Click here to switch to the map view.

The map label for this gene is butB [H]

Identifier: 125624441

GI number: 125624441

Start: 1620222

End: 1621202

Strand: Reverse

Name: butB [H]

Synonym: llmg_1642

Alternate gene names: 125624441

Gene position: 1621202-1620222 (Counterclockwise)

Preceding gene: 125624442

Following gene: 125624440

Centisome position: 64.09

GC content: 38.12

Gene sequence:

>981_bases
GTGGCTTGGTGTGGAATCTGTGGTACAGATTTGCACGAATTTTTAGATGGACCAATTTTTTGTCCATCAGCAGAACATCC
AAATCCTATTACAGGTGAAGTTCCACCAGTTACTCTCGGACATGAAATGTCTGGTATTGTAAACTTTGTAGGTCAAGGGG
TAAGTGGGCTCAAAGTAGGTGACCATGTCGTTGTTGAACCTTATATCGTTCCCGAAGGTACTGATACAAGTGAAACTGGA
CATTACAATCTCTCAGAAGGATCAAACTTTATTGGTTTGGGCGGAAATGGCGGCGGTCTGGCTGAAAAAATTTCAGTTGA
TGAACGTTGGGTACATAAAATTCCTGACGATTTACCATTAGATGAAGCAGCACTAATTGAACCACTTTCTGTGGGATATC
ATGCTGTTGAACGTGCTAATTTGAGTGAAAAGAGTACGGTACTAGTTGTTGGAGCTGGTCCAATCGGACTTTTGACAGCT
GCAGTTGCCAAAGCTCAAGGGCATACAGTAATTATTAGTGAGCCTAGTGGTTTGCGTCGTAAAAAAGCTCAAGAAGCAGA
AGTTGCTGATTATTTCTTTAATCCAATTGAAGATGATATTCAGGCAAAAGTTCATCAAATTAATGAAAAAGGAGTTGATG
CTGCTTTTGAATGTACTTCTGTTCAACCAGGATTTGATGCGTGTTTAGATTCTATTCGCATGGGTGGAACAGTTGTTATC
GTTGCAATTTGGGGTAAACCAGCTAGTGTTGACATGGCAAAATTAGTCATTAAAGAAGCTAATCTTTTAGGGACTATTGC
TTATAATAATACTCATCCTAAAACCATTGATTTAGTTGCAACTGGTAAGATTAAATTGAATCAATTTATTACAGGTAAAA
TTGGCTTAGATGACCTGATTGATAAAGGTTTTGATACTTTGATTCATCACAATGAAACAGCAGTTAAGATTTTAGTTTCA
CCAACTGGAAAAGGTCTATAA

Upstream 100 bases:

>100_bases
CAACCATCCTATTCAGAGGAGGCGTTTTTATGATCGCGGAGATATTCGCGTTGAAGAAATTAATGAACCAGTAGTAAAAG
CTGGTCAAGTAGGTATAGAT

Downstream 100 bases:

>100_bases
ATATAAATTTCACTCATTTTAAAGGAGAAATAAAGATGTCTAAAGTTGCAGCAGTTACTGGCGCAGGTCAAGGAATTGGC
TTTGCTATCGCAAAACGTTT

Product: 2,3-butanediol dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MAWCGICGTDLHEFLDGPIFCPSAEHPNPITGEVPPVTLGHEMSGIVNFVGQGVSGLKVGDHVVVEPYIVPEGTDTSETG
HYNLSEGSNFIGLGGNGGGLAEKISVDERWVHKIPDDLPLDEAALIEPLSVGYHAVERANLSEKSTVLVVGAGPIGLLTA
AVAKAQGHTVIISEPSGLRRKKAQEAEVADYFFNPIEDDIQAKVHQINEKGVDAAFECTSVQPGFDACLDSIRMGGTVVI
VAIWGKPASVDMAKLVIKEANLLGTIAYNNTHPKTIDLVATGKIKLNQFITGKIGLDDLIDKGFDTLIHHNETAVKILVS
PTGKGL

Sequences:

>Translated_326_residues
MAWCGICGTDLHEFLDGPIFCPSAEHPNPITGEVPPVTLGHEMSGIVNFVGQGVSGLKVGDHVVVEPYIVPEGTDTSETG
HYNLSEGSNFIGLGGNGGGLAEKISVDERWVHKIPDDLPLDEAALIEPLSVGYHAVERANLSEKSTVLVVGAGPIGLLTA
AVAKAQGHTVIISEPSGLRRKKAQEAEVADYFFNPIEDDIQAKVHQINEKGVDAAFECTSVQPGFDACLDSIRMGGTVVI
VAIWGKPASVDMAKLVIKEANLLGTIAYNNTHPKTIDLVATGKIKLNQFITGKIGLDDLIDKGFDTLIHHNETAVKILVS
PTGKGL
>Mature_325_residues
AWCGICGTDLHEFLDGPIFCPSAEHPNPITGEVPPVTLGHEMSGIVNFVGQGVSGLKVGDHVVVEPYIVPEGTDTSETGH
YNLSEGSNFIGLGGNGGGLAEKISVDERWVHKIPDDLPLDEAALIEPLSVGYHAVERANLSEKSTVLVVGAGPIGLLTAA
VAKAQGHTVIISEPSGLRRKKAQEAEVADYFFNPIEDDIQAKVHQINEKGVDAAFECTSVQPGFDACLDSIRMGGTVVIV
AIWGKPASVDMAKLVIKEANLLGTIAYNNTHPKTIDLVATGKIKLNQFITGKIGLDDLIDKGFDTLIHHNETAVKILVSP
TGKGL

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=310, Percent_Identity=32.9032258064516, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1788073, Length=316, Percent_Identity=27.8481012658228, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI226510992, Length=320, Percent_Identity=30.9375, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790045, Length=308, Percent_Identity=30.1948051948052, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788407, Length=167, Percent_Identity=37.125748502994, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788075, Length=302, Percent_Identity=26.4900662251656, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787863, Length=306, Percent_Identity=27.1241830065359, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790718, Length=310, Percent_Identity=26.1290322580645, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082125, Length=276, Percent_Identity=26.4492753623188, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87081918, Length=268, Percent_Identity=28.3582089552239, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=299, Percent_Identity=32.1070234113712, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17562878, Length=301, Percent_Identity=28.9036544850498, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25146526, Length=321, Percent_Identity=28.0373831775701, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=321, Percent_Identity=28.0373831775701, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=349, Percent_Identity=35.5300859598854, Blast_Score=207, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6319257, Length=350, Percent_Identity=33.4285714285714, Blast_Score=198, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6323099, Length=325, Percent_Identity=31.6923076923077, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6322619, Length=325, Percent_Identity=32.3076923076923, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319955, Length=325, Percent_Identity=32.3076923076923, Blast_Score=139, Evalue=5e-34,
Organism=Drosophila melanogaster, GI17737897, Length=327, Percent_Identity=29.0519877675841, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI17137530, Length=326, Percent_Identity=28.5276073619632, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45551930, Length=296, Percent_Identity=23.3108108108108, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI45550770, Length=296, Percent_Identity=23.3108108108108, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI221457811, Length=296, Percent_Identity=23.3108108108108, Blast_Score=81, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 34495; Mature: 34363

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWCGICGTDLHEFLDGPIFCPSAEHPNPITGEVPPVTLGHEMSGIVNFVGQGVSGLKVG
CCCCCCCCHHHHHHHCCCEECCCCCCCCCCCCCCCCEECCHHHHHHHHHHHCCCCCCEEC
DHVVVEPYIVPEGTDTSETGHYNLSEGSNFIGLGGNGGGLAEKISVDERWVHKIPDDLPL
CEEEEEEEEECCCCCCCCCCCEECCCCCCEEEECCCCCCCCEEECCCHHHHHHCCCCCCC
DEAALIEPLSVGYHAVERANLSEKSTVLVVGAGPIGLLTAAVAKAQGHTVIISEPSGLRR
CHHHHHHHHHHCHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCHH
KKAQEAEVADYFFNPIEDDIQAKVHQINEKGVDAAFECTSVQPGFDACLDSIRMGGTVVI
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHCCCCEEEE
VAIWGKPASVDMAKLVIKEANLLGTIAYNNTHPKTIDLVATGKIKLNQFITGKIGLDDLI
EEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCCEEEEEEECCEEEEEEEECCCCHHHHH
DKGFDTLIHHNETAVKILVSPTGKGL
HCCHHHHHCCCCEEEEEEEECCCCCC
>Mature Secondary Structure 
AWCGICGTDLHEFLDGPIFCPSAEHPNPITGEVPPVTLGHEMSGIVNFVGQGVSGLKVG
CCCCCCCHHHHHHHCCCEECCCCCCCCCCCCCCCCEECCHHHHHHHHHHHCCCCCCEEC
DHVVVEPYIVPEGTDTSETGHYNLSEGSNFIGLGGNGGGLAEKISVDERWVHKIPDDLPL
CEEEEEEEEECCCCCCCCCCCEECCCCCCEEEECCCCCCCCEEECCCHHHHHHCCCCCCC
DEAALIEPLSVGYHAVERANLSEKSTVLVVGAGPIGLLTAAVAKAQGHTVIISEPSGLRR
CHHHHHHHHHHCHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCHH
KKAQEAEVADYFFNPIEDDIQAKVHQINEKGVDAAFECTSVQPGFDACLDSIRMGGTVVI
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHCCCCEEEE
VAIWGKPASVDMAKLVIKEANLLGTIAYNNTHPKTIDLVATGKIKLNQFITGKIGLDDLI
EEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCCEEEEEEECCEEEEEEEECCCCHHHHH
DKGFDTLIHHNETAVKILVSPTGKGL
HCCHHHHHCCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]