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The map label for this gene is lacA [C]

Identifier: 124265795

GI number: 124265795

Start: 633981

End: 634577

Strand: Direct

Name: lacA [C]

Synonym: Mpe_A0602

Alternate gene names: 124265795

Gene position: 633981-634577 (Clockwise)

Preceding gene: 124265794

Following gene: 124265796

Centisome position: 15.68

GC content: 72.7

Gene sequence:

>597_bases
ATGAACGGCTTGAAGCGACCTCTGATCGGACTCTGGCAGCGCCTCGTCGCGCCCCGCATGGTCTATGGCGTGCGCAGTGC
CGACGGCGGATGGCGTGCCCACAGCCGCATCGGCAGCCACACCCACGTGGAGGCCCGCGAGCGGCTCGTGCTGGGCGACC
ACGTGTTCATCGGCCAGTTCAACTTCATCGACGCCTCGGGCGGCCTGCGCATCGACGAGGGCTGCCAGATCACGAACTTC
GTCTCGGTGCTGACGCATTCCAGCCACCTGGCGCTGCGCCTGGAGCGCGAGCGCTACTGGGGCCACGCGGCGCCGGCCGG
CGTGCAGCGCGCGCCGGTGGCGCTGGGCGCCTGGAGCTTCATCGGACCGCACAGCGTGATCGCACCCGGCAGCACGCTCG
GCCGCGGCGTGCTGGTCAAGGCCGGCGGCTACGTGAGCGGCGACGTGCCGGCCTTCGCCATCGTCGAGGGCCAGCCGGCG
CGGGTGGTCGGCGACACGCGCGAACTCGACCGGGCGTGGATCGAGCAGCACGAGGCCAGCTACGGCGAGCCGGCGCGCCT
CGCCTACGAGGCCTGGGCGCGCGGGGAGGACGCGTGA

Upstream 100 bases:

>100_bases
GCGTGGCGATCGCGGTCGCGCTGGCGCTGTTTCTTCGCGATACGAAGTTGCCCTGGACGGCCTTGTTCAGCGGCTGGCGC
GCGCCACAATCCGGGCCGGC

Downstream 100 bases:

>100_bases
GAGATCCGGTGTCGATTCTTGCGGCGAGCGGGGTGTCGTCATGGACCCGGGCCGCAGCGCCGGGCCGCCCCAAGCAAGGC
CCGACCCTCACGGAGGGTCG

Product: hypothetical protein

Products: CoA; aacetyl-beta-D-galactoside [C]

Alternate protein names: NA

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MNGLKRPLIGLWQRLVAPRMVYGVRSADGGWRAHSRIGSHTHVEARERLVLGDHVFIGQFNFIDASGGLRIDEGCQITNF
VSVLTHSSHLALRLERERYWGHAAPAGVQRAPVALGAWSFIGPHSVIAPGSTLGRGVLVKAGGYVSGDVPAFAIVEGQPA
RVVGDTRELDRAWIEQHEASYGEPARLAYEAWARGEDA

Sequences:

>Translated_198_residues
MNGLKRPLIGLWQRLVAPRMVYGVRSADGGWRAHSRIGSHTHVEARERLVLGDHVFIGQFNFIDASGGLRIDEGCQITNF
VSVLTHSSHLALRLERERYWGHAAPAGVQRAPVALGAWSFIGPHSVIAPGSTLGRGVLVKAGGYVSGDVPAFAIVEGQPA
RVVGDTRELDRAWIEQHEASYGEPARLAYEAWARGEDA
>Mature_198_residues
MNGLKRPLIGLWQRLVAPRMVYGVRSADGGWRAHSRIGSHTHVEARERLVLGDHVFIGQFNFIDASGGLRIDEGCQITNF
VSVLTHSSHLALRLERERYWGHAAPAGVQRAPVALGAWSFIGPHSVIAPGSTLGRGVLVKAGGYVSGDVPAFAIVEGQPA
RVVGDTRELDRAWIEQHEASYGEPARLAYEAWARGEDA

Specific function: May Assist Cellular Detoxification By Acetylating Nonmetabolizable Pyranosides, Thereby Preventing Their Reentry Into The Cell. [C]

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.3.1.18 [C]

Molecular weight: Translated: 21523; Mature: 21523

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGLKRPLIGLWQRLVAPRMVYGVRSADGGWRAHSRIGSHTHVEARERLVLGDHVFIGQF
CCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHCCCCCCHHHHHEEEECCEEEEEEE
NFIDASGGLRIDEGCQITNFVSVLTHSSHLALRLERERYWGHAAPAGVQRAPVALGAWSF
EEEECCCCEEECCCCCHHHHHHHHHCCCEEEEEEEHHHHCCCCCCCCCCCCCEEEECCCC
IGPHSVIAPGSTLGRGVLVKAGGYVSGDVPAFAIVEGQPARVVGDTRELDRAWIEQHEAS
CCCCCEECCCCCCCCEEEEEECCEECCCCCEEEEECCCCCEEECCHHHHHHHHHHHHHCC
YGEPARLAYEAWARGEDA
CCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MNGLKRPLIGLWQRLVAPRMVYGVRSADGGWRAHSRIGSHTHVEARERLVLGDHVFIGQF
CCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHCCCCCCHHHHHEEEECCEEEEEEE
NFIDASGGLRIDEGCQITNFVSVLTHSSHLALRLERERYWGHAAPAGVQRAPVALGAWSF
EEEECCCCEEECCCCCHHHHHHHHHCCCEEEEEEEHHHHCCCCCCCCCCCCCEEEECCCC
IGPHSVIAPGSTLGRGVLVKAGGYVSGDVPAFAIVEGQPARVVGDTRELDRAWIEQHEAS
CCCCCEECCCCCCCCEEEEEECCEECCCCCEEEEECCCCCEEECCHHHHHHHHHHHHHCC
YGEPARLAYEAWARGEDA
CCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: MgSO4; Mn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 1500 {isopropyl} 1200 {isopropyl} 770 {isopropyl} 360 {isopropyl} 0.18 {acetyl-CoA}} 0.049 {acetyl-CoA}} 0.045 {acetyl-CoA}} 0.04 {acetyl-CoA}} [C]

Substrates: Acetyl-CoA; a beta-D-galactoside [C]

Specific reaction: Acetyl-CoA + a beta-D-galactoside = CoA + aacetyl-beta-D-galactoside [C]

General reaction: Acyl group transfer [C]

Inhibitor: 1, 10-Phenanthroline; Acetyl-CoA; Co2+; CoA; Cu2+; MgSO4; Mn2+; p-Chloromercuribenzoate; Zn2+ [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA