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The map label for this gene is lysA [H]

Identifier: 125624015

GI number: 125624015

Start: 1157315

End: 1158574

Strand: Direct

Name: lysA [H]

Synonym: llmg_1185

Alternate gene names: 125624015

Gene position: 1157315-1158574 (Clockwise)

Preceding gene: 125624014

Following gene: 125624016

Centisome position: 45.75

GC content: 37.54

Gene sequence:

>1260_bases
ATGAAAATACCATTCGTAACAAAAGAACAACTCGAACAAATTACAGCTGAATACCCCACTCCTTTTCATCTTTATGATGA
GAAAGGAATTCGCCAGAAAGCGCGTGATCTTCACAAAGCTTTTGCTTGGAATAAAGGATTTAAAGAATTCTTTGCTGTTA
AAGCTACACCAACCCCAGCAATATTAAAGATACTACATGAAGAAGGTTGTGGAGTCGATTGTGCTTCTTATGTCGAACTA
TTGCTTTCAGAAAAATGTGGTTTTGATGGCACTGAAATGATGTTTTCATCCAATGACACTCCAGCAGAAGAGTTTCAATT
TGCTAATCAATTGGGCGCGACAATCAATCTTGATGCCTATGAACACATTGAGTTTTTGAAAAATCTGCCAGATTTTGTCT
TTCCAAAGACAATGAGCTTGAGATACAATCCAGGTGGAGTTTTTGCGATGGGTACAAAAATCATGGACAATCCAGAAGAA
TCAAAATTTGGTATGACCAAAGCACAACTCATTCAAGGAATTAAAGACTTACAAAAACTAGGAGTCAAAGAATTTGGAAT
GCACAGCTTTCTGGCTTCAAATACTGTGACCAATGATTATTATCCAGAACTCGCCCGCAAACTCTTTGAACTTGCATTAG
AAATTCGTCAAGAAACAGGAATTACCCTTGATTTTATTAATTTATCAGGTGGAATCGGTGTAAACTATCGTCCTGATGAA
GAAGCCAATGATATCGCAAAAATTGGACAAGGTGTTCATAAGGCTTATGAAGAAATATTGACTGCTAATGGCATTGAAAA
TCTAAAAATTTACACGGAATTAGGTCGTTTTATGCTTGCGCCGCATGGTCACTTGATTACAAAAGTCCTGCATTTAAAAG
AAACTTACCGGAAATATGTTGGGGTTGACGCATCAGCAGTTAACTTGATGCGCCCAGCTTTTTATGATGCTTACCATCAC
ATCACAGTCGCTGGAAAGGAAAAGCAAGAGGCGACTGAAACCTATGATATTACGGGTTCTTTGTGTGAAAACAATGATAA
GTTTGCTAAAGAACGTGCTTTTCCAGAAATCAAAGTAGGAGATTTATTGGTCATTCATGATACAGGAGCACATGGATTTT
CGATGGGTTATCAGTATAATGCGAAGCTAAGAAGTGCTGAAATTTTACTTCAAGAAGATGGAAAAACACGTTTGATTCGT
CGAGCAGAAAAGCCGGCTGATTATTTTGCGACATTAGATGGTTTTGATTTCGACAATTGA

Upstream 100 bases:

>100_bases
AGTAAAAAAGTTTCTGTCAGTAAAATGATGGGAACTTTTTTGTGTTTAAGTTTTTGACGATATGCTATACTTATAAATAA
TCTAAAAATGAGGTGAAAAA

Downstream 100 bases:

>100_bases
TTTATAAAAGTTACTGATGATTCTGTCAGTAACTTATCTTTTTCTCAGTCCTTTTGTCACTAATATAAAGAGCTGACAAA
AAGACTAAAATTTGATATAA

Product: LysA protein

Products: L-lysine; CO2

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MKIPFVTKEQLEQITAEYPTPFHLYDEKGIRQKARDLHKAFAWNKGFKEFFAVKATPTPAILKILHEEGCGVDCASYVEL
LLSEKCGFDGTEMMFSSNDTPAEEFQFANQLGATINLDAYEHIEFLKNLPDFVFPKTMSLRYNPGGVFAMGTKIMDNPEE
SKFGMTKAQLIQGIKDLQKLGVKEFGMHSFLASNTVTNDYYPELARKLFELALEIRQETGITLDFINLSGGIGVNYRPDE
EANDIAKIGQGVHKAYEEILTANGIENLKIYTELGRFMLAPHGHLITKVLHLKETYRKYVGVDASAVNLMRPAFYDAYHH
ITVAGKEKQEATETYDITGSLCENNDKFAKERAFPEIKVGDLLVIHDTGAHGFSMGYQYNAKLRSAEILLQEDGKTRLIR
RAEKPADYFATLDGFDFDN

Sequences:

>Translated_419_residues
MKIPFVTKEQLEQITAEYPTPFHLYDEKGIRQKARDLHKAFAWNKGFKEFFAVKATPTPAILKILHEEGCGVDCASYVEL
LLSEKCGFDGTEMMFSSNDTPAEEFQFANQLGATINLDAYEHIEFLKNLPDFVFPKTMSLRYNPGGVFAMGTKIMDNPEE
SKFGMTKAQLIQGIKDLQKLGVKEFGMHSFLASNTVTNDYYPELARKLFELALEIRQETGITLDFINLSGGIGVNYRPDE
EANDIAKIGQGVHKAYEEILTANGIENLKIYTELGRFMLAPHGHLITKVLHLKETYRKYVGVDASAVNLMRPAFYDAYHH
ITVAGKEKQEATETYDITGSLCENNDKFAKERAFPEIKVGDLLVIHDTGAHGFSMGYQYNAKLRSAEILLQEDGKTRLIR
RAEKPADYFATLDGFDFDN
>Mature_419_residues
MKIPFVTKEQLEQITAEYPTPFHLYDEKGIRQKARDLHKAFAWNKGFKEFFAVKATPTPAILKILHEEGCGVDCASYVEL
LLSEKCGFDGTEMMFSSNDTPAEEFQFANQLGATINLDAYEHIEFLKNLPDFVFPKTMSLRYNPGGVFAMGTKIMDNPEE
SKFGMTKAQLIQGIKDLQKLGVKEFGMHSFLASNTVTNDYYPELARKLFELALEIRQETGITLDFINLSGGIGVNYRPDE
EANDIAKIGQGVHKAYEEILTANGIENLKIYTELGRFMLAPHGHLITKVLHLKETYRKYVGVDASAVNLMRPAFYDAYHH
ITVAGKEKQEATETYDITGSLCENNDKFAKERAFPEIKVGDLLVIHDTGAHGFSMGYQYNAKLRSAEILLQEDGKTRLIR
RAEKPADYFATLDGFDFDN

Specific function: Involved in tabtoxin production and pathogenicity [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=415, Percent_Identity=30.1204819277108, Blast_Score=155, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: 4.1.1.20

Molecular weight: Translated: 47283; Mature: 47283

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIPFVTKEQLEQITAEYPTPFHLYDEKGIRQKARDLHKAFAWNKGFKEFFAVKATPTPA
CCCCCCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCHH
ILKILHEEGCGVDCASYVELLLSEKCGFDGTEMMFSSNDTPAEEFQFANQLGATINLDAY
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHCCCEEECCHH
EHIEFLKNLPDFVFPKTMSLRYNPGGVFAMGTKIMDNPEESKFGMTKAQLIQGIKDLQKL
HHHHHHHCCCHHHCCCCEEEEECCCCEEEECCHHHCCCCHHHCCCCHHHHHHHHHHHHHC
GVKEFGMHSFLASNTVTNDYYPELARKLFELALEIRQETGITLDFINLSGGIGVNYRPDE
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
EANDIAKIGQGVHKAYEEILTANGIENLKIYTELGRFMLAPHGHLITKVLHLKETYRKYV
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GVDASAVNLMRPAFYDAYHHITVAGKEKQEATETYDITGSLCENNDKFAKERAFPEIKVG
CCCHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHCCCCHHHCCCHHHHHHHCCCCEEEC
DLLVIHDTGAHGFSMGYQYNAKLRSAEILLQEDGKTRLIRRAEKPADYFATLDGFDFDN
CEEEEECCCCCCCCCCEEECCCCCCEEEEEECCCHHHHHHHHCCCHHHHEECCCCCCCC
>Mature Secondary Structure
MKIPFVTKEQLEQITAEYPTPFHLYDEKGIRQKARDLHKAFAWNKGFKEFFAVKATPTPA
CCCCCCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCHH
ILKILHEEGCGVDCASYVELLLSEKCGFDGTEMMFSSNDTPAEEFQFANQLGATINLDAY
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHCCCEEECCHH
EHIEFLKNLPDFVFPKTMSLRYNPGGVFAMGTKIMDNPEESKFGMTKAQLIQGIKDLQKL
HHHHHHHCCCHHHCCCCEEEEECCCCEEEECCHHHCCCCHHHCCCCHHHHHHHHHHHHHC
GVKEFGMHSFLASNTVTNDYYPELARKLFELALEIRQETGITLDFINLSGGIGVNYRPDE
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
EANDIAKIGQGVHKAYEEILTANGIENLKIYTELGRFMLAPHGHLITKVLHLKETYRKYV
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GVDASAVNLMRPAFYDAYHHITVAGKEKQEATETYDITGSLCENNDKFAKERAFPEIKVG
CCCHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHCCCCHHHCCCHHHHHHHCCCCEEEC
DLLVIHDTGAHGFSMGYQYNAKLRSAEILLQEDGKTRLIRRAEKPADYFATLDGFDFDN
CEEEEECCCCCCCCCCEEECCCCCCEEEEEECCCHHHHHHHHCCCHHHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: D-Lysine; Pyridoxal 5'-phosphate [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 1.7 {meso-2,6-diamininoheptanedioate}} [C]

Substrates: meso-2,6-diaminoheptanedioate

Specific reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2

General reaction: Decarboxylation [C]

Inhibitor: 2, 3-Diaminopropionic acid; Glutamic acid; L-Cystine; L-Lysine; Penicillamine [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1515668 [H]