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The map label for this gene is ribA [H]

Identifier: 125624334

GI number: 125624334

Start: 1501524

End: 1502720

Strand: Reverse

Name: ribA [H]

Synonym: llmg_1530

Alternate gene names: 125624334

Gene position: 1502720-1501524 (Counterclockwise)

Preceding gene: 125624335

Following gene: 125624333

Centisome position: 59.41

GC content: 37.68

Gene sequence:

>1197_bases
ATGTTTCAATATAATACAGTAGAAGAAGCCTTAACAGCCCTTAAAGCAGGTGAAATAATTATTGTCACTGATGATGAGAA
TAGAGAAAATGAAGGAGATCTGATTTGTGCAGCCGAAATGATTAGTCCAGAAAAGATAAATTTCATGGCCAGTCAGGCAA
AGGGATTAATTTGTAGTCCGATGAGTGAAAAATATGCTAAGAGTCTGCATTTGTCAGCAATGACGGAGAGAAATACAGAC
AACCACGGGACAGCTTTTACTGTTTCTGTCGATCATGTAGAGACAAGTACAGGGGTATCAGCCTTTGACCGTTCGCTGAC
TATTAGAAAACTTGCTGATGAAGAAAGTTCAGTCGAAGATTTTCGAAGACCTGGTCATGTCTTTCCTCTGATTGCAAGGA
AAAATGGAGTCTTAGAACGCAATGGACACACAGAAGCAACAGTTGATTTGTTACGACTTGCTGGTCTAAAGGAAGTGGGA
GTTTGTGTTGAAATAATGGCCGAAGATGGTAGCATGATGCGCACAGAAGAACTTCAAGAAAAAGCAAAAGAATGGGACTT
GAATTTTATCACAATCAAGGCCATACAAAAATATCGAAAACAAAATGAACAACTGGTTGAGCAAGTTACCAGAGCGAAAC
TTCCAACAAAATATGGTTATTTTGAAATCTTTGGATTTGTCAATAAAATAAATGGTGAGCATCATGTCGCCCTAGTTAAG
GGGGACATTGGAGAGGGAGAAGCAGTGCTTTGCCGAGTTCATTCGGAATGTTTGACTGGAGATGCTTTTGGCTCAATGAA
ATGTGATTGTGGTGAACAATTAGAACAAGCTCTAACACAGATAAATGTCGAGGGACGAGGGATTTTATTATATCTTCGGC
AAGAAGGGCGAGGAATCGGTTTAATCAACAAACTTCGTGCATATTCACTTCAAGATGAGGGGCTTGATACAATTGAAGCA
AATTTAGCCCTAGGTTTTGAAGAAGATGCGCGTGAATACTCCATAGGTGCTCAAATTTTGAAAACACTTGGTGTGAAGTC
TTTAAGATTAATGACTAATAACCCACAAAAAATCAATGATTTTTCAAAATATGGACTACCAGTTAAAGAAAGAGTTCCAA
TTCAAATTAAAGAAAATGAATTTGATCAGGATTATTTAAAAGTAAAGCAAACTAAAATGGGACATTTGTTCGATTAA

Upstream 100 bases:

>100_bases
AATATATCGAAAAATTACTTACTGGGAAAGATTCTTTTACAGGGCCTTCCTTGCTGACAAAGGATAAAATAATTGATTAT
GGATTTTAAGAGGAGATAAA

Downstream 100 bases:

>100_bases
AATAAAAAGAAAGCATGGATAGAAAAATGACAGTATTTGAGGGAAATTTAACAACAGGAAATGCCAAATATGGAATTGTA
GTTGCACGTTTTAACGAATT

Product: riboflavin biosynthesis protein ribA

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MFQYNTVEEALTALKAGEIIIVTDDENRENEGDLICAAEMISPEKINFMASQAKGLICSPMSEKYAKSLHLSAMTERNTD
NHGTAFTVSVDHVETSTGVSAFDRSLTIRKLADEESSVEDFRRPGHVFPLIARKNGVLERNGHTEATVDLLRLAGLKEVG
VCVEIMAEDGSMMRTEELQEKAKEWDLNFITIKAIQKYRKQNEQLVEQVTRAKLPTKYGYFEIFGFVNKINGEHHVALVK
GDIGEGEAVLCRVHSECLTGDAFGSMKCDCGEQLEQALTQINVEGRGILLYLRQEGRGIGLINKLRAYSLQDEGLDTIEA
NLALGFEEDAREYSIGAQILKTLGVKSLRLMTNNPQKINDFSKYGLPVKERVPIQIKENEFDQDYLKVKQTKMGHLFD

Sequences:

>Translated_398_residues
MFQYNTVEEALTALKAGEIIIVTDDENRENEGDLICAAEMISPEKINFMASQAKGLICSPMSEKYAKSLHLSAMTERNTD
NHGTAFTVSVDHVETSTGVSAFDRSLTIRKLADEESSVEDFRRPGHVFPLIARKNGVLERNGHTEATVDLLRLAGLKEVG
VCVEIMAEDGSMMRTEELQEKAKEWDLNFITIKAIQKYRKQNEQLVEQVTRAKLPTKYGYFEIFGFVNKINGEHHVALVK
GDIGEGEAVLCRVHSECLTGDAFGSMKCDCGEQLEQALTQINVEGRGILLYLRQEGRGIGLINKLRAYSLQDEGLDTIEA
NLALGFEEDAREYSIGAQILKTLGVKSLRLMTNNPQKINDFSKYGLPVKERVPIQIKENEFDQDYLKVKQTKMGHLFD
>Mature_398_residues
MFQYNTVEEALTALKAGEIIIVTDDENRENEGDLICAAEMISPEKINFMASQAKGLICSPMSEKYAKSLHLSAMTERNTD
NHGTAFTVSVDHVETSTGVSAFDRSLTIRKLADEESSVEDFRRPGHVFPLIARKNGVLERNGHTEATVDLLRLAGLKEVG
VCVEIMAEDGSMMRTEELQEKAKEWDLNFITIKAIQKYRKQNEQLVEQVTRAKLPTKYGYFEIFGFVNKINGEHHVALVK
GDIGEGEAVLCRVHSECLTGDAFGSMKCDCGEQLEQALTQINVEGRGILLYLRQEGRGIGLINKLRAYSLQDEGLDTIEA
NLALGFEEDAREYSIGAQILKTLGVKSLRLMTNNPQKINDFSKYGLPVKERVPIQIKENEFDQDYLKVKQTKMGHLFD

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=54.9222797927461, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1789420, Length=202, Percent_Identity=43.0693069306931, Blast_Score=170, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320695, Length=207, Percent_Identity=42.512077294686, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6319438, Length=172, Percent_Identity=44.7674418604651, Blast_Score=134, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44590; Mature: 44590

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQYNTVEEALTALKAGEIIIVTDDENRENEGDLICAAEMISPEKINFMASQAKGLICSP
CCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCEECC
MSEKYAKSLHLSAMTERNTDNHGTAFTVSVDHVETSTGVSAFDRSLTIRKLADEESSVED
HHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEECCCCHHHHHHCCHHHHHHCCHHHHHH
FRRPGHVFPLIARKNGVLERNGHTEATVDLLRLAGLKEVGVCVEIMAEDGSMMRTEELQE
HHCCCCEEEEEECCCCCEECCCCCHHHHHHHHHCCCHHHCEEEEEEECCCCCHHHHHHHH
KAKEWDLNFITIKAIQKYRKQNEQLVEQVTRAKLPTKYGYFEIFGFVNKINGEHHVALVK
HHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEE
GDIGEGEAVLCRVHSECLTGDAFGSMKCDCGEQLEQALTQINVEGRGILLYLRQEGRGIG
CCCCCCCEEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCC
LINKLRAYSLQDEGLDTIEANLALGFEEDAREYSIGAQILKTLGVKSLRLMTNNPQKIND
HHHHHHHCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHCH
FSKYGLPVKERVPIQIKENEFDQDYLKVKQTKMGHLFD
HHHHCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFQYNTVEEALTALKAGEIIIVTDDENRENEGDLICAAEMISPEKINFMASQAKGLICSP
CCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCEECC
MSEKYAKSLHLSAMTERNTDNHGTAFTVSVDHVETSTGVSAFDRSLTIRKLADEESSVED
HHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEECCCCHHHHHHCCHHHHHHCCHHHHHH
FRRPGHVFPLIARKNGVLERNGHTEATVDLLRLAGLKEVGVCVEIMAEDGSMMRTEELQE
HHCCCCEEEEEECCCCCEECCCCCHHHHHHHHHCCCHHHCEEEEEEECCCCCHHHHHHHH
KAKEWDLNFITIKAIQKYRKQNEQLVEQVTRAKLPTKYGYFEIFGFVNKINGEHHVALVK
HHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEE
GDIGEGEAVLCRVHSECLTGDAFGSMKCDCGEQLEQALTQINVEGRGILLYLRQEGRGIG
CCCCCCCEEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCC
LINKLRAYSLQDEGLDTIEANLALGFEEDAREYSIGAQILKTLGVKSLRLMTNNPQKIND
HHHHHHHCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHCH
FSKYGLPVKERVPIQIKENEFDQDYLKVKQTKMGHLFD
HHHHCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA