Click here to switch to the map view.

The map label for this gene is dnaA

Identifier: 124265194

GI number: 124265194

Start: 186

End: 1589

Strand: Direct

Name: dnaA

Synonym: Mpe_A0001

Alternate gene names: 124265194

Gene position: 186-1589 (Clockwise)

Preceding gene: NA

Following gene: 124265195

Centisome position: 0.0

GC content: 66.52

Gene sequence:

>1404_bases
ATGAGCGCCGACGTCTGGTCTCAAGGCTGCGAACGCCTGGCGACCGAACTGCCCGAGCAGCAGTTCAACACCTGGATCCG
TCCTCTCCCCGCGGCCGAACTCGTCGATCGCGGCGATACGGCCGTGGCCACGCTGCGGGTTCCCAACCGCTTCAAGCTCG
ACTGGATCCGCAATCAGTACGCCGCGCGCATCGAATCGGTGTTGAGCGACCTGGCGGGCAAGCCGGTGCGTCTGGACCTG
CAGCTCGCCGCACGCGAGGCGCCGCCGCGGCCTTCATCGGATGCGCCGCGCAGCAACGGCCATCCGCAGGCCGCCGGCCA
GTGGCTCGGTGCCCCCTCGTCGTCGAACGCAGGGGCCTACACACAGGCCAGCGCGCCGACGCCGACGCACCGGCTCAACA
CCGCCCTGACCTTCGACACCCTGGTGCCGGGACGCGCCAACCAGATGGCGCGCACCGCCGCGCTGCACGTGGCCGGCGCG
CCGGGGGTCATGTACAACCCGCTGTTCATCTACGGCGGCGTGGGCCTGGGCAAGACCCACCTGATCCACGCCGTGGGCAA
CGCGCTGCTGCGCGACAAGCCCGACGCGCGCATCCTCTACCTGCACGCCGAGCAGTTCATCACCGACGTGGTGAAGAACT
ACCAGCGCAAGACCTTCGACGAGCTCAAGGCCAAGTACCACTCGCTCGACCTGCTGCTGATCGACGACGTGCAGTTCTTC
GCCGGCAAGGAGCGCACCCAGGAGGAGTTCTTCAACGCCTTCGAGGCGCTGCTGGCCAAGCGCGCGCACATCATCATGAC
CAGCGACACCTACCCCAAGGGGCTGGCCGACATCGACGAGCGCCTCACCTCGCGCTTCGATGCCGGACTCACAGTGGCGA
TCGAGCCGCCCGAGCTGGAAATGCGCGTCGCGATCCTGATGAAGAAGTCCGACGTCGAAGGCACGCCGATGCCCGAGGAC
GTGGCCTTCTTCGTCGCCAAGAACGTGCGCGCCAACGTGCGCGAGCTCGAGGGCGCGCTGCGCAAGGTGCTGGCCTATGC
ACGCTTCAGCCAGAAGGACATCAACATCGCGCTGGCCCGCGAGGCACTGAAGGACCTGCTGTCGATCCAGAACCGCCAGG
TCGGCGTGGAGAACATCCAGAAGACGGTGGCCGACTTCTACAAGATCAAGGTCGCCGACATGTACTCCAAGAAGCGTCCC
GCCAGCATCGCCCGGCCACGCCAGATCGCCATGTACCTCGCCAAGGAACTGACGCAGAAGAGCCTGCCCGAGATCGGCGA
GCTGTTCGGTGGTCGTGACCACACCACCGTGCTGCATGCGGTGCGCAAGATCGGCGGCGAGCGCGGCAAGAACACCGAAC
TGAACCAGCAGCTCCACGTGCTGGAACAGACCCTCAAGGGCTGA

Upstream 100 bases:

>100_bases
GCCGGTTCGTCAGACGCAAAACGACTGTGGATAACCTCTTCCCAGCCGCGCTTCGACCGCTAGAATCGTTCGGCTGAAGA
AAGAATTGTCCACAAGAACG

Downstream 100 bases:

>100_bases
AGCATGCGCATGCCGAGGCCGTCAAGTGACAAAGCTGGGGACAACTCCGGAACAAGCAGAGAGTCATCCACAGCCCGAGC
CAGGCCACCAGAGTTGTTGT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSADVWSQGCERLATELPEQQFNTWIRPLPAAELVDRGDTAVATLRVPNRFKLDWIRNQYAARIESVLSDLAGKPVRLDL
QLAAREAPPRPSSDAPRSNGHPQAAGQWLGAPSSSNAGAYTQASAPTPTHRLNTALTFDTLVPGRANQMARTAALHVAGA
PGVMYNPLFIYGGVGLGKTHLIHAVGNALLRDKPDARILYLHAEQFITDVVKNYQRKTFDELKAKYHSLDLLLIDDVQFF
AGKERTQEEFFNAFEALLAKRAHIIMTSDTYPKGLADIDERLTSRFDAGLTVAIEPPELEMRVAILMKKSDVEGTPMPED
VAFFVAKNVRANVRELEGALRKVLAYARFSQKDINIALAREALKDLLSIQNRQVGVENIQKTVADFYKIKVADMYSKKRP
ASIARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIGGERGKNTELNQQLHVLEQTLKG

Sequences:

>Translated_467_residues
MSADVWSQGCERLATELPEQQFNTWIRPLPAAELVDRGDTAVATLRVPNRFKLDWIRNQYAARIESVLSDLAGKPVRLDL
QLAAREAPPRPSSDAPRSNGHPQAAGQWLGAPSSSNAGAYTQASAPTPTHRLNTALTFDTLVPGRANQMARTAALHVAGA
PGVMYNPLFIYGGVGLGKTHLIHAVGNALLRDKPDARILYLHAEQFITDVVKNYQRKTFDELKAKYHSLDLLLIDDVQFF
AGKERTQEEFFNAFEALLAKRAHIIMTSDTYPKGLADIDERLTSRFDAGLTVAIEPPELEMRVAILMKKSDVEGTPMPED
VAFFVAKNVRANVRELEGALRKVLAYARFSQKDINIALAREALKDLLSIQNRQVGVENIQKTVADFYKIKVADMYSKKRP
ASIARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIGGERGKNTELNQQLHVLEQTLKG
>Mature_466_residues
SADVWSQGCERLATELPEQQFNTWIRPLPAAELVDRGDTAVATLRVPNRFKLDWIRNQYAARIESVLSDLAGKPVRLDLQ
LAAREAPPRPSSDAPRSNGHPQAAGQWLGAPSSSNAGAYTQASAPTPTHRLNTALTFDTLVPGRANQMARTAALHVAGAP
GVMYNPLFIYGGVGLGKTHLIHAVGNALLRDKPDARILYLHAEQFITDVVKNYQRKTFDELKAKYHSLDLLLIDDVQFFA
GKERTQEEFFNAFEALLAKRAHIIMTSDTYPKGLADIDERLTSRFDAGLTVAIEPPELEMRVAILMKKSDVEGTPMPEDV
AFFVAKNVRANVRELEGALRKVLAYARFSQKDINIALAREALKDLLSIQNRQVGVENIQKTVADFYKIKVADMYSKKRPA
SIARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIGGERGKNTELNQQLHVLEQTLKG

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=470, Percent_Identity=50.6382978723404, Blast_Score=458, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_METPP (A2SBM4)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019198.1
- ProteinModelPortal:   A2SBM4
- STRING:   A2SBM4
- GeneID:   4787008
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0001
- NMPDR:   fig|279263.3.peg.600
- eggNOG:   COG0593
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- PhylomeDB:   A2SBM4
- ProtClustDB:   PRK00149
- BioCyc:   MPET420662:MPE_A0001-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 51850; Mature: 51719

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADVWSQGCERLATELPEQQFNTWIRPLPAAELVDRGDTAVATLRVPNRFKLDWIRNQY
CCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHCCCCCEEEEEECCCCEEHHHHHHHH
AARIESVLSDLAGKPVRLDLQLAAREAPPRPSSDAPRSNGHPQAAGQWLGAPSSSNAGAY
HHHHHHHHHHHCCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCE
TQASAPTPTHRLNTALTFDTLVPGRANQMARTAALHVAGAPGVMYNPLFIYGGVGLGKTH
EECCCCCCCHHHCCEEEECCCCCCCHHHHHHHHHEEECCCCCCEECCEEEECCCCCCHHH
LIHAVGNALLRDKPDARILYLHAEQFITDVVKNYQRKTFDELKAKYHSLDLLLIDDVQFF
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCHHHH
AGKERTQEEFFNAFEALLAKRAHIIMTSDTYPKGLADIDERLTSRFDAGLTVAIEPPELE
HCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCC
MRVAILMKKSDVEGTPMPEDVAFFVAKNVRANVRELEGALRKVLAYARFSQKDINIALAR
EEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
EALKDLLSIQNRQVGVENIQKTVADFYKIKVADMYSKKRPASIARPRQIAMYLAKELTQK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
SLPEIGELFGGRDHTTVLHAVRKIGGERGKNTELNQQLHVLEQTLKG
CCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SADVWSQGCERLATELPEQQFNTWIRPLPAAELVDRGDTAVATLRVPNRFKLDWIRNQY
CCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHCCCCCEEEEEECCCCEEHHHHHHHH
AARIESVLSDLAGKPVRLDLQLAAREAPPRPSSDAPRSNGHPQAAGQWLGAPSSSNAGAY
HHHHHHHHHHHCCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCE
TQASAPTPTHRLNTALTFDTLVPGRANQMARTAALHVAGAPGVMYNPLFIYGGVGLGKTH
EECCCCCCCHHHCCEEEECCCCCCCHHHHHHHHHEEECCCCCCEECCEEEECCCCCCHHH
LIHAVGNALLRDKPDARILYLHAEQFITDVVKNYQRKTFDELKAKYHSLDLLLIDDVQFF
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCHHHH
AGKERTQEEFFNAFEALLAKRAHIIMTSDTYPKGLADIDERLTSRFDAGLTVAIEPPELE
HCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCC
MRVAILMKKSDVEGTPMPEDVAFFVAKNVRANVRELEGALRKVLAYARFSQKDINIALAR
EEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
EALKDLLSIQNRQVGVENIQKTVADFYKIKVADMYSKKRPASIARPRQIAMYLAKELTQK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
SLPEIGELFGGRDHTTVLHAVRKIGGERGKNTELNQQLHVLEQTLKG
CCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA