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The map label for this gene is glmS [H]

Identifier: 124485487

GI number: 124485487

Start: 634298

End: 636040

Strand: Reverse

Name: glmS [H]

Synonym: Mlab_0664

Alternate gene names: 124485487

Gene position: 636040-634298 (Counterclockwise)

Preceding gene: 124485488

Following gene: 124485485

Centisome position: 35.24

GC content: 49.8

Gene sequence:

>1743_bases
ATGTGCGGGATTGTCGGTTATATCGGGTATCATGAGGCAGCTCCCATATGTACGAACGGCCTTCTTTCATTAGAATACCG
TGGATATGACTCATTTGGGATCGCTACTCTCGCTCCCAGCCTCTCTGTCTACAAACATCTTGGAAAAATCTCGGATGCCA
AAACATCTGCCAGTCATCTGACGGGAACTATTGGTATAGGGCACACGCGCTGGGCCACCCACGGTGTTCCAAGCGAGATA
AATGCGCATCCTCACCTCGATGAAGCAGGAAAGATCGCGGTGGTCCATAACGGGATTATTGAAAATTATGCCGAACTGAA
ACGCGGGCTGGAGGAGCGTGGGGTCGTGTTTACATCCCAGACGGACACAGAAGTCATCCCCCACCTGATTGCCGAAAAGT
ATTCGGGAAACCTTTTCGAGGCGGTATCAGGCATCATTCCGCTTCTTGAAGGGTCGTATGCTTTGCTGATACTCGCCGAA
GGTGAAGAGAAGATCGTTGCCGTCAGAAAAGGCAGTCCTCTGGTTCTTGGAATCGGTGATCAGGAATTCATTCTGGGGTC
AGACGCGCTTCCGCTTCTGGAGTATACACGGAATGCGGTGTATTTCGAGGACGGCGATATCGCTGAAATCGGCAGAGGTG
AATATAGAATCCATAATACCGGAGTTCCGGTGTCGCGCGAGATCACCGAAATCGAATGGAGCGGCGATGAGGTCAGGAAA
GGAGGGTTCCGGCATTTCATGCTCAAAGAGATTTATGAACAGCCGGATGCTTTTGCCAACACCCTCTCATCAGTCAAACG
TTGTTCAGAGATAGTTGATTCAATCAAAAAGGCCCGTTCCATAACGGTTGTTGCCTGCGGAACCTCCGCAAATGCATCTC
TGGTCTTTTCCTATCTGATGGAGAGCGTCTGTCACATCCCAACCCGCGTGGTTCTTGGATCAGAGTTCAAGTACTTCCCG
ACTCCAGGCACTGATCTGGTGATCGGGGTTTCACAGTCCGGAGAGACGGCGGATACGATAGCGGCGCTGAAACTTGCAAA
AAGTCTCGGGGCACAGACCATCGCAGTAACAAATGTTCTGGGGAGTTCCATCACACGCGTGGCTTCCTCCGTCCTGTATA
CGAGAGCGGGACCCGAGATAAGTGTCGCGGCAACAAAATCATTCATATCTCAGGTTGCTGCATTTATGCAGATCGTAAAT
CTCCTCACTGACCATTCCCTTGAGGCGGAGTTAGCTGAAGTTCGCCGATATATTCCGGACGTCTTCACCATTGATCTTTC
AAAGGCAGTCGATATATGCAAAGATGCCGCAACTTTGCTGTATATTGGAAGGGGGATGTTCTATCCTGCAGCATTGGAGG
GGGCATTAAAGATGAAAGAGATCTCCTATATCCATGCAGAAGGATATGCGGCCGGTGAGTTGAAGCACGGGCCGTTTGCA
TTGCTTTCTTTGGAAACGCCGGTCATCGGGCTATGCTTTTCAAGTACCGTTTATCCCGTGATGATGTCAAACCTGAAAGA
GGTAAAGGCCCGCAGTGCACCCCTTATCGTGATTGGAAAAGAACATGATGCCGATCTTGAAGAGGTGGCCGATGTCTGTA
TTATGCTTCCCGACGTGTCAGAATACGGTTCGGTTATTCTGTCTTCGATCATATTACAGCTGCTCGCATATCACACCGCA
GTCGCTCTTGAAAGAGATGTGGATATGCCGAGAAATCTGGCAAAAAGTGTGACGGTTGAATAA

Upstream 100 bases:

>100_bases
TTTACCGCCATCAAGGACGGGGTTATTGGAAACAATGCCAGCATCGAAGGCGGAAAGCTCCTCGAAAAAGAGATTCCCGA
TAACACTCTGGTGATGTAAA

Downstream 100 bases:

>100_bases
AATTACTCTCCGACTTTTTTCGAGGTGCTTTTCCAGAGAACAGCATCTTTGCGTCTGGAATACAGACCGGCCAGAAGATA
AAACTGATTCGTCACAAAAG

Product: glutamine--fructose-6-phosphate transaminase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MCGIVGYIGYHEAAPICTNGLLSLEYRGYDSFGIATLAPSLSVYKHLGKISDAKTSASHLTGTIGIGHTRWATHGVPSEI
NAHPHLDEAGKIAVVHNGIIENYAELKRGLEERGVVFTSQTDTEVIPHLIAEKYSGNLFEAVSGIIPLLEGSYALLILAE
GEEKIVAVRKGSPLVLGIGDQEFILGSDALPLLEYTRNAVYFEDGDIAEIGRGEYRIHNTGVPVSREITEIEWSGDEVRK
GGFRHFMLKEIYEQPDAFANTLSSVKRCSEIVDSIKKARSITVVACGTSANASLVFSYLMESVCHIPTRVVLGSEFKYFP
TPGTDLVIGVSQSGETADTIAALKLAKSLGAQTIAVTNVLGSSITRVASSVLYTRAGPEISVAATKSFISQVAAFMQIVN
LLTDHSLEAELAEVRRYIPDVFTIDLSKAVDICKDAATLLYIGRGMFYPAALEGALKMKEISYIHAEGYAAGELKHGPFA
LLSLETPVIGLCFSSTVYPVMMSNLKEVKARSAPLIVIGKEHDADLEEVADVCIMLPDVSEYGSVILSSIILQLLAYHTA
VALERDVDMPRNLAKSVTVE

Sequences:

>Translated_580_residues
MCGIVGYIGYHEAAPICTNGLLSLEYRGYDSFGIATLAPSLSVYKHLGKISDAKTSASHLTGTIGIGHTRWATHGVPSEI
NAHPHLDEAGKIAVVHNGIIENYAELKRGLEERGVVFTSQTDTEVIPHLIAEKYSGNLFEAVSGIIPLLEGSYALLILAE
GEEKIVAVRKGSPLVLGIGDQEFILGSDALPLLEYTRNAVYFEDGDIAEIGRGEYRIHNTGVPVSREITEIEWSGDEVRK
GGFRHFMLKEIYEQPDAFANTLSSVKRCSEIVDSIKKARSITVVACGTSANASLVFSYLMESVCHIPTRVVLGSEFKYFP
TPGTDLVIGVSQSGETADTIAALKLAKSLGAQTIAVTNVLGSSITRVASSVLYTRAGPEISVAATKSFISQVAAFMQIVN
LLTDHSLEAELAEVRRYIPDVFTIDLSKAVDICKDAATLLYIGRGMFYPAALEGALKMKEISYIHAEGYAAGELKHGPFA
LLSLETPVIGLCFSSTVYPVMMSNLKEVKARSAPLIVIGKEHDADLEEVADVCIMLPDVSEYGSVILSSIILQLLAYHTA
VALERDVDMPRNLAKSVTVE
>Mature_580_residues
MCGIVGYIGYHEAAPICTNGLLSLEYRGYDSFGIATLAPSLSVYKHLGKISDAKTSASHLTGTIGIGHTRWATHGVPSEI
NAHPHLDEAGKIAVVHNGIIENYAELKRGLEERGVVFTSQTDTEVIPHLIAEKYSGNLFEAVSGIIPLLEGSYALLILAE
GEEKIVAVRKGSPLVLGIGDQEFILGSDALPLLEYTRNAVYFEDGDIAEIGRGEYRIHNTGVPVSREITEIEWSGDEVRK
GGFRHFMLKEIYEQPDAFANTLSSVKRCSEIVDSIKKARSITVVACGTSANASLVFSYLMESVCHIPTRVVLGSEFKYFP
TPGTDLVIGVSQSGETADTIAALKLAKSLGAQTIAVTNVLGSSITRVASSVLYTRAGPEISVAATKSFISQVAAFMQIVN
LLTDHSLEAELAEVRRYIPDVFTIDLSKAVDICKDAATLLYIGRGMFYPAALEGALKMKEISYIHAEGYAAGELKHGPFA
LLSLETPVIGLCFSSTVYPVMMSNLKEVKARSAPLIVIGKEHDADLEEVADVCIMLPDVSEYGSVILSSIILQLLAYHTA
VALERDVDMPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=684, Percent_Identity=34.9415204678363, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI205277386, Length=681, Percent_Identity=33.920704845815, Blast_Score=345, Evalue=8e-95,
Organism=Homo sapiens, GI29570798, Length=253, Percent_Identity=28.4584980237154, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1790167, Length=612, Percent_Identity=44.281045751634, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1788651, Length=215, Percent_Identity=29.7674418604651, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532899, Length=429, Percent_Identity=35.8974358974359, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17532897, Length=429, Percent_Identity=35.8974358974359, Blast_Score=243, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17539970, Length=429, Percent_Identity=36.1305361305361, Blast_Score=242, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6322745, Length=474, Percent_Identity=35.4430379746835, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6323731, Length=430, Percent_Identity=32.5581395348837, Blast_Score=183, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=40, Blast_Score=120, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6323958, Length=181, Percent_Identity=31.4917127071823, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357745, Length=686, Percent_Identity=35.8600583090379, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24659598, Length=237, Percent_Identity=30.379746835443, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24659604, Length=234, Percent_Identity=30.3418803418803, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28573187, Length=256, Percent_Identity=30.078125, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 62531; Mature: 62531

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGYHEAAPICTNGLLSLEYRGYDSFGIATLAPSLSVYKHLGKISDAKTSASHL
CCCEEEECCCCCCCCHHCCCEEEEEECCCCCCCHHHHCCHHHHHHHHHCCCCCCCCHHHC
TGTIGIGHTRWATHGVPSEINAHPHLDEAGKIAVVHNGIIENYAELKRGLEERGVVFTSQ
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHCHHHCCEEEECC
TDTEVIPHLIAEKYSGNLFEAVSGIIPLLEGSYALLILAEGEEKIVAVRKGSPLVLGIGD
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCEEEECCC
QEFILGSDALPLLEYTRNAVYFEDGDIAEIGRGEYRIHNTGVPVSREITEIEWSGDEVRK
CCEEECCCCCHHHHHCCCEEEECCCCCHHCCCCCEEEECCCCCCCCCCEEEECCCCHHHH
GGFRHFMLKEIYEQPDAFANTLSSVKRCSEIVDSIKKARSITVVACGTSANASLVFSYLM
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHH
ESVCHIPTRVVLGSEFKYFPTPGTDLVIGVSQSGETADTIAALKLAKSLGAQTIAVTNVL
HHHHCCCCEEEECCCCEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
GSSITRVASSVLYTRAGPEISVAATKSFISQVAAFMQIVNLLTDHSLEAELAEVRRYIPD
HHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
VFTIDLSKAVDICKDAATLLYIGRGMFYPAALEGALKMKEISYIHAEGYAAGELKHGPFA
EEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCEE
LLSLETPVIGLCFSSTVYPVMMSNLKEVKARSAPLIVIGKEHDADLEEVADVCIMLPDVS
EEEECCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHEECCCHH
EYGSVILSSIILQLLAYHTAVALERDVDMPRNLAKSVTVE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGYHEAAPICTNGLLSLEYRGYDSFGIATLAPSLSVYKHLGKISDAKTSASHL
CCCEEEECCCCCCCCHHCCCEEEEEECCCCCCCHHHHCCHHHHHHHHHCCCCCCCCHHHC
TGTIGIGHTRWATHGVPSEINAHPHLDEAGKIAVVHNGIIENYAELKRGLEERGVVFTSQ
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHCHHHCCEEEECC
TDTEVIPHLIAEKYSGNLFEAVSGIIPLLEGSYALLILAEGEEKIVAVRKGSPLVLGIGD
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCEEEECCC
QEFILGSDALPLLEYTRNAVYFEDGDIAEIGRGEYRIHNTGVPVSREITEIEWSGDEVRK
CCEEECCCCCHHHHHCCCEEEECCCCCHHCCCCCEEEECCCCCCCCCCEEEECCCCHHHH
GGFRHFMLKEIYEQPDAFANTLSSVKRCSEIVDSIKKARSITVVACGTSANASLVFSYLM
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHH
ESVCHIPTRVVLGSEFKYFPTPGTDLVIGVSQSGETADTIAALKLAKSLGAQTIAVTNVL
HHHHCCCCEEEECCCCEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
GSSITRVASSVLYTRAGPEISVAATKSFISQVAAFMQIVNLLTDHSLEAELAEVRRYIPD
HHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
VFTIDLSKAVDICKDAATLLYIGRGMFYPAALEGALKMKEISYIHAEGYAAGELKHGPFA
EEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCEE
LLSLETPVIGLCFSSTVYPVMMSNLKEVKARSAPLIVIGKEHDADLEEVADVCIMLPDVS
EEEECCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHEECCCHH
EYGSVILSSIILQLLAYHTAVALERDVDMPRNLAKSVTVE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]