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The map label for this gene is cheA [H]

Identifier: 126174331

GI number: 126174331

Start: 2451514

End: 2453211

Strand: Direct

Name: cheA [H]

Synonym: Sbal_2112

Alternate gene names: 126174331

Gene position: 2451514-2453211 (Clockwise)

Preceding gene: 126174330

Following gene: 126174332

Centisome position: 47.81

GC content: 46.17

Gene sequence:

>1698_bases
ATGTCCATCAATATGGCCGAGTTCCATCAGGTCTTTTTTGAAGAAAGTCATGAACATCTTGAAAATATGGAACAATTGCT
ATTGGCATTGGACCTCGCTTCTCCCGATCCTGAAGAACTGAACACGATTTTCCGTGCTGCCCACTCGATTAAAGGTGGCA
GTGGTATTTTTGGTTTTACCGCACTGACCAGTGTCACCCATGTGATGGAAAACCTGCTGGACATGACCCGCAAGGGCAAC
TTCCAACTCACCTCATCGATTATCGATTTACTGCTGAGTACCGTTGATACGCTATCCCATATATTGAGCCTGTACCGCGA
AGAAGAACAAATTGATTGGCAGGAGGTGGAGTACAGTAAAAGCCAATTGGTGGCAGCGTTAAATGGTGAATCCTTTAGCT
CATCGGTTGCAGTACAAAATGGCACTGATATCGCTAACACTCCTGTGACTCCAACTCTCAATGCAGAGCCTTCTGCACTA
GTGGAAACCGAGGATGAGCTGGGTTTTGGATTTTTCGAAGATGAAATGGCACGCGATATTGCCATTGAAGGTGAAGACTT
TGGCTTTTTTGAAGAGGCTTATCAAGCCGAAGAAATCAGCGCACAAAGTGTCATAAATGATGTAAGCAATACTGAGAAAG
CGGCAGAGCCCTTTGATTTCACATCCGATGATGAATTAGGCTTTGGCTTTTTTGAGGCATTAACGCCGGAATCCTTCGCC
AATGAATCGGTGCGTATGCTGCCGGTATCTTTTGTGTTTAACCGTTTCAATCGTTTGGTGAGGGATCTTTCTGAGCAACT
GGGTAAAAACGTCAATCTCGTGATTGAAGGTGGCAACACAGAAATTGATAAGGGCATGATTGAAAAGCTTGTCGATCCGC
TGACCCACTTAGTGCGCAATAGCTTAGATCATGGCATCGAAAAACCTGATAAACGGCTTGCGGCGGGTAAATCTGAAGTG
GGCGTATTGTCCCTAAAAGCCAGCCAAAGGGGGGGCAATATTGTTATCGCTGTGCATGATAATGGCGCAGGTTTAAACCG
TGAGCGCATTATTCAAAAGGCGCGGGAAAACGGTTTGCAAGTGGCTGATAACATTAGCGACAAGCAAGTCTGGCAATTGA
TTTTTGCCGCAGGTTTTTCAACCGCAGTGGAAGTCACAGACGTGTCTGGCCGCGGTGTCGGTATGGATGTGGTGCGCCGT
AATATTGAAGCCTTAGGCGGACGCATTGATATTGAGTCGACTGAGGGTCAAGGTTCAACCTTTGAAATCCAATTGCCACT
TACGCTGGCGATTGTCGATGGTATGACGGTTTCTGTGGGAAGTCAGATCTACATTTTGCCCTTAGTGCACATCATTGAAT
CTATTCAGCCGCAAACTGAACAACTCAAATTTCTAGCCAAAGAAAGACTTTTAAAAGTACGTGAAGAATACTTACCCCTG
CTAAACCTTTATCAGCTGATGGAAATTGAGCCCAATGCTAAGAGCCCTGAAGAGGGCATAGTGGTATTGCTCGAAAGCAA
CCACAAGCGCTTTGGCCTGTGCGTTGATGCCTTAGTTGGCCAGCAGCAAGTCGTGATCAAGAGTCTTGAAAAACATTATC
GTAGGATCCCCGGAGTTTCAGGCGCCACCATCATGGGCGATGGCAGCGTCGCTTTGATCCTCGATGTCGAATCGCTCGCT
CTGCACATAAAAAATTAA

Upstream 100 bases:

>100_bases
AAGCGGCAGGTGCGACGGGATGGATGGTAAAACCCTTTGATCCTCAAAAGCTGTTAGCGATTACGGCTAAAGTGCTGGGT
TAACTGCAACGGGGTGCGCT

Downstream 100 bases:

>100_bases
GGAAATAGCCATGGAGAGTCGATCAACTATGACTGCCAAAGTGGAATACAACTCCCATGATGAGGTGGAGTTTTTGAGTT
TTATGCTGGGCGAAGAGCAC

Product: CheA signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MSINMAEFHQVFFEESHEHLENMEQLLLALDLASPDPEELNTIFRAAHSIKGGSGIFGFTALTSVTHVMENLLDMTRKGN
FQLTSSIIDLLLSTVDTLSHILSLYREEEQIDWQEVEYSKSQLVAALNGESFSSSVAVQNGTDIANTPVTPTLNAEPSAL
VETEDELGFGFFEDEMARDIAIEGEDFGFFEEAYQAEEISAQSVINDVSNTEKAAEPFDFTSDDELGFGFFEALTPESFA
NESVRMLPVSFVFNRFNRLVRDLSEQLGKNVNLVIEGGNTEIDKGMIEKLVDPLTHLVRNSLDHGIEKPDKRLAAGKSEV
GVLSLKASQRGGNIVIAVHDNGAGLNRERIIQKARENGLQVADNISDKQVWQLIFAAGFSTAVEVTDVSGRGVGMDVVRR
NIEALGGRIDIESTEGQGSTFEIQLPLTLAIVDGMTVSVGSQIYILPLVHIIESIQPQTEQLKFLAKERLLKVREEYLPL
LNLYQLMEIEPNAKSPEEGIVVLLESNHKRFGLCVDALVGQQQVVIKSLEKHYRRIPGVSGATIMGDGSVALILDVESLA
LHIKN

Sequences:

>Translated_565_residues
MSINMAEFHQVFFEESHEHLENMEQLLLALDLASPDPEELNTIFRAAHSIKGGSGIFGFTALTSVTHVMENLLDMTRKGN
FQLTSSIIDLLLSTVDTLSHILSLYREEEQIDWQEVEYSKSQLVAALNGESFSSSVAVQNGTDIANTPVTPTLNAEPSAL
VETEDELGFGFFEDEMARDIAIEGEDFGFFEEAYQAEEISAQSVINDVSNTEKAAEPFDFTSDDELGFGFFEALTPESFA
NESVRMLPVSFVFNRFNRLVRDLSEQLGKNVNLVIEGGNTEIDKGMIEKLVDPLTHLVRNSLDHGIEKPDKRLAAGKSEV
GVLSLKASQRGGNIVIAVHDNGAGLNRERIIQKARENGLQVADNISDKQVWQLIFAAGFSTAVEVTDVSGRGVGMDVVRR
NIEALGGRIDIESTEGQGSTFEIQLPLTLAIVDGMTVSVGSQIYILPLVHIIESIQPQTEQLKFLAKERLLKVREEYLPL
LNLYQLMEIEPNAKSPEEGIVVLLESNHKRFGLCVDALVGQQQVVIKSLEKHYRRIPGVSGATIMGDGSVALILDVESLA
LHIKN
>Mature_564_residues
SINMAEFHQVFFEESHEHLENMEQLLLALDLASPDPEELNTIFRAAHSIKGGSGIFGFTALTSVTHVMENLLDMTRKGNF
QLTSSIIDLLLSTVDTLSHILSLYREEEQIDWQEVEYSKSQLVAALNGESFSSSVAVQNGTDIANTPVTPTLNAEPSALV
ETEDELGFGFFEDEMARDIAIEGEDFGFFEEAYQAEEISAQSVINDVSNTEKAAEPFDFTSDDELGFGFFEALTPESFAN
ESVRMLPVSFVFNRFNRLVRDLSEQLGKNVNLVIEGGNTEIDKGMIEKLVDPLTHLVRNSLDHGIEKPDKRLAAGKSEVG
VLSLKASQRGGNIVIAVHDNGAGLNRERIIQKARENGLQVADNISDKQVWQLIFAAGFSTAVEVTDVSGRGVGMDVVRRN
IEALGGRIDIESTEGQGSTFEIQLPLTLAIVDGMTVSVGSQIYILPLVHIIESIQPQTEQLKFLAKERLLKVREEYLPLL
NLYQLMEIEPNAKSPEEGIVVLLESNHKRFGLCVDALVGQQQVVIKSLEKHYRRIPGVSGATIMGDGSVALILDVESLAL
HIKN

Specific function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY [H]

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HPt domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=318, Percent_Identity=57.8616352201258, Blast_Score=384, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR015162
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR004105
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF01584 CheW; PF09078 CheY-binding; PF02895 H-kinase_dim; PF02518 HATPase_c; PF01627 Hpt [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 62233; Mature: 62102

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSINMAEFHQVFFEESHEHLENMEQLLLALDLASPDPEELNTIFRAAHSIKGGSGIFGFT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHH
ALTSVTHVMENLLDMTRKGNFQLTSSIIDLLLSTVDTLSHILSLYREEEQIDWQEVEYSK
HHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SQLVAALNGESFSSSVAVQNGTDIANTPVTPTLNAEPSALVETEDELGFGFFEDEMARDI
HHEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEECCHHCCCCCHHHHHHHHE
AIEGEDFGFFEEAYQAEEISAQSVINDVSNTEKAAEPFDFTSDDELGFGFFEALTPESFA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCHHHC
NESVRMLPVSFVFNRFNRLVRDLSEQLGKNVNLVIEGGNTEIDKGMIEKLVDPLTHLVRN
CCCEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
SLDHGIEKPDKRLAAGKSEVGVLSLKASQRGGNIVIAVHDNGAGLNRERIIQKARENGLQ
HHHHCCCCCHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCE
VADNISDKQVWQLIFAAGFSTAVEVTDVSGRGVGMDVVRRNIEALGGRIDIESTEGQGST
ECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCE
FEIQLPLTLAIVDGMTVSVGSQIYILPLVHIIESIQPQTEQLKFLAKERLLKVREEYLPL
EEEEECEEEEEECCEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LNLYQLMEIEPNAKSPEEGIVVLLESNHKRFGLCVDALVGQQQVVIKSLEKHYRRIPGVS
HHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCC
GATIMGDGSVALILDVESLALHIKN
CCEEECCCCEEEEEEEEHHEEEECC
>Mature Secondary Structure 
SINMAEFHQVFFEESHEHLENMEQLLLALDLASPDPEELNTIFRAAHSIKGGSGIFGFT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHH
ALTSVTHVMENLLDMTRKGNFQLTSSIIDLLLSTVDTLSHILSLYREEEQIDWQEVEYSK
HHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SQLVAALNGESFSSSVAVQNGTDIANTPVTPTLNAEPSALVETEDELGFGFFEDEMARDI
HHEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEECCHHCCCCCHHHHHHHHE
AIEGEDFGFFEEAYQAEEISAQSVINDVSNTEKAAEPFDFTSDDELGFGFFEALTPESFA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCHHHC
NESVRMLPVSFVFNRFNRLVRDLSEQLGKNVNLVIEGGNTEIDKGMIEKLVDPLTHLVRN
CCCEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
SLDHGIEKPDKRLAAGKSEVGVLSLKASQRGGNIVIAVHDNGAGLNRERIIQKARENGLQ
HHHHCCCCCHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCE
VADNISDKQVWQLIFAAGFSTAVEVTDVSGRGVGMDVVRRNIEALGGRIDIESTEGQGST
ECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCE
FEIQLPLTLAIVDGMTVSVGSQIYILPLVHIIESIQPQTEQLKFLAKERLLKVREEYLPL
EEEEECEEEEEECCEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LNLYQLMEIEPNAKSPEEGIVVLLESNHKRFGLCVDALVGQQQVVIKSLEKHYRRIPGVS
HHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCC
GATIMGDGSVALILDVESLALHIKN
CCEEECCCCEEEEEEEEHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2002011; 9097040; 9278503; 3510184; 2832069; 2068106; 8555213; 8639521; 9020767; 9437425; 9636149 [H]