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The map label for this gene is trpS

Identifier: 124027820

GI number: 124027820

Start: 953949

End: 955070

Strand: Reverse

Name: trpS

Synonym: Hbut_0947

Alternate gene names: 124027820

Gene position: 955070-953949 (Counterclockwise)

Preceding gene: 124027823

Following gene: 124027819

Centisome position: 57.29

GC content: 51.6

Gene sequence:

>1122_bases
GTGGAGGGCTATAGGTTAGATCCATGGGCTTCGGCTATAAGGCTTGAGTACGAGAAGCTCTTCCGCTATTTTGGCATAAA
GCCGTTCCAGCCTCTTCTACCAGAAGTAGAGAAGGCATTTGGTAAGCCTCATAGATTGATGAGGCGCGGTATCATATTCG
GCCACCGCGATTACGAGAAGATACTTGAGGCTTACCGGTCTGGCGAGCGTATAGCTCTAGTGACCGGGTTTATGCCAAGC
GGCAAGTTCCATTTCGGCCACAAGATGGTTGCCGACCAGATAATATACTATCAGAAGCTTGGCTTCGAAATATTCGTCGT
TATAGCCGACGCTGAGGCCTATGCTGTGAGGAGGCTTGACAGGAGAAAAATCATAGAGATAGGATTGTACGAGTATGTTG
CTAACCTGATAGCTCTCGGGCTCGAGAAGAACAAACACACCCACATTTACTTCCAGACAAACTATGAGACCCCCTACTAC
CGGCTCATACAGATGTTCTCGCGGAGGGTTACACTGGAGGAGATGAGCGCAATCTATGGCGATCTAGAGCCCAGCAAGAT
AATGGCAGCACTAACACAAGCAGCCGACATTCTACATCCACAGCTAGACTACTTCGGTGGCTTCAAGTACGTCGTGGTGC
CTGTGGGAGCTGATCAAGATCCCCACATAAGGTTAACTAGGGATATAGCTGCTAGGTTCGAGAACGAGCTAGGCCTTAGG
AGGCCTGCATCGACGTACCACCGATTCCAGACTGGGCTTGACGGCAATAAGATGAGTAGCTCTAGGCCGGAGTACACTAT
ATTCCTCACAGATCCTGTGGACATTGCTGTAAGGAAGCTTAAGCGGGCACTCACGGGAGGCCGTGCCACGGTAGAGGAGC
AGCGTCGCCTGGGCGGCGAGCCAGAGAAATGCACAGTGTACGAGTTCTACCTCTACCATCTCATAGAGGATGACACACAG
CTAAGGAAGATCTACGAAGACTGCCGAGGCAGCCGGCTCCTATGCGGCCCCGATAAGGAGTATGCTGCTGAACTCCTAGC
AAAGTTCCTCGAGGAGCATCAGCGCCGCCTCGAAAGGGCTAGGGATCGAGTCCTAGAGTATGTCGAGCCTCCAAAGTTCT
AA

Upstream 100 bases:

>100_bases
CTTAGCCGGAAAGGGTTTAAAGTAGACCTCTTAGAGGCTCTACTTGAACCGCCATCTAGTAGCCCAGCCTAAGGGATGGG
GGCTCGGGTGAGGGCTTATT

Downstream 100 bases:

>100_bases
GCGCATGAAGGAGGTGGCAATGTTTTGGGCACTGTACTGCTATCTGGGCTTTTTGCCCGCTACACGGTGAAGAGAGAGAA
GGGGGATGCAATGACTAGTC

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MEGYRLDPWASAIRLEYEKLFRYFGIKPFQPLLPEVEKAFGKPHRLMRRGIIFGHRDYEKILEAYRSGERIALVTGFMPS
GKFHFGHKMVADQIIYYQKLGFEIFVVIADAEAYAVRRLDRRKIIEIGLYEYVANLIALGLEKNKHTHIYFQTNYETPYY
RLIQMFSRRVTLEEMSAIYGDLEPSKIMAALTQAADILHPQLDYFGGFKYVVVPVGADQDPHIRLTRDIAARFENELGLR
RPASTYHRFQTGLDGNKMSSSRPEYTIFLTDPVDIAVRKLKRALTGGRATVEEQRRLGGEPEKCTVYEFYLYHLIEDDTQ
LRKIYEDCRGSRLLCGPDKEYAAELLAKFLEEHQRRLERARDRVLEYVEPPKF

Sequences:

>Translated_373_residues
MEGYRLDPWASAIRLEYEKLFRYFGIKPFQPLLPEVEKAFGKPHRLMRRGIIFGHRDYEKILEAYRSGERIALVTGFMPS
GKFHFGHKMVADQIIYYQKLGFEIFVVIADAEAYAVRRLDRRKIIEIGLYEYVANLIALGLEKNKHTHIYFQTNYETPYY
RLIQMFSRRVTLEEMSAIYGDLEPSKIMAALTQAADILHPQLDYFGGFKYVVVPVGADQDPHIRLTRDIAARFENELGLR
RPASTYHRFQTGLDGNKMSSSRPEYTIFLTDPVDIAVRKLKRALTGGRATVEEQRRLGGEPEKCTVYEFYLYHLIEDDTQ
LRKIYEDCRGSRLLCGPDKEYAAELLAKFLEEHQRRLERARDRVLEYVEPPKF
>Mature_373_residues
MEGYRLDPWASAIRLEYEKLFRYFGIKPFQPLLPEVEKAFGKPHRLMRRGIIFGHRDYEKILEAYRSGERIALVTGFMPS
GKFHFGHKMVADQIIYYQKLGFEIFVVIADAEAYAVRRLDRRKIIEIGLYEYVANLIALGLEKNKHTHIYFQTNYETPYY
RLIQMFSRRVTLEEMSAIYGDLEPSKIMAALTQAADILHPQLDYFGGFKYVVVPVGADQDPHIRLTRDIAARFENELGLR
RPASTYHRFQTGLDGNKMSSSRPEYTIFLTDPVDIAVRKLKRALTGGRATVEEQRRLGGEPEKCTVYEFYLYHLIEDDTQ
LRKIYEDCRGSRLLCGPDKEYAAELLAKFLEEHQRRLERARDRVLEYVEPPKF

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI47419920, Length=390, Percent_Identity=32.0512820512821, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI47419918, Length=390, Percent_Identity=32.0512820512821, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI47419916, Length=390, Percent_Identity=32.0512820512821, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI47419914, Length=390, Percent_Identity=32.0512820512821, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI239750058, Length=146, Percent_Identity=32.1917808219178, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI310120693, Length=146, Percent_Identity=32.1917808219178, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI72001474, Length=383, Percent_Identity=28.4595300261097, Blast_Score=121, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6324475, Length=376, Percent_Identity=28.7234042553192, Blast_Score=133, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17864462, Length=382, Percent_Identity=32.4607329842932, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24645295, Length=382, Percent_Identity=32.4607329842932, Blast_Score=148, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYW_HYPBU (A2BLD4)

Other databases:

- EMBL:   CP000493
- RefSeq:   YP_001013140.1
- ProteinModelPortal:   A2BLD4
- SMR:   A2BLD4
- STRING:   A2BLD4
- GeneID:   4782824
- GenomeReviews:   CP000493_GR
- KEGG:   hbu:Hbut_0947
- eggNOG:   arNOG04974
- HOGENOM:   HBG435805
- OMA:   ADILHPQ
- PhylomeDB:   A2BLD4
- ProtClustDB:   PRK12285
- BioCyc:   HBUT415426:HBUT_0947-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00140_A
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306
- InterPro:   IPR020653
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10055
- PRINTS:   PR01039
- TIGRFAMs:   TIGR00233

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.2

Molecular weight: Translated: 43647; Mature: 43647

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGYRLDPWASAIRLEYEKLFRYFGIKPFQPLLPEVEKAFGKPHRLMRRGIIFGHRDYEK
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHH
ILEAYRSGERIALVTGFMPSGKFHFGHKMVADQIIYYQKLGFEIFVVIADAEAYAVRRLD
HHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHH
RRKIIEIGLYEYVANLIALGLEKNKHTHIYFQTNYETPYYRLIQMFSRRVTLEEMSAIYG
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHC
DLEPSKIMAALTQAADILHPQLDYFGGFKYVVVPVGADQDPHIRLTRDIAARFENELGLR
CCCHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEEECCCCCCCEEEHHHHHHHHHHHCCCC
RPASTYHRFQTGLDGNKMSSSRPEYTIFLTDPVDIAVRKLKRALTGGRATVEEQRRLGGE
CCHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHCCCC
PEKCTVYEFYLYHLIEDDTQLRKIYEDCRGSRLLCGPDKEYAAELLAKFLEEHQRRLERA
CCCEEHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
RDRVLEYVEPPKF
HHHHHHHCCCCCC
>Mature Secondary Structure
MEGYRLDPWASAIRLEYEKLFRYFGIKPFQPLLPEVEKAFGKPHRLMRRGIIFGHRDYEK
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHH
ILEAYRSGERIALVTGFMPSGKFHFGHKMVADQIIYYQKLGFEIFVVIADAEAYAVRRLD
HHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHH
RRKIIEIGLYEYVANLIALGLEKNKHTHIYFQTNYETPYYRLIQMFSRRVTLEEMSAIYG
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHC
DLEPSKIMAALTQAADILHPQLDYFGGFKYVVVPVGADQDPHIRLTRDIAARFENELGLR
CCCHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEEECCCCCCCEEEHHHHHHHHHHHCCCC
RPASTYHRFQTGLDGNKMSSSRPEYTIFLTDPVDIAVRKLKRALTGGRATVEEQRRLGGE
CCHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHCCCC
PEKCTVYEFYLYHLIEDDTQLRKIYEDCRGSRLLCGPDKEYAAELLAKFLEEHQRRLERA
CCCEEHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
RDRVLEYVEPPKF
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA