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The map label for this gene is hemD [H]

Identifier: 124027710

GI number: 124027710

Start: 830967

End: 831716

Strand: Reverse

Name: hemD [H]

Synonym: Hbut_0834

Alternate gene names: 124027710

Gene position: 831716-830967 (Counterclockwise)

Preceding gene: 124027711

Following gene: 124027709

Centisome position: 49.89

GC content: 56.0

Gene sequence:

>750_bases
TTGGCGGCTAAGTTAGCGGGTAAGCCGACGATACTACTGCTTCGTCCTCCCGATTCCCAGCCGGGCCCACTAGCCGAGAT
AGGGTATGTGGCACACATACCCATTGTAGAAGTCGTAGCGAGGAGCGGGGCTGTGGAAGAGGTTGCTAGGCTGCTCGGGG
GCTGTGACTGGATAGTATTTACGAGTCCTAGGGCGCCAAGGTTTCTCGCAAAGCTGCTACCTGAGATACGAAGGCTACAG
GAGCAAGGTAGACTACACGTAGCAGTTGTCGGACCCCGCACTGCGAATGTGCTCTCAGAGGCAGGGCTAAGGGTTGACCT
AGTGCCAGGCGAGTACCGTGGAAAAGCAGTGGCGGAGGAGCTCCGTCGGAGAAATCCGCGCTGCGTACTAATACCCAGAT
CTGCGGCGGCAGAGCATAACGACTTCATGTTGTTGCAGAGCATGGGTGTCGAAGTCCGCATAGTACACCTCTACACCGCG
AAACCCGTAGAGAGGCTTGCAAGAATAGCTGCAAGCATAGCAGATGAGTTCGACTACGTGGTCTTCACCAGCCCGAGCAT
AGTCCAGACACTGGCCAGGCACTACAACGGCTCCTACAAGTTTACTGCAGCAGTAATAGGGCCAACTACCCTGGCAGCAC
TGAAGGAGTCCAAGCTAGCCAGGGCCAGGACCATAGTAGCAGAAAAGTATACGATGGATGGCCTAGCGGAGGCTATTCGC
AGGGATTGGGGGAAGAGAGCCGGGTTGTAG

Upstream 100 bases:

>100_bases
TCGGCACCCTAAAGAACATAGCCGTGAAGGCACGCGAGGCGGGCATCGCGCCCCCGGCTGTCATTGTTATTGGTAGAGTG
GTTGAGCTGAGGGAGAAGCT

Downstream 100 bases:

>100_bases
TGGTAGCCGGGCGGGGATTCGAACCCCGGTCACGGGGGTTCCTCCCGGCCAGCCGGCCGGCCCAAAGCCCCGCATCCTTG
GCCGCTAGACGACCCGGCTA

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MAAKLAGKPTILLLRPPDSQPGPLAEIGYVAHIPIVEVVARSGAVEEVARLLGGCDWIVFTSPRAPRFLAKLLPEIRRLQ
EQGRLHVAVVGPRTANVLSEAGLRVDLVPGEYRGKAVAEELRRRNPRCVLIPRSAAAEHNDFMLLQSMGVEVRIVHLYTA
KPVERLARIAASIADEFDYVVFTSPSIVQTLARHYNGSYKFTAAVIGPTTLAALKESKLARARTIVAEKYTMDGLAEAIR
RDWGKRAGL

Sequences:

>Translated_249_residues
MAAKLAGKPTILLLRPPDSQPGPLAEIGYVAHIPIVEVVARSGAVEEVARLLGGCDWIVFTSPRAPRFLAKLLPEIRRLQ
EQGRLHVAVVGPRTANVLSEAGLRVDLVPGEYRGKAVAEELRRRNPRCVLIPRSAAAEHNDFMLLQSMGVEVRIVHLYTA
KPVERLARIAASIADEFDYVVFTSPSIVQTLARHYNGSYKFTAAVIGPTTLAALKESKLARARTIVAEKYTMDGLAEAIR
RDWGKRAGL
>Mature_248_residues
AAKLAGKPTILLLRPPDSQPGPLAEIGYVAHIPIVEVVARSGAVEEVARLLGGCDWIVFTSPRAPRFLAKLLPEIRRLQE
QGRLHVAVVGPRTANVLSEAGLRVDLVPGEYRGKAVAEELRRRNPRCVLIPRSAAAEHNDFMLLQSMGVEVRIVHLYTAK
PVERLARIAASIADEFDYVVFTSPSIVQTLARHYNGSYKFTAAVIGPTTLAALKESKLARARTIVAEKYTMDGLAEAIRR
DWGKRAGL

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 27261; Mature: 27130

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKLAGKPTILLLRPPDSQPGPLAEIGYVAHIPIVEVVARSGAVEEVARLLGGCDWIVF
CCCCCCCCCEEEEEECCCCCCCCHHHHCEEEHHHHHHHHHCCCCHHHHHHHHCCCCEEEE
TSPRAPRFLAKLLPEIRRLQEQGRLHVAVVGPRTANVLSEAGLRVDLVPGEYRGKAVAEE
ECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCEEEECCCCCCCHHHHHH
LRRRNPRCVLIPRSAAAEHNDFMLLQSMGVEVRIVHLYTAKPVERLARIAASIADEFDYV
HHHCCCCEEEEECCCCCCCCCEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCEE
VFTSPSIVQTLARHYNGSYKFTAAVIGPTTLAALKESKLARARTIVAEKYTMDGLAEAIR
EEECCHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDWGKRAGL
HHHHHCCCC
>Mature Secondary Structure 
AAKLAGKPTILLLRPPDSQPGPLAEIGYVAHIPIVEVVARSGAVEEVARLLGGCDWIVF
CCCCCCCCEEEEEECCCCCCCCHHHHCEEEHHHHHHHHHCCCCHHHHHHHHCCCCEEEE
TSPRAPRFLAKLLPEIRRLQEQGRLHVAVVGPRTANVLSEAGLRVDLVPGEYRGKAVAEE
ECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCEEEECCCCCCCHHHHHH
LRRRNPRCVLIPRSAAAEHNDFMLLQSMGVEVRIVHLYTAKPVERLARIAASIADEFDYV
HHHCCCCEEEEECCCCCCCCCEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCEE
VFTSPSIVQTLARHYNGSYKFTAAVIGPTTLAALKESKLARARTIVAEKYTMDGLAEAIR
EEECCHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDWGKRAGL
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]