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The map label for this gene is ghrA [H]

Identifier: 124265406

GI number: 124265406

Start: 229628

End: 230560

Strand: Direct

Name: ghrA [H]

Synonym: Mpe_A0213

Alternate gene names: 124265406

Gene position: 229628-230560 (Clockwise)

Preceding gene: 124265405

Following gene: 124265416

Centisome position: 5.68

GC content: 74.17

Gene sequence:

>933_bases
GTGAGCCTGCTGCTGGCCTGCGATGTCGGTGCCGACGAAGCCGAGACCTGGCGCGCGGCGCTGTCCGCCGCGCTGTCCGG
CGAACACCTGCTGACATCGAGCCAGGGCGCTGCCGACGACATCGAGGTCGCGATCGTCGCGAACCCGCGTCCCGGCACGC
TGGCCGGGCTGCCGCGGCTGCGCCTGATCCAGTCGCTGTGGGCCGGCGTCGACCGCCTGCTGGCCGACCCGACGCTGCCG
GCAGGCGTGCCGATCGTGCGCATGGTCGATCCGGCGATGAGCGCGGCGATGGCCGAGACGGCGCTGTGGGCGGTGCTGGC
GCTGCACCGCGGCTTCTTCCGCTACGCCCGACTGCAAGGTGAGGGACGCTGGGCGCCGCACGGTCAACGCCGCGCCGACG
AACTGGTGGTGGCGGTGCTGGGGCTCGGGCAGATGGGCCGCGGCACCTCGCTGCGGCTGGCGGCGCAGGGCTACCGGGTG
CGGGGTTGGAGCACGCGGCCGACCGCCATCGAGGGCATCGAGACGCATGCCGGCGAGGCCGCGCTCGACACGCTGTTGGC
GCAGGCCGACATCGTGCTCAATCTGCTGCCGCTGACGCCCGCCACGCGCGGGCTGTTCGATGCCGCTCGCCTCGCGCGCA
TGAAGCCCGGCGCCGGCCTCGTGAACCTGGCGCGCGGCGAGCACGTGGTCGAGGCGGACCTGCTGGCCGCACTGGATGCT
GGGCGGCTGCGCCATGCGGTGCTCGACGTGTTCCAGACGGAACCGCTGCCGGCCGGGCATGCGTTCTGGTCCCACCCCCG
CGTCACCGTGCTGCCTCATGCGGCCGCGCAGACCGATCCGCGCAGCGCGGCCGGCGTGGTGGCGGCCAACCTGCAGGCCT
GGCGGGCCGGCCGCCCGTTGGCGAATCTGGTGGATCGCCAGCGCGGCTATTAG

Upstream 100 bases:

>100_bases
CGCCGCGGGCCGAGTTGCTGCAGCTGTCGGGCGATCGCGCCGGCATCCGCGCGCAGACCGTGCTGCGGGCGCTGCAGCGC
CTGCTGGAGGCCGCGCGGCC

Downstream 100 bases:

>100_bases
GGCTTGTCAGAGCGCCAGCCGGCTGAAGTCGGTGTCCAGCCGCACCGCTTGCACCTGCGGTGCGGTCCAGTCGCGGATCC
AGTCGGCGAACAGGGCCTCG

Product: putative 2-hydroxyacid dehydrogenase in PhoH-CsgG intergenic region

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSLLLACDVGADEAETWRAALSAALSGEHLLTSSQGAADDIEVAIVANPRPGTLAGLPRLRLIQSLWAGVDRLLADPTLP
AGVPIVRMVDPAMSAAMAETALWAVLALHRGFFRYARLQGEGRWAPHGQRRADELVVAVLGLGQMGRGTSLRLAAQGYRV
RGWSTRPTAIEGIETHAGEAALDTLLAQADIVLNLLPLTPATRGLFDAARLARMKPGAGLVNLARGEHVVEADLLAALDA
GRLRHAVLDVFQTEPLPAGHAFWSHPRVTVLPHAAAQTDPRSAAGVVAANLQAWRAGRPLANLVDRQRGY

Sequences:

>Translated_310_residues
MSLLLACDVGADEAETWRAALSAALSGEHLLTSSQGAADDIEVAIVANPRPGTLAGLPRLRLIQSLWAGVDRLLADPTLP
AGVPIVRMVDPAMSAAMAETALWAVLALHRGFFRYARLQGEGRWAPHGQRRADELVVAVLGLGQMGRGTSLRLAAQGYRV
RGWSTRPTAIEGIETHAGEAALDTLLAQADIVLNLLPLTPATRGLFDAARLARMKPGAGLVNLARGEHVVEADLLAALDA
GRLRHAVLDVFQTEPLPAGHAFWSHPRVTVLPHAAAQTDPRSAAGVVAANLQAWRAGRPLANLVDRQRGY
>Mature_309_residues
SLLLACDVGADEAETWRAALSAALSGEHLLTSSQGAADDIEVAIVANPRPGTLAGLPRLRLIQSLWAGVDRLLADPTLPA
GVPIVRMVDPAMSAAMAETALWAVLALHRGFFRYARLQGEGRWAPHGQRRADELVVAVLGLGQMGRGTSLRLAAQGYRVR
GWSTRPTAIEGIETHAGEAALDTLLAQADIVLNLLPLTPATRGLFDAARLARMKPGAGLVNLARGEHVVEADLLAALDAG
RLRHAVLDVFQTEPLPAGHAFWSHPRVTVLPHAAAQTDPRSAAGVVAANLQAWRAGRPLANLVDRQRGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=253, Percent_Identity=29.2490118577075, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI23308577, Length=258, Percent_Identity=27.906976744186, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI61743967, Length=236, Percent_Identity=28.8135593220339, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4557497, Length=236, Percent_Identity=28.8135593220339, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI145580578, Length=275, Percent_Identity=27.6363636363636, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI4557499, Length=275, Percent_Identity=27.6363636363636, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI87081824, Length=303, Percent_Identity=35.6435643564356, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI87082289, Length=239, Percent_Identity=29.7071129707113, Blast_Score=82, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=258, Percent_Identity=31.0077519379845, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=220, Percent_Identity=30, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45552429, Length=253, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585514, Length=253, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574282, Length=253, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45551003, Length=253, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28574284, Length=253, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28574286, Length=254, Percent_Identity=29.5275590551181, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI19921140, Length=233, Percent_Identity=31.3304721030043, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646446, Length=240, Percent_Identity=30, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24646448, Length=240, Percent_Identity=30, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24646452, Length=240, Percent_Identity=30, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24646450, Length=240, Percent_Identity=30, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI62472511, Length=239, Percent_Identity=29.7071129707113, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585516, Length=240, Percent_Identity=27.9166666666667, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28571528, Length=164, Percent_Identity=31.0975609756098, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 32865; Mature: 32734

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS50003 PH_DOMAIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLLACDVGADEAETWRAALSAALSGEHLLTSSQGAADDIEVAIVANPRPGTLAGLPRL
CCEEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEEECCCCCCCCCCHHH
RLIQSLWAGVDRLLADPTLPAGVPIVRMVDPAMSAAMAETALWAVLALHRGFFRYARLQG
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EGRWAPHGQRRADELVVAVLGLGQMGRGTSLRLAAQGYRVRGWSTRPTAIEGIETHAGEA
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEECCCCCCCHHCCHHHHCCHH
ALDTLLAQADIVLNLLPLTPATRGLFDAARLARMKPGAGLVNLARGEHVVEADLLAALDA
HHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHH
GRLRHAVLDVFQTEPLPAGHAFWSHPRVTVLPHAAAQTDPRSAAGVVAANLQAWRAGRPL
HHHHHHHHHHHHCCCCCCCCCHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCHH
ANLVDRQRGY
HHHHHHHCCC
>Mature Secondary Structure 
SLLLACDVGADEAETWRAALSAALSGEHLLTSSQGAADDIEVAIVANPRPGTLAGLPRL
CEEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEEECCCCCCCCCCHHH
RLIQSLWAGVDRLLADPTLPAGVPIVRMVDPAMSAAMAETALWAVLALHRGFFRYARLQG
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EGRWAPHGQRRADELVVAVLGLGQMGRGTSLRLAAQGYRVRGWSTRPTAIEGIETHAGEA
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEECCCCCCCHHCCHHHHCCHH
ALDTLLAQADIVLNLLPLTPATRGLFDAARLARMKPGAGLVNLARGEHVVEADLLAALDA
HHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHH
GRLRHAVLDVFQTEPLPAGHAFWSHPRVTVLPHAAAQTDPRSAAGVVAANLQAWRAGRPL
HHHHHHHHHHHHCCCCCCCCCHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCHH
ANLVDRQRGY
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA