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The map label for this gene is deoA [C]

Identifier: 124027276

GI number: 124027276

Start: 370391

End: 371899

Strand: Reverse

Name: deoA [C]

Synonym: Hbut_0381

Alternate gene names: 124027276

Gene position: 371899-370391 (Counterclockwise)

Preceding gene: 124027279

Following gene: 124027275

Centisome position: 22.31

GC content: 54.21

Gene sequence:

>1509_bases
ATGCCGGTTAAGGGCTTAAAGGTTGAGGCAGCATCAATAGATCCGGGTCACGATGCTGTCATCCTAAACCCCCGTGATGC
TGAGCATCTCGGTGTAGTAGCCGGCCTGAGAGCCAGCGTAGTCTGCAGGGGTAGAGGTGTCGGAGCAGTAGTTATTGTTG
ATCCCCGGGTCCCCGAGCGTGTTGCACAACTAACCAAGGGCCTCGTTGAGAGACTTGGTGACTGCGATACTGTGGATGTA
CACCCCATTGATGTGCCGCCAAGCTTTGATGCGTTTAAGAAAAGGCTCTCCGGAGCTAGGCTATCCGCTGCAGAGTATAA
GATGCTTATAGCAGACATAGTTGCAGGATACTATGACGATGCACAGATAGCCTCGTTCCTAGTAAGCCAGCTCTACAGCA
AGCTAGCCGACGAGGAGCTAGAGCACCTCATAAGAGCCATGGTGGAGACTGGCGAGGTTGTAAAGTTTGGCGAACCAGTT
TACGATGTTCATAGTATAGGTGGTGTACCCGGAAACAGCAAGGTTGCACTCCTGGTCGTACCCATAGTTGCGTCGCGAGG
CCTACTCATACCAAAGACTAGTAGCAGGGCGATAACGAGTCCGGCAGGCACGGCAGACACGATGGAGGTCCTCGCTAAGG
TCGCGTTCAAGCCACAAGAACTGCATGATATGGCGCTAAGAGCCCGTGGCCTCATAGTCTGGGGTGGCGCGCTAAACCTC
GCACCGGCTGACGACATCTTCGTAAGGGTTGAACGCAGGATAGGTGTGGATCCCCCTACCCAGATGGTTGCCAGTATACT
CGCGAAGAAGCTGGCTATGAGCGTGTCGAGACTGGTGATAGACCTCCCTACAGGCCGGGGCGCTAAGGTGCAGGATGAGA
GTGAGGCTGAGCTACTAGCATCTATGTTCCTTGCCCAGGCTGGGAGGCTAAACATAGCGATGAGAGTTGCGATAACCTTT
GGTGGCGAACCCATAGGCTTCAGTGTTGGCCCAGCACTAGAAGCACGGGAAGCTCTACAAACACTGATGAAGGGTGATGG
AGCGTCAAGCCTGGTGGAGAAGGCTTGCAGCCTAGCAGGCCTAGTCTTTGAACTCGGCGGCGTAGTGCCACGCGGGCGGG
GCTACAGTCTGGCATGCGAGATACTTCGCAGCGGTGCAGCATACCGCAAGTTCCGCGAGATAATAGAGGTTCAGGAGGGT
GATCCCGACATAAAGCCTGAAGACATAAAGTTGGCGCCCAAGCAGTTCACTCTTGAAGCTCCGCGTGACGGCATAGTAAC
AATGATAGACAACCGCGCAATATCGCTCGCAGCTCGTGCGGCAGGAGCACCCGAGGACAAGGGCGCAGGCATACAGCTAC
ACGTCAAGACAGGCTACCGTGTAAGGAAGGGAGACCCCCTGCTAACGATATACGCTTCAAGCGATACAAGGCTCCATGAG
GCAGTGAGACTCCTAGATGAATACAATGCAGTACTTATAGAGGGAGTCGTAGTAAAAGTCTTACCATAG

Upstream 100 bases:

>100_bases
CAACTAGCCCTTAGCGAGTAGGTTTATATGTAGCGTGTAGAATCGAAACCTACCTGTCCCCCGATAATCCAGGCTAAAGG
GGAAGGCGTGGCTGGTGAAT

Downstream 100 bases:

>100_bases
CACGCAGCCACGAAAAATATATACACACCCCATGCCTAGCAGTGCGGTGGCCCCAAACACATCCCAACAAAGCACATGGT
TAGGGGATGAACGGGATGAA

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MPVKGLKVEAASIDPGHDAVILNPRDAEHLGVVAGLRASVVCRGRGVGAVVIVDPRVPERVAQLTKGLVERLGDCDTVDV
HPIDVPPSFDAFKKRLSGARLSAAEYKMLIADIVAGYYDDAQIASFLVSQLYSKLADEELEHLIRAMVETGEVVKFGEPV
YDVHSIGGVPGNSKVALLVVPIVASRGLLIPKTSSRAITSPAGTADTMEVLAKVAFKPQELHDMALRARGLIVWGGALNL
APADDIFVRVERRIGVDPPTQMVASILAKKLAMSVSRLVIDLPTGRGAKVQDESEAELLASMFLAQAGRLNIAMRVAITF
GGEPIGFSVGPALEAREALQTLMKGDGASSLVEKACSLAGLVFELGGVVPRGRGYSLACEILRSGAAYRKFREIIEVQEG
DPDIKPEDIKLAPKQFTLEAPRDGIVTMIDNRAISLAARAAGAPEDKGAGIQLHVKTGYRVRKGDPLLTIYASSDTRLHE
AVRLLDEYNAVLIEGVVVKVLP

Sequences:

>Translated_502_residues
MPVKGLKVEAASIDPGHDAVILNPRDAEHLGVVAGLRASVVCRGRGVGAVVIVDPRVPERVAQLTKGLVERLGDCDTVDV
HPIDVPPSFDAFKKRLSGARLSAAEYKMLIADIVAGYYDDAQIASFLVSQLYSKLADEELEHLIRAMVETGEVVKFGEPV
YDVHSIGGVPGNSKVALLVVPIVASRGLLIPKTSSRAITSPAGTADTMEVLAKVAFKPQELHDMALRARGLIVWGGALNL
APADDIFVRVERRIGVDPPTQMVASILAKKLAMSVSRLVIDLPTGRGAKVQDESEAELLASMFLAQAGRLNIAMRVAITF
GGEPIGFSVGPALEAREALQTLMKGDGASSLVEKACSLAGLVFELGGVVPRGRGYSLACEILRSGAAYRKFREIIEVQEG
DPDIKPEDIKLAPKQFTLEAPRDGIVTMIDNRAISLAARAAGAPEDKGAGIQLHVKTGYRVRKGDPLLTIYASSDTRLHE
AVRLLDEYNAVLIEGVVVKVLP
>Mature_501_residues
PVKGLKVEAASIDPGHDAVILNPRDAEHLGVVAGLRASVVCRGRGVGAVVIVDPRVPERVAQLTKGLVERLGDCDTVDVH
PIDVPPSFDAFKKRLSGARLSAAEYKMLIADIVAGYYDDAQIASFLVSQLYSKLADEELEHLIRAMVETGEVVKFGEPVY
DVHSIGGVPGNSKVALLVVPIVASRGLLIPKTSSRAITSPAGTADTMEVLAKVAFKPQELHDMALRARGLIVWGGALNLA
PADDIFVRVERRIGVDPPTQMVASILAKKLAMSVSRLVIDLPTGRGAKVQDESEAELLASMFLAQAGRLNIAMRVAITFG
GEPIGFSVGPALEAREALQTLMKGDGASSLVEKACSLAGLVFELGGVVPRGRGYSLACEILRSGAAYRKFREIIEVQEGD
PDIKPEDIKLAPKQFTLEAPRDGIVTMIDNRAISLAARAAGAPEDKGAGIQLHVKTGYRVRKGDPLLTIYASSDTRLHEA
VRLLDEYNAVLIEGVVVKVLP

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI166158925, Length=406, Percent_Identity=29.5566502463054, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI4503445, Length=406, Percent_Identity=29.5566502463054, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI166158922, Length=406, Percent_Identity=29.5566502463054, Blast_Score=125, Evalue=9e-29,
Organism=Escherichia coli, GI1790842, Length=408, Percent_Identity=26.7156862745098, Blast_Score=96, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_HYPBU (A2BJU0)

Other databases:

- EMBL:   CP000493
- RefSeq:   YP_001012596.1
- ProteinModelPortal:   A2BJU0
- SMR:   A2BJU0
- STRING:   A2BJU0
- GeneID:   4782885
- GenomeReviews:   CP000493_GR
- KEGG:   hbu:Hbut_0381
- eggNOG:   arNOG04585
- HOGENOM:   HBG460532
- OMA:   GGTADLM
- PhylomeDB:   A2BJU0
- ProtClustDB:   CLSK2399321
- BioCyc:   HBUT415426:HBUT_0381-MONOMER
- HAMAP:   MF_00703
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- SMART:   SM00941
- TIGRFAMs:   TIGR02645

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 53500; Mature: 53369

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKGLKVEAASIDPGHDAVILNPRDAEHLGVVAGLRASVVCRGRGVGAVVIVDPRVPER
CCCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHCCCEEEEEECCCCEEEEEECCCCHHH
VAQLTKGLVERLGDCDTVDVHPIDVPPSFDAFKKRLSGARLSAAEYKMLIADIVAGYYDD
HHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCH
AQIASFLVSQLYSKLADEELEHLIRAMVETGEVVKFGEPVYDVHSIGGVPGNSKVALLVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHCCCCCCCCCEEEEEE
PIVASRGLLIPKTSSRAITSPAGTADTMEVLAKVAFKPQELHDMALRARGLIVWGGALNL
EEHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCEEEECCCCCC
APADDIFVRVERRIGVDPPTQMVASILAKKLAMSVSRLVIDLPTGRGAKVQDESEAELLA
CCCCHHEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHH
SMFLAQAGRLNIAMRVAITFGGEPIGFSVGPALEAREALQTLMKGDGASSLVEKACSLAG
HHHHHCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LVFELGGVVPRGRGYSLACEILRSGAAYRKFREIIEVQEGDPDIKPEDIKLAPKQFTLEA
HHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCEEEEEC
PRDGIVTMIDNRAISLAARAAGAPEDKGAGIQLHVKTGYRVRKGDPLLTIYASSDTRLHE
CCCCEEEEECCCCEEHHHHHCCCCCCCCCCEEEEEECCEEEECCCEEEEEEECCCHHHHH
AVRLLDEYNAVLIEGVVVKVLP
HHHHHHHCCEEEEEEEEEEECC
>Mature Secondary Structure 
PVKGLKVEAASIDPGHDAVILNPRDAEHLGVVAGLRASVVCRGRGVGAVVIVDPRVPER
CCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHCCCEEEEEECCCCEEEEEECCCCHHH
VAQLTKGLVERLGDCDTVDVHPIDVPPSFDAFKKRLSGARLSAAEYKMLIADIVAGYYDD
HHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCH
AQIASFLVSQLYSKLADEELEHLIRAMVETGEVVKFGEPVYDVHSIGGVPGNSKVALLVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHCCCCCCCCCEEEEEE
PIVASRGLLIPKTSSRAITSPAGTADTMEVLAKVAFKPQELHDMALRARGLIVWGGALNL
EEHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCEEEECCCCCC
APADDIFVRVERRIGVDPPTQMVASILAKKLAMSVSRLVIDLPTGRGAKVQDESEAELLA
CCCCHHEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHH
SMFLAQAGRLNIAMRVAITFGGEPIGFSVGPALEAREALQTLMKGDGASSLVEKACSLAG
HHHHHCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LVFELGGVVPRGRGYSLACEILRSGAAYRKFREIIEVQEGDPDIKPEDIKLAPKQFTLEA
HHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCEEEEEC
PRDGIVTMIDNRAISLAARAAGAPEDKGAGIQLHVKTGYRVRKGDPLLTIYASSDTRLHE
CCCCEEEEECCCCEEHHHHHCCCCCCCCCCEEEEEECCEEEECCCEEEEEEECCCHHHHH
AVRLLDEYNAVLIEGVVVKVLP
HHHHHHHCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA