Click here to switch to the map view.

The map label for this gene is mutT [H]

Identifier: 124265696

GI number: 124265696

Start: 543075

End: 543488

Strand: Direct

Name: mutT [H]

Synonym: Mpe_A0503

Alternate gene names: 124265696

Gene position: 543075-543488 (Clockwise)

Preceding gene: 124265695

Following gene: 124265704

Centisome position: 13.43

GC content: 65.46

Gene sequence:

>414_bases
ATGCCGGTCGATGTGGCGGTCGGGGTGCTGTTCGACGCGCAGGGGCGCTTCCTGATGACCTCGCGGCCGGACGGCAAGGT
GTATGCCGGCTACTGGGAATTTCCGGGCGGCAAGCTGGAGGCCGGTGAAACGGTCGAGCAGGCACTGCGCCGCGAACTGC
AGGAAGAATTGGGCATCTGCATTGCCGACGCGCAACTCTGGAAAACGGAGCTGATCGACTATCCGCACGCTCGCGTCCGG
TTGCATTTCTGCAAGGTGCACGCGTGGAGCGGCGAACTGGAGATGCGCGAACGGCAGGCGGCGCGTTGGCAGATGCTGCC
GGTCGAGGTACGCCCGATCCTGCCGGGAACGGTGCCGGTGCTGAATTGGCTGGCCGAGGAGCAGGCGTTTTCGGGCAGCA
CTCACGCGGACTAG

Upstream 100 bases:

>100_bases
TGGAGCGGGGTTCGCGCTCGGGCCGGGTGGCCTGGCAGTTCGCGCGTGACTACGCGGGGCGCGGCCGTCAGCGCGACGAG
GTGCCGGGGTGAGCGAGCGC

Downstream 100 bases:

>100_bases
CGCGCAGCCCGATGCTTCAGTGCTCGGCGTCGTCGCCTTCCACCGGCGGTGAGGCCTCGACGCGATAGCGTTCGTTGGCC
CAGGCGCCCAGATCACCGTT

Product: putative mutator mutt protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 137; Mature: 136

Protein sequence:

>137_residues
MPVDVAVGVLFDAQGRFLMTSRPDGKVYAGYWEFPGGKLEAGETVEQALRRELQEELGICIADAQLWKTELIDYPHARVR
LHFCKVHAWSGELEMRERQAARWQMLPVEVRPILPGTVPVLNWLAEEQAFSGSTHAD

Sequences:

>Translated_137_residues
MPVDVAVGVLFDAQGRFLMTSRPDGKVYAGYWEFPGGKLEAGETVEQALRRELQEELGICIADAQLWKTELIDYPHARVR
LHFCKVHAWSGELEMRERQAARWQMLPVEVRPILPGTVPVLNWLAEEQAFSGSTHAD
>Mature_136_residues
PVDVAVGVLFDAQGRFLMTSRPDGKVYAGYWEFPGGKLEAGETVEQALRRELQEELGICIADAQLWKTELIDYPHARVRL
HFCKVHAWSGELEMRERQAARWQMLPVEVRPILPGTVPVLNWLAEEQAFSGSTHAD

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=104, Percent_Identity=37.5, Blast_Score=69, Evalue=1e-13,
Organism=Escherichia coli, GI1788056, Length=118, Percent_Identity=34.7457627118644, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 15518; Mature: 15387

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVDVAVGVLFDAQGRFLMTSRPDGKVYAGYWEFPGGKLEAGETVEQALRRELQEELGIC
CCCCEEEEEEECCCCCEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCEE
IADAQLWKTELIDYPHARVRLHFCKVHAWSGELEMRERQAARWQMLPVEVRPILPGTVPV
EECHHHHHHHHCCCCCHHEEEEEEEEEECCCCHHHHHHHHHHEEECCEEEEECCCCHHHH
LNWLAEEQAFSGSTHAD
HHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PVDVAVGVLFDAQGRFLMTSRPDGKVYAGYWEFPGGKLEAGETVEQALRRELQEELGIC
CCCEEEEEEECCCCCEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCEE
IADAQLWKTELIDYPHARVRLHFCKVHAWSGELEMRERQAARWQMLPVEVRPILPGTVPV
EECHHHHHHHHCCCCCHHEEEEEEEEEECCCCHHHHHHHHHHEEECCEEEEECCCCHHHH
LNWLAEEQAFSGSTHAD
HHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]