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The map label for this gene is purM [H]

Identifier: 126173964

GI number: 126173964

Start: 2018704

End: 2019741

Strand: Reverse

Name: purM [H]

Synonym: Sbal_1735

Alternate gene names: 126173964

Gene position: 2019741-2018704 (Counterclockwise)

Preceding gene: 126173966

Following gene: 126173963

Centisome position: 39.39

GC content: 47.3

Gene sequence:

>1038_bases
GTGAGCACACCTACCCCACTGAGCTATAAAGATGCCGGCGTTGATATTGATGCAGGTAATGCACTGGTAAGTAACATTAA
AGCAGCCGTTAAACGTACCCGTCGTCCAGAAGTTATGGGCAACTTAGGTGGTTTTGGCGCCCTGTGTGAAATCCCCACTA
AATACAAGCAACCGGTTTTAGTGTCTGGCACCGACGGTGTTGGGACTAAATTGCGTTTAGCTATCGACTATAAAAAACAT
GACACAGTCGGCATAGACTTAGTTGCTATGTGTGTGAACGATTTAATCGTTCAAGGTGCTGAGCCACTGTTTTTCCTCGA
TTACTATGCGACAGGCAAGCTGGATGTTGAAACCGCGACGTCTGTTGTCAACGGTATCGGCGAAGGTTGTTTCCAATCTG
GTTGTGCGTTAATCGGCGGTGAAACCGCTGAAATGCCAGGCATGTACGAAGGTGAAGATTACGACCTAGCAGGTTTCTGC
GTAGGCGTAGTTGAAAAAGCCGACATCATTGACGGTAGCAAAGTTGCAGCGGGTGATGCGCTTATCGCATTAGCCTCGAG
CGGCCCTCATTCAAATGGTTACTCTTTAGTACGTAAAGTATTAGAAGTGAGCCAAGCAGACCCTCAACAAGATCTCAATG
GCAAACCGCTAATTGAGCATCTACTTGAGCCAACCAAAATTTACGTGAAATCATTGCTAAAACTGATCGCAGCATCAGAC
GTACATGCAATGGCACACATTACTGGCGGCGGCTTCTGGGAAAACATCCCACGCGTACTACCAGATAATTTAAAAGCGGT
TATCCAAGGCGATTCATGGCAATGGCCTGCTGTTTTCAGTTGGTTAATGGAAAATGGCAACATTGCAGAATATGAAATGT
ATCGCACCTTCAACTGTGGCGTCGGCATGTTAGTCGCGCTGCCAGCCGATAAAGTGGATGCAGCACTTGCATTACTGGCT
GCAGAAGGCGAACAAGCTTGGCTGATCGGTGCTATCGCAGATCGTGAAGGCAATGAAGAGCAAGTGGAGATCCTGTAA

Upstream 100 bases:

>100_bases
GAGGGGCATAAATCCAAATCATGACTTTCGACCCCTAGCACAAGCTGGTAGAATACCGCCGCATAAAATCCAATAACGAT
GTACCCGAGAGGATCCCTCC

Downstream 100 bases:

>100_bases
TGCCCCAGAGCTGTCGTGTAGTTGTATTAATTTCCGGAAATGGCAGTAACCTGCAAGCGATTATCGACGGTTGCGACGAT
AATCTGCAGGCCGAAGTTGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSTPTPLSYKDAGVDIDAGNALVSNIKAAVKRTRRPEVMGNLGGFGALCEIPTKYKQPVLVSGTDGVGTKLRLAIDYKKH
DTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETATSVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFC
VGVVEKADIIDGSKVAAGDALIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIEHLLEPTKIYVKSLLKLIAASD
VHAMAHITGGGFWENIPRVLPDNLKAVIQGDSWQWPAVFSWLMENGNIAEYEMYRTFNCGVGMLVALPADKVDAALALLA
AEGEQAWLIGAIADREGNEEQVEIL

Sequences:

>Translated_345_residues
MSTPTPLSYKDAGVDIDAGNALVSNIKAAVKRTRRPEVMGNLGGFGALCEIPTKYKQPVLVSGTDGVGTKLRLAIDYKKH
DTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETATSVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFC
VGVVEKADIIDGSKVAAGDALIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIEHLLEPTKIYVKSLLKLIAASD
VHAMAHITGGGFWENIPRVLPDNLKAVIQGDSWQWPAVFSWLMENGNIAEYEMYRTFNCGVGMLVALPADKVDAALALLA
AEGEQAWLIGAIADREGNEEQVEIL
>Mature_344_residues
STPTPLSYKDAGVDIDAGNALVSNIKAAVKRTRRPEVMGNLGGFGALCEIPTKYKQPVLVSGTDGVGTKLRLAIDYKKHD
TVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETATSVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFCV
GVVEKADIIDGSKVAAGDALIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIEHLLEPTKIYVKSLLKLIAASDV
HAMAHITGGGFWENIPRVLPDNLKAVIQGDSWQWPAVFSWLMENGNIAEYEMYRTFNCGVGMLVALPADKVDAALALLAA
EGEQAWLIGAIADREGNEEQVEIL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=350, Percent_Identity=47.7142857142857, Blast_Score=328, Evalue=5e-90,
Organism=Homo sapiens, GI209869995, Length=350, Percent_Identity=47.7142857142857, Blast_Score=328, Evalue=5e-90,
Organism=Homo sapiens, GI209869993, Length=350, Percent_Identity=47.7142857142857, Blast_Score=328, Evalue=5e-90,
Organism=Escherichia coli, GI1788845, Length=343, Percent_Identity=74.3440233236152, Blast_Score=538, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17567511, Length=348, Percent_Identity=41.3793103448276, Blast_Score=244, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6321203, Length=342, Percent_Identity=49.4152046783626, Blast_Score=319, Evalue=4e-88,
Organism=Drosophila melanogaster, GI24582400, Length=318, Percent_Identity=42.7672955974843, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36733; Mature: 36602

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPTPLSYKDAGVDIDAGNALVSNIKAAVKRTRRPEVMGNLGGFGALCEIPTKYKQPVL
CCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCEECCCCCCCCCEE
VSGTDGVGTKLRLAIDYKKHDTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETAT
EECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEHHHHH
SVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFCVGVVEKADIIDGSKVAAGDA
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCE
LIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIEHLLEPTKIYVKSLLKLIAASD
EEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCC
VHAMAHITGGGFWENIPRVLPDNLKAVIQGDSWQWPAVFSWLMENGNIAEYEMYRTFNCG
HHEEEEECCCCHHHHCCHHCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEEEEEEECCC
VGMLVALPADKVDAALALLAAEGEQAWLIGAIADREGNEEQVEIL
CEEEEEECCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEEEEC
>Mature Secondary Structure 
STPTPLSYKDAGVDIDAGNALVSNIKAAVKRTRRPEVMGNLGGFGALCEIPTKYKQPVL
CCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCEECCCCCCCCCEE
VSGTDGVGTKLRLAIDYKKHDTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETAT
EECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEHHHHH
SVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFCVGVVEKADIIDGSKVAAGDA
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCE
LIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIEHLLEPTKIYVKSLLKLIAASD
EEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCC
VHAMAHITGGGFWENIPRVLPDNLKAVIQGDSWQWPAVFSWLMENGNIAEYEMYRTFNCG
HHEEEEECCCCHHHHCCHHCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEEEEEEECCC
VGMLVALPADKVDAALALLAAEGEQAWLIGAIADREGNEEQVEIL
CEEEEEECCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]