACTTATAGCAAGGTCGGTTTCGGTAAAGATACCGGTTTAGGCTTGGGCGAACAAAAAGGGACGAACGGCGATCGTAA
ACGTTGGTCGGATATCGAACGTGCAACCATGGCGTACGGTTACGGTTTAAATATTACACCGTTACAGCTTGCGCGAGCTT
ATGCGACCTTGGGAAGTTTCGGTATTTATCGACCGCTTTCGATTACCAAAGTGGATCCGCCGGTTATCGGCGAACGAGTA
TTACCGGAAAAAATTACTCGTGACGTAGTGCATATGATGGAAAGTGTGGCGCAAAAAGGCGAAGGCGGTCAGAAAGCGAT
GGTGGAAGGTTATCGTGTGGCGGTGAAAACCGGTACGGCTCGTAAACTTGAAAAAGGGCAATACGTCGAAAAATATATTG
CCTATACCGCAGGTGTTGCGCCGGCAAGTGATCCCCGCTTTGCCTTGGTTGTGTTGATTAACGAACCGAAAGCCGGACAA
TACTACGGCGGTTCGGTTTCCGCGCCGTTATTCTCGAGTATTATGGGCTATACCCTGAAAACGAGAAATATCAAACCGGA
TAACCTCACCGACACCGAAAGTGCCGTACGAGAAATTAAATTAGAACAAAAAGTAAATTAG

Upstream 100 bases:

>100_bases
AAATGCGAAGAGCCAGAAATCTCGCGTAGAGGCGGCGGCGGCAAGTTTCGGTTTACAGTCGATAAAAAAAGAGCAAGAAG
TTATTTTGGTTGAATAAAGC

Downstream 100 bases:

>100_bases
AACAGAATAAATTAGGTAACAATATGAAACGTTTACTTCCCTTTCTCACCGAACTTGATGCTTGGGTGACGGAATTAAAA
CCGCTTAAGCAAATGACGTT

Product: peptidoglycan synthetase FtsI

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 686; Mature: 685

Protein sequence:

>686_residues
MAKSVKLKRKPVAIEPNTEVKKQTNTKNEPSYLPIRFGVVGFFILVMAGMLIAKAAHIQLFDSERLINEANNRSLRTKEL
PFTRGRILDRNGRFLSISVPMYSLTLDPREYFDSKLRRSPERWKLLAMEMGASKSKIEKNVNDFIEKKNTSKEKVAFDPR
SILNTKSEDYWTLLAQSTGLDYNTLIQSVRNNPSSAFLMQEISASQLERSKLEAIAKATGEKYNDLMARLYKAVRQRFIY
IARHEPESIANYAQELKIDGMVLKAESRRFYPLAEEASQLIGFTDIDDVHGTEGLERSFDSLLIGKNGRQVIRKDARGNV
IENIRDEKQYDPQDVMLSIDEELQSEVYKKIKEAVIANNAESGTAVLVDVQTGEILAMANAPSFNPNKRDSFKPELMRNR
AITDTFEPGSTVKPLVVLTALQNGATYRDEVINTRPFVVNGHTIKDVAPRESLSLTGILQKSSNIGVSRLALRMPSTALV
DTYSKVGFGKDTGLGLGEQKGTNGDRKRWSDIERATMAYGYGLNITPLQLARAYATLGSFGIYRPLSITKVDPPVIGERV
LPEKITRDVVHMMESVAQKGEGGQKAMVEGYRVAVKTGTARKLEKGQYVEKYIAYTAGVAPASDPRFALVVLINEPKAGQ
YYGGSVSAPLFSSIMGYTLKTRNIKPDNLTDTESAVREIKLEQKVN

Sequences:

>Translated_686_residues
MAKSVKLKRKPVAIEPNTEVKKQTNTKNEPSYLPIRFGVVGFFILVMAGMLIAKAAHIQLFDSERLINEANNRSLRTKEL
PFTRGRILDRNGRFLSISVPMYSLTLDPREYFDSKLRRSPERWKLLAMEMGASKSKIEKNVNDFIEKKNTSKEKVAFDPR
SILNTKSEDYWTLLAQSTGLDYNTLIQSVRNNPSSAFLMQEISASQLERSKLEAIAKATGEKYNDLMARLYKAVRQRFIY
IARHEPESIANYAQELKIDGMVLKAESRRFYPLAEEASQLIGFTDIDDVHGTEGLERSFDSLLIGKNGRQVIRKDARGNV
IENIRDEKQYDPQDVMLSIDEELQSEVYKKIKEAVIANNAESGTAVLVDVQTGEILAMANAPSFNPNKRDSFKPELMRNR
AITDTFEPGSTVKPLVVLTALQNGATYRDEVINTRPFVVNGHTIKDVAPRESLSLTGILQKSSNIGVSRLALRMPSTALV
DTYSKVGFGKDTGLGLGEQKGTNGDRKRWSDIERATMAYGYGLNITPLQLARAYATLGSFGIYRPLSITKVDPPVIGERV
LPEKITRDVVHMMESVAQKGEGGQKAMVEGYRVAVKTGTARKLEKGQYVEKYIAYTAGVAPASDPRFALVVLINEPKAGQ
YYGGSVSAPLFSSIMGYTLKTRNIKPDNLTDTESAVREIKLEQKVN
>Mature_685_residues
AKSVKLKRKPVAIEPNTEVKKQTNTKNEPSYLPIRFGVVGFFILVMAGMLIAKAAHIQLFDSERLINEANNRSLRTKELP
FTRGRILDRNGRFLSISVPMYSLTLDPREYFDSKLRRSPERWKLLAMEMGASKSKIEKNVNDFIEKKNTSKEKVAFDPRS
ILNTKSEDYWTLLAQSTGLDYNTLIQSVRNNPSSAFLMQEISASQLERSKLEAIAKATGEKYNDLMARLYKAVRQRFIYI
ARHEPESIANYAQELKIDGMVLKAESRRFYPLAEEASQLIGFTDIDDVHGTEGLERSFDSLLIGKNGRQVIRKDARGNVI
ENIRDEKQYDPQDVMLSIDEELQSEVYKKIKEAVIANNAESGTAVLVDVQTGEILAMANAPSFNPNKRDSFKPELMRNRA
ITDTFEPGSTVKPLVVLTALQNGATYRDEVINTRPFVVNGHTIKDVAPRESLSLTGILQKSSNIGVSRLALRMPSTALVD
TYSKVGFGKDTGLGLGEQKGTNGDRKRWSDIERATMAYGYGLNITPLQLARAYATLGSFGIYRPLSITKVDPPVIGERVL
PEKITRDVVHMMESVAQKGEGGQKAMVEGYRVAVKTGTARKLEKGQYVEKYIAYTAGVAPASDPRFALVVLINEPKAGQY
YGGSVSAPLFSSIMGYTLKTRNIKPDNLTDTESAVREIKLEQKVN

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=462, Percent_Identity=59.5238095238095, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1786854, Length=481, Percent_Identity=23.0769230769231, Blast_Score=90, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 76610; Mature: 76479

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSVKLKRKPVAIEPNTEVKKQTNTKNEPSYLPIRFGVVGFFILVMAGMLIAKAAHIQL
CCCCCCCCCCCEEECCCCCHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHEEE
FDSERLINEANNRSLRTKELPFTRGRILDRNGRFLSISVPMYSLTLDPREYFDSKLRRSP
ECHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEEEECCEEEEEECHHHHHHHHHHCCC
ERWKLLAMEMGASKSKIEKNVNDFIEKKNTSKEKVAFDPRSILNTKSEDYWTLLAQSTGL
HHHEEEHHHHCCCHHHHHHHHHHHHHHCCCCCHHEECCCHHHHCCCCCCCEEEEECCCCC
DYNTLIQSVRNNPSSAFLMQEISASQLERSKLEAIAKATGEKYNDLMARLYKAVRQRFIY
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEEE
IARHEPESIANYAQELKIDGMVLKAESRRFYPLAEEASQLIGFTDIDDVHGTEGLERSFD
EEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHH
SLLIGKNGRQVIRKDARGNVIENIRDEKQYDPQDVMLSIDEELQSEVYKKIKEAVIANNA
HEEECCCCHHHHHHHHCCCHHHHHHHHCCCCHHHHHEEHHHHHHHHHHHHHHHHHHCCCC
ESGTAVLVDVQTGEILAMANAPSFNPNKRDSFKPELMRNRAITDTFEPGSTVKPLVVLTA
CCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHEEEE
LQNGATYRDEVINTRPFVVNGHTIKDVAPRESLSLTGILQKSSNIGVSRLALRMPSTALV
HHCCCCHHHHHCCCCCEEEECCEECCCCCCCCCEEEEEEECCCCCCHHHHHHHCCCHHHH
DTYSKVGFGKDTGLGLGEQKGTNGDRKRWSDIERATMAYGYGLNITPLQLARAYATLGSF
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
GIYRPLSITKVDPPVIGERVLPEKITRDVVHMMESVAQKGEGGQKAMVEGYRVAVKTGTA
CCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEEECCCH
RKLEKGQYVEKYIAYTAGVAPASDPRFALVVLINEPKAGQYYGGSVSAPLFSSIMGYTLK
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHCCEEE
TRNIKPDNLTDTESAVREIKLEQKVN
ECCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKSVKLKRKPVAIEPNTEVKKQTNTKNEPSYLPIRFGVVGFFILVMAGMLIAKAAHIQL
CCCCCCCCCCEEECCCCCHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHEEE
FDSERLINEANNRSLRTKELPFTRGRILDRNGRFLSISVPMYSLTLDPREYFDSKLRRSP
ECHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEEEECCEEEEEECHHHHHHHHHHCCC
ERWKLLAMEMGASKSKIEKNVNDFIEKKNTSKEKVAFDPRSILNTKSEDYWTLLAQSTGL
HHHEEEHHHHCCCHHHHHHHHHHHHHHCCCCCHHEECCCHHHHCCCCCCCEEEEECCCCC
DYNTLIQSVRNNPSSAFLMQEISASQLERSKLEAIAKATGEKYNDLMARLYKAVRQRFIY
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEEE
IARHEPESIANYAQELKIDGMVLKAESRRFYPLAEEASQLIGFTDIDDVHGTEGLERSFD
EEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHH
SLLIGKNGRQVIRKDARGNVIENIRDEKQYDPQDVMLSIDEELQSEVYKKIKEAVIANNA
HEEECCCCHHHHHHHHCCCHHHHHHHHCCCCHHHHHEEHHHHHHHHHHHHHHHHHHCCCC
ESGTAVLVDVQTGEILAMANAPSFNPNKRDSFKPELMRNRAITDTFEPGSTVKPLVVLTA
CCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHEEEE
LQNGATYRDEVINTRPFVVNGHTIKDVAPRESLSLTGILQKSSNIGVSRLALRMPSTALV
HHCCCCHHHHHCCCCCEEEECCEECCCCCCCCCEEEEEEECCCCCCHHHHHHHCCCHHHH
DTYSKVGFGKDTGLGLGEQKGTNGDRKRWSDIERATMAYGYGLNITPLQLARAYATLGSF
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
GIYRPLSITKVDPPVIGERVLPEKITRDVVHMMESVAQKGEGGQKAMVEGYRVAVKTGTA
CCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEEECCCH
RKLEKGQYVEKYIAYTAGVAPASDPRFALVVLINEPKAGQYYGGSVSAPLFSSIMGYTLK
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHCCEEE
TRNIKPDNLTDTESAVREIKLEQKVN
ECCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]