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The map label for this gene is argB

Identifier: 124265692

GI number: 124265692

Start: 539812

End: 540726

Strand: Direct

Name: argB

Synonym: Mpe_A0499

Alternate gene names: 124265692

Gene position: 539812-540726 (Clockwise)

Preceding gene: 124265684

Following gene: 124265693

Centisome position: 13.35

GC content: 66.78

Gene sequence:

>915_bases
ATGGCCCCACCCGTTCCCGCCCCCTCGTCCGACCTGCCGAACATCGCTCCGCGCGACAAGGCAGAGATCCTCGCGCAGGC
TCTGCCTTACATCCGCAAGTTCCACGGCAAGACGCTGGTCATCAAGTACGGCGGCAACGCCATGACGGACCCCGCGCTGC
AGCAGGACTTCGCCGAGGACATCGTGCTGCTCAAGCTGGTGGGCATGAACCCGGTGGTCGTGCACGGCGGCGGGCCGCAG
ATCGACGAGGCGCTGTCGCGCCTGGGCAAGAAGGGCACCTTCATCCAGGGCATGCGCGTGACCGACGAGGAAACGATGGA
GGTCGTCGAGTGGGTGCTCGGCGGTGAGGTGCAGCAGGACATCGTCGGTCTCATCAACGCGGTGGGCGGCAAGGCGGTCG
GGCTCACTGGCCGCGACGGCGGCATGATCCGGGCGCGCAAGCTGAAGATGGTGGACAAGGACGACCCCAGCATCGAGCAC
GACGTCGGCCAGGTCGGCGAGATCACCGCCATCGACCCCGCGGTGGTCAAGGCGCTGCAGGACGACCAGTTCATCCCGGT
CGTGAGCCCCATCGGCTTCGGCGAGCACAACGAGAGCTACAACATCAACGCCGACATGGTGGCGAGCAAGCTGGCCACCG
TGCTGCAGGCGGAGAAGCTGATGCTGCTGACGAACACGCCGGGCGTGCTCGACAAGGCGGGCAAGCTGCTCACCAACCTG
TCGGCCCGCGAGATCGACGAACTGTTCGCCGACGGCACGATCAGCGGCGGCATGCTGCCGAAGATCGCCGGCGCGCTGGA
TGCCGCGAAGAGCGGCGTCAATGCGGTGCACATCATCGACGGCCGGGTGCCGCATGCGATGCTGCTCGAGATCCTGAGCG
ACCAGGCCTACGGCACGATGATCCGGTCGCACTGA

Upstream 100 bases:

>100_bases
CTGCGGCGAAAAGTTCCGCGGCGCACGGTCCGGTGCAGGCGCTGGACTAGGGCGAACCCTAGAATCTCTTGCGACAGACC
CTGAGTTCGGAGATCCCGTC

Downstream 100 bases:

>100_bases
GCAGTGGCTGCCGCCGGCCGGCCGGTCGTCTGGCTGTTCGACCTCGACAACACGCTGCACGACGCCTCGCACGCGGCGTT
CGGCCTGCTCGACGAGGCGA

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MAPPVPAPSSDLPNIAPRDKAEILAQALPYIRKFHGKTLVIKYGGNAMTDPALQQDFAEDIVLLKLVGMNPVVVHGGGPQ
IDEALSRLGKKGTFIQGMRVTDEETMEVVEWVLGGEVQQDIVGLINAVGGKAVGLTGRDGGMIRARKLKMVDKDDPSIEH
DVGQVGEITAIDPAVVKALQDDQFIPVVSPIGFGEHNESYNINADMVASKLATVLQAEKLMLLTNTPGVLDKAGKLLTNL
SAREIDELFADGTISGGMLPKIAGALDAAKSGVNAVHIIDGRVPHAMLLEILSDQAYGTMIRSH

Sequences:

>Translated_304_residues
MAPPVPAPSSDLPNIAPRDKAEILAQALPYIRKFHGKTLVIKYGGNAMTDPALQQDFAEDIVLLKLVGMNPVVVHGGGPQ
IDEALSRLGKKGTFIQGMRVTDEETMEVVEWVLGGEVQQDIVGLINAVGGKAVGLTGRDGGMIRARKLKMVDKDDPSIEH
DVGQVGEITAIDPAVVKALQDDQFIPVVSPIGFGEHNESYNINADMVASKLATVLQAEKLMLLTNTPGVLDKAGKLLTNL
SAREIDELFADGTISGGMLPKIAGALDAAKSGVNAVHIIDGRVPHAMLLEILSDQAYGTMIRSH
>Mature_303_residues
APPVPAPSSDLPNIAPRDKAEILAQALPYIRKFHGKTLVIKYGGNAMTDPALQQDFAEDIVLLKLVGMNPVVVHGGGPQI
DEALSRLGKKGTFIQGMRVTDEETMEVVEWVLGGEVQQDIVGLINAVGGKAVGLTGRDGGMIRARKLKMVDKDDPSIEHD
VGQVGEITAIDPAVVKALQDDQFIPVVSPIGFGEHNESYNINADMVASKLATVLQAEKLMLLTNTPGVLDKAGKLLTNLS
AREIDELFADGTISGGMLPKIAGALDAAKSGVNAVHIIDGRVPHAMLLEILSDQAYGTMIRSH

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetylglutamate kinase family

Homologues:

Organism=Escherichia coli, GI1789181, Length=288, Percent_Identity=29.1666666666667, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI145693208, Length=235, Percent_Identity=30.2127659574468, Blast_Score=88, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320913, Length=299, Percent_Identity=27.0903010033445, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ARGB_METPP (A2SD22)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019696.1
- ProteinModelPortal:   A2SD22
- SMR:   A2SD22
- STRING:   A2SD22
- GeneID:   4787096
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0499
- NMPDR:   fig|279263.3.peg.2741
- eggNOG:   COG0548
- HOGENOM:   HBG497643
- OMA:   MDIVEMV
- PhylomeDB:   A2SD22
- ProtClustDB:   PRK00942
- BioCyc:   MPET420662:MPE_A0499-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00082_B
- InterPro:   IPR004662
- InterPro:   IPR001048
- InterPro:   IPR001057
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF000728
- PRINTS:   PR00474
- TIGRFAMs:   TIGR00761

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.2.8

Molecular weight: Translated: 32277; Mature: 32146

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: BINDING 99-99 BINDING 201-201

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPPVPAPSSDLPNIAPRDKAEILAQALPYIRKFHGKTLVIKYGGNAMTDPALQQDFAED
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHH
IVLLKLVGMNPVVVHGGGPQIDEALSRLGKKGTFIQGMRVTDEETMEVVEWVLGGEVQQD
EEHHEEECCCEEEEECCCCCHHHHHHHHCCCCCEEECEECCCHHHHHHHHHHHCCHHHHH
IVGLINAVGGKAVGLTGRDGGMIRARKLKMVDKDDPSIEHDVGQVGEITAIDPAVVKALQ
HHHHHHHCCCCEEEECCCCCCEEEEEEEEECCCCCCCHHHHHCCCCCEEECCHHHHHHHC
DDQFIPVVSPIGFGEHNESYNINADMVASKLATVLQAEKLMLLTNTPGVLDKAGKLLTNL
CCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHCC
SAREIDELFADGTISGGMLPKIAGALDAAKSGVNAVHIIDGRVPHAMLLEILSDQAYGTM
CHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCHHHHHH
IRSH
HCCC
>Mature Secondary Structure 
APPVPAPSSDLPNIAPRDKAEILAQALPYIRKFHGKTLVIKYGGNAMTDPALQQDFAED
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHH
IVLLKLVGMNPVVVHGGGPQIDEALSRLGKKGTFIQGMRVTDEETMEVVEWVLGGEVQQD
EEHHEEECCCEEEEECCCCCHHHHHHHHCCCCCEEECEECCCHHHHHHHHHHHCCHHHHH
IVGLINAVGGKAVGLTGRDGGMIRARKLKMVDKDDPSIEHDVGQVGEITAIDPAVVKALQ
HHHHHHHCCCCEEEECCCCCCEEEEEEEEECCCCCCCHHHHHCCCCCEEECCHHHHHHHC
DDQFIPVVSPIGFGEHNESYNINADMVASKLATVLQAEKLMLLTNTPGVLDKAGKLLTNL
CCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHCC
SAREIDELFADGTISGGMLPKIAGALDAAKSGVNAVHIIDGRVPHAMLLEILSDQAYGTM
CHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCHHHHHH
IRSH
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA