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The map label for this gene is purE [H]

Identifier: 124265488

GI number: 124265488

Start: 320108

End: 320587

Strand: Direct

Name: purE [H]

Synonym: Mpe_A0295

Alternate gene names: 124265488

Gene position: 320108-320587 (Clockwise)

Preceding gene: 124265486

Following gene: 124265489

Centisome position: 7.92

GC content: 71.25

Gene sequence:

>480_bases
ATGGGCTCCAGCAGCGACTGGGACGTCATGCACCATGCGGCCGATATTCTGACCGAGTTCGGCGTGCCCTTCGAAGCGCA
GGTCGTCTCGGCGCACCGCATGCCCGACGAGATGTTCGCGTACGCCGAGGCGGCGCGCGGGCGCGGGTTGCGCGCCATCA
TCGCCGGCGCCGGCGGTGCGGCCCACCTGCCCGGCATGCTGGCGGCCAAGACGCCAGTGCCGGTGCTCGGCGTGCCGGTG
CCCAGCAAGCACCTGCAGGGCGTCGATTCGCTGCATTCGATCGTCCAGATGCCCAAGGGCGTGCCGGTCGCCACCTTCGC
GATCGGCGTGGCCGGCGCGGCCAACGCGGCGCTGTTCGCGGTGGCCCTGCTGGCGCACGATGATCAGAGCCTGCGCGAAC
AGCTCGATGCCTGGCGCGCCCGCCAGACCGAGGCAGCGCGTGCGCAAAGCGCCGCCTTGTCGAAGCACTCACCCTCCTGA

Upstream 100 bases:

>100_bases
GTTGGGGTCGCCGGCCGCAAAGCCAAGCGCCGCCTACAATTTGGGGTTTTCCGGAACCGGAGCGGCTGTGAACGCAGCGA
TTCCCCTGATCGGCGTGGTG

Downstream 100 bases:

>100_bases
CGTCTTGGCCGGCCCGCGACGGTCGGTCCCGCTGAAAGCTCCGCCGATGTCGAGCCACCACAAGACCCTTCTGCCCGCGG
CCGTTGCCGCCGGTGCCCAG

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MGSSSDWDVMHHAADILTEFGVPFEAQVVSAHRMPDEMFAYAEAARGRGLRAIIAGAGGAAHLPGMLAAKTPVPVLGVPV
PSKHLQGVDSLHSIVQMPKGVPVATFAIGVAGAANAALFAVALLAHDDQSLREQLDAWRARQTEAARAQSAALSKHSPS

Sequences:

>Translated_159_residues
MGSSSDWDVMHHAADILTEFGVPFEAQVVSAHRMPDEMFAYAEAARGRGLRAIIAGAGGAAHLPGMLAAKTPVPVLGVPV
PSKHLQGVDSLHSIVQMPKGVPVATFAIGVAGAANAALFAVALLAHDDQSLREQLDAWRARQTEAARAQSAALSKHSPS
>Mature_158_residues
GSSSDWDVMHHAADILTEFGVPFEAQVVSAHRMPDEMFAYAEAARGRGLRAIIAGAGGAAHLPGMLAAKTPVPVLGVPVP
SKHLQGVDSLHSIVQMPKGVPVATFAIGVAGAANAALFAVALLAHDDQSLREQLDAWRARQTEAARAQSAALSKHSPS

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=144, Percent_Identity=61.8055555555556, Blast_Score=149, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6324702, Length=153, Percent_Identity=56.2091503267974, Blast_Score=162, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16504; Mature: 16373

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSSSDWDVMHHAADILTEFGVPFEAQVVSAHRMPDEMFAYAEAARGRGLRAIIAGAGGA
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCH
AHLPGMLAAKTPVPVLGVPVPSKHLQGVDSLHSIVQMPKGVPVATFAIGVAGAANAALFA
HHCCCHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHH
VALLAHDDQSLREQLDAWRARQTEAARAQSAALSKHSPS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GSSSDWDVMHHAADILTEFGVPFEAQVVSAHRMPDEMFAYAEAARGRGLRAIIAGAGGA
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCH
AHLPGMLAAKTPVPVLGVPVPSKHLQGVDSLHSIVQMPKGVPVATFAIGVAGAANAALFA
HHCCCHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHH
VALLAHDDQSLREQLDAWRARQTEAARAQSAALSKHSPS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]