Click here to switch to the map view.

The map label for this gene is nuoL [H]

Identifier: 124027088

GI number: 124027088

Start: 171291

End: 173255

Strand: Direct

Name: nuoL [H]

Synonym: Hbut_0191

Alternate gene names: 124027088

Gene position: 171291-173255 (Clockwise)

Preceding gene: 124027087

Following gene: 124027089

Centisome position: 10.27

GC content: 59.03

Gene sequence:

>1965_bases
ATGGTTGAGCCTGGCGTTGCAGCTCTCGTGGCGGTGTTCGCGGAGTATGCCGCGGCACTTGTAGCCCTACTGCTGGGTGC
TGCTGGAGCCCGGTGGCGTGGCATAGCGTGGACCGGTGTTGCCGGCGCAGCAGTATCAATGGTTGCTTCGTGGCTGGCGT
TCCTCGGCGGCGAGGGTAGGCTGGAGTACGAGTGGGTTAGGAGCCTGGGCGTAGCCTTTAGCCTCGACGTGGACCTACTA
GCAGCCATCATGGGTGTTGTTGTCGCCACGCTGAGCTTCCTAATAGCAGTCTACAGCGTCGAGTATATCGGTGAGTGGGG
TGCGCCCAGGTACTGGTTCTTCTACAGCTTCTTCGTTGCCAGCATGCTATTGCTAGTCTACGCTGGCGACATGATAACAC
TGTTCATAGGCTGGGAGGGCACTGGGCTTTCGAGCTGGGCGCTGATAGGCTTCTACTACGATGAGAGGGAGGAGGCGTGG
GTTGGCGATCCTGGCCGTGTAGCGCTAGGCGTGCCGATGTGGTTTACTCCGACCCATAGCGGGCTGAGGGCGATAGTGTT
TACGAGGCTCGGCGATATGGGTATGCTGATAGGCATGGGTATGGTGTACGCCATTATAGGTACTACCAGCATAGCAGCAA
TGGCAGTTGCTATGAACAGTGTAGCGCTCAACATGTATGTTAAGGGCGTACTGGCTGCATGGGTGATACTATTCTACCTT
GGCGCGCTGGCTAAGAGCGCACAGTTCCCCTTCCACGAGTGGCTTGTAACGGCAATGACAGGCCCAACATCGGTATCAGC
GCTAATACATGCTGCGACAATGGTGAAGGCTGGCGTCTACTTTGCGCTGCGTTTCACCCCGTTCATAGCGCCGGCGCTGT
TCTGGGTTGGCGCCGGGATAGCTTCGATGAAGGCACTTGCGTGGCTAGCACTCCTAACAGCCTTCGCCACGGCGACAATG
GCGATTGTAGCTAGGGAGCTGAAGCTCATACTAGCGTTCTCGACGGCTAGCCAGCTATCCTACATGCTCGGCGCTGTCTT
CGCAGCAGCGGCTGCAGGAGACCCGGCACTGGGCAGCCTCGGCGGCCTAGCTCATCTAGTGTCACATGCAGTGTTCAAGG
CAGCACTATTCCTCGGTGCTGGCGCGATAATACATGCTGTCCACAGCAGATACATAACCGACATGGGCGGCCTACGCCGC
CACATGCCCTACACGTTCGCCGCAATGCTACTGGCTGGCGCTAGCCTGGCGGCACTGCCACCGTTCTCGGGCTGGTGGAG
CAAGGACCTAGCAGTAAGGGCTATAGCTAGCCTTGGAGGCTTCGCCGAGGCAGTGGCGCTGCTGACAGCTGTTATCACGG
CCGCGTACACGTTCAGAATGATATACTACGTGTTCTTTGGCGAGCCTCGGTTCCACGGCGAGCACGTCCACGAGGCTCCA
GGGCTTATGCTCGGCCCCTACCTGGTGCTCGGCCTAGCAGCCCTCGGCCTAGGCGCAGTGTGGCCCTGGGTGGAGCATTA
CTTCGCGGAGGCCAGCGGCGCGGGCCACGTGGGCATGGAGCTGGCGACGGTGCTGTGGGGCACTCTGGCCGCCCTAGCTG
GCACCTCAACAGTAGCACTCTACTTTGCCGGCATGCTGAAGCCAAACAGGCCCATTGTGAGCCCGGTTGAGAGAGCAATT
CACGACTTCCTATACGACCGCTGGTACGTAAACGCTATCATCTACAAGCTGATAGTCTATCCAGGCGCTAGCCTTGCCAG
GGCCCTATGGGGGCTGGAGAAGCTGCTCGACACCGGCCTACATGTTGTGTTGCCAAGTGCCGCGGAGGCTGTTAGCACCG
GGCTTCGGAGGAGGTTACAGTCGGGCGACCTACGCCTATACCTTGCGCTATTCGCCGTTGGACTTGCTTTAGCCCTACTC
CTTGCCCTTGCTTTTTCACCAGCCCAACTCCATGTTGGTAGCTAG

Upstream 100 bases:

>100_bases
CTCGCGGTTCTCGGTGTCACCCTGTTTGTTGCTGCGGGTGTACTCGTGGATCCACTCGTAGACTTCCTAAGGGTGGTGTA
TGGCTAGGGGGTGATGCCTA

Downstream 100 bases:

>100_bases
CAGTGACGCGTGTTGGCCGGGTGAGAGGCCATGGCGGTGGTTGAGCTGCTCGTGGGCGACTACGGGTTTGCCCTAGGCGT
AGGCCTCTACGCTGCAGCAG

Product: NADH-quinone oxidoreductase chain 12

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 654; Mature: 654

Protein sequence:

>654_residues
MVEPGVAALVAVFAEYAAALVALLLGAAGARWRGIAWTGVAGAAVSMVASWLAFLGGEGRLEYEWVRSLGVAFSLDVDLL
AAIMGVVVATLSFLIAVYSVEYIGEWGAPRYWFFYSFFVASMLLLVYAGDMITLFIGWEGTGLSSWALIGFYYDEREEAW
VGDPGRVALGVPMWFTPTHSGLRAIVFTRLGDMGMLIGMGMVYAIIGTTSIAAMAVAMNSVALNMYVKGVLAAWVILFYL
GALAKSAQFPFHEWLVTAMTGPTSVSALIHAATMVKAGVYFALRFTPFIAPALFWVGAGIASMKALAWLALLTAFATATM
AIVARELKLILAFSTASQLSYMLGAVFAAAAAGDPALGSLGGLAHLVSHAVFKAALFLGAGAIIHAVHSRYITDMGGLRR
HMPYTFAAMLLAGASLAALPPFSGWWSKDLAVRAIASLGGFAEAVALLTAVITAAYTFRMIYYVFFGEPRFHGEHVHEAP
GLMLGPYLVLGLAALGLGAVWPWVEHYFAEASGAGHVGMELATVLWGTLAALAGTSTVALYFAGMLKPNRPIVSPVERAI
HDFLYDRWYVNAIIYKLIVYPGASLARALWGLEKLLDTGLHVVLPSAAEAVSTGLRRRLQSGDLRLYLALFAVGLALALL
LALAFSPAQLHVGS

Sequences:

>Translated_654_residues
MVEPGVAALVAVFAEYAAALVALLLGAAGARWRGIAWTGVAGAAVSMVASWLAFLGGEGRLEYEWVRSLGVAFSLDVDLL
AAIMGVVVATLSFLIAVYSVEYIGEWGAPRYWFFYSFFVASMLLLVYAGDMITLFIGWEGTGLSSWALIGFYYDEREEAW
VGDPGRVALGVPMWFTPTHSGLRAIVFTRLGDMGMLIGMGMVYAIIGTTSIAAMAVAMNSVALNMYVKGVLAAWVILFYL
GALAKSAQFPFHEWLVTAMTGPTSVSALIHAATMVKAGVYFALRFTPFIAPALFWVGAGIASMKALAWLALLTAFATATM
AIVARELKLILAFSTASQLSYMLGAVFAAAAAGDPALGSLGGLAHLVSHAVFKAALFLGAGAIIHAVHSRYITDMGGLRR
HMPYTFAAMLLAGASLAALPPFSGWWSKDLAVRAIASLGGFAEAVALLTAVITAAYTFRMIYYVFFGEPRFHGEHVHEAP
GLMLGPYLVLGLAALGLGAVWPWVEHYFAEASGAGHVGMELATVLWGTLAALAGTSTVALYFAGMLKPNRPIVSPVERAI
HDFLYDRWYVNAIIYKLIVYPGASLARALWGLEKLLDTGLHVVLPSAAEAVSTGLRRRLQSGDLRLYLALFAVGLALALL
LALAFSPAQLHVGS
>Mature_654_residues
MVEPGVAALVAVFAEYAAALVALLLGAAGARWRGIAWTGVAGAAVSMVASWLAFLGGEGRLEYEWVRSLGVAFSLDVDLL
AAIMGVVVATLSFLIAVYSVEYIGEWGAPRYWFFYSFFVASMLLLVYAGDMITLFIGWEGTGLSSWALIGFYYDEREEAW
VGDPGRVALGVPMWFTPTHSGLRAIVFTRLGDMGMLIGMGMVYAIIGTTSIAAMAVAMNSVALNMYVKGVLAAWVILFYL
GALAKSAQFPFHEWLVTAMTGPTSVSALIHAATMVKAGVYFALRFTPFIAPALFWVGAGIASMKALAWLALLTAFATATM
AIVARELKLILAFSTASQLSYMLGAVFAAAAAGDPALGSLGGLAHLVSHAVFKAALFLGAGAIIHAVHSRYITDMGGLRR
HMPYTFAAMLLAGASLAALPPFSGWWSKDLAVRAIASLGGFAEAVALLTAVITAAYTFRMIYYVFFGEPRFHGEHVHEAP
GLMLGPYLVLGLAALGLGAVWPWVEHYFAEASGAGHVGMELATVLWGTLAALAGTSTVALYFAGMLKPNRPIVSPVERAI
HDFLYDRWYVNAIIYKLIVYPGASLARALWGLEKLLDTGLHVVLPSAAEAVSTGLRRRLQSGDLRLYLALFAVGLALALL
LALAFSPAQLHVGS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=426, Percent_Identity=29.5774647887324, Blast_Score=166, Evalue=5e-41,
Organism=Escherichia coli, GI1788614, Length=437, Percent_Identity=37.2997711670481, Blast_Score=202, Evalue=6e-53,
Organism=Escherichia coli, GI1788829, Length=369, Percent_Identity=27.6422764227642, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI1788827, Length=464, Percent_Identity=28.8793103448276, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788831, Length=378, Percent_Identity=26.4550264550265, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI2367154, Length=218, Percent_Identity=32.5688073394495, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 69553; Mature: 69553

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEPGVAALVAVFAEYAAALVALLLGAAGARWRGIAWTGVAGAAVSMVASWLAFLGGEGR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCC
LEYEWVRSLGVAFSLDVDLLAAIMGVVVATLSFLIAVYSVEYIGEWGAPRYWFFYSFFVA
CHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
SMLLLVYAGDMITLFIGWEGTGLSSWALIGFYYDEREEAWVGDPGRVALGVPMWFTPTHS
HHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCEEECCCCC
GLRAIVFTRLGDMGMLIGMGMVYAIIGTTSIAAMAVAMNSVALNMYVKGVLAAWVILFYL
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GALAKSAQFPFHEWLVTAMTGPTSVSALIHAATMVKAGVYFALRFTPFIAPALFWVGAGI
HHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ASMKALAWLALLTAFATATMAIVARELKLILAFSTASQLSYMLGAVFAAAAAGDPALGSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
GGLAHLVSHAVFKAALFLGAGAIIHAVHSRYITDMGGLRRHMPYTFAAMLLAGASLAALP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHCCC
PFSGWWSKDLAVRAIASLGGFAEAVALLTAVITAAYTFRMIYYVFFGEPRFHGEHVHEAP
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCC
GLMLGPYLVLGLAALGLGAVWPWVEHYFAEASGAGHVGMELATVLWGTLAALAGTSTVAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
YFAGMLKPNRPIVSPVERAIHDFLYDRWYVNAIIYKLIVYPGASLARALWGLEKLLDTGL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
HVVLPSAAEAVSTGLRRRLQSGDLRLYLALFAVGLALALLLALAFSPAQLHVGS
EEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCC
>Mature Secondary Structure
MVEPGVAALVAVFAEYAAALVALLLGAAGARWRGIAWTGVAGAAVSMVASWLAFLGGEGR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCC
LEYEWVRSLGVAFSLDVDLLAAIMGVVVATLSFLIAVYSVEYIGEWGAPRYWFFYSFFVA
CHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
SMLLLVYAGDMITLFIGWEGTGLSSWALIGFYYDEREEAWVGDPGRVALGVPMWFTPTHS
HHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCEEECCCCC
GLRAIVFTRLGDMGMLIGMGMVYAIIGTTSIAAMAVAMNSVALNMYVKGVLAAWVILFYL
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GALAKSAQFPFHEWLVTAMTGPTSVSALIHAATMVKAGVYFALRFTPFIAPALFWVGAGI
HHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ASMKALAWLALLTAFATATMAIVARELKLILAFSTASQLSYMLGAVFAAAAAGDPALGSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
GGLAHLVSHAVFKAALFLGAGAIIHAVHSRYITDMGGLRRHMPYTFAAMLLAGASLAALP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHCCC
PFSGWWSKDLAVRAIASLGGFAEAVALLTAVITAAYTFRMIYYVFFGEPRFHGEHVHEAP
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCC
GLMLGPYLVLGLAALGLGAVWPWVEHYFAEASGAGHVGMELATVLWGTLAALAGTSTVAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
YFAGMLKPNRPIVSPVERAIHDFLYDRWYVNAIIYKLIVYPGASLARALWGLEKLLDTGL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
HVVLPSAAEAVSTGLRRRLQSGDLRLYLALFAVGLALALLLALAFSPAQLHVGS
EEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]