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The map label for this gene is dctS [H]

Identifier: 124265401

GI number: 124265401

Start: 224727

End: 226853

Strand: Direct

Name: dctS [H]

Synonym: Mpe_A0208

Alternate gene names: 124265401

Gene position: 224727-226853 (Clockwise)

Preceding gene: 124265397

Following gene: 124265402

Centisome position: 5.56

GC content: 71.18

Gene sequence:

>2127_bases
ATGCGCGAAACTGCTTACCTCTTTCGCTTGCGAGCTCTCGATACTGAGGCTATGGCCGATGTCGATGCCCCCGTCGTGCC
CACGCCGCTCGCTTCACGCTGGCGGCGACTGTTGCCGTGGGCGCTGCTCGTGCTATTGCTGGGCGTGGCCCAGACACTGC
TGCTGGCACTGACGGTGCAGCACGAGAACAACCGCGAGCAGGAGCGAGTGGAGATGGCCGCCGCCTCGGCCGCGGCCAAC
GTGCGGCAGCTGCTCCTGCGCGACGTGCAGAGTCTGCAGGCCCTGCTGTGGAACGATCCGCAACCCGCCCAATGGCGCTC
CGACGCGGCCGACCTGCTGCGTGCGCGGCGCGAGATGCTGCGCATCGAATGGCGCAGTGGCGCCAACGTGATCGAGACGG
CCGCCGATTCGCCCTACGGTGGGCCGCTGTTCGTCAGCCTGGCGCGCAGTGACCTCGATCTGGACACGCAGGCCGCGTGT
GCCGACGCGCAGCGGCTGGCGGCGCCGGCCTGGTCACGCAGCTACTTCGTGCCTCAGCCCGGCGGACTCGGGGTCGAGGT
GATCGACGTCTGCCTGCCGATCGGTCCGAATGGCGAGCGCGGCGCGATGGTGGCCACGCTGGCGCTCGGCGGGGTGATCG
ACGAAGCCGTCGCGCCTGAACTGGCGCGCAGCCACGAGCTGTCGTTCGTCGAAGGTGACGGTACGCGCCTGGCGCGCGGA
GGGCTGACGCGCGGAGCCGGCATCTATGTCACCGAGCGCCTGGTCAACCTGTCGAGCCTCACGCTGGCGTTGCGGCTCGA
CAGCGCGGCCGGCGCGCCGCGACTGATCCCCAACGTGGCGACCTCGCTGGTGCTCGGCCTCTCGCTTGCGCTGGCGGCGG
TGGTGGCGTTGCTGGCGCGCGACGTGCGTCGCCGCGCGGCGGCGGAGCAGCGTCTCGGTGAGGAACTGACGCTGCGACGC
GCGATGGAGGACTCGCTGGTGACCGGCCTGCGCGCGCGTGACCGGCAGGGCCGCGTCACCTACGTCAATCCGGCCTTCTG
CAAGATGGTGGGCTTCAGTGCCGAGCAGCTGGTCGGGCAGACCACACCGCCCTACTGGCCGCCCGAGATGCTCAGCGCCT
ACGAGGCGCGCCAGGTGCAGCGCATGGCGCAGGGCGTGCCGGCGCACGAGTCGCGCGACGGATTCGAGACCACTTTCATG
CGCGCTGGCGGTGAGCGCTTCCCGGTGCTGATCTTCGAGGCGCCGCTGGTGGGTCCCGACGGGCTGCAGAGCGGCTGGAT
GAGTGCGGTGCTCGATCTCAGCGCGCAGCGCCGCGTCGAGGAGCGCGCGCGCCAGCAGCAGGAGCAGCTGCAGGCCACCG
CCCGGCTTGCCAGCGTCGGCGAGATGGCCTCGCTGCTGAGCCACGAGCTCAATCAGCCGCTCGCGGCCATTGCCAGTTAC
GCGACCGGCTCGCTGAACCTGATCGACGATGCCGGCGAGCGACCCGATCCGCCGAGCTTGGCGATGATCCGCGAGGCCAC
GCAGCACATCGCCGAGCAGGCCGAGCGCGCCGGCCGCGTCATCCGCAGCGTGCACGACTTCGTGCGTCGCCGCGAGCAGA
GCCGCGAGAGCCTGAGCTGCGACCAGCTCGTGGAGGCGGTGATGCCGCTGCTGCGCCTGCAGGCGCGCAAGTGCGGCGCG
CGCATCGAGTTCGAGTTCGGCAGCCCGCCACCGCGTGTCGTGTGCGACCGCACGATGGTCGAGCAGGTGCTGCTCAACCT
GACCCGTAACGCGCTGCAGGCAATGGTGGGCGAGCCGGCGGAGCGCCGCGTGGTGCGGCTCGGCGCCCGCACCCACGGCG
CCTGGGTGCGGCTGAGCGTGACCGATCACGGCCCCGGCATCGAGCCCGAGGTCGCAGCCCGGCTGTTCACGCCCTTCTTC
ACCACCAAGGCCGAAGGGATGGGGCTGGGCCTGAGCCTGTGCCGGACGGTCGTCGAGCAGCACGGCGGGGCGCTCGACTT
CACGACGCTGCGCGACGGCGAGGGCCGCGTGCGCGGCACCTGTTTCGAGTTCACACTTCCGGCTGCCGGGCCCGCTTCCT
CCCCGGCGGCAGCCCCTCCGGGCGTTCTCGATGGAGTCTCTGCATGA

Upstream 100 bases:

>100_bases
ACGAGGGGCAGCGGGCCGGGTCGACGATTGTAAGAAGACCCCCTTTTGCGGCCAGAGCGGCTTGCGCAGGGCAGTGTTGC
AAATCCCGGAGGTAACGGCC

Downstream 100 bases:

>100_bases
GCCATGGCGTGCTGCCGGCCACCGCGCCGCTGGGTCTGCCGGTCGTCCACCTCGTGGACGACGAGGCGGTGGTGCGCAAT
GCGATCGCCTGGCTGTTGCG

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 708; Mature: 708

Protein sequence:

>708_residues
MRETAYLFRLRALDTEAMADVDAPVVPTPLASRWRRLLPWALLVLLLGVAQTLLLALTVQHENNREQERVEMAAASAAAN
VRQLLLRDVQSLQALLWNDPQPAQWRSDAADLLRARREMLRIEWRSGANVIETAADSPYGGPLFVSLARSDLDLDTQAAC
ADAQRLAAPAWSRSYFVPQPGGLGVEVIDVCLPIGPNGERGAMVATLALGGVIDEAVAPELARSHELSFVEGDGTRLARG
GLTRGAGIYVTERLVNLSSLTLALRLDSAAGAPRLIPNVATSLVLGLSLALAAVVALLARDVRRRAAAEQRLGEELTLRR
AMEDSLVTGLRARDRQGRVTYVNPAFCKMVGFSAEQLVGQTTPPYWPPEMLSAYEARQVQRMAQGVPAHESRDGFETTFM
RAGGERFPVLIFEAPLVGPDGLQSGWMSAVLDLSAQRRVEERARQQQEQLQATARLASVGEMASLLSHELNQPLAAIASY
ATGSLNLIDDAGERPDPPSLAMIREATQHIAEQAERAGRVIRSVHDFVRRREQSRESLSCDQLVEAVMPLLRLQARKCGA
RIEFEFGSPPPRVVCDRTMVEQVLLNLTRNALQAMVGEPAERRVVRLGARTHGAWVRLSVTDHGPGIEPEVAARLFTPFF
TTKAEGMGLGLSLCRTVVEQHGGALDFTTLRDGEGRVRGTCFEFTLPAAGPASSPAAAPPGVLDGVSA

Sequences:

>Translated_708_residues
MRETAYLFRLRALDTEAMADVDAPVVPTPLASRWRRLLPWALLVLLLGVAQTLLLALTVQHENNREQERVEMAAASAAAN
VRQLLLRDVQSLQALLWNDPQPAQWRSDAADLLRARREMLRIEWRSGANVIETAADSPYGGPLFVSLARSDLDLDTQAAC
ADAQRLAAPAWSRSYFVPQPGGLGVEVIDVCLPIGPNGERGAMVATLALGGVIDEAVAPELARSHELSFVEGDGTRLARG
GLTRGAGIYVTERLVNLSSLTLALRLDSAAGAPRLIPNVATSLVLGLSLALAAVVALLARDVRRRAAAEQRLGEELTLRR
AMEDSLVTGLRARDRQGRVTYVNPAFCKMVGFSAEQLVGQTTPPYWPPEMLSAYEARQVQRMAQGVPAHESRDGFETTFM
RAGGERFPVLIFEAPLVGPDGLQSGWMSAVLDLSAQRRVEERARQQQEQLQATARLASVGEMASLLSHELNQPLAAIASY
ATGSLNLIDDAGERPDPPSLAMIREATQHIAEQAERAGRVIRSVHDFVRRREQSRESLSCDQLVEAVMPLLRLQARKCGA
RIEFEFGSPPPRVVCDRTMVEQVLLNLTRNALQAMVGEPAERRVVRLGARTHGAWVRLSVTDHGPGIEPEVAARLFTPFF
TTKAEGMGLGLSLCRTVVEQHGGALDFTTLRDGEGRVRGTCFEFTLPAAGPASSPAAAPPGVLDGVSA
>Mature_708_residues
MRETAYLFRLRALDTEAMADVDAPVVPTPLASRWRRLLPWALLVLLLGVAQTLLLALTVQHENNREQERVEMAAASAAAN
VRQLLLRDVQSLQALLWNDPQPAQWRSDAADLLRARREMLRIEWRSGANVIETAADSPYGGPLFVSLARSDLDLDTQAAC
ADAQRLAAPAWSRSYFVPQPGGLGVEVIDVCLPIGPNGERGAMVATLALGGVIDEAVAPELARSHELSFVEGDGTRLARG
GLTRGAGIYVTERLVNLSSLTLALRLDSAAGAPRLIPNVATSLVLGLSLALAAVVALLARDVRRRAAAEQRLGEELTLRR
AMEDSLVTGLRARDRQGRVTYVNPAFCKMVGFSAEQLVGQTTPPYWPPEMLSAYEARQVQRMAQGVPAHESRDGFETTFM
RAGGERFPVLIFEAPLVGPDGLQSGWMSAVLDLSAQRRVEERARQQQEQLQATARLASVGEMASLLSHELNQPLAAIASY
ATGSLNLIDDAGERPDPPSLAMIREATQHIAEQAERAGRVIRSVHDFVRRREQSRESLSCDQLVEAVMPLLRLQARKCGA
RIEFEFGSPPPRVVCDRTMVEQVLLNLTRNALQAMVGEPAERRVVRLGARTHGAWVRLSVTDHGPGIEPEVAARLFTPFF
TTKAEGMGLGLSLCRTVVEQHGGALDFTTLRDGEGRVRGTCFEFTLPAAGPASSPAAAPPGVLDGVSA

Specific function: Member of the two-component regulatory system dctS/dctR involved in the transport of C4-dicarboxylates. DctS functions as a membrane-associated protein kinase that phosphorylates dctR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=261, Percent_Identity=29.8850574712644, Blast_Score=118, Evalue=2e-27,
Organism=Escherichia coli, GI1788549, Length=383, Percent_Identity=27.4151436031332, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI1790300, Length=358, Percent_Identity=30.7262569832402, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI1786912, Length=256, Percent_Identity=28.125, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1790346, Length=217, Percent_Identity=24.4239631336406, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 76743; Mature: 76743

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRETAYLFRLRALDTEAMADVDAPVVPTPLASRWRRLLPWALLVLLLGVAQTLLLALTVQ
CCCHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HENNREQERVEMAAASAAANVRQLLLRDVQSLQALLWNDPQPAQWRSDAADLLRARREML
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
RIEWRSGANVIETAADSPYGGPLFVSLARSDLDLDTQAACADAQRLAAPAWSRSYFVPQP
HHHHCCCCCHHHHCCCCCCCCCEEEEEHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
GGLGVEVIDVCLPIGPNGERGAMVATLALGGVIDEAVAPELARSHELSFVEGDGTRLARG
CCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEECCC
GLTRGAGIYVTERLVNLSSLTLALRLDSAAGAPRLIPNVATSLVLGLSLALAAVVALLAR
CCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVRRRAAAEQRLGEELTLRRAMEDSLVTGLRARDRQGRVTYVNPAFCKMVGFSAEQLVGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHCCCHHHHHCC
TTPPYWPPEMLSAYEARQVQRMAQGVPAHESRDGFETTFMRAGGERFPVLIFEAPLVGPD
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCC
GLQSGWMSAVLDLSAQRRVEERARQQQEQLQATARLASVGEMASLLSHELNQPLAAIASY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
ATGSLNLIDDAGERPDPPSLAMIREATQHIAEQAERAGRVIRSVHDFVRRREQSRESLSC
CCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DQLVEAVMPLLRLQARKCGARIEFEFGSPPPRVVCDRTMVEQVLLNLTRNALQAMVGEPA
HHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
ERRVVRLGARTHGAWVRLSVTDHGPGIEPEVAARLFTPFFTTKAEGMGLGLSLCRTVVEQ
HHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
HGGALDFTTLRDGEGRVRGTCFEFTLPAAGPASSPAAAPPGVLDGVSA
CCCCEEEEEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRETAYLFRLRALDTEAMADVDAPVVPTPLASRWRRLLPWALLVLLLGVAQTLLLALTVQ
CCCHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HENNREQERVEMAAASAAANVRQLLLRDVQSLQALLWNDPQPAQWRSDAADLLRARREML
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
RIEWRSGANVIETAADSPYGGPLFVSLARSDLDLDTQAACADAQRLAAPAWSRSYFVPQP
HHHHCCCCCHHHHCCCCCCCCCEEEEEHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
GGLGVEVIDVCLPIGPNGERGAMVATLALGGVIDEAVAPELARSHELSFVEGDGTRLARG
CCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEECCC
GLTRGAGIYVTERLVNLSSLTLALRLDSAAGAPRLIPNVATSLVLGLSLALAAVVALLAR
CCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVRRRAAAEQRLGEELTLRRAMEDSLVTGLRARDRQGRVTYVNPAFCKMVGFSAEQLVGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHCCCHHHHHCC
TTPPYWPPEMLSAYEARQVQRMAQGVPAHESRDGFETTFMRAGGERFPVLIFEAPLVGPD
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCC
GLQSGWMSAVLDLSAQRRVEERARQQQEQLQATARLASVGEMASLLSHELNQPLAAIASY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
ATGSLNLIDDAGERPDPPSLAMIREATQHIAEQAERAGRVIRSVHDFVRRREQSRESLSC
CCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DQLVEAVMPLLRLQARKCGARIEFEFGSPPPRVVCDRTMVEQVLLNLTRNALQAMVGEPA
HHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
ERRVVRLGARTHGAWVRLSVTDHGPGIEPEVAARLFTPFFTTKAEGMGLGLSLCRTVVEQ
HHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
HGGALDFTTLRDGEGRVRGTCFEFTLPAAGPASSPAAAPPGVLDGVSA
CCCCEEEEEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8455557 [H]