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The map label for this gene is gyaR [H]

Identifier: 124027736

GI number: 124027736

Start: 862651

End: 863451

Strand: Reverse

Name: gyaR [H]

Synonym: Hbut_0860

Alternate gene names: 124027736

Gene position: 863451-862651 (Counterclockwise)

Preceding gene: 124027737

Following gene: 124027732

Centisome position: 51.79

GC content: 54.93

Gene sequence:

>801_bases
GTGGGCTACGACAACATTGACGTGGAGTGTGCTACTAGGCTCGGAGTGTACGTAACTAATACCCCGGACGTGCTTACAGA
GGCGACAGCTGAGCTCACATGGGCTCTCATATTCGCTGTTGCGCGTCGCATAGTGGAGGCAGACAGCTATGTCCGGAGTG
GCGAGTGGTACCGTGGGCGCACTGGCTGGCATCCAGAGCTAATGCTTGGCATGGAGCTTTACGGCAAAACCCTCGGTGTA
ATAGGGTTTGGGAGAATTGGCAGAGCTGTAGCCAGGATTGGTGCTCGCGCATTCAACATGAAGGTGCTCTACTATAGTAG
GAGGCGTGCGCCACAGCATGTGGAAAGAGAGCTGAACGCCGAGTATGTGTCCCTCGAGGAGCTGTTGAAAAGGGCCGACA
TAGTAACGATACATGTGCCATTAACCCCTGAGACCCGGGGGATGATCGGGGAGCGAGAGCTAAGACTCATGAAGCCAACG
GCTATACTGATAAATACGGCGCGAGGGGCAGTCATAGACACCAATGCGCTCATACGCGCCCTCCGGGAGGGCTGGATAGC
TGGCGCGGGTCTCGACGTGTTTGAGGAAGAGCCACTACCACCAGACCATCCTCTCACAAGCCTTAAGAATGTGGTTCTAA
CCCCGCACATTGGTAGTGCTACACGAGAAGCAAGACAAGCAATGACTTGTGCGGTTCTAGAGAACCTGCTCGCCTTCCGC
GACGGAAAGATACCACCAAACCTTGTAAATCCCGACGTAATACGGGTTAGGCCTCCAGGCTTCCGTGCAACACGGTGCTA
A

Upstream 100 bases:

>100_bases
GCGAGGTTGATGGTATTGTATCGTTGTTACAGACCGTATAGACTGTGCCGTTCTCGAGGCTGGTACTCGTGGTAGGCTTA
GCATAGTATCCCAGTACGCT

Downstream 100 bases:

>100_bases
GGCCGCTGACCAGCTTTATTCCCCCTCTCCAGTCTGGCACAAGTACACAGAAGCCAGGCTCACGTTCCTCGAGGACGCCC
CAAGCCTCAATAACAGCTTT

Product: glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MGYDNIDVECATRLGVYVTNTPDVLTEATAELTWALIFAVARRIVEADSYVRSGEWYRGRTGWHPELMLGMELYGKTLGV
IGFGRIGRAVARIGARAFNMKVLYYSRRRAPQHVERELNAEYVSLEELLKRADIVTIHVPLTPETRGMIGERELRLMKPT
AILINTARGAVIDTNALIRALREGWIAGAGLDVFEEEPLPPDHPLTSLKNVVLTPHIGSATREARQAMTCAVLENLLAFR
DGKIPPNLVNPDVIRVRPPGFRATRC

Sequences:

>Translated_266_residues
MGYDNIDVECATRLGVYVTNTPDVLTEATAELTWALIFAVARRIVEADSYVRSGEWYRGRTGWHPELMLGMELYGKTLGV
IGFGRIGRAVARIGARAFNMKVLYYSRRRAPQHVERELNAEYVSLEELLKRADIVTIHVPLTPETRGMIGERELRLMKPT
AILINTARGAVIDTNALIRALREGWIAGAGLDVFEEEPLPPDHPLTSLKNVVLTPHIGSATREARQAMTCAVLENLLAFR
DGKIPPNLVNPDVIRVRPPGFRATRC
>Mature_265_residues
GYDNIDVECATRLGVYVTNTPDVLTEATAELTWALIFAVARRIVEADSYVRSGEWYRGRTGWHPELMLGMELYGKTLGVI
GFGRIGRAVARIGARAFNMKVLYYSRRRAPQHVERELNAEYVSLEELLKRADIVTIHVPLTPETRGMIGERELRLMKPTA
ILINTARGAVIDTNALIRALREGWIAGAGLDVFEEEPLPPDHPLTSLKNVVLTPHIGSATREARQAMTCAVLENLLAFRD
GKIPPNLVNPDVIRVRPPGFRATRC

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=247, Percent_Identity=40.4858299595142, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI23308577, Length=253, Percent_Identity=37.5494071146245, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI61743967, Length=251, Percent_Identity=35.8565737051793, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI4557497, Length=251, Percent_Identity=35.8565737051793, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI145580578, Length=251, Percent_Identity=34.6613545816733, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI4557499, Length=251, Percent_Identity=34.6613545816733, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI145580575, Length=251, Percent_Identity=34.6613545816733, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI87082289, Length=254, Percent_Identity=45.2755905511811, Blast_Score=218, Evalue=4e-58,
Organism=Escherichia coli, GI1789279, Length=262, Percent_Identity=35.8778625954198, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787645, Length=259, Percent_Identity=33.2046332046332, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI87081824, Length=149, Percent_Identity=34.8993288590604, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788660, Length=177, Percent_Identity=37.8531073446328, Blast_Score=77, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=246, Percent_Identity=35.7723577235772, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=253, Percent_Identity=30.8300395256917, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=257, Percent_Identity=38.1322957198444, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320925, Length=242, Percent_Identity=35.1239669421488, Blast_Score=136, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=246, Percent_Identity=34.1463414634146, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=235, Percent_Identity=29.7872340425532, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324980, Length=164, Percent_Identity=33.5365853658537, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=165, Percent_Identity=32.7272727272727, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6321253, Length=153, Percent_Identity=30.718954248366, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571528, Length=241, Percent_Identity=44.8132780082988, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI28574286, Length=225, Percent_Identity=40.4444444444444, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI28574284, Length=237, Percent_Identity=38.3966244725738, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI45551003, Length=237, Percent_Identity=38.3966244725738, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24585514, Length=237, Percent_Identity=38.3966244725738, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28574282, Length=237, Percent_Identity=38.3966244725738, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45552429, Length=237, Percent_Identity=38.3966244725738, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI19921140, Length=246, Percent_Identity=39.8373983739837, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24585516, Length=242, Percent_Identity=31.8181818181818, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24646446, Length=267, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24646448, Length=267, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24646452, Length=267, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24646450, Length=267, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI62472511, Length=217, Percent_Identity=36.405529953917, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 29655; Mature: 29524

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYDNIDVECATRLGVYVTNTPDVLTEATAELTWALIFAVARRIVEADSYVRSGEWYRGR
CCCCCCCCEEEEEECEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TGWHPELMLGMELYGKTLGVIGFGRIGRAVARIGARAFNMKVLYYSRRRAPQHVERELNA
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHCC
EYVSLEELLKRADIVTIHVPLTPETRGMIGERELRLMKPTAILINTARGAVIDTNALIRA
HHCCHHHHHHHCCEEEEEEECCCCCCCCCCCCHHEEECCEEEEEECCCCCEEEHHHHHHH
LREGWIAGAGLDVFEEEPLPPDHPLTSLKNVVLTPHIGSATREARQAMTCAVLENLLAFR
HHHCCCCCCCCCHHCCCCCCCCCCHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
DGKIPPNLVNPDVIRVRPPGFRATRC
CCCCCCCCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure 
GYDNIDVECATRLGVYVTNTPDVLTEATAELTWALIFAVARRIVEADSYVRSGEWYRGR
CCCCCCCEEEEEECEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TGWHPELMLGMELYGKTLGVIGFGRIGRAVARIGARAFNMKVLYYSRRRAPQHVERELNA
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHCC
EYVSLEELLKRADIVTIHVPLTPETRGMIGERELRLMKPTAILINTARGAVIDTNALIRA
HHCCHHHHHHHCCEEEEEEECCCCCCCCCCCCHHEEECCEEEEEECCCCCEEEHHHHHHH
LREGWIAGAGLDVFEEEPLPPDHPLTSLKNVVLTPHIGSATREARQAMTCAVLENLLAFR
HHHCCCCCCCCCHHCCCCCCCCCCHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
DGKIPPNLVNPDVIRVRPPGFRATRC
CCCCCCCCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]