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The map label for this gene is hrcA [H]

Identifier: 125624378

GI number: 125624378

Start: 1552096

End: 1553139

Strand: Reverse

Name: hrcA [H]

Synonym: llmg_1576

Alternate gene names: 125624378

Gene position: 1553139-1552096 (Counterclockwise)

Preceding gene: 125624379

Following gene: 125624377

Centisome position: 61.4

GC content: 34.48

Gene sequence:

>1044_bases
ATGATTACAGAACGTCAAAGACAAATTTTAAATTTGATTGTTTCACTTTATGCTAAGGACCATACACCAATCGGTTCAAA
ATCGCTCCTTGATAGTATCCAAGCCTCTAGCGCAACCATTCGAAATGATATGAAAGCTTTGGAAAGGCTGGGTTTGATTC
AAAAGGAACATACCTCAAGTGGACGCATTCCGAGCGTTTCGGGCTATAAGTATTTTGTGGAAAATGTCATCCAGTTAGAA
GAGTTCAGTCAAAATGACTTGTTCAAAGTGATGAAAGCTTTTGATGGCGATTTTTATCGCTTGTCCGATTTGTTTAAAAC
TGCGGCTAAAAGCTTATCAGAACTAACAGGATTGACGAGTTTTGTTCTTAATGCTCCGCAACGTGACCAACAATTAGTCT
CATTTGAAATGGTTATGCTTGATAATCACTCGGTGCTCTCGGTCATTACTTTGGGAACTGGTGAGGTAAGAACAAATCAA
TTTATTTTACCAAAATCAATGACAGAAGCAGATTTAGCTGTTTTTAGCAACTTGGTTAAGGAACGATTAGTCGGTAAAAA
AGTGATTGATATTCACTATACGTTACGCACTGAAATTCCACAAATTGTTCAACGCTATTTTAAGGTTACGAGTGAAGTTT
TACAACTCTTTGAATCAATCTTTGATGATTTATTCAAAGAACATCTGACAGTCGCTGGTCATAAAAATATTTTTGACTAT
GCGACGGATAATCTTGCAGAGCTCTATAAACTCTTTAGTGATGATGAGCGAATGCTTCATGAAATTCGCGAGATTACAAA
TAATGATGAAATGAGAGCTGTTAAATTTGATAATGATGAAAAATTTATGAAAAATTTAACAATTATCTCGCAAAAATTTG
TCATTCCTTATCGTGGATTTGGTACATTGACAGTTGTAGGACCTGTAGAAATGGATTATCAAAGAACTTTATCAGTTCTT
GATTTAGTTGCTAAAGTTCTAACAATGAAATTAAGTGATTATTATCGTTACCTTGATGGTAACCATTATGAAATTAGTAA
ATGA

Upstream 100 bases:

>100_bases
TTCTTGACAAGGTATAAACAAAGGGTTATAATAAACTTGTTAGCACTTAGAGGTAAAGAGTGCTAAAAGAAAAAACTTAG
AGATAAAAAAAGGAGCAGCT

Downstream 100 bases:

>100_bases
TTAAAAAGTTATTTAAAAAAGGAGGGCCTATGTCCGAAGAAACTAAAGAAGAAATCAAAAACGAAAAAGTTGATGAAGAA
GTGACTGAGGAGTTAACAGA

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MITERQRQILNLIVSLYAKDHTPIGSKSLLDSIQASSATIRNDMKALERLGLIQKEHTSSGRIPSVSGYKYFVENVIQLE
EFSQNDLFKVMKAFDGDFYRLSDLFKTAAKSLSELTGLTSFVLNAPQRDQQLVSFEMVMLDNHSVLSVITLGTGEVRTNQ
FILPKSMTEADLAVFSNLVKERLVGKKVIDIHYTLRTEIPQIVQRYFKVTSEVLQLFESIFDDLFKEHLTVAGHKNIFDY
ATDNLAELYKLFSDDERMLHEIREITNNDEMRAVKFDNDEKFMKNLTIISQKFVIPYRGFGTLTVVGPVEMDYQRTLSVL
DLVAKVLTMKLSDYYRYLDGNHYEISK

Sequences:

>Translated_347_residues
MITERQRQILNLIVSLYAKDHTPIGSKSLLDSIQASSATIRNDMKALERLGLIQKEHTSSGRIPSVSGYKYFVENVIQLE
EFSQNDLFKVMKAFDGDFYRLSDLFKTAAKSLSELTGLTSFVLNAPQRDQQLVSFEMVMLDNHSVLSVITLGTGEVRTNQ
FILPKSMTEADLAVFSNLVKERLVGKKVIDIHYTLRTEIPQIVQRYFKVTSEVLQLFESIFDDLFKEHLTVAGHKNIFDY
ATDNLAELYKLFSDDERMLHEIREITNNDEMRAVKFDNDEKFMKNLTIISQKFVIPYRGFGTLTVVGPVEMDYQRTLSVL
DLVAKVLTMKLSDYYRYLDGNHYEISK
>Mature_347_residues
MITERQRQILNLIVSLYAKDHTPIGSKSLLDSIQASSATIRNDMKALERLGLIQKEHTSSGRIPSVSGYKYFVENVIQLE
EFSQNDLFKVMKAFDGDFYRLSDLFKTAAKSLSELTGLTSFVLNAPQRDQQLVSFEMVMLDNHSVLSVITLGTGEVRTNQ
FILPKSMTEADLAVFSNLVKERLVGKKVIDIHYTLRTEIPQIVQRYFKVTSEVLQLFESIFDDLFKEHLTVAGHKNIFDY
ATDNLAELYKLFSDDERMLHEIREITNNDEMRAVKFDNDEKFMKNLTIISQKFVIPYRGFGTLTVVGPVEMDYQRTLSVL
DLVAKVLTMKLSDYYRYLDGNHYEISK

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons [H]

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005104
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991 [H]

Pfam domain/function: PF03444 DUF293; PF01628 HrcA [H]

EC number: NA

Molecular weight: Translated: 39922; Mature: 39922

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITERQRQILNLIVSLYAKDHTPIGSKSLLDSIQASSATIRNDMKALERLGLIQKEHTSS
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
GRIPSVSGYKYFVENVIQLEEFSQNDLFKVMKAFDGDFYRLSDLFKTAAKSLSELTGLTS
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
FVLNAPQRDQQLVSFEMVMLDNHSVLSVITLGTGEVRTNQFILPKSMTEADLAVFSNLVK
HHHCCCCHHHHHHHHHHEEECCCCEEEEEEECCCCEECCCEECCCCCCHHHHHHHHHHHH
ERLVGKKVIDIHYTLRTEIPQIVQRYFKVTSEVLQLFESIFDDLFKEHLTVAGHKNIFDY
HHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
ATDNLAELYKLFSDDERMLHEIREITNNDEMRAVKFDNDEKFMKNLTIISQKFVIPYRGF
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHEEEEECCC
GTLTVVGPVEMDYQRTLSVLDLVAKVLTMKLSDYYRYLDGNHYEISK
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC
>Mature Secondary Structure
MITERQRQILNLIVSLYAKDHTPIGSKSLLDSIQASSATIRNDMKALERLGLIQKEHTSS
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
GRIPSVSGYKYFVENVIQLEEFSQNDLFKVMKAFDGDFYRLSDLFKTAAKSLSELTGLTS
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
FVLNAPQRDQQLVSFEMVMLDNHSVLSVITLGTGEVRTNQFILPKSMTEADLAVFSNLVK
HHHCCCCHHHHHHHHHHEEECCCCEEEEEEECCCCEECCCEECCCCCCHHHHHHHHHHHH
ERLVGKKVIDIHYTLRTEIPQIVQRYFKVTSEVLQLFESIFDDLFKEHLTVAGHKNIFDY
HHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
ATDNLAELYKLFSDDERMLHEIREITNNDEMRAVKFDNDEKFMKNLTIISQKFVIPYRGF
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHEEEEECCC
GTLTVVGPVEMDYQRTLSVLDLVAKVLTMKLSDYYRYLDGNHYEISK
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]