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The map label for this gene is hexR [H]

Identifier: 126174458

GI number: 126174458

Start: 2592849

End: 2593703

Strand: Direct

Name: hexR [H]

Synonym: Sbal_2242

Alternate gene names: 126174458

Gene position: 2592849-2593703 (Clockwise)

Preceding gene: 126174453

Following gene: 126174459

Centisome position: 50.57

GC content: 43.74

Gene sequence:

>855_bases
ATGAATACCCTAGAAAAGGTTCAAAAAAGCCTCACCCATTTTAGTAAATCAGAACGCAAAGTTGCAGAGGTGATCTTAGC
ATCACCACAGACAGCTATACATTCTAGCATCGCCACACTGGCTAAGATGGCAGATGTCAGTGAACCTACTGTGAATCGTT
TCTGCCGCCGCTTAGATACTAAAGGCTTCCCTGATTTTAAGTTACATCTAGCGCAAAGTCTTGCGAACGGTACTCCTTAT
GTGAGCCGCCACGTTGAAGAAGATGACTCGACTGAGTCGTATACGACAAAAATCTTTGAATCTTCAATGGCTTCGCTTGA
TACCGCACGTCAAAGTTTAGATATTTCAGCCATAAACAAAGCGGTTGATATACTTACTCAAGCTAAGACTATTTCCTTTT
TCGGCTTAGGCGCATCCGCTTCTGTTGCCCATGACGCCCAAAATAAATTCTTCCGCTTTAATGTGCCTGTAATTTGTTTT
GACGATGTTCTAATGCAACGCATGAGCTGTATCAACAGCAATGAAGGTGATGTTGTTGTATTAATTTCCCACACAGGCCG
CACTAAGTCATTGATTGAGATAGCACGTTTAGCGAGAGAAAACGGTGCAGCAGTGATTGGTATTACCGCCCGTAACTCGC
CTTTGTCGATGGAATGTACGCTGCCCGTGACAATGGAAGTGCCAGAAGATACCGACATGTATTTACCTATGGCCTCGCGT
TTAGCCCAATTAGTCACTATAGATGTATTGGCAACCGGCTTTACCTTACGCAGAGGTCCACGTTTCCGCGATAATTTGAA
ACGGGTGAAAGAGGTGTTAAAAGAGTCTCGCATCAATAAAGATCCGATACTGTAA

Upstream 100 bases:

>100_bases
AGTTACTACATAGAGTCTCTTTGTGGGCCGCCAGCCTTGATCTGTCCCCACAAAACAAAAATAAATAAAATTACATTCTC
AATTTAGCGGACATACGCGT

Downstream 100 bases:

>100_bases
CTCACTTCCTTTTCTAAAAATGGCTAGTGTTGATCCTTAACCTAGCCATTTATCGTGCAAATATCAGCGATACCTCACAA
TTTTCATACATAACTTTAGA

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNTLEKVQKSLTHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VSRHVEEDDSTESYTTKIFESSMASLDTARQSLDISAINKAVDILTQAKTISFFGLGASASVAHDAQNKFFRFNVPVICF
DDVLMQRMSCINSNEGDVVVLISHTGRTKSLIEIARLARENGAAVIGITARNSPLSMECTLPVTMEVPEDTDMYLPMASR
LAQLVTIDVLATGFTLRRGPRFRDNLKRVKEVLKESRINKDPIL

Sequences:

>Translated_284_residues
MNTLEKVQKSLTHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VSRHVEEDDSTESYTTKIFESSMASLDTARQSLDISAINKAVDILTQAKTISFFGLGASASVAHDAQNKFFRFNVPVICF
DDVLMQRMSCINSNEGDVVVLISHTGRTKSLIEIARLARENGAAVIGITARNSPLSMECTLPVTMEVPEDTDMYLPMASR
LAQLVTIDVLATGFTLRRGPRFRDNLKRVKEVLKESRINKDPIL
>Mature_284_residues
MNTLEKVQKSLTHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VSRHVEEDDSTESYTTKIFESSMASLDTARQSLDISAINKAVDILTQAKTISFFGLGASASVAHDAQNKFFRFNVPVICF
DDVLMQRMSCINSNEGDVVVLISHTGRTKSLIEIARLARENGAAVIGITARNSPLSMECTLPVTMEVPEDTDMYLPMASR
LAQLVTIDVLATGFTLRRGPRFRDNLKRVKEVLKESRINKDPIL

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=280, Percent_Identity=73.9285714285714, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI87082369, Length=237, Percent_Identity=23.6286919831224, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1788767, Length=262, Percent_Identity=26.3358778625954, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082130, Length=214, Percent_Identity=28.0373831775701, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31423; Mature: 31423

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLEKVQKSLTHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
KGFPDFKLHLAQSLANGTPYVSRHVEEDDSTESYTTKIFESSMASLDTARQSLDISAINK
CCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDILTQAKTISFFGLGASASVAHDAQNKFFRFNVPVICFDDVLMQRMSCINSNEGDVVV
HHHHHHHHHHEEEEECCCCCHHHHHHCCCEEEECCCEEEHHHHHHHHHHHHCCCCCCEEE
LISHTGRTKSLIEIARLARENGAAVIGITARNSPLSMECTLPVTMEVPEDTDMYLPMASR
EEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECEEEEECCCCCCCCCHHHHH
LAQLVTIDVLATGFTLRRGPRFRDNLKRVKEVLKESRINKDPIL
HHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNTLEKVQKSLTHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
KGFPDFKLHLAQSLANGTPYVSRHVEEDDSTESYTTKIFESSMASLDTARQSLDISAINK
CCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDILTQAKTISFFGLGASASVAHDAQNKFFRFNVPVICFDDVLMQRMSCINSNEGDVVV
HHHHHHHHHHEEEEECCCCCHHHHHHCCCEEEECCCEEEHHHHHHHHHHHHCCCCCCEEE
LISHTGRTKSLIEIARLARENGAAVIGITARNSPLSMECTLPVTMEVPEDTDMYLPMASR
EEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECEEEEECCCCCCCCCHHHHH
LAQLVTIDVLATGFTLRRGPRFRDNLKRVKEVLKESRINKDPIL
HHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]